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  1. Book ; Online: Emerging Concepts on the NKG2D Receptor- NKG2D Ligand Axis in Health and Diseases

    Guerra, Nadia / Lanier, Lewis L.

    2020  

    Keywords Medicine ; Immunology ; NKG2D ; natural killer cells ; tumor immunology ; autoimmunity ; cytomegalovirus (CMV)
    Size 1 electronic resource (212 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230173
    ISBN 9782889637454 ; 288963745X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: ITAM-based receptors in natural killer cells.

    Aguilar, Oscar A / Fong, Lam-Kiu / Lanier, Lewis L

    Immunological reviews

    2024  

    Abstract: The ability of cells of the immune system to acquire features such as increased longevity and enhanced secondary responses was long thought to be restricted to cells of the adaptive immune system. Natural killer (NK) cells have challenged this notion by ... ...

    Abstract The ability of cells of the immune system to acquire features such as increased longevity and enhanced secondary responses was long thought to be restricted to cells of the adaptive immune system. Natural killer (NK) cells have challenged this notion by demonstrating that they can also gain adaptive features. This has been observed in both humans and mice during infection with cytomegalovirus (CMV). The generation of adaptive NK cells requires antigen-specific recognition of virally infected cells through stimulatory NK receptors. These receptors lack the ability to signal on their own and rather rely on adaptor molecules that contain ITAMs for driving signals. Here, we highlight our understanding of how these receptors influence the production of adaptive NK cells and propose areas in the field that merit further investigation.
    Language English
    Publishing date 2024-02-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/imr.13313
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Natural killer cells

    Lanier, Lewis L.

    (Immunological reviews ; 214)

    2006  

    Author's details Lewis L. Lanier, guest ed
    Series title Immunological reviews ; 214
    Collection
    Language English
    Size 263 S. : Ill., graph. Darst.
    Publisher Blackwell Munksgaard
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT014920399
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Se 160 -214- verfügbar in Königswinter Königswinter

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  4. Article ; Online: Plastic fantastic innate lymphoid cells.

    Lanier, Lewis L

    The Journal of experimental medicine

    2019  Volume 216, Issue 8, Page(s) 1726–1727

    Abstract: In this issue ... ...

    Abstract In this issue of
    MeSH term(s) Cell Count ; Humans ; Immunity, Innate ; Lectins, C-Type ; Lymphocytes ; Plastics ; Receptors, Immunologic ; Trans-Activators
    Chemical Substances KLRG1 protein, human ; Lectins, C-Type ; Plastics ; Receptors, Immunologic ; Trans-Activators
    Language English
    Publishing date 2019-07-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20191183
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Editorial: Emerging Concepts on the NKG2D Receptor-Ligand Axis in Health and Diseases.

    Guerra, Nadia / Lanier, Lewis L

    Frontiers in immunology

    2020  Volume 11, Page(s) 562

    MeSH term(s) Animals ; Humans ; Killer Cells, Natural/immunology ; NK Cell Lectin-Like Receptor Subfamily K/immunology
    Chemical Substances NK Cell Lectin-Like Receptor Subfamily K
    Language English
    Publishing date 2020-04-07
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.00562
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Data analysis to modeling to building theory in NK cell biology and beyond: How can computational modeling contribute?

    Das, Jayajit / Lanier, Lewis L

    Journal of leukocyte biology

    2019  Volume 105, Issue 6, Page(s) 1305–1317

    Abstract: The use of mathematical and computational tools in investigating Natural Killer (NK) cell biology and in general the immune system has increased steadily in the last few decades. However, unlike the physical sciences, there is a persistent ambivalence, ... ...

    Abstract The use of mathematical and computational tools in investigating Natural Killer (NK) cell biology and in general the immune system has increased steadily in the last few decades. However, unlike the physical sciences, there is a persistent ambivalence, which however is increasingly diminishing, in the biology community toward appreciating the utility of quantitative tools in addressing questions of biological importance. We survey some of the recent developments in the application of quantitative approaches for investigating different problems in NK cell biology and evaluate opportunities and challenges of using quantitative methods in providing biological insights in NK cell biology.
    MeSH term(s) Computational Biology ; Computer Simulation ; Humans ; Killer Cells, Natural/immunology ; Models, Immunological
    Language English
    Publishing date 2019-05-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1002/JLB.6MR1218-505R
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Differential IL-12 signaling induces human natural killer cell activating receptor-mediated ligand-specific expansion.

    Shemesh, Avishai / Pickering, Harry / Roybal, Kole T / Lanier, Lewis L

    The Journal of experimental medicine

    2022  Volume 219, Issue 8

    Abstract: IL-12 is an essential cytokine involved in the generation of memory or memory-like NK cells. Mouse cytomegalovirus infection triggers NK receptor-induced, ligand-specific IL-12-dependent NK cell expansion, yet specific IL-12 stimulation ex vivo leading ... ...

    Abstract IL-12 is an essential cytokine involved in the generation of memory or memory-like NK cells. Mouse cytomegalovirus infection triggers NK receptor-induced, ligand-specific IL-12-dependent NK cell expansion, yet specific IL-12 stimulation ex vivo leading to NK cell proliferation and expansion is not established. Here, we show that IL-12 alone can sustain human primary NK cell survival without providing IL-2 or IL-15 but was insufficient to promote human NK cell proliferation. IL-12 signaling analysis revealed STAT5 phosphorylation and weak mTOR activation, which was enhanced by activating NK receptor upregulation and crosslinking leading to STAT5-dependent, rapamycin-sensitive, or TGFβ-sensitive NK cell IL-12-dependent expansion, independently of IL-12 receptor upregulation. Prolonged IL-2 culture did not impair IL-12-dependent ligand-specific NK cell expansion. These findings demonstrate that activating NK receptor stimulation promotes differential IL-12 signaling, leading to human NK cell expansion, and suggest adopting strategies to provide IL-12 signaling in vivo for ligand-specific IL-2-primed NK cell-based therapies.
    MeSH term(s) Cell Proliferation ; Humans ; Interleukin-12 ; Interleukin-2/pharmacology ; Ligands ; Receptors, Natural Killer Cell ; STAT5 Transcription Factor
    Chemical Substances Interleukin-2 ; Ligands ; Receptors, Natural Killer Cell ; STAT5 Transcription Factor ; Interleukin-12 (187348-17-0)
    Language English
    Publishing date 2022-06-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20212434
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: NKG2D Receptor and Its Ligands in Host Defense.

    Lanier, Lewis L

    Cancer immunology research

    2015  Volume 3, Issue 6, Page(s) 575–582

    Abstract: NKG2D is an activating receptor expressed on the surface of natural killer (NK) cells, CD8(+) T cells, and subsets of CD4(+) T cells, invariant NKT cells (iNKT), and γδ T cells. In humans, NKG2D transmits signals by its association with the DAP10 adapter ...

    Abstract NKG2D is an activating receptor expressed on the surface of natural killer (NK) cells, CD8(+) T cells, and subsets of CD4(+) T cells, invariant NKT cells (iNKT), and γδ T cells. In humans, NKG2D transmits signals by its association with the DAP10 adapter subunit, and in mice alternatively spliced isoforms transmit signals either using DAP10 or DAP12 adapter subunits. Although NKG2D is encoded by a highly conserved gene (KLRK1) with limited polymorphism, the receptor recognizes an extensive repertoire of ligands, encoded by at least eight genes in humans (MICA, MICB, RAET1E, RAET1G, RAET1H, RAET1I, RAET1L, and RAET1N), some with extensive allelic polymorphism. Expression of the NKG2D ligands is tightly regulated at the level of transcription, translation, and posttranslation. In general, healthy adult tissues do not express NKG2D glycoproteins on the cell surface, but these ligands can be induced by hyperproliferation and transformation, as well as when cells are infected by pathogens. Thus, the NKG2D pathway serves as a mechanism for the immune system to detect and eliminate cells that have undergone "stress." Viruses and tumor cells have devised numerous strategies to evade detection by the NKG2D surveillance system, and diversification of the NKG2D ligand genes likely has been driven by selective pressures imposed by pathogens. NKG2D provides an attractive target for therapeutics in the treatment of infectious diseases, cancer, and autoimmune diseases.
    MeSH term(s) Animals ; Communicable Diseases/genetics ; Communicable Diseases/immunology ; Communicable Diseases/metabolism ; Communicable Diseases/therapy ; Disease Resistance/physiology ; Humans ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Ligands ; Lymphocyte Activation/immunology ; Lymphocyte Subsets/immunology ; Lymphocyte Subsets/metabolism ; NK Cell Lectin-Like Receptor Subfamily K/genetics ; NK Cell Lectin-Like Receptor Subfamily K/metabolism ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/metabolism ; Neoplasms/therapy
    Chemical Substances Ligands ; NK Cell Lectin-Like Receptor Subfamily K
    Language English
    Publishing date 2015-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2732489-8
    ISSN 2326-6074 ; 2326-6066
    ISSN (online) 2326-6074
    ISSN 2326-6066
    DOI 10.1158/2326-6066.CIR-15-0098
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Natural killers join the fight against cancer.

    Cerwenka, Adelheid / Lanier, Lewis L

    Science (New York, N.Y.)

    2018  Volume 359, Issue 6383, Page(s) 1460–1461

    MeSH term(s) Humans ; Killer Cells, Natural ; Neoplasms
    Language English
    Publishing date 2018--30
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aat2184
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  10. Article ; Online: Just the FACS.

    Lanier, Lewis L

    Journal of immunology (Baltimore, Md. : 1950)

    2014  Volume 193, Issue 5, Page(s) 2043–2044

    MeSH term(s) Animals ; Flow Cytometry/history ; Flow Cytometry/instrumentation ; Flow Cytometry/methods ; History, 20th Century ; History, 21st Century ; Humans
    Language English
    Publishing date 2014-08-15
    Publishing country United States
    Document type Historical Article ; Journal Article ; Review
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.1401725
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