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  1. Article ; Online: Fever in Children With Sickle Cell Disease-Rethinking the Approach When Bacteremia Is Rare.

    Noronha, Suzie A / Strouse, John J

    JAMA network open

    2023  Volume 6, Issue 6, Page(s) e2318837

    MeSH term(s) Child ; Humans ; Bacteremia/diagnosis ; Retrospective Studies ; Anemia, Sickle Cell/complications ; Fever
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.18837
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  2. Article ; Online: Web Exclusive. Annals for Hospitalists Inpatient Notes - Clinical Pearls-Acute Pain Episodes in Sickle Cell Disease.

    Strouse, John J / Brandow, Amanda M

    Annals of internal medicine

    2022  Volume 175, Issue 3, Page(s) HO2–HO3

    Language English
    Publishing date 2022-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/M22-0305
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  3. Article ; Online: Addressing fertility in adolescent boys with sickle cell disease: emerging clinical and ethical dilemmas.

    Nahata, Leena / Quinn, Gwendolyn P / Strouse, John J / Creary, Susan E

    Blood advances

    2023  Volume 7, Issue 18, Page(s) 5351–5353

    MeSH term(s) Male ; Humans ; Adolescent ; Anemia, Sickle Cell/complications ; Anemia, Sickle Cell/therapy ; Fertility
    Language English
    Publishing date 2023-05-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2023010292
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  4. Article ; Online: Management of Older Adults with Sickle Cell Disease: Considerations for Current and Emerging Therapies.

    Oyedeji, Charity I / Hodulik, Kimberly L / Telen, Marilyn J / Strouse, John J

    Drugs & aging

    2023  Volume 40, Issue 4, Page(s) 317–334

    Abstract: People with sickle cell disease (SCD) are living longer than ever before, with the median survival increasing from age 14 years in 1973, beyond age 40 years in the 1990s, and as high as 61 years in recent cohorts from academic centers. Improvements in ... ...

    Abstract People with sickle cell disease (SCD) are living longer than ever before, with the median survival increasing from age 14 years in 1973, beyond age 40 years in the 1990s, and as high as 61 years in recent cohorts from academic centers. Improvements in survival have been attributed to initiatives, such as newborn screening, penicillin prophylaxis, vaccination against encapsulated organisms, better detection and treatment of splenic sequestration, and improved transfusion support. There are an estimated 100,000 people living with SCD in the United States and millions of people with SCD globally. Given that the number of older adults with SCD will likely continue to increase as survival improves, better evidence on how to manage this population is needed. When managing older adults with SCD (defined herein as age ≥ 40 years), healthcare providers should consider the potential pitfalls of extrapolating evidence from existing studies on current and emerging therapies that have typically been conducted with participants at mean ages far below 40 years. Older adults with SCD have historically had little to no representation in clinical trials; therefore, more guidance is needed on how to use current and emerging therapies in this population. This article summarizes the available evidence for managing older adults with SCD and discusses potential challenges to using approved and emerging drugs in this population.
    MeSH term(s) Humans ; United States ; Aged ; Anemia, Sickle Cell/drug therapy ; Antibiotic Prophylaxis
    Language English
    Publishing date 2023-02-28
    Publishing country New Zealand
    Document type Journal Article ; Review ; Research Support, U.S. Gov't, P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1075770-3
    ISSN 1179-1969 ; 1170-229X
    ISSN (online) 1179-1969
    ISSN 1170-229X
    DOI 10.1007/s40266-023-01014-8
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    Zs.A 3481: Show issues Location:
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  5. Article ; Online: Improving the Quality of Care for Adolescents and Adults With Sickle Cell Disease-It's a Long Road.

    Oyedeji, Charity / Strouse, John J

    JAMA network open

    2020  Volume 3, Issue 5, Page(s) e206377

    MeSH term(s) Adolescent ; Adult ; Anemia, Sickle Cell ; Humans ; Quality of Health Care
    Language English
    Publishing date 2020-05-01
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2020.6377
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  6. Article ; Online: Hydroxyurea for Sickle Cell Disease: Now Is the Time!

    Strouse, John J

    Southern medical journal

    2016  Volume 109, Issue 9, Page(s) 535–537

    Language English
    Publishing date 2016-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 185329-6
    ISSN 1541-8243 ; 0038-4348
    ISSN (online) 1541-8243
    ISSN 0038-4348
    DOI 10.14423/SMJ.0000000000000515
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  7. Article ; Online: Cerebral Oxygenation and Transfusion for Severe Anemia: Searching for Functional Outcomes to Guide Transfusion.

    Strouse, John J

    JAMA pediatrics

    2016  Volume 170, Issue 10, Page(s) 936–937

    MeSH term(s) Anemia ; Erythrocyte Transfusion ; Humans
    Language English
    Publishing date 2016-08-15
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2701223-2
    ISSN 2168-6211 ; 2168-6203
    ISSN (online) 2168-6211
    ISSN 2168-6203
    DOI 10.1001/jamapediatrics.2016.1730
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  8. Article ; Online: Is low dose hydroxyurea the solution to the global epidemic of sickle cell disease?

    Strouse, John J

    Pediatric blood & cancer

    2015  Volume 62, Issue 6, Page(s) 929–930

    MeSH term(s) Adult ; Anemia, Sickle Cell/drug therapy ; Anemia, Sickle Cell/epidemiology ; Child ; Humans ; Hydroxyurea/adverse effects ; Hydroxyurea/therapeutic use
    Chemical Substances Hydroxyurea (X6Q56QN5QC)
    Language English
    Publishing date 2015-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.25471
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    Zs.A 1131: Show issues Location:
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  9. Article ; Online: Cognitive-motor dual-task interference in adults with sickle cell disease.

    Subramaniam, Arvind P / Oyedeji, Charity I / Parikh, Jhana S / Feld, Jody A / Strouse, John J

    Gait & posture

    2023  Volume 102, Page(s) 164–170

    Abstract: Background: Sickle cell disease (SCD) is a genetic disorder that causes physical and cognitive impairment due to hemolysis, painful vaso-occlusion episodes, joint avascular necrosis, and strokes. As individuals with SCD age and develop conditions ... ...

    Abstract Background: Sickle cell disease (SCD) is a genetic disorder that causes physical and cognitive impairment due to hemolysis, painful vaso-occlusion episodes, joint avascular necrosis, and strokes. As individuals with SCD age and develop conditions impacting their physical and cognitive function, their ability to multitask successfully and safely may decline. Cognitive-motor dual-task interference occurs when there is deterioration in one or both tasks while dual-tasking relative to single-tasking. Dual-task assessment (DTA) is a valuable measure of physical and cognitive function; however, there is limited data on DTA in adults with SCD.
    Research question: Is DTA a feasible and safe method of measuring physical and cognitive function in adults with SCD? What patterns of cognitive-motor interference occur in adults with SCD?
    Methods: We enrolled 40 adults with SCD (mean age 44 years, range 20-71) in a single-center prospective cohort study. We used usual gait speed as the measure of motor performance and verbal fluency (F, A, and S) as the measure of cognitive performance. We measured feasibility as the proportion of consented participants able to complete the DTA. We calculated the relative dual-task effect (DTE %) for each task and identified patterns of dual-task interference.
    Results: Most consented participants completed the DTA (91%, 40/44) and there were no adverse events. There were 3 main dual-task interference patterns for the first trial using letter 'A': Motor Interference (53%, n = 21), Mutual Interference (23%, n = 9), and Cognitive-Priority Tradeoff (15%, n = 6). For the second trial using letter 'S', there were two main dual-task interference patterns: Cognitive-Priority Tradeoff (53%, n = 21) and Motor Interference (25%, n = 10).
    Statement of significance: DTA was feasible and safe in adults with SCD. We identified specific patterns of cognitive-motor interference. This study supports further evaluation of DTA as a potentially useful tool to measure physical and cognitive function in ambulatory adults with SCD.
    MeSH term(s) Adult ; Aged ; Humans ; Middle Aged ; Young Adult ; Anemia, Sickle Cell/complications ; Cognition ; Cognitive Dysfunction ; Gait ; Prospective Studies ; Walking
    Language English
    Publishing date 2023-03-17
    Publishing country England
    Document type Clinical Study ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1162323-8
    ISSN 1879-2219 ; 0966-6362
    ISSN (online) 1879-2219
    ISSN 0966-6362
    DOI 10.1016/j.gaitpost.2023.03.009
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    Zs.A 3804: Show issues Location:
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  10. Article ; Online: "Death is as Much Part of Life as Living": Attitudes and Experiences Preparing for Death from Older Adults with Sickle Cell Disease.

    Oyedeji, Charity I / Strouse, John J / Masese, Rita / Gray, Nathan / Oyesanya, Tolu O

    Omega

    2022  , Page(s) 302228221116513

    Abstract: The life-limiting and unpredictable nature of sickle cell disease (SCD) is well-established, yet there is limited literature on end-of-life planning. The purpose of this study was to describe perspectives about preparing for death for older adults with ... ...

    Abstract The life-limiting and unpredictable nature of sickle cell disease (SCD) is well-established, yet there is limited literature on end-of-life planning. The purpose of this study was to describe perspectives about preparing for death for older adults with SCD. We enrolled 19 older adults with SCD (age ≥ 50 years) into this qualitative descriptive study. Theme 1 was "anticipation of early death," with sub-themes: (a) informed of early death and (b) making plans for death. Theme 2 was "near death experiences." Theme 3 was "differences in level of comfort with death" with subthemes: (a) death as a part of life and (b) differences in level of comfort discussing death. Theme 4 was "influence of spirituality" with subthemes: (a) God controls the timing of death and (b) belief in the afterlife. These results will inform interventions to improve the quality of patient-provider communication to provide goal-concordant end-of-life care for adults with SCD.
    Language English
    Publishing date 2022-07-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207363-8
    ISSN 1541-3764 ; 0030-2228
    ISSN (online) 1541-3764
    ISSN 0030-2228
    DOI 10.1177/00302228221116513
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