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  1. Article ; Online: Surviving Serum: the Escherichia coli

    Biran, Dvora / Sura, Thomas / Otto, Andreas / Yair, Yael / Becher, Dörte / Ron, Eliora Z

    Infection and immunity

    2021  Volume 89, Issue 10, Page(s) e0031621

    Abstract: Extraintestinal pathogenic Escherichia coli (ExPEC) strains constitute a serious and emerging clinical problem, as they cause a variety of infections and are usually highly antibiotic resistant. Many ExPEC strains are capable of evading the bactericidal ... ...

    Abstract Extraintestinal pathogenic Escherichia coli (ExPEC) strains constitute a serious and emerging clinical problem, as they cause a variety of infections and are usually highly antibiotic resistant. Many ExPEC strains are capable of evading the bactericidal effects of serum and causing sepsis. One critical factor for the development of septicemia is the increased serum survival (
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Drug Resistance, Bacterial/genetics ; Escherichia coli Infections/drug therapy ; Escherichia coli Infections/microbiology ; Escherichia coli Proteins/genetics ; Extraintestinal Pathogenic Escherichia coli/drug effects ; Extraintestinal Pathogenic Escherichia coli/genetics ; Humans ; Sepsis/drug therapy ; Sepsis/microbiology ; Serum/microbiology
    Chemical Substances Anti-Bacterial Agents ; Escherichia coli Proteins ; Iss protein, E coli
    Language English
    Publishing date 2021-06-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/IAI.00316-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: D-dimer and C-reactive Protein Blood Levels Over Time Used to Predict Pulmonary Embolism in Two COVID-19 Patients.

    Becher, Yael / Goldman, Leonid / Schacham, Nadav / Gringauz, Irina / Justo, Dan

    European journal of case reports in internal medicine

    2020  Volume 7, Issue 6, Page(s) 1725

    Abstract: The diagnosis of pulmonary embolism is challenging in symptomatic COVID-19 patients since shortness of breath, chest pain, tachycardia, tachypnoea, fever, oxygen desaturation and high D-dimer blood levels might be features of both diseases. We present ... ...

    Abstract The diagnosis of pulmonary embolism is challenging in symptomatic COVID-19 patients since shortness of breath, chest pain, tachycardia, tachypnoea, fever, oxygen desaturation and high D-dimer blood levels might be features of both diseases. We present two COVID-19 patients in whom pulmonary embolism was suspected (and diagnosed) due to a discrepancy between an increase in D-dimer blood levels and a decrease in C-reactive protein blood levels over time. We believe that an opposite change in the blood levels of both biomarkers over time may be used as a novel method to predict pulmonary embolism in COVID-19 patients.
    Learning points: The diagnosis of pulmonary embolism is challenging in COVID-19 patients since symptoms, signs and high D-dimer blood levels might be similar in both diseases.An increase in D-dimer blood levels and a decrease in C-reactive protein blood levels over time may be used as a novel method to predict pulmonary embolism in COVID-19 patients.
    Keywords covid19
    Language English
    Publishing date 2020-05-20
    Publishing country Italy
    Document type Journal Article
    ISSN 2284-2594
    ISSN (online) 2284-2594
    DOI 10.12890/2020_001725
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: D-dimer and C-reactive Protein Blood Levels Over Time Used to Predict Pulmonary Embolism in Two COVID-19 Patients

    Yael Becher / Leonid Goldman / Nadav Schacham / Irina Gringauz / Dan Justo

    European Journal of Case Reports in Internal Medicine (2020)

    2020  

    Abstract: The diagnosis of pulmonary embolism is challenging in symptomatic COVID-19 patients since shortness of breath, chest pain, tachycardia, tachypnoea, fever, oxygen desaturation and high D-dimer blood levels might be features of both diseases. We present ... ...

    Abstract The diagnosis of pulmonary embolism is challenging in symptomatic COVID-19 patients since shortness of breath, chest pain, tachycardia, tachypnoea, fever, oxygen desaturation and high D-dimer blood levels might be features of both diseases. We present two COVID-19 patients in whom pulmonary embolism was suspected (and diagnosed) due to a discrepancy between an increase in D-dimer blood levels and a decrease in C-reactive protein blood levels over time. We believe that an opposite change in the blood levels of both biomarkers over time may be used as a novel method to predict pulmonary embolism in COVID-19 patients.
    Keywords covid-19 ; c-reactive protein ; d-dimer ; pulmonary embolism ; Medicine ; R ; covid19
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher SMC MEDIA SRL
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: D-dimer and C-reactive protein blood levels over time used to predict pulmonary embolism in two covid-19 patients

    Becher, Yael / Goldman, Leonid / Schacham, Nadav / Gringauz, Irina / Justo, Dan

    Eur. J. Case Rep. Intern. Med.

    Abstract: The diagnosis of pulmonary embolism is challenging in symptomatic COVID-19 patients since shortness of breath, chest pain, tachycardia, tachypnoea, fever, oxygen desaturation and high D-dimer blood levels might be features of both diseases. We present ... ...

    Abstract The diagnosis of pulmonary embolism is challenging in symptomatic COVID-19 patients since shortness of breath, chest pain, tachycardia, tachypnoea, fever, oxygen desaturation and high D-dimer blood levels might be features of both diseases. We present two COVID-19 patients in whom pulmonary embolism was suspected (and diagnosed) due to a discrepancy between an increase in D-dimer blood levels and a decrease in C-reactive protein blood levels over time. We believe that an opposite change in the blood levels of both biomarkers over time may be used as a novel method to predict pulmonary embolism in COVID-19 patients.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #596645
    Database COVID19

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  5. Article ; Online: The Escherichia coli Type III Secretion System 2 Has a Global Effect on Cell Surface.

    Shulman, Alexander / Yair, Yael / Biran, Dvora / Sura, Thomas / Otto, Andreas / Gophna, Uri / Becher, Dörte / Hecker, Michael / Ron, Eliora Z

    mBio

    2018  Volume 9, Issue 4

    Abstract: Many strains ... ...

    Abstract Many strains of
    MeSH term(s) Escherichia coli/enzymology ; Escherichia coli/genetics ; Escherichia coli/physiology ; Escherichia coli Proteins/metabolism ; Fimbriae, Bacterial/metabolism ; Flagella/metabolism ; Flagella/physiology ; Flagellin/genetics ; Flagellin/metabolism ; Genomic Islands ; Locomotion ; Membrane Proteins/metabolism ; Multigene Family ; Sequence Deletion ; Type III Secretion Systems/genetics ; Type III Secretion Systems/metabolism
    Chemical Substances Escherichia coli Proteins ; Membrane Proteins ; Type III Secretion Systems ; Flagellin (12777-81-0)
    Language English
    Publishing date 2018-07-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.01070-18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Author Correction: A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers.

    Coignard, Juliette / Lush, Michael / Beesley, Jonathan / O'Mara, Tracy A / Dennis, Joe / Tyrer, Jonathan P / Barnes, Daniel R / McGuffog, Lesley / Leslie, Goska / Bolla, Manjeet K / Adank, Muriel A / Agata, Simona / Ahearn, Thomas / Aittomäki, Kristiina / Andrulis, Irene L / Anton-Culver, Hoda / Arndt, Volker / Arnold, Norbert / Aronson, Kristan J /
    Arun, Banu K / Augustinsson, Annelie / Azzollini, Jacopo / Barrowdale, Daniel / Baynes, Caroline / Becher, Heko / Bermisheva, Marina / Bernstein, Leslie / Białkowska, Katarzyna / Blomqvist, Carl / Bojesen, Stig E / Bonanni, Bernardo / Borg, Ake / Brauch, Hiltrud / Brenner, Hermann / Burwinkel, Barbara / Buys, Saundra S / Caldés, Trinidad / Caligo, Maria A / Campa, Daniele / Carter, Brian D / Castelao, Jose E / Chang-Claude, Jenny / Chanock, Stephen J / Chung, Wendy K / Claes, Kathleen B M / Clarke, Christine L / Collée, J Margriet / Conroy, Don M / Czene, Kamila / Daly, Mary B / Devilee, Peter / Diez, Orland / Ding, Yuan Chun / Domchek, Susan M / Dörk, Thilo / Dos-Santos-Silva, Isabel / Dunning, Alison M / Dwek, Miriam / Eccles, Diana M / Eliassen, A Heather / Engel, Christoph / Eriksson, Mikael / Evans, D Gareth / Fasching, Peter A / Flyger, Henrik / Fostira, Florentia / Friedman, Eitan / Fritschi, Lin / Frost, Debra / Gago-Dominguez, Manuela / Gapstur, Susan M / Garber, Judy / Garcia-Barberan, Vanesa / García-Closas, Montserrat / García-Sáenz, José A / Gaudet, Mia M / Gayther, Simon A / Gehrig, Andrea / Georgoulias, Vassilios / Giles, Graham G / Godwin, Andrew K / Goldberg, Mark S / Goldgar, David E / González-Neira, Anna / Greene, Mark H / Guénel, Pascal / Haeberle, Lothar / Hahnen, Eric / Haiman, Christopher A / Håkansson, Niclas / Hall, Per / Hamann, Ute / Harrington, Patricia A / Hart, Steven N / He, Wei / Hogervorst, Frans B L / Hollestelle, Antoinette / Hopper, John L / Horcasitas, Darling J / Hulick, Peter J / Hunter, David J / Imyanitov, Evgeny N / Jager, Agnes / Jakubowska, Anna / James, Paul A / Jensen, Uffe Birk / John, Esther M / Jones, Michael E / Kaaks, Rudolf / Kapoor, Pooja Middha / Karlan, Beth Y / Keeman, Renske / Khusnutdinova, Elza / Kiiski, Johanna I / Ko, Yon-Dschun / Kosma, Veli-Matti / Kraft, Peter / Kurian, Allison W / Laitman, Yael / Lambrechts, Diether / Le Marchand, Loic / Lester, Jenny / Lesueur, Fabienne / Lindstrom, Tricia / Lopez-Fernández, Adria / Loud, Jennifer T / Luccarini, Craig / Mannermaa, Arto / Manoukian, Siranoush / Margolin, Sara / Martens, John W M / Mebirouk, Noura / Meindl, Alfons / Miller, Austin / Milne, Roger L / Montagna, Marco / Nathanson, Katherine L / Neuhausen, Susan L / Nevanlinna, Heli / Nielsen, Finn C / O'Brien, Katie M / Olopade, Olufunmilayo I / Olson, Janet E / Olsson, Håkan / Osorio, Ana / Ottini, Laura / Park-Simon, Tjoung-Won / Parsons, Michael T / Pedersen, Inge Sokilde / Peshkin, Beth / Peterlongo, Paolo / Peto, Julian / Pharoah, Paul D P / Phillips, Kelly-Anne / Polley, Eric C / Poppe, Bruce / Presneau, Nadege / Pujana, Miquel Angel / Punie, Kevin / Radice, Paolo / Rantala, Johanna / Rashid, Muhammad U / Rennert, Gad / Rennert, Hedy S / Robson, Mark / Romero, Atocha / Rossing, Maria / Saloustros, Emmanouil / Sandler, Dale P / Santella, Regina / Scheuner, Maren T / Schmidt, Marjanka K / Schmidt, Gunnar / Scott, Christopher / Sharma, Priyanka / Soucy, Penny / Southey, Melissa C / Spinelli, John J / Steinsnyder, Zoe / Stone, Jennifer / Stoppa-Lyonnet, Dominique / Swerdlow, Anthony / Tamimi, Rulla M / Tapper, William J / Taylor, Jack A / Terry, Mary Beth / Teulé, Alex / Thull, Darcy L / Tischkowitz, Marc / Toland, Amanda E / Torres, Diana / Trainer, Alison H / Truong, Thérèse / Tung, Nadine / Vachon, Celine M / Vega, Ana / Vijai, Joseph / Wang, Qin / Wappenschmidt, Barbara / Weinberg, Clarice R / Weitzel, Jeffrey N / Wendt, Camilla / Wolk, Alicja / Yadav, Siddhartha / Yang, Xiaohong R / Yannoukakos, Drakoulis / Zheng, Wei / Ziogas, Argyrios / Zorn, Kristin K / Park, Sue K / Thomassen, Mads / Offit, Kenneth / Schmutzler, Rita K / Couch, Fergus J / Simard, Jacques / Chenevix-Trench, Georgia / Easton, Douglas F / Andrieu, Nadine / Antoniou, Antonis C

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 2986

    Abstract: A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-23162-4. ...

    Abstract A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-23162-4.
    Language English
    Publishing date 2021-05-14
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-23162-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers.

    Coignard, Juliette / Lush, Michael / Beesley, Jonathan / O'Mara, Tracy A / Dennis, Joe / Tyrer, Jonathan P / Barnes, Daniel R / McGuffog, Lesley / Leslie, Goska / Bolla, Manjeet K / Adank, Muriel A / Agata, Simona / Ahearn, Thomas / Aittomäki, Kristiina / Andrulis, Irene L / Anton-Culver, Hoda / Arndt, Volker / Arnold, Norbert / Aronson, Kristan J /
    Arun, Banu K / Augustinsson, Annelie / Azzollini, Jacopo / Barrowdale, Daniel / Baynes, Caroline / Becher, Heiko / Bermisheva, Marina / Bernstein, Leslie / Białkowska, Katarzyna / Blomqvist, Carl / Bojesen, Stig E / Bonanni, Bernardo / Borg, Ake / Brauch, Hiltrud / Brenner, Hermann / Burwinkel, Barbara / Buys, Saundra S / Caldés, Trinidad / Caligo, Maria A / Campa, Daniele / Carter, Brian D / Castelao, Jose E / Chang-Claude, Jenny / Chanock, Stephen J / Chung, Wendy K / Claes, Kathleen B M / Clarke, Christine L / Collée, J Margriet / Conroy, Don M / Czene, Kamila / Daly, Mary B / Devilee, Peter / Diez, Orland / Ding, Yuan Chun / Domchek, Susan M / Dörk, Thilo / Dos-Santos-Silva, Isabel / Dunning, Alison M / Dwek, Miriam / Eccles, Diana M / Eliassen, A Heather / Engel, Christoph / Eriksson, Mikael / Evans, D Gareth / Fasching, Peter A / Flyger, Henrik / Fostira, Florentia / Friedman, Eitan / Fritschi, Lin / Frost, Debra / Gago-Dominguez, Manuela / Gapstur, Susan M / Garber, Judy / Garcia-Barberan, Vanesa / García-Closas, Montserrat / García-Sáenz, José A / Gaudet, Mia M / Gayther, Simon A / Gehrig, Andrea / Georgoulias, Vassilios / Giles, Graham G / Godwin, Andrew K / Goldberg, Mark S / Goldgar, David E / González-Neira, Anna / Greene, Mark H / Guénel, Pascal / Haeberle, Lothar / Hahnen, Eric / Haiman, Christopher A / Håkansson, Niclas / Hall, Per / Hamann, Ute / Harrington, Patricia A / Hart, Steven N / He, Wei / Hogervorst, Frans B L / Hollestelle, Antoinette / Hopper, John L / Horcasitas, Darling J / Hulick, Peter J / Hunter, David J / Imyanitov, Evgeny N / Jager, Agnes / Jakubowska, Anna / James, Paul A / Jensen, Uffe Birk / John, Esther M / Jones, Michael E / Kaaks, Rudolf / Kapoor, Pooja Middha / Karlan, Beth Y / Keeman, Renske / Khusnutdinova, Elza / Kiiski, Johanna I / Ko, Yon-Dschun / Kosma, Veli-Matti / Kraft, Peter / Kurian, Allison W / Laitman, Yael / Lambrechts, Diether / Le Marchand, Loic / Lester, Jenny / Lesueur, Fabienne / Lindstrom, Tricia / Lopez-Fernández, Adria / Loud, Jennifer T / Luccarini, Craig / Mannermaa, Arto / Manoukian, Siranoush / Margolin, Sara / Martens, John W M / Mebirouk, Noura / Meindl, Alfons / Miller, Austin / Milne, Roger L / Montagna, Marco / Nathanson, Katherine L / Neuhausen, Susan L / Nevanlinna, Heli / Nielsen, Finn C / O'Brien, Katie M / Olopade, Olufunmilayo I / Olson, Janet E / Olsson, Håkan / Osorio, Ana / Ottini, Laura / Park-Simon, Tjoung-Won / Parsons, Michael T / Pedersen, Inge Sokilde / Peshkin, Beth / Peterlongo, Paolo / Peto, Julian / Pharoah, Paul D P / Phillips, Kelly-Anne / Polley, Eric C / Poppe, Bruce / Presneau, Nadege / Pujana, Miquel Angel / Punie, Kevin / Radice, Paolo / Rantala, Johanna / Rashid, Muhammad U / Rennert, Gad / Rennert, Hedy S / Robson, Mark / Romero, Atocha / Rossing, Maria / Saloustros, Emmanouil / Sandler, Dale P / Santella, Regina / Scheuner, Maren T / Schmidt, Marjanka K / Schmidt, Gunnar / Scott, Christopher / Sharma, Priyanka / Soucy, Penny / Southey, Melissa C / Spinelli, John J / Steinsnyder, Zoe / Stone, Jennifer / Stoppa-Lyonnet, Dominique / Swerdlow, Anthony / Tamimi, Rulla M / Tapper, William J / Taylor, Jack A / Terry, Mary Beth / Teulé, Alex / Thull, Darcy L / Tischkowitz, Marc / Toland, Amanda E / Torres, Diana / Trainer, Alison H / Truong, Thérèse / Tung, Nadine / Vachon, Celine M / Vega, Ana / Vijai, Joseph / Wang, Qin / Wappenschmidt, Barbara / Weinberg, Clarice R / Weitzel, Jeffrey N / Wendt, Camilla / Wolk, Alicja / Yadav, Siddhartha / Yang, Xiaohong R / Yannoukakos, Drakoulis / Zheng, Wei / Ziogas, Argyrios / Zorn, Kristin K / Park, Sue K / Thomassen, Mads / Offit, Kenneth / Schmutzler, Rita K / Couch, Fergus J / Simard, Jacques / Chenevix-Trench, Georgia / Easton, Douglas F / Andrieu, Nadine / Antoniou, Antonis C

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 1078

    Abstract: Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general population studies. Other ... ...

    Abstract Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general population studies. Other mutation carrier-specific susceptibility variants may exist but studies of mutation carriers have so far been underpowered. We conduct a novel case-only genome-wide association study comparing genotype frequencies between 60,212 general population BC cases and 13,007 cases with BRCA1 or BRCA2 mutations. We identify robust novel associations for 2 variants with BC for BRCA1 and 3 for BRCA2 mutation carriers, P < 10
    MeSH term(s) Adult ; Alleles ; BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; Breast Neoplasms/genetics ; Female ; Genetic Predisposition to Disease/genetics ; Genome-Wide Association Study/methods ; Genotype ; Humans ; Linkage Disequilibrium ; Middle Aged ; Mutation ; Polymorphism, Single Nucleotide ; Quantitative Trait Loci/genetics ; Risk Factors
    Chemical Substances BRCA1 Protein ; BRCA1 protein, human ; BRCA2 Protein ; BRCA2 protein, human
    Language English
    Publishing date 2021-02-17
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-020-20496-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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