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Article ; Online: Evaluation of a point-of-care method for screening blood donors for sickle cell status.

Badawi, Maha / Garoot, Sara / Tahlawi, Mofida / Hindawi, Salwa / Adam, Soheir

2020 Volume 60 Suppl 1, Page(s) S10–S14

Abstract: ... S among blood donors and when used for testing blood units. ...

Abstract	Background: Turbidity tests are commonly used for screening blood units for the presence of sickle cell trait (SCT) before transfusion to specific patient populations, based on recommendations of the AABB. In this pilot study, we evaluate a new method for screening blood donors and blood units for the presence of sickle hemoglobin. Study design and methods: This study was based at King Abdulaziz University Hospital in Jeddah, Saudi Arabia. Study participants were approached consecutively between July 24, 2016, and August 8, 2016. Blood donors, control individuals, and known patients with sickle cell disease (SCD) were tested using both a point-of-care testing technology (Sickle SCAN, Biomedomics, Inc.) and hemoglobin capillary electrophoresis (HEP). Corresponding blood units were also tested using Sickle SCAN. Results: A total of 200 donors, 13 blood units, and 57 patients and controls were included. Sensitivity and specificity of Sickle SCAN for detection of SCT and SCD was 100%, when compared to HEP as the gold standard. Conclusion: Sickle SCAN is a rapid test that shows high sensitivity and specificity for identification of hemoglobin S among blood donors and when used for testing blood units.
MeSH term(s)	Adult ; Anemia, Sickle Cell/diagnosis ; Blood Donors ; Electrophoresis, Capillary/methods ; Female ; Hemoglobin A/analysis ; Hospitals, University ; Humans ; Male ; Pilot Projects ; Point-of-Care Systems ; Reagent Kits, Diagnostic ; Young Adult
Chemical Substances	Reagent Kits, Diagnostic ; Hemoglobin A (9034-51-9)
Language	English
Publishing date	2020-03-05
Publishing country	United States
Document type	Evaluation Study ; Journal Article
ZDB-ID	208417-x
ISSN	1537-2995 ; 0041-1132
ISSN (online)	1537-2995
ISSN	0041-1132
DOI	10.1111/trf.15586
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Zs.A 284: Show issues

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Article ; Online: Quality of life outcomes in thalassaemia patients in Saudi Arabia: a cross-sectional study.

Adam, Soheir

Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit

2019 Volume 25, Issue 12, Page(s) 887–895

Abstract: Background: Research focusing on health-related quality of life (HRQoL) in thalassaemia patients remains limited in Saudi Arabia.: Aims: To report on HRQoL outcomes in thalassaemia patients, and study associations with psychosocial and clinical ... ...

Abstract	Background: Research focusing on health-related quality of life (HRQoL) in thalassaemia patients remains limited in Saudi Arabia. Aims: To report on HRQoL outcomes in thalassaemia patients, and study associations with psychosocial and clinical factors. Methods: Thalassaemia patients attending King Abdulaziz University Hospital were sequentially approached for enrolment. HRQoL outcomes were assessed using a validated Arabic version of the Medical Outcomes Study Short form (SF-36). Results: This study included 105 individuals with β-thalassaemia major, with a mean age of 22.9 (± 11.7) (range 5-35) years, and 52.4% were male. Participants aged ≥ 14 years had a mean physical HRQoL score of 43.7 (± 10.1) and mental HRQoL score of 46.6 (± 10.5). Participants aged < 14 years, had corresponding scores of 48.4 (± 10.7) and 52.9 (± 8.0), respectively. Physical functioning scores were significantly worse for older patients, and those reporting chronic pain. Lower scores of vitality were associated with older age, chronic pain and history of splenectomy. Older age and history of splenectomy were associated with lower scores of mental health. Controlling for other variables, younger age and higher pretransfusion haemoglobin were associated with better mental HRQoL. Professional workers had better physical HRQoL scores compared to nonprofessional workers.. Conclusions: Controlling for other variables, higher pretransfusion haemoglobin and younger age were associated with better mental HRQoL outcomes in thalassaemia patients. Professionals reported better physical HRQoL outcomes, compared to non-professionals. Preventive and comprehensive care models are needed in Saudi Arabia to improve HRQoL outcomes in thalassaemia patients.
MeSH term(s)	Adolescent ; Adult ; Child ; Child, Preschool ; Cross-Sectional Studies ; Female ; Humans ; Male ; Quality of Life/psychology ; Saudi Arabia ; Thalassemia/psychology ; Thalassemia/therapy ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2019-12-29
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	1291071-5
ISSN	1687-1634 ; 1020-3397
ISSN (online)	1687-1634
ISSN	1020-3397
DOI	10.26719/2019.25.12.887
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Article: Machine Learning-Based Prediction of COVID-19 Prognosis Using Clinical and Hematologic Data.

Kamel, Fatemah O / Magadmi, Rania / Qutub, Sulafah / Badawi, Maha / Badawi, Mazen / Madani, Tariq A / Alhothali, Areej / Abozinadah, Ehab A / Bakhshwin, Duaa M / Jamal, Maha H / Burzangi, Abdulhadi S / Bazuhair, Mohammed / Alqutub, Hussamaldin / Alqutub, Abdulaziz / Felemban, Sameera M / Al-Sayes, Fatin / Adam, Soheir

Cureus

2023 Volume 15, Issue 12, Page(s) e50212

Abstract: The coronavirus disease 2019 (COVID-19) pandemic is challenging healthcare systems worldwide. The prediction of disease prognosis has a critical role in confronting the burden of COVID-19. We aimed to investigate the feasibility of predicting COVID-19 ... ...

Abstract	The coronavirus disease 2019 (COVID-19) pandemic is challenging healthcare systems worldwide. The prediction of disease prognosis has a critical role in confronting the burden of COVID-19. We aimed to investigate the feasibility of predicting COVID-19 patient outcomes and disease severity based on clinical and hematological parameters using machine learning techniques. This multicenter retrospective study analyzed records of 485 patients with COVID-19, including demographic information, symptoms, hematological variables, treatment information, and clinical outcomes. Different machine learning approaches, including random forest, multilayer perceptron, and support vector machine, were examined in this study. All models showed a comparable performance, yielding the best area under the curve of 0.96, in predicting the severity of disease and clinical outcome. We also identified the most relevant features in predicting COVID-19 patient outcomes, and we concluded that hematological parameters (neutrophils, lymphocytes, D-dimer, and monocytes) are the most predictive features of severity and patient outcome.
Language	English
Publishing date	2023-12-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.50212
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Book ; Online: Comparative effectiveness of warfarin and newer oral anticoagulants for the long-term prevention and treatment of arterial and venous thromboembolism

Adam, Soheir S

(Evidence-based synthesis program)

2012

Abstract: The Veterans Health Administration (VHA) System serves a largely older, male population with a high prevalence of chronic atrial fibrillation (AF) and venous thromboembolism (VTE). Many veterans with chronic AF have risk profiles for stroke that, ... ...

Institution	United States. / Department of Veterans Affairs. Durham VA Medical Center. / Evidence-based Synthesis Program Center. Quality Enhancement Research Initiative (U.S.)
Author's details	prepared for, Department of Veterans Affairs, Veterans Health Administration, Quality Enhancement Research Initiative, Health Services Research & Development Service ; prepared by, Evidence-based Synthesis Program (ESP) Center, Durham Veterans Affairs Healthcare System ; investigators, Soheir S. Adam ... [et al.]
Series title	Evidence-based synthesis program
Abstract	The Veterans Health Administration (VHA) System serves a largely older, male population with a high prevalence of chronic atrial fibrillation (AF) and venous thromboembolism (VTE). Many veterans with chronic AF have risk profiles for stroke that, according to current clinical guidelines, place them in a risk group where chronic anticoagulation is recommended. Adjusted-dose warfarin has been the preferred approach to chronic anticoagulation in the VHA, and in many VHA settings, specialized therapeutic drug-monitoring services provide high-quality warfarin treatment. However, the advent of newer anticoagulants with the promise of simplified long-term anticoagulation requires reconsideration of current treatment practices. The purpose of this systematic review was to study the comparative effectiveness of warfarin and the newer oral anticoagulants used for the long-term prevention and treatment of arterial and venous thromboembolism. An evaluation of newer oral anticoagulants for VTE prophylaxis in the perioperative period will be the subject of a later report.
MeSH term(s)	Thromboembolism/drug therapy ; Anticoagulants/therapeutic use ; Warfarin/therapeutic use ; Comparative Effectiveness Research
Language	English
Size	1 online resource (PDF file (iv, 115 p.)) :, ill.
Publisher	Department of Veterans Affairs, Health Services Research and Development Service
Publishing place	Washington, DC
Document type	Book ; Online
Note	"April 2012."
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Potential role for statins in sickle cell disease.

Adam, Soheir S / Hoppe, Carolyn

Pediatric blood & cancer

2013 Volume 60, Issue 4, Page(s) 550–557

Abstract: The complex pathophysiology of sickle cell disease (SCD) is remarkably similar to that observed in other chronic vascular diseases and involves multiple biologic pathways triggered by ischemia reperfusion injury, coagulation activation, and inflammation. ...

Abstract	The complex pathophysiology of sickle cell disease (SCD) is remarkably similar to that observed in other chronic vascular diseases and involves multiple biologic pathways triggered by ischemia reperfusion injury, coagulation activation, and inflammation. Statins are potent lipid-lowering agents commonly used to reduce the risk of cardiovascular disease. Independent of their lipid lowering effect, statins have been shown to down-regulate inflammatory mediators and endothelial adhesion molecules, reduce tissue factor expression and restore nitric oxide bioavailability. The pleiotropic effects of statins make these agents attractive therapeutic candidates for SCD. This article reviews available evidence for the potential role of statins in SCD.
MeSH term(s)	Anemia, Sickle Cell/drug therapy ; Cell Adhesion/drug effects ; Endothelium, Vascular/drug effects ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use
Chemical Substances	Hydroxymethylglutaryl-CoA Reductase Inhibitors
Language	English
Publishing date	2013-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.24443
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Zs.A 1131: Show issues

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Article ; Online: Comparative effectiveness of warfarin and new anticoagulants.

Adam, Soheir S / Ortel, Thomas L / Williams, John W

Annals of internal medicine

2013 Volume 158, Issue 8, Page(s) 637–638

MeSH term(s)	Anticoagulants/therapeutic use ; Atrial Fibrillation/drug therapy ; Humans ; Venous Thromboembolism/drug therapy ; Warfarin/therapeutic use
Chemical Substances	Anticoagulants ; Warfarin (5Q7ZVV76EI)
Language	English
Publishing date	2013-04-16
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	336-0
ISSN	1539-3704 ; 0003-4819
ISSN (online)	1539-3704
ISSN	0003-4819
DOI	10.7326/0003-4819-158-8-201304160-00017
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Article ; Online: SUCCESSFUL LONG TERM ERADICATION OF FACTOR VIII INHIBITOR IN PATIENTS WITH ACQUIRED HAEMOPHILIA A IN SAUDI ARABIA

Galila F Zaher / Soheir S Adam

Mediterranean Journal of Hematology and Infectious Diseases, Vol 4, Iss 1, Pp e2012021-e

2012 Volume 2012021

Abstract: Acquired haemophilia A is a serious and potentially fatal bleeding disorder. Diagnosis is difficult and maybe delayed due to its rarity. The high mortality rate and the complex nature of treatment necessitate patient management at a haemophilia centre, ... ...

Abstract	Acquired haemophilia A is a serious and potentially fatal bleeding disorder. Diagnosis is difficult and maybe delayed due to its rarity. The high mortality rate and the complex nature of treatment necessitate patient management at a haemophilia centre, where the required expertise and resources are available. Prompt diagnosis is crucial and early initiation of therapy could be life saving. Management includes initial control of bleeding followed by an approach to eradicate the coagulation factor inhibitor. In this paper we describe our local experience with acquired haemophilia A, which resulted in the successful control of major bleeding at presentation and eradication of inhibitors.
Keywords	Acquired Hemophilia ; Acquired Bleeding Disorders ; Diseases of the blood and blood-forming organs ; RC633-647.5 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	306
Language	English
Publishing date	2012-01-01T00:00:00Z
Publisher	Catholic University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: SUCCESSFUL LONG TERM ERADICATION OF FACTOR VIII INHIBITOR IN PATIENTS WITH ACQUIRED HAEMOPHILIA A IN SAUDI ARABIA

Galila F Zaher / Soheir S Adam

Mediterranean Journal of Hematology and Infectious Diseases, Vol 4, Iss 1, Pp e2012021-e

2012 Volume 2012021

Abstract	Acquired haemophilia A is a serious and potentially fatal bleeding disorder. Diagnosis is difficult and maybe delayed due to its rarity. The high mortality rate and the complex nature of treatment necessitate patient management at a haemophilia centre, where the required expertise and resources are available. Prompt diagnosis is crucial and early initiation of therapy could be life saving. Management includes initial control of bleeding followed by an approach to eradicate the coagulation factor inhibitor. In this paper we describe our local experience with acquired haemophilia A, which resulted in the successful control of major bleeding at presentation and eradication of inhibitors.
Keywords	Acquired Hemophilia ; Acquired Bleeding Disorders ; Medicine ; R ; Internal medicine ; RC31-1245 ; Specialties of internal medicine ; RC581-951 ; Diseases of the blood and blood-forming organs ; RC633-647.5
Language	English
Publishing date	2012-04-01T00:00:00Z
Publisher	PAGEPress Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Depression, quality of life, and medical resource utilization in sickle cell disease.

Adam, Soheir S / Flahiff, Charlene M / Kamble, Shital / Telen, Marilyn J / Reed, Shelby D / De Castro, Laura M

Blood advances

2017 Volume 1, Issue 23, Page(s) 1983–1992

Abstract: Sickle cell disease (SCD) is a chronic, debilitating disorder. Chronically ill patients are at risk for depression, which can affect health-related quality of life (HRQoL), health care utilization, and cost. We performed an analytic epidemiologic ... ...

Abstract	Sickle cell disease (SCD) is a chronic, debilitating disorder. Chronically ill patients are at risk for depression, which can affect health-related quality of life (HRQoL), health care utilization, and cost. We performed an analytic epidemiologic prospective study to determine the prevalence of depression in adult patients with SCD and its association with HRQoL and medical resource utilization. Depression was measured by the Beck Depression Inventory and clinical history in adult SCD outpatients at a comprehensive SCD center. HRQoL was assessed using the SF36 form, and data were collected on medical resource utilization and corresponding cost. Neurocognitive functions were assessed using the CNS Vital Signs tool. Pain diaries were used to record daily pain. Out of 142 enrolled patients, 42 (35.2%) had depression. Depression was associated with worse physical and mental HRQoL scores (
Language	English
Publishing date	2017-10-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2876449-3
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2017006940
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Article ; Online: Effectiveness of Acute Care Remote Triage Systems: a Systematic Review.

Boggan, Joel C / Shoup, John Paul / Whited, John D / Van Voorhees, Elizabeth / Gordon, Adelaide M / Rushton, Sharron / Lewinski, Allison A / Tabriz, Amir A / Adam, Soheir / Fulton, Jessica / Kosinski, Andrzej S / Van Noord, Megan G / Williams, John W / Goldstein, Karen M / Gierisch, Jennifer M

Journal of general internal medicine

2020 Volume 35, Issue 7, Page(s) 2136–2145

Abstract: Background: Technology-based systems can facilitate remote decision-making to triage patients to the appropriate level of care. Despite technologic advances, the effects of implementation of these systems on patient and utilization outcomes are unclear. ...

Abstract	Background: Technology-based systems can facilitate remote decision-making to triage patients to the appropriate level of care. Despite technologic advances, the effects of implementation of these systems on patient and utilization outcomes are unclear. We evaluated the effects of remote triage systems on healthcare utilization, case resolution, and patient safety outcomes. Methods: English-language searches of MEDLINE (via PubMed), EMBASE, and CINAHL were performed from inception until July 2018. Randomized and nonrandomized comparative studies of remote triage services that reported healthcare utilization, case resolution, and patient safety outcomes were included. Two reviewers assessed study and intervention characteristics independently for study quality, strength of evidence, and risk of bias. Results: The literature search identified 5026 articles, of which eight met eligibility criteria. Five randomized, two controlled before-and-after, and one interrupted time series study assessed 3 categories of remote triage services: mode of delivery, triage professional type, and system organizational level. No study evaluated any other delivery mode other than telephone and in-person. Meta-analyses were unable to be performed because of study design and outcome heterogeneity; therefore, we narratively synthesized data. Overall, most studies did not demonstrate a decrease in primary care (PC) or emergency department (ED) utilization, with some studies showing a significant increase. Evidence suggested local, practice-based triage systems have greater case resolution and refer fewer patients to PC or ED services than regional/national systems. No study identified statistically significant differences in safety outcomes. Conclusion: Our review found limited evidence that remote triage reduces the burden of PC or ED utilization. However, remote triage by telephone can produce a high rate of call resolution and appears to be safe. Further study of other remote triage modalities is needed to realize the promise of remote triage services in optimizing healthcare outcomes. Protocol registration: This study was registered and followed a published protocol (PROSPERO: CRD42019112262).
MeSH term(s)	Emergency Medical Services ; Emergency Service, Hospital ; Humans ; Primary Health Care ; Telephone ; Triage
Language	English
Publishing date	2020-01-02
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Review ; Systematic Review
ZDB-ID	639008-0
ISSN	1525-1497 ; 0884-8734
ISSN (online)	1525-1497
ISSN	0884-8734
DOI	10.1007/s11606-019-05585-4
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