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Article ; Online: Comprehensive chemical profiling and quantitative analysis of ethnicYi medicine Miao-Fu-Zhi-Tong granules using UHPLC-MS/MS.

Lei, Xiaoying / Zhang, Chen / Zhao, Suqing / Cheng, Shuohan / Zhou, Wenbin / Xu, Jiapeng / Zhan, Ping / Zeper, Abliz

2023 Volume 21, Issue 3, Page(s) 214–225

Abstract: ... due to its diversity and complexity. Miao-Fu-Zhi-Tong (MFZT) granules, an ethnic Yi herbal ...

Abstract	Developing analytical methods for the chemical components of natural medicines remains a challenge due to its diversity and complexity. Miao-Fu-Zhi-Tong (MFZT) granules, an ethnic Yi herbal prescription, comprises 10 herbs and has been clinically applied for gouty arthritis (GA) therapy. Herein, a series of chemical profiling strategies including in-house library matching, molecular networking and MS/MS fragmentation behavior validation based on ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) were developed for qualitative analysis of MFZT granules. A total of 207 compounds were identified or characterized in which several rare guanidines were discovered and profiled into alkyl substituted or cyclic subtypes. Moreover, network pharmacology analysis indicated that MFZT's anti-gout mechanism was mostly associated with the nuclear factor kappa-B (NF-κB) signaling, nucleotide oligomerization domain (NOD)-like signaling and rheumatoid arthritis pathways, along with the synergistic effect of 84 potential active compounds. In addition, a quantitative analytical method was developed to simultaneously determine the 29 potential effective components. Among them, berberine, pellodendrine, 3-feruloylquinic acid, neoastilbin, isoacteoside and chlorogenic acid derivatives at higher concentrations were considered as the chemical markers for quality control. These findings provide a holistic chemical basis for MFZT granules and will support the development of effective analytical methods for the herbal formulas of natural medicines.
MeSH term(s)	Humans ; Chromatography, High Pressure Liquid/methods ; Tandem Mass Spectrometry/methods ; Drugs, Chinese Herbal/chemistry ; Quality Control ; Arthritis, Gouty
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2023-01-10
Publishing country	China
Document type	Journal Article
ZDB-ID	2192577-X
ISSN	1875-5364 ; 2095-6975 ; 1672-3651
ISSN (online)	1875-5364
ISSN	2095-6975 ; 1672-3651
DOI	10.1016/S1875-5364(23)60422-4
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Zs.A 6113: Show issues

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Article ; Online: Qi-Zhi-Wei-Tong granules alleviates chronic non-atrophic gastritis in mice by altering the gut microbiota and bile acid metabolism.

Chen, Man / Li, Ying / Li, Lan / Ma, Qingyu / Zhou, Xuan / Ding, Fengmin / Mo, Xiaowei / Zhu, Wenjun / Bian, Qinglai / Zou, Xiaojuan / Xue, Feifei / Yan, Li / Li, Xiaojuan / Chen, Jiaxu

Journal of ethnopharmacology

2023 Volume 319, Issue Pt 3, Page(s) 117304

Abstract: Ethnopharmacological relevance: In traditional Chinese medicine, Qi-zhi-wei-tong granule (QZWT ...

Abstract	Ethnopharmacological relevance: In traditional Chinese medicine, Qi-zhi-wei-tong granule (QZWT) significantly reduced the major gastrointestinal and psychological symptoms of functional dyspepsia. Aim of the study: We aimed to explore the therapeutic effect of QZWT treated chronic non-atrophic gastritis (CNAG) and to elucidate its potential mechanism. Materials and methods: The composition of QZWT was analysed by UPLC-Q/TOF-MS. The CNAG mice model was established by chronic restraint stress (CRS) in combination with iodoacetamide (IAA). Morphological staining was utilized to reveal the impact of QZWT on stomach and gut integrity. RT‒qPCR and ELISA were used to measure proinflammatory cytokines in the stomach, colon tissues and serum of CNAG mice. Next-generation sequencing of 16 S rDNA was applied to analyse the gut microbiota community of faecal samples. Finally, we investigated the faecal bile acid composition using GC‒MS. Results: Twenty-one of the compounds from QZWT were successfully identified by UPLC-Q/TOF-MS analysis. QZWT enhanced gastric and intestinal integrity and suppressed inflammatory responses in CNAG mice. Moreover, QZWT treatment reshaped the gut microbiota structure by increasing the levels of the Akkermansia genus and decreasing the populations of the Desulfovibrio genus in CNAG mice. The alteration of gut microbiota was associated with gut bacteria BA metabolism. In addition, QZWT reduced BAs and especially decreased conjugated BAs in CNAG mice. Spearman's correlation analysis further confirmed the links between the changes in the gut microbiota and CNAG indices. Conclusions: QZWT can effectively inhibited gastrointestinal inflammatory responses of CNAG symptoms in mice; these effects may be closely related to restoring the balance of the gut microbiota and regulating BA metabolism to protect the gastric mucosa. This study provides a scientific reference for the pathogenesis of CNAG and the mechanism of QZWT treatment.
MeSH term(s)	Animals ; Mice ; Gastrointestinal Microbiome ; Qi ; Lipid Metabolism ; Bile Acids and Salts ; Gastritis/drug therapy
Chemical Substances	Bile Acids and Salts
Language	English
Publishing date	2023-10-12
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.117304
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Article: Mechanism of the Treatment of Irritable Bowel Syndrome with Sini Powder and Tong Xie Yao Fang Decoction Based on Network Pharmacology.

Tang, Rong / Peng, Xiaoqing / Zhou, Xiaohong / Zheng, Zhimin / Yin, Jiayu / Liu, Hong

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 3598856

Abstract	This study used a network pharmacology approach to investigate the potential active ingredients of Sini Powder and Tong xie yao fang decoction and the underlying mechanisms in irritable bowel syndrome (IBS) treatment. The potential active ingredients of Sini Powder and Tong xie yao fang decoction were obtained from TCMSP databases, and the potential targets of the active ingredients were predicted and analyzed by using the Swiss Target Prediction database. T Genecard, DisGeNET, and OMIM databases were processed to screen the potential therapeutic targets in IBS. The interaction of overlapped candidates between the potential biotarget of herb extracts and the potential therapeutic target of IBS were analyzed by STRING website and visualized by the Cytoscape V3.8.0 software. Gene ontology (GO) analysis and Kyoto Genomics and Genomics Encyclopedia (KEGG) pathway were processed to categorize and map the potential biofunctions and effects of these candidates by using David database.
Language	English
Publishing date	2022-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/3598856
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Article ; Online: Metabolomics-Based Pharmacodynamic Analysis of Zhuang Yao Shuang Lu Tong Nao Granules in a Rat Model of Ischemic Cerebral Infarction.

Zhai, Yang / Chen, Yangling / Luo, Yihui / Mei, Xiaoping / Wu, Lin / Mo, Xueni / Zou, Min / Zhou, Mingzhao / Wu, Yangling / Zheng, Guangshan / Yang, Peng / He, Qingyu / Chen, Rui

Analytical cellular pathology (Amsterdam)

2022 Volume 2022, Page(s) 8776079

Abstract: ... related metabolic pathways before and after Zhuang Yao Shuang Lu Tong Nao granule (YHT) treatment in rats ...

Abstract	This study used a metabolomic approach to reveal changes in the levels of metabolic biomarkers and related metabolic pathways before and after Zhuang Yao Shuang Lu Tong Nao granule (YHT) treatment in rats with cerebral ischemia. The neurological deficit scores were significantly higher in the MCAO_R group than in the NC group, indicating that the mice had significantly impaired motor functions. The YHT group had significantly lower scores than the MCAO_R group, suggesting that YHT significantly improved motor function in rats. TTC staining of the brain tissue revealed that YHT significantly reduced the area of cerebral infarction in the treated rats. The MCAO_R group was better separated from the NC rent, sham, and YHT groups via metabolomic PCA. Moreover, there were significant differences in the differential metabolites between the MACO_R and YHT groups. Eighteen common differential metabolites were detected between the MACO_R and NC groups, MACO_R and sham groups, and MACO_R and YHT groups, indicating that YHT significantly increased the levels of various metabolites in the serum of cerebral ischemic stroke (CIS) rats. Moreover, a total of 23 metabolic pathways were obtained. We identified 11 metabolic pathways with the most significant effects in the bubble plots. In conclusion, from a systems biology perspective, this metabolomics-based study showed that YHT could be used to treat ischemic stroke by modulating changes in endogenous metabolites.
MeSH term(s)	Animals ; Brain Ischemia/drug therapy ; Cerebral Infarction ; Disease Models, Animal ; Ischemic Stroke ; Metabolomics ; Mice ; Rats ; Rats, Sprague-Dawley
Language	English
Publishing date	2022-07-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2583629-8
ISSN	2210-7185 ; 2210-7177
ISSN (online)	2210-7185
ISSN	2210-7177
DOI	10.1155/2022/8776079
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Zs.A 3139: Show issues

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Article ; Online: A randomized, double-blind, placebo-controlled trial for Yi-Qi Hua-Yu tong-sui granule in the treatment of mild or moderate cervical spondylotic myelopathy.

Xu, Chongqing / Zhou, Xiaoning / Tong, Zhengyi / Ma, Junming / Ye, Jie / Xu, Jinhai / Mo, Wen

Medicine

2020 Volume 99, Issue 33, Page(s) e21776

Abstract: Background: Neck pain, sensory disturbance and motor dysfunction in most patients suffered cervical spondylotic myelopathy (CSM). However, some conservative treatments are limited by their modest effectiveness. In the other hand, surgical treatment is ... ...

Abstract	Background: Neck pain, sensory disturbance and motor dysfunction in most patients suffered cervical spondylotic myelopathy (CSM). However, some conservative treatments are limited by their modest effectiveness. In the other hand, surgical treatment is necessary when symptoms are refractory to conservative treatments and neurological function of the patients has deteriorated. Many patients use complementary and alternative medicine, including traditional Chinese medicine, to address their symptoms. The purpose of the present study is to examine effectiveness and safety of Yiqi-Huayu-Tongsui (YQHYTS) granule, a compound traditional Chinese herbal medicine, on symptoms in patients with mild or moderate CSM. Methods/design: A randomized, double blinded, placebo-controlled clinical trial to evaluate the efficacy and safety of YQHYTS granule is proposed. 72 patients in Longhua Hospital with the diagnosis of mild or moderate CSM will be randomly allocated into 2 groups, and treated with YQHYTS granule or placebo. The prescription of the trial drugs (YQHYTS granule/placebo) is 20 grams twice a day for 3 months. The primary outcome measurements include visual analog scale, Japanese Orthopedic Association, and Neck Disability Index score. The secondary outcome measurements are electromyogram and Pfirrmann classification. Discussion: YQHYTS granule has been established and applied in Longhua Hospital for many years. As it has a potential benefit in treating mild or moderate CSM, we designed a double-blind, prospective, randomized controlled trial and would like to publish the results and conclusions later. If YQHYTS granule can alleviate neck pain, sensory disturbance, and even motor dysfunction without adverse effects, it may be a unique strategy for the treatment of mild or moderate CSM. Trial registration: Chinese Clinical Trial Registry ID: ChiCTR1900028192. Registered 15 December 2019, Available at: http://www.chictr.org.cn/edit.aspx?pid=46913&htm=4.
MeSH term(s)	Cervical Vertebrae ; Double-Blind Method ; Humans ; Randomized Controlled Trials as Topic ; Spinal Cord Diseases/drug therapy ; Spinal Cord Diseases/etiology ; Spondylosis/complications
Language	English
Publishing date	2020-09-14
Publishing country	United States
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000021776
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Article: Ai-Tong-An-Gao-Ji and Fisetin Inhibit Tumor Cell Growth in Rat CIBP Models by Inhibiting the AKT/HIF-1

Wang, Jing / Lai, Zonglang / Zhou, Xin / Na, Song / Zhang, Liufan / Cheng, Jun

Journal of oncology

2022 Volume 2022, Page(s) 1459636

Abstract: Background: Ai-Tong-An-Gao-Ji (ATAGJ) has been extensively applied for acute bone cancer pain ...

Abstract	Background: Ai-Tong-An-Gao-Ji (ATAGJ) has been extensively applied for acute bone cancer pain treatment with a satisfactory efficacy, while the specific mechanisms remain unclear and require further investigation. Methods: Overlapped genes of ATAGJ and CIBP obtained from SwissTargetPrediction website and GeneCards database were presented as a Venn diagram. A network diagram of drug-component-target was further established using the Cytoscape 3.6.0 software. The effect of fisetin on Walker 256 cell proliferation was observed by clone formation assay and EDU assay, and the interaction between fisetin and AKT was revealed using the immunoprecipitation assay. Effects of fisetin on AKT/HIF-1 Results: The key component fisetin and core target gene AKT were sorted out using the drug-component-target network with a binding energy between fisetin and AKT less than -5 kcal/mol. Clone formation assay and EDU assay showed that fisetin substantially suppressed the proliferation of Walker 256 cells. Immunoprecipitation assay results revealed that the combination of fisetin and AKT decreased the level of AKT/HIF-1 Conclusions: The fisetin of ATAGJ can markedly suppress Walker 256 cells, and the mechanisms may be intimately associated with the combination of fisetin and AKT. Furthermore, fisetin decreased the level of p-AKT and inhibited the expression of the AKT/HIF-1
Language	English
Publishing date	2022-02-16
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2461349-6
ISSN	1687-8469 ; 1687-8450
ISSN (online)	1687-8469
ISSN	1687-8450
DOI	10.1155/2022/1459636
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Article ; Online: Dan-Deng-Tong-Nao softgel capsule promotes angiogenesis of cerebral microvasculature to protect cerebral ischemia reperfusion injury via activating HIF-1α-VEGFA-Notch1 signaling pathway.

Wang, Lei / Li, Jiacheng / Wang, Yang / Ge, Chaowen / Huang, Qi / Li, Lili / Wang, Ning / Chen, Yuang / Zhou, Xian / Chang, Dennis / Li, Dan / Hou, Jincai

Phytomedicine : international journal of phytotherapy and phytopharmacology

2023 Volume 118, Page(s) 154966

Abstract: Background: A proprietary Chinese herbal product called Dan-Deng-Tong-Nao softgel capsule (DDTNC ...

Abstract	Background: A proprietary Chinese herbal product called Dan-Deng-Tong-Nao softgel capsule (DDTNC) is used to treat ischemic stroke. However, the preventive mechanisms of DDTNC against cerebral ischemia reperfusion injury (CIRI) haven not been characterized. Objective: To explore the mechanisms of protective effects of DDTNC against CIRI from both internal and external levels. Methods: Chemical characterization was performed using UPLC. The potential protective mechanisms of DDTNC against CIRI were predicted using network pharmacology. Model of middle cerebral artery occlusion/reperfusion (MCAO/R) was established in rats. An model of brain microvascular endothelial cells (BMECs) induced by oxygen-glucose deprivation/reoxygenation (OGD/R) was also established. We evaluated neurological deficits, cerebral infarct volume, cortical neuron damage, and mitochondrial swelling in vivo. We evaluated the expression of VEGFR2, VEGFA, HIF-1α, CD31, and CD34 in ischemic cortex, and VEGF, bFGF, BDNF, angiostatin, and endostatin in serum of rats and in BMEC supernatants. We also evaluated cell viability, cytotoxicity, intracellular ROS, apoptosis, and migration ability in vitro. Results: Seven components were detected in DDTNC. KEGG enrichment analysis showed that DDTNC may modulate angiogenesis via the HIF-1 signaling pathway. DDTNC treatment reduced neurological score and infarct volume, and improved cell morphology of damaged neurons. Transmission electron microscopy showed that DDTNC reduced mitochondria swelling in cortical neurons. Furthermore, DDTNC reduced intracellular ROS and inhibited apoptosis. DDTNC boosted the expression of CD31, CD34, VEGFR2, VEGFA and HIF-1α, highlighting its involvement in angiogenesis, according to immunofluorescence studies. Furthermore, DDTNC enhanced tube formation and migration of BMECs in vitro. ELISA and western blotting indicated that DDTNCCSF induced the expression of VEGF, BDNF and bFGF, reduced the level of angiostatin and endostatin, increased the protein expression of VEGFA, Notch1 and HIF-1α in vitro and in vivo. Conclusions: DDTNC promoted angiogenesis to protect brain tissue against MCAO/R, and exerted protective effects against OGD/R in BMECs via activating HIF-1α-VEGFA-NOTCH1 signal transduction pathway.
MeSH term(s)	Rats ; Animals ; Endothelial Cells ; Vascular Endothelial Growth Factor A/metabolism ; Angiostatins/metabolism ; Angiostatins/pharmacology ; Angiostatins/therapeutic use ; Brain-Derived Neurotrophic Factor/metabolism ; Endostatins/metabolism ; Endostatins/pharmacology ; Endostatins/therapeutic use ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Brain Ischemia/drug therapy ; Brain Ischemia/metabolism ; Infarction, Middle Cerebral Artery/drug therapy ; Infarction, Middle Cerebral Artery/metabolism ; Reperfusion Injury/drug therapy ; Reperfusion Injury/metabolism ; Microvessels/metabolism ; Receptor, Notch1/metabolism
Chemical Substances	Vascular Endothelial Growth Factor A ; Angiostatins (86090-08-6) ; Brain-Derived Neurotrophic Factor ; Endostatins ; Reactive Oxygen Species ; Notch1 protein, rat ; Receptor, Notch1
Language	English
Publishing date	2023-07-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2023.154966
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Zs.A 4115: Show issues

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Article ; Online: Systemic pharmacological investigation of the Feng Shi Gu Tong capsule in the treatment of rheumatoid arthritis.

Wei, Xin / Fu, Wanjin / Zhou, Renpeng / Chen, Yong / Lu, Chao / Hu, Wei

Naunyn-Schmiedeberg's archives of pharmacology

2021 Volume 394, Issue 6, Page(s) 1285–1299

Abstract: Feng Shi Gu Tong (FSGT) capsule is a commonly used Chinese Traditional Patent Medicine in clinical ...

Abstract	Feng Shi Gu Tong (FSGT) capsule is a commonly used Chinese Traditional Patent Medicine in clinical practice, which has been proven to be effective for the treatment of active rheumatoid arthritis (RA). However, due to its complex composition, the precise molecular mechanism of the FSGT capsule in the treatment of RA is still indistinct. Therefore, the method of systemic pharmacology was used to obtain candidate compounds through absorption, distribution, metabolism, elimination (ADME) parameters, and supplementation of references. Network construction and analysis were also included to reveal the potential mechanism of FSGT capsule in treating RA. A total of 119 compounds were obtained in FSGT capsule, and a total of 107 compounds with targets were included in the study. These compounds acted on 267 targets in total. In addition, there were 317 targets related to RA disease. All constructed networks included four major networks and four minor networks. In addition, the clusters of RA disease protein-protein interaction (PPI) network and FSGT capsule-RA disease targets network revealed that the biological process involved in these clusters including immune response and apoptosis, etc. The pathways enriched by the direct targets of FSGT capsule acted on RA also highly overlapped with the pathways enriched by the RA PPI network, such as the TNF signaling pathway. Our research has managed to predict and explain the pharmacological effects and the molecular mechanisms of the FSGT capsule in RA, and provided a realistic exploration method for studying the potentially active ingredients of traditional Chinese medicines simultaneously.
MeSH term(s)	Antirheumatic Agents/chemistry ; Antirheumatic Agents/pharmacokinetics ; Antirheumatic Agents/pharmacology ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/physiopathology ; Caco-2 Cells ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacokinetics ; Drugs, Chinese Herbal/pharmacology ; Humans ; Medicine, Chinese Traditional ; Network Pharmacology ; Protein Interaction Maps ; Signal Transduction/drug effects
Chemical Substances	Antirheumatic Agents ; Drugs, Chinese Herbal
Language	English
Publishing date	2021-02-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	121471-8
ISSN	1432-1912 ; 0028-1298
ISSN (online)	1432-1912
ISSN	0028-1298
DOI	10.1007/s00210-021-02048-8
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Article ; Online: Integrated pharmacology reveals the mechanism of action of Bu-Shen-Tong-Du prescription against collagen-induced arthritis.

Wei, Xiaolu / Peng, Mingming / Liu, Danbing / Zhao, Lijuan / Gu, Xinru / Wang, Linna / Zhou, Yanyan / Zhao, Haiyu / Si, Nan / Wang, Hongjie / Hou, Liping / Shu, Zunpeng / Bian, Baolin

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2021 Volume 143, Page(s) 112160

Abstract: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease. Bu-Shen-Tong-Du ...

Abstract	Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease. Bu-Shen-Tong-Du prescription (BSP) has traditionally been used in to treat RA but its underlying mechanisms remain unclear. In this study, we explored the potential mechanisms of BSP in collagen-induced arthritis (CIA) rats, a classic animal model of RA. We employed an integrated pharmacology approach in combination with network pharmacology,
MeSH term(s)	Animals ; Anti-Inflammatory Agents/pharmacology ; Antirheumatic Agents/pharmacology ; Arthritis, Experimental/chemically induced ; Arthritis, Experimental/drug therapy ; Arthritis, Experimental/immunology ; Arthritis, Experimental/metabolism ; Collagen Type II ; Cytokines/metabolism ; Drugs, Chinese Herbal/pharmacology ; Energy Metabolism/drug effects ; Joints/drug effects ; Joints/immunology ; Joints/metabolism ; Joints/pathology ; Male ; Medicine, Chinese Traditional ; NF-kappa B/metabolism ; Network Pharmacology ; Rats, Sprague-Dawley ; Signal Transduction ; Toll-Like Receptor 4/metabolism ; Rats
Chemical Substances	Anti-Inflammatory Agents ; Antirheumatic Agents ; Collagen Type II ; Cytokines ; Drugs, Chinese Herbal ; NF-kappa B ; Tlr4 protein, rat ; Toll-Like Receptor 4
Language	English
Publishing date	2021-09-21
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2021.112160
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Article ; Online: Mechanism of the Treatment of Irritable Bowel Syndrome with Sini Powder and Tong Xie Yao Fang Decoction Based on Network Pharmacology

Rong Tang / Xiaoqing Peng / Xiaohong Zhou / Zhimin Zheng / Jiayu Yin / Hong Liu

Evidence-Based Complementary and Alternative Medicine, Vol

2022 Volume 2022

Abstract: ... of Sini Powder and Tong xie yao fang decoction and the underlying mechanisms in irritable bowel syndrome ... IBS) treatment. The potential active ingredients of Sini Powder and Tong xie yao fang decoction were ... components and 248 related biotargets of Sini Powder and Tong xie yao fang decoction which were involved ...

Abstract	This study used a network pharmacology approach to investigate the potential active ingredients of Sini Powder and Tong xie yao fang decoction and the underlying mechanisms in irritable bowel syndrome (IBS) treatment. The potential active ingredients of Sini Powder and Tong xie yao fang decoction were obtained from TCMSP databases, and the potential targets of the active ingredients were predicted and analyzed by using the Swiss Target Prediction database. T Genecard, DisGeNET, and OMIM databases were processed to screen the potential therapeutic targets in IBS. The interaction of overlapped candidates between the potential biotarget of herb extracts and the potential therapeutic target of IBS were analyzed by STRING website and visualized by the Cytoscape V3.8.0 software. Gene ontology (GO) analysis and Kyoto Genomics and Genomics Encyclopedia (KEGG) pathway were processed to categorize and map the potential biofunctions and effects of these candidates by using David database. Result. There were 139 predicted active components and 248 related biotargets of Sini Powder and Tong xie yao fang decoction which were involved in IBS treatment, and 522 annotations and 101 related pathways are obtained by enrichment analysis (P<0.01, FDR < 0.05). The underlying mechanisms of Sini Powder and Tong xie yao fang decoction may be related to neuroactive ligand-receptor interaction, calcium, cAMP, and HIF-1 signaling pathways. In conclusion, our results showed that the effect and mechanism of Sini Powder and Tong xie yao fang decoction in IBS treatment were in multi-ingredient, multitargets and multipathways, which would provide several potential and promising strategies for the further research and development of Sini Powder and Tong xie yao fang decoction on IBS treatment.
Keywords	Other systems of medicine ; RZ201-999
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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