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Article: Breast Cancer Risk and Prevention: A Step Forward.

Vidali, Sofia / Susini, Tommaso

2023 Volume 15, Issue 23

Abstract: Breast cancer (BC) is a leading topic in medical research as it is the most common cancer occurring in women worldwide; its incidence is progressively increasing in all age groups [ ... ]. ...

Abstract	Breast cancer (BC) is a leading topic in medical research as it is the most common cancer occurring in women worldwide; its incidence is progressively increasing in all age groups [...].
Language	English
Publishing date	2023-11-23
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15235559
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Article ; Online: Endovascular thromboaspiration with neurointerventional devices for early hepatic artery thrombosis after split liver transplant.

Argirò, Renato / Raso, Armando / Vidali, Sofia / Morosetti, Daniele

BMJ case reports

2021 Volume 14, Issue 5

Abstract: We report the case of a 38-year-old woman who underwent orthotopic 'split' liver transplant, complicated by hepatic artery thrombosis on the first postoperative day. The patient was successfully treated with an endovascular approach by mechanical ... ...

Abstract	We report the case of a 38-year-old woman who underwent orthotopic 'split' liver transplant, complicated by hepatic artery thrombosis on the first postoperative day. The patient was successfully treated with an endovascular approach by mechanical thromboaspiration of the hepatic artery, using neurovascular devices, angioplasty and stenting at the site of the surgical anastomosis.
MeSH term(s)	Adult ; Angioplasty ; Female ; Hepatic Artery/diagnostic imaging ; Hepatic Artery/surgery ; Humans ; Liver Diseases ; Liver Transplantation/adverse effects ; Thrombosis/diagnostic imaging ; Thrombosis/etiology
Language	English
Publishing date	2021-05-05
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2020-240583
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Article ; Online: Direct ultrasound-guided puncture of vertebral artery V2 segment during mechanical thrombectomy.

Semeraro, Vittorio / Gasparrini, Fulvio / Vidali, Sofia / Gandini, Roberto

BMJ case reports

2021 Volume 14, Issue 1

Abstract: An 83-year-old man experienced left upper limb uncontrolled movements preceded by intense gasping during night rest, which progressed to unconsciousness and respiratory arrest requiring intubation. He was diagnosed with acute stroke due to distal ... ...

Abstract	An 83-year-old man experienced left upper limb uncontrolled movements preceded by intense gasping during night rest, which progressed to unconsciousness and respiratory arrest requiring intubation. He was diagnosed with acute stroke due to distal occlusion of the basilar artery and received indication for endovascular thrombectomy. Standard endovascular approach includes percutaneous puncture of the femoral or radial arteries; however, the presence of unfavourable vascular anatomies (stenotic origin and tortuosity) did not allow catheterisation of the intracranial vessels through conventional access, and based on the consistent time lapse from onset of symptoms and deterioration of the clinical condition, a direct right vertebral artery ultrasound-guided puncture was performed. After one attempt of a triaxial technique, a complete recanalisation of the basilar artery and of its distal branches was achieved. Direct percutaneous puncture of the vertebral artery represents a rescue access strategy for treatment of posterior circulation stroke when other routes are not feasible.
MeSH term(s)	Aged, 80 and over ; Cerebral Angiography ; Computed Tomography Angiography ; Endovascular Procedures/methods ; Femoral Artery ; Humans ; Male ; Punctures/methods ; Surgery, Computer-Assisted ; Thrombectomy/methods ; Ultrasonography ; Vascular Closure Devices ; Vertebral Artery/diagnostic imaging ; Vertebral Artery/surgery ; Vertebrobasilar Insufficiency/diagnostic imaging ; Vertebrobasilar Insufficiency/physiopathology ; Vertebrobasilar Insufficiency/surgery
Language	English
Publishing date	2021-01-26
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2020-238979
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Article ; Online: PCB cause global DNA hypomethylation of human peripheral blood monocytes in vitro.

Vidali, Maria-Sofia / Dailianis, Stefanos / Vlastos, Dimitris / Georgiadis, Panagiotis

Environmental toxicology and pharmacology

2021 Volume 87, Page(s) 103696

Abstract: We have recently reported significant associations between exposure to polychlorinated biphenyls (PCB) and alterations on genome-wide methylation of leukocyte DNA of healthy volunteers and provided evidence in support of an etiological link between the ... ...

Abstract	We have recently reported significant associations between exposure to polychlorinated biphenyls (PCB) and alterations on genome-wide methylation of leukocyte DNA of healthy volunteers and provided evidence in support of an etiological link between the observed CpG methylation variations and chronic lymphocytic leukemia. The present study aimed to elucidate the effects of PCB in human lymphocytes' methylome in vitro. Therefore, U937 cells and human peripheral blood monocytes (PBMC) were exposed in vitro to the dioxin-like PCB-118, the non-dioxin-like PCB-153, and hexachlorobenzene (HCB) and thorough cytotoxicity, genotoxicity and global CpG methylation analyses were performed. All compounds currently tested did not show any consistent significant genotoxicity at all exposure periods and concentrations used. On the contrary, extensive dose-dependent hypomethylation was observed, even at low concentrations, in stimulated PBMC treated with PCB-118 and PCB-153 as well as a small but statistically significant hypomethylation in HCB-treated stimulated cells.
MeSH term(s)	Adult ; Cell Survival/drug effects ; DNA Damage ; DNA Methylation/drug effects ; Environmental Pollutants/toxicity ; Hexachlorobenzene/toxicity ; Humans ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/metabolism ; Polychlorinated Biphenyls/toxicity ; U937 Cells
Chemical Substances	Environmental Pollutants ; 2,3',4,4',5-pentachlorobiphenyl (2B2AQE8U50) ; Hexachlorobenzene (4Z87H0LKUY) ; Polychlorinated Biphenyls (DFC2HB4I0K) ; 2,4,5,2',4',5'-hexachlorobiphenyl (ZRU0C9E32O)
Language	English
Publishing date	2021-06-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1318302-3
ISSN	1872-7077 ; 1382-6689
ISSN (online)	1872-7077
ISSN	1382-6689
DOI	10.1016/j.etap.2021.103696
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Zs.A 4490: Show issues

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Article ; Online: First total synthesis of type II abyssomicins: (±)-abyssomicin 2 and (±)-neoabyssomicin B.

Canko, Aleksander / Athanassopoulou, Georgia D / Psycharis, Vassilis / Raptopoulou, Catherine P / Herniman, Julie M / Mouchtouris, Vasileios / Foscolos, Angeliki Sofia / Couladouros, Elias A / Vidali, Veroniki P

Organic & biomolecular chemistry

2023 Volume 21, Issue 18, Page(s) 3761–3765

Abstract: The intramolecular Diels-Alder reaction (IMDA) of a butenolide derivative, as an entry to the type II abyssomicin scaffold, and the total synthesis of (±)-abyssomicin 2 and (±)-neoabyssomicin B are reported for the first time. A facile route to the IMDA ... ...

Abstract	The intramolecular Diels-Alder reaction (IMDA) of a butenolide derivative, as an entry to the type II abyssomicin scaffold, and the total synthesis of (±)-abyssomicin 2 and (±)-neoabyssomicin B are reported for the first time. A facile route to the IMDA precursor, the formation of a type I intermediate and two paths to (±)-neoabyssomicin B are also discussed.
Language	English
Publishing date	2023-05-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/d3ob00476g
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Article ; Online: Imaging of the chemotherapy-induced hepatic damage: Yellow liver, blue liver, and pseudocirrhosis.

Calistri, Linda / Rastrelli, Vieri / Nardi, Cosimo / Maraghelli, Davide / Vidali, Sofia / Pietragalla, Michele / Colagrande, Stefano

World journal of gastroenterology

2021 Volume 27, Issue 46, Page(s) 7866–7893

Abstract: The liver is the major drug-metabolizing and drug-detoxifying organ. Many drugs can cause liver damage through various mechanisms; however, the liver response to injury includes a relatively narrow spectrum of alterations that, regardless of the cause, ... ...

Abstract	The liver is the major drug-metabolizing and drug-detoxifying organ. Many drugs can cause liver damage through various mechanisms; however, the liver response to injury includes a relatively narrow spectrum of alterations that, regardless of the cause, are represented by phlogosis, oxidative stress and necrosis. The combination of these alterations mainly results in three radiological findings: vascular alterations, structural changes and metabolic function reduction. Chemotherapy has changed in recent decades in terms of the drugs, protocols and duration, allowing patients a longer life expectancy. As a consequence, we are currently observing an increase in chemotherapy-associated liver injury patterns once considered unusual. Recognizing this form of damage in an early stage is crucial for reconsidering the therapy regimen and thus avoiding severe complications. In this frontier article, we analyze the role of imaging in detecting some of these pathological patterns, such as pseudocirrhosis, "yellow liver" due to chemotherapy-associated steatosis-steatohepatitis, and "blue liver", including sinusoidal obstruction syndrome, veno-occlusive disease and peliosis.
MeSH term(s)	Antineoplastic Agents/adverse effects ; Fatty Liver ; Hepatic Veno-Occlusive Disease ; Humans ; Liver/diagnostic imaging ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/drug therapy
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2021-09-09
Publishing country	United States
Document type	Editorial
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v27.i46.7866
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Zs.A 6039: Show issues

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Article ; Online: Glue Embolization in the Management of Rectus Sheath Hematomas.

Semeraro, Vittorio / Vidali, Sofia / Borghese, Ottavia / Ganimede, Maria Porzia / Gandini, Roberto / Di Stasi, Carmine / Burdi, Nicola

Vascular and endovascular surgery

2022 Volume 56, Issue 3, Page(s) 269–276

Abstract: Objective: This study aims to describe the results achieved in the management of rectus sheath hematoma (RSH) using glue embolization.: Method: Data about all consecutive patients presenting with RSH, between January 2005 and December 2020 were ... ...

Abstract	Objective: This study aims to describe the results achieved in the management of rectus sheath hematoma (RSH) using glue embolization. Method: Data about all consecutive patients presenting with RSH, between January 2005 and December 2020 were retrospectively reviewed. RSHs were classified according to the Berna CT scan Classification. Clinical and technical outcomes were evaluated during in-hospital period and 1-month follow-up. Results: Among 74 patients presenting with RSH, CTA revealed an active bleeding in 61 (n = 42, 69% women; median age = 68.8 y range: 47-91). 19 cases of type 1 RSH (25.7%), under anticoagulation therapy and hemodynamically stable, were successfully managed conservatively. Conversely, endovascular embolization with cyanoacrylate glue diluted with ethiodized oil (Lipiodol Ultrafluid, Guerbet, France) was needed in n = 42 (56.8%) patients, in 16 cases after failure of conservative management; a single session of percutaneous glue embolization was adequate to achieve technical and clinical success in all patients with stabilization or progressive improvement of hemoglobin values after procedure (7.1 + 1.8 g/dL pre-procedure vs 11.1 + 1.6 g/dL post-procedure). No major complications occurred. Two minor complications were reported: 1 case (2.4%) of puncture site-related complication (local self-limiting hematoma) and 1 case (2.4%) of post-embolization syndrome (abdominal pain) spontaneously regressive. The median hospital stay was 7 d. At 30-day follow-up, 2 patients (2.7%) died of multiorgan failure. Conclusions: In the management of RSH, glue embolization was shown to be safe and efficacious. Glue allowed the immediate occlusion of both the "front and back doors" of bleeding without the need to reach the bleeding point, preventing potentially life-threatening recurrence.
MeSH term(s)	Aged ; Embolization, Therapeutic/adverse effects ; Embolization, Therapeutic/methods ; Female ; Gastrointestinal Hemorrhage/therapy ; Hematoma/diagnostic imaging ; Hematoma/etiology ; Hematoma/therapy ; Humans ; Male ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2022-01-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2076272-0
ISSN	1938-9116 ; 1538-5744
ISSN (online)	1938-9116
ISSN	1538-5744
DOI	10.1177/15385744211068742
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Zs.A 622: Show issues

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Article ; Online: Magnetic resonance imaging of inflammatory pseudotumor of the liver: a 2021 systematic literature update and series presentation.

Calistri, Linda / Maraghelli, Davide / Nardi, Cosimo / Vidali, Sofia / Rastrelli, Vieri / Crocetti, Laura / Grazioli, Luigi / Colagrande, Stefano

Abdominal radiology (New York)

2022 Volume 47, Issue 8, Page(s) 2795–2810

Abstract: Purpose: Inflammatory pseudotumors of the liver (IPTL) are not exceptional benign lesions with various etiologies, histology, and imaging appearances. The incomplete knowledge of this pathology and the wide polymorphism sometimes resembling malignancy ... ...

Abstract	Purpose: Inflammatory pseudotumors of the liver (IPTL) are not exceptional benign lesions with various etiologies, histology, and imaging appearances. The incomplete knowledge of this pathology and the wide polymorphism sometimes resembling malignancy often induce long and expensive diagnostic flow, biopsy and occasionally unnecessary surgery. We propose a systematic revision of MRI literature data (2000-2021) with some narrative inserts and 10 new complete MRI cases, with the aim of organizing the data about IPTL and identifying some typical features able to improve its diagnosis from imaging. Methods: We performed a systematic revision of literature from 2000 to 2021 to obtain MRI features, epidemiological, and clinical data of IPTL. The basic online search algorithm on the PubMed database was "(pseudotumor) AND (liver) AND (imaging)." Quality assessment was performed using both scales by Moola for case report studies and by Munn for cross-sectional studies reporting prevalence data. A case-based retrospective study by collecting patients diagnosed with IPTL from three different university hospitals from 2015 to 2021 was done as well. Only cases with MR examinations complete with T1/T2/contrast-enhanced T1/Diffusion-Weighted (W) images and pathology-proven IPTL were selected. Results: After screening/selection 38 articles were included for a total of 114 patients. In our experience we selected 10 cases for a total of 16 IPTLs; 8 out of 10 patients underwent at least 1 MRI follow-up. Some reproducible and rather typical imaging findings for IPTL were found. The targetoid aspect of IPTL is very frequent in our experience (75% on T1W, 44% on T2W, 81% on contrast-enhanced T1W (at least one phase), 100% on Diffusion-W images) but is also recurrent in the literature (6% on T1W, 31% on T2W, 51% on CE-T1W (at least one phase), 18% on Diffusion-W images, and 67% on hepatobiliary phase). In our experience, Apparent Diffusion Coefficient map values were always equal to or higher than those of the surrounding parenchyma, and at MRI follow-up, nodule/s disappeared at first/second control, in six patients, while in the remaining 2, lesions persisted with tendency to dehydration. Conclusion: A targetoid-like aspect of a focal liver lesion must raise diagnostic suspicion, especially if IgG4-positive plasma is detected. MRI follow-up mainly shows the disappearance of the lesion or its reduction with dehydration.
MeSH term(s)	Contrast Media ; Cross-Sectional Studies ; Dehydration/pathology ; Diffusion Magnetic Resonance Imaging ; Granuloma, Plasma Cell/diagnostic imaging ; Humans ; Liver/diagnostic imaging ; Liver/pathology ; Magnetic Resonance Imaging/methods ; Retrospective Studies
Chemical Substances	Contrast Media
Language	English
Publishing date	2022-06-01
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2839786-1
ISSN	2366-0058 ; 2366-004X
ISSN (online)	2366-0058
ISSN	2366-004X
DOI	10.1007/s00261-022-03555-9
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Zs.A 1262: Show issues

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Article ; Online: Endovascular treatment of calcific lesions of the common femoral artery using atherectomy device associated with scoring balloon angioplasty in diabetic patients with high "major amputation" risk.

Morosetti, Daniele / Chiocchi, Marcello / Argirò, Renato / Salimei, Fabio / Nezzo, Marco / Vidali, Sofia / Gasparrini, Fulvio / Meloni, Marco / Uccioli, Luigi / Gandini, Roberto

Vascular

2021 Volume 30, Issue 3, Page(s) 463–473

Abstract: Objectives: To investigate the outcomes of patients with calcific lesions in the common femoral artery undergoing endovascular procedures with atherectomy device and scoring balloon angioplasty combined with treatment of steno-occlusive disease of the ... ...

Abstract	Objectives: To investigate the outcomes of patients with calcific lesions in the common femoral artery undergoing endovascular procedures with atherectomy device and scoring balloon angioplasty combined with treatment of steno-occlusive disease of the remaining arterial districts of the lower limb. Methods: Between January 2015 and December 2018, 11 diabetic patients at high risk for "major amputation", with calcific lesions of the common femoral artery and ischemic ulcers requiring endovascular treatment were retrospectively evaluated. Technical success was defined as revascularization of the common femoral artery with a residual stenosis lower than 30%. Primary endpoints were an immediate increase of perilesional transcutaneous oxygen pressure (TCPO Results: The success rate of the revascularization procedures was 100%. No patient underwent surgical conversion. One case of peri-operative bleeding at the brachial access site was observed. There were no cases of arterial dissection or undesired distal embolization. The average baseline value of perilesional TCPO Conclusions: Endovascular approach for severely calcified atherosclerotic lesions of the common femoral artery seems to represent a valid therapeutic option associated with promising results in terms of clinical outcome and low complication rates.
MeSH term(s)	Amputation ; Angioplasty, Balloon/adverse effects ; Atherectomy/adverse effects ; Diabetes Mellitus ; Femoral Artery/diagnostic imaging ; Femoral Artery/surgery ; Humans ; Peripheral Arterial Disease/diagnostic imaging ; Peripheral Arterial Disease/therapy ; Popliteal Artery ; Retrospective Studies ; Time Factors ; Treatment Outcome ; Vascular Patency
Language	English
Publishing date	2021-05-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2137151-9
ISSN	1708-539X ; 1708-5381
ISSN (online)	1708-539X
ISSN	1708-5381
DOI	10.1177/17085381211019244
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Zs.A 4277: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 590: Show issues

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Article ; Online: The Minimally Invasive Treatment of Visceral Artery Pseudoaneurysms: A Retrospective Observational Single Centre Cohort Study on Glue Embolization.

Borghese, Ottavia / Ganimede, Maria Porzia / Briatico Vangosa, Alessandra / Pisani, Angelo / Vidali, Sofia / Di Stasi, Carmine / Burdi, Nicola / Semeraro, Vittorio

Vascular and endovascular surgery

2021 Volume 55, Issue 8, Page(s) 831–837

Abstract: Objective: The objective is to report a single centre experience in the embolization of visceral artery pseudoaneurysms with N-butyl-cyanoacrylate-methacryloxy sulfolane (NBCA-MS).: Methods: A retrospective observational cohort study was conducted on ...

Abstract	Objective: The objective is to report a single centre experience in the embolization of visceral artery pseudoaneurysms with N-butyl-cyanoacrylate-methacryloxy sulfolane (NBCA-MS). Methods: A retrospective observational cohort study was conducted on data about all consecutive patients treated for visceral artery pseudoaneurysms in the Interventional Radiology Unit of SS Annunziata Hospital, in Taranto (Italy) between January 2016 and July 2020. Only patients treated with NBCA-MS embolization were included. Clinical and technical outcomes were evaluated during in-hospital stay and at 3-month follow-up by computed angiotomography (CTA). Results: Among 89 patients undergoing treatment for visceral artery pseudoaneurysm, a total of 58 (65.2%) patients (n = 32, 55.2% men; median age 45.8 years, range: 35-81) treated with NBCA-MS only were enrolled. Pseudoaneurysms were located in the renal artery (n = 18 cases, 31%), in the splenic artery (n = 27, 46.6%), in the intra-parenchymal hepatic artery (n = 3, 5.2%), in the common hepatic artery (n = 4, 6.9%) or in the pancreatic artery (n = 6, 10.3%). N-butyl-cyanoacrylate was diluted 1:1 with Lipiodol ultra-fluid, and mean volume injected was 0.6 ± 0.3 mL (range: 0.2-2.8 mL). Embolization was technically and clinically successful in all patients (n = 58, 100%) with an immediate total thrombosis of the pseudoaneurysm at the completion angiography. No systemic complications were noted in all cases. Five cases (8.6%) of non-target vessel embolization occurred without any clinical complication. No pseudoaneurysm recurrence was detected at the CTA control 1 day postoperatively. In one case (1.7%), a recurrence was detected 4 days after the initial treatment and successfully managed by a repeated NBCA-MS embolization. During the hospital stay, 56 patients recovered well but 2 (3.4%) died from multi-organ failure not related to the embolization. No recurrences were detected at the 3-month postoperative CTA in the remaining patients. Conclusions: In properly selected patients affected with visceral artery pseudoaneurysms, NBCA-MS represents a definitive and safe embolization agent.
MeSH term(s)	Aneurysm, False/diagnostic imaging ; Aneurysm, False/therapy ; Cohort Studies ; Embolization, Therapeutic/adverse effects ; Enbucrilate/adverse effects ; Female ; Humans ; Male ; Middle Aged ; Renal Artery ; Retrospective Studies ; Treatment Outcome
Chemical Substances	Enbucrilate (F8CEP82QNP)
Language	English
Publishing date	2021-07-14
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	2076272-0
ISSN	1938-9116 ; 1538-5744
ISSN (online)	1938-9116
ISSN	1538-5744
DOI	10.1177/15385744211028730
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