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  1. Article: D-dimers: a most misunderstood test.

    Carter-Brzezinski, Luke / Houston, Scott / Thachil, Jecko

    British journal of hospital medicine (London, England : 2005)

    2021  Volume 82, Issue 8, Page(s) 1–5

    Abstract: The role of D-dimers in the management of venous thromboembolism is well established and testing for D-dimers has become common in most acute settings. Although it has been validated for the purpose of excluding venous thromboembolism, the test is ... ...

    Abstract The role of D-dimers in the management of venous thromboembolism is well established and testing for D-dimers has become common in most acute settings. Although it has been validated for the purpose of excluding venous thromboembolism, the test is increasingly ordered to 'diagnose' venous thromboembolism. Furthermore, in the COVID-19 pandemic, heavy reliance has been put on this test with the inclusion of D-dimers to guide treatment pathways. This review summarises the appropriateness of D-dimer tests in these different clinical settings.
    MeSH term(s) COVID-19 ; Fibrin Fibrinogen Degradation Products ; Humans ; Pandemics ; SARS-CoV-2 ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/epidemiology
    Chemical Substances Fibrin Fibrinogen Degradation Products ; fibrin fragment D
    Language English
    Publishing date 2021-08-17
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1750-8460
    ISSN 1750-8460
    DOI 10.12968/hmed.2021.0279
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Management of venous thromboembolism in athletes.

    Swan, Dawn / Carter-Brzezinski, Luke / Thachil, Jecko

    Blood reviews

    2020  Volume 47, Page(s) 100780

    Abstract: Venous thromboembolism (VTE) is a common condition with high associated morbidity and mortality. Athletes have unique VTE risk factors compared with the general population, and may have a higher than anticipated risk of thrombosis. Anticoagulant ... ...

    Abstract Venous thromboembolism (VTE) is a common condition with high associated morbidity and mortality. Athletes have unique VTE risk factors compared with the general population, and may have a higher than anticipated risk of thrombosis. Anticoagulant treatment poses additional challenges in athletes, as these individuals usually wish to return to sporting activities without delay. In addition, those athletes who engage in contact sports may have bleeding complications with extended anticoagulation. In this paper, we discuss VTE risk factors in athletes, the impact of exertion on haemostasis, measures which could be adopted to mitigate VTE risks in these highly active individuals and options to deal with bleeding risks from anticoagulation during injury-prone sporting activities.
    MeSH term(s) Anticoagulants/adverse effects ; Anticoagulants/therapeutic use ; Hemorrhage/chemically induced ; Hemorrhage/epidemiology ; Humans ; Risk Factors ; Venous Thromboembolism/epidemiology ; Venous Thromboembolism/prevention & control
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2020-11-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639015-8
    ISSN 1532-1681 ; 0268-960X
    ISSN (online) 1532-1681
    ISSN 0268-960X
    DOI 10.1016/j.blre.2020.100780
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2207: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article ; Online: Successful provision of CAR-T therapy during a pandemic: low SARS-CoV-2 infection rates and reduction in ICU admissions following modification of patient pathway.

    Carter-Brzezinski, Luke / Davies, Elizabeth / Norman, Jane / Rubio, Lourdes / Dixon, Christopher / Brett, Sarah / Dunne, Tony / Iqbal, Shahid / Dignan, Fiona L / Ahmad, Shazaad / Machin, Nicholas / Morriss, Henry / Wilson, Anthony / Tholouli, Eleni

    Leukemia & lymphoma

    2022  , Page(s) 1–3

    Language English
    Publishing date 2022-08-22
    Publishing country United States
    Document type Letter
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2022.2109156
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2997: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Article ; Online: Outcomes and characteristics of nonmelanoma skin cancers in patients with myeloproliferative neoplasms on ruxolitinib.

    Rampotas, Alex / Carter-Brzezinski, Luke / Somervaille, Tim C P / Forryan, James / Panitsas, Fotios / Harrison, Claire / Witherall, Ruth / Innes, Andrew J / Wallis, Louise / Butt, Naumann M / Psaila, Bethan / Mead, Adam J / Carter, Matthew / Godfrey, Anna L / Laing, Heather / Garg, Mamta / Francis, Sebastian / Ewing, Joanne / Teh, Chun Huat /
    Cowen, Hannah Bibi / Dyer, Peter / McConville, Conall / Wadelin, Frances / Sahra, Ali / McGregor, Andrew / Kulakov, Elizabeth / McLornan, Donal P / Lambert, Jonathan

    Blood

    2023  Volume 143, Issue 2, Page(s) 178–182

    Abstract: Abstract: Nonmelanoma skin cancers (NMSCs) in ruxolitinib-treated patients with myeloproliferative neoplasms behave aggressively, with adverse features and high recurrence. In our cohort, mortality from metastatic NMSC exceeded that from myelofibrosis. ... ...

    Abstract Abstract: Nonmelanoma skin cancers (NMSCs) in ruxolitinib-treated patients with myeloproliferative neoplasms behave aggressively, with adverse features and high recurrence. In our cohort, mortality from metastatic NMSC exceeded that from myelofibrosis. Vigilant skin assessment, counseling on NMSC risks, and prospective ruxolitinib-NMSC studies are crucial.
    MeSH term(s) Humans ; Prospective Studies ; Myeloproliferative Disorders/drug therapy ; Nitriles ; Skin Neoplasms/drug therapy ; Pyrazoles ; Pyrimidines
    Chemical Substances ruxolitinib (82S8X8XX8H) ; Nitriles ; Pyrazoles ; Pyrimidines
    Language English
    Publishing date 2023-11-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2023022345
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.140: Show issues Location:
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    Zs.MO 364: Show issues

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  5. Article ; Online: Inhibition of NF-κB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes prosurvival stimuli to induce apoptosis in chronic lymphocytic leukemia cells.

    Cosimo, Emilio / McCaig, Alison M / Carter-Brzezinski, Luke J M / Wheadon, Helen / Leach, Michael T / Le Ster, Karine / Berthou, Christian / Durieu, Emilie / Oumata, Nassima / Galons, Hervé / Meijer, Laurent / Michie, Alison M

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2013  Volume 19, Issue 9, Page(s) 2393–2405

    Abstract: Purpose: Chronic lymphocytic leukemia (CLL) is currently incurable with standard chemotherapeutic agents, highlighting the need for novel therapies. Overcoming proliferative and cytoprotective signals generated within the microenvironment of lymphoid ... ...

    Abstract Purpose: Chronic lymphocytic leukemia (CLL) is currently incurable with standard chemotherapeutic agents, highlighting the need for novel therapies. Overcoming proliferative and cytoprotective signals generated within the microenvironment of lymphoid organs is essential for limiting CLL progression and ultimately developing a cure.
    Experimental design: We assessed the potency of cyclin-dependent kinase (CDK) inhibitor CR8, a roscovitine analog, to induce apoptosis in primary CLL from distinct prognostic subsets using flow cytometry-based assays. CLL cells were cultured in in vitro prosurvival and proproliferative conditions to mimic microenvironmental signals in the lymphoid organs, to elucidate the mechanism of action of CR8 in quiescent and proliferating CLL cells using flow cytometry, Western blotting, and quantitative real-time PCR.
    Results: CR8 was 100-fold more potent at inducing apoptosis in primary CLL cells than roscovitine, both in isolated culture and stromal-coculture conditions. Importantly, CR8 induced apoptosis in CD40-ligated CLL cells and preferentially targeted actively proliferating cells within these cultures. CR8 treatment induced downregulation of the antiapoptotic proteins Mcl-1 and XIAP, through inhibition of RNA polymerase II, and inhibition of NF-κB signaling at the transcriptional level and through inhibition of the inhibitor of IκB kinase (IKK) complex, resulting in stabilization of IκBα expression.
    Conclusions: CR8 is a potent CDK inhibitor that subverts pivotal prosurvival and proproliferative signals present in the tumor microenvironment of CLL patient lymphoid organs. Our data support the clinical development of selective CDK inhibitors as novel therapies for CLL.
    MeSH term(s) Adult ; Aged ; Antineoplastic Agents/pharmacology ; Apoptosis ; CD40 Ligand/physiology ; Cell Cycle Checkpoints/drug effects ; Cell Proliferation ; Cell Survival/drug effects ; Cyclin-Dependent Kinases/antagonists & inhibitors ; Cyclin-Dependent Kinases/metabolism ; Drug Evaluation, Preclinical ; Female ; Gene Expression Regulation, Leukemic/drug effects ; Humans ; Inhibitory Concentration 50 ; Interleukin-4/physiology ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Male ; Middle Aged ; Myeloid Cell Leukemia Sequence 1 Protein ; NF-kappa B/antagonists & inhibitors ; NF-kappa B/metabolism ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Purines/pharmacology ; Pyridines/pharmacology ; RNA Polymerase II/antagonists & inhibitors ; Roscovitine ; Signal Transduction/drug effects ; Tumor Cells, Cultured/drug effects ; X-Linked Inhibitor of Apoptosis Protein/genetics ; X-Linked Inhibitor of Apoptosis Protein/metabolism
    Chemical Substances Antineoplastic Agents ; CR8 compound ; IL4 protein, human ; Myeloid Cell Leukemia Sequence 1 Protein ; NF-kappa B ; Proto-Oncogene Proteins c-bcl-2 ; Purines ; Pyridines ; X-Linked Inhibitor of Apoptosis Protein ; XIAP protein, human ; Roscovitine (0ES1C2KQ94) ; CD40 Ligand (147205-72-9) ; Interleukin-4 (207137-56-2) ; Cyclin-Dependent Kinases (EC 2.7.11.22) ; RNA Polymerase II (EC 2.7.7.-)
    Language English
    Publishing date 2013-03-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-12-2170
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4223: Show issues Location:
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