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  1. Article: What Helping Babies Breathe knowledge and skills are formidable for healthcare workers?

    Patel, Archana B / Bang, Akash / Kurhe, Kunal / Bhargav, Savita / Hibberd, Patricia L

    Frontiers in pediatrics

    2023  Volume 10, Page(s) 891266

    Abstract: Introduction: Most neonatal deaths occur in the first week of life, due to birth asphyxia. Helping Babies Breathe (HBB), is a simulation-based neonatal resuscitation training program to improve knowledge and skills. There is little information on which ... ...

    Abstract Introduction: Most neonatal deaths occur in the first week of life, due to birth asphyxia. Helping Babies Breathe (HBB), is a simulation-based neonatal resuscitation training program to improve knowledge and skills. There is little information on which knowledge items or skill steps are challenging for the learners.
    Methods: We used training data from NICHD's Global Network study to understand the items most challenging for Birth Attendants (BA) to guide future curriculum modifications. HBB training was provided in 15 primary, secondary and tertiary level care facilities in Nagpur, India. Refresher training was provided 6 months later. Each knowledge item and skill step was ranked from difficulty level 1 to 6 based on whether 91%-100%, 81%-90%, 71%-80%, 61%-70%, 51%-60% or <50% of learners answered/performed the step correctly.
    Results: The initial HBB training was conducted in 272 physicians and 516 midwives of which 78 (28%) physicians and 161 (31%) midwives received refresher training. Questions related to timing of cord clamping, management of a meconium-stained baby, and steps to improve ventilation were most difficult for both physicians and midwives. The initial steps of Objective Structured Clinical Examination (OSCE)-A i.e. equipment checking, removing wet linen and immediate skin-to-skin contact were most difficult for both groups. Midwives missed stimulating newborns while physicians missed cord clamping and communicating with mother. In OSCE-B, starting ventilation in the first minute of life was the most missed step after both initial and 6 months refresher training for physicians and midwives. At the retraining, the retention was worst for cutting the cord (physicians level 3), optimal rate of ventilation, improving ventilation & counting heart rate (midwives level 3), calling for help (both groups level 3) and scenario ending step of monitoring the baby and communicating with mother (physicians level 4, midwives 3).
    Conclusion: All BAs found skill testing more difficult than knowledge testing. The difficulty level was more for midwives than for physicians. So, the HBB training duration and frequency of retraining can be tailored accordingly. This study will also inform subsequent refinement in the curriculum so that both trainers and trainees will be able to achieve the required proficiency.
    Language English
    Publishing date 2023-01-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2022.891266
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Recurrent Catatonia and Demyelinating Disorders.

    Jiang, Stephanie M / Koepsell, Marybeth / Patel, Bhargav / Athanasiadi, Argyro

    Cureus

    2023  Volume 15, Issue 7, Page(s) e41656

    Abstract: Catatonia, a neuropsychiatric syndrome characterized by psychomotor and behavioral symptoms, can be associated with various underlying conditions, including demyelinating diseases such as multiple sclerosis. This paper presents a case study of a 47-year- ... ...

    Abstract Catatonia, a neuropsychiatric syndrome characterized by psychomotor and behavioral symptoms, can be associated with various underlying conditions, including demyelinating diseases such as multiple sclerosis. This paper presents a case study of a 47-year-old female with recurrent catatonic relapses and an underlying demyelinating disease. The patient exhibited symptoms of confusion, decreased oral intake, and difficulty with movement and speech. Neurological examinations, brain imaging, and laboratory tests were conducted to evaluate the etiology and guide treatment. The patient showed improvement with lorazepam and electroconvulsive therapy (ECT). However, relapses occurred after the abrupt withdrawal of medication. The case study highlights the potential connection between demyelinating diseases and catatonia and emphasizes the importance of considering demyelinating diseases in the workup, treatment, and relapse prevention of catatonia. Further research is needed to explore the mechanisms underlying the relationship between demyelination and catatonia and to investigate how different etiologies may impact the recurrence rates of catatonic episodes.
    Language English
    Publishing date 2023-07-10
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.41656
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Late-Onset Bipolar Disorder: Considerations for Diagnosis and Treatment.

    McKenzie, Anna K / Chawla, Rishab / Patel, Bhargav / Shashank, Reddy B

    Cureus

    2023  Volume 15, Issue 5, Page(s) e39278

    Abstract: Bipolar I disorder is characterized by the presence of at least one manic episode (DSM-5). Despite a decent percentage of individuals being diagnosed later in life, there currently exist no formal treatment guidelines for late-onset bipolar disorder ( ... ...

    Abstract Bipolar I disorder is characterized by the presence of at least one manic episode (DSM-5). Despite a decent percentage of individuals being diagnosed later in life, there currently exist no formal treatment guidelines for late-onset bipolar disorder (LOBD), which remains poorly understood. Typically, manic or manic-like episodes in elderly individuals can be thought of as arising from a secondary, physical cause. However, in the absence of a pre-existing neurological disorder - and when laboratory, imaging, and exam findings do not fully support a neurological picture - the determination of a structural versus primary etiology for LOBD becomes challenging. We present the case of Ms. S, a 79-year-old woman with a past psychiatry history of bipolar disorder diagnosed after 2012 and non-contributory past medical history who was admitted to a state mental hospital on a probate court order from local jail secondary to labile mood and physical aggression toward an officer. Initial labs were remarkable for slightly elevated low-density lipoprotein and a B12 at the lower limit of normal. She was started on a regiment oral B12 supplement, valproic acid 500 mg twice daily, haloperidol 5 mg nightly, and diphenhydramine 25 mg nightly. Despite her medication regimen, she continued to display marked mood lability, tangential thought processes, grandiose delusions, and paranoia. A CT head one week into admission revealed bilateral periventricular white-matter hyperintensities with decreased attenuation and chronic white-matter infarcts. She underwent five sessions of electroconvulsive therapy (ECT), with significantly improving Montreal Cognitive Assessment and Young Mania Rating Scale scores. At the time of discharge on day 32, the patient was fully oriented to self and surroundings with good hygiene, a normal rate of speech, euthymic mood, and congruent affect. The case of Ms. S underscores the importance of a thorough workup to rule out secondary causes of mania. In addition, it is a clarion call for revisiting and researching a comprehensive management approach to LOBD, for which serial cognitive assessments and ECTs may play an important role.
    Language English
    Publishing date 2023-05-20
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.39278
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Forensic evaluation of mitochondrial DNA heteroplasmy in Gujarat population, India.

    Alqaisi, Mohammed H M / Ekka, Molina Madhulika / Patel, Bhargav C

    Annals of human biology

    2022  Volume 49, Issue 7-8, Page(s) 332–341

    Abstract: Background: Owing to its high copy number and its small size, mtDNA analysis is the most reliable choice when biological materials from crime scenes are degraded or have mixed STR profiles.: Aim: To examine the occurrence of heteroplasmy along with ... ...

    Abstract Background: Owing to its high copy number and its small size, mtDNA analysis is the most reliable choice when biological materials from crime scenes are degraded or have mixed STR profiles.
    Aim: To examine the occurrence of heteroplasmy along with its frequency and pattern in both HV1 and HV2 regions of the mtDNA among unrelated individuals from India.
    Subjects and methods: Mitochondrial DNA control region [hypervariable region one (HV1) and hypervariable region two (HV2)] were analysed in blood and buccal tissues of 104 unrelated individuals from the Indian state of Gujarat.
    Results: A high frequency of point heteroplasmy (PH) and length heteroplasmy (LH) was revealed. PH was detected in 7.69% of the population, with a higher frequency observed in blood than in buccal samples. However, there were no statistically significant differences in PH between the two tissues (Chi-square = 0.552,
    Conclusions: Our findings suggest that differences in the pattern of heteroplasmy found in different tissues can complicate the forensic analysis, on the other hand, the probability of a match between the questioned and reference samples increases when the heteroplasmy is identical in both tissues. Variability of PH among persons and even within tissues recommends analysing multiple tissue samples before drawing a conclusion in forensic mtDNA analyses.
    MeSH term(s) Humans ; DNA, Mitochondrial/genetics ; DNA, Mitochondrial/analysis ; Heteroplasmy ; India ; Sequence Analysis, DNA
    Chemical Substances DNA, Mitochondrial
    Language English
    Publishing date 2022-11-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 186656-4
    ISSN 1464-5033 ; 0301-4460
    ISSN (online) 1464-5033
    ISSN 0301-4460
    DOI 10.1080/03014460.2022.2144447
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Durum wheat semolina-modified ceramic membranes as novel porous separators for enhanced power generation and wastewater remediation using microbial fuel cell.

    Patel, Bhargav R / Noroozifar, Meissam / Mohebbi-Kalhori, Davod / Kerman, Kagan

    Bioresource technology

    2022  Volume 361, Page(s) 127752

    Abstract: This proof-of-concept study describes the enhanced performance efficiency of the dual-chambered microbial fuel cell equipped with the fabricated unmodified ceramic membranes and ceramic membranes modified with 5 % and 10 % (w/w) durum wheat semolina in ... ...

    Abstract This proof-of-concept study describes the enhanced performance efficiency of the dual-chambered microbial fuel cell equipped with the fabricated unmodified ceramic membranes and ceramic membranes modified with 5 % and 10 % (w/w) durum wheat semolina in comparison with the commercially available Nafion
    MeSH term(s) Bioelectric Energy Sources ; Ceramics/chemistry ; Electrodes ; Porosity ; Triticum ; Waste Water
    Chemical Substances Waste Water
    Language English
    Publishing date 2022-08-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1065195-0
    ISSN 1873-2976 ; 0960-8524
    ISSN (online) 1873-2976
    ISSN 0960-8524
    DOI 10.1016/j.biortech.2022.127752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Gossypiboma: a rare complication diagnosed on esophagogastroduodenoscopy.

    Yagnik, Vipul D / Garg, Pankaj / Patel, Mayank I / Yagnik, Bhargav / Oza, Rajesh / Dawka, Sushil

    ANZ journal of surgery

    2022  Volume 92, Issue 11, Page(s) 3065–3066

    MeSH term(s) Humans ; Foreign Bodies/diagnostic imaging ; Foreign Bodies/surgery ; Surgical Sponges/adverse effects ; Endoscopy, Digestive System
    Language English
    Publishing date 2022-02-03
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.17533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A systematic evaluation of 'Bidi - a hand-rolled cigarette' as a forensic DNA evidence.

    Ekka, Molina Madhulika / Arya, Lakshita / Patel, Bhargav C

    Forensic science international

    2021  Volume 324, Page(s) 110821

    Abstract: Bidis are small handmade cigarettes consisting of ~0.2 g of tobacco flakes rolled in a dried leaf of 'Tendu' (Diospyros melanoxylon) or Piliostigma racemosum and tied with a thin thread. They have gained worldwide popularity among smokers and are often ... ...

    Abstract Bidis are small handmade cigarettes consisting of ~0.2 g of tobacco flakes rolled in a dried leaf of 'Tendu' (Diospyros melanoxylon) or Piliostigma racemosum and tied with a thin thread. They have gained worldwide popularity among smokers and are often collected as forensic DNA evidence from crime scenes and processed similarly to cigarette butts. However, bidi's composition and manufacturing process differs distinctly from the cigarette, and hence the optimal processing for DNA analysis should not be assumed to be similar to cigarette butts. In the present study, the methodical evaluation of the bidi for DNA analysis is reported and an additional process of cell elution from bidi stubs prior to DNA extraction is systematically compared with the direct lysis of bidi stubs which is identical to the standard practice in forensic labs for cigarette butts. In terms of cell recovery from bidi stubs, the SDS based Cell Elution Buffer (CEB) proved to be better than Tween20 based CEB. The three components (cell-elute, supernatant, and processed stub) obtained after the cell elution process of smoked bidi stubs showed varying amounts of DNA. The cell-elute and processed stub exhibited high quality DNA, resulting in 90-100% of the samples giving a full STR profile. On the contrary, the directly lysed stubs yielded high quantity but low quality of DNA, resulting in only 40% of the samples with full STR profiles. The cell elution process enables three components namely cell-elute, supernatant and processed stub from the same bidi to be used for forensic DNA analysis, although the cell-elute proved to be the best source of DNA for STR profiling. The current study demonstrates that the additional cell elution process proved to be an essential step prior to DNA extraction procedure for bidi stubs.
    MeSH term(s) Cell Separation/methods ; DNA/analysis ; DNA Fingerprinting ; Forensic Sciences/methods ; Humans ; Microsatellite Repeats ; Smoking ; Tobacco Products
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2021-05-12
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 424042-x
    ISSN 1872-6283 ; 0379-0738
    ISSN (online) 1872-6283
    ISSN 0379-0738
    DOI 10.1016/j.forsciint.2021.110821
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: An Unusual Case of Chronic Hemoptysis.

    Chopra, Madhav / Patel, Bhargav / Puthalapattu, Swathy / Nguyen, Tan

    Chest

    2021  Volume 159, Issue 5, Page(s) e331–e335

    Abstract: Case presentation: A 62-year-old African American man was admitted to the hospital with hemoptysis. He had a complicated medical history significant for active tobacco use (>50 pack-year history), coronary artery disease, and heart failure with reduced ... ...

    Abstract Case presentation: A 62-year-old African American man was admitted to the hospital with hemoptysis. He had a complicated medical history significant for active tobacco use (>50 pack-year history), coronary artery disease, and heart failure with reduced ejection fraction. He reported intermittent episodes of coughing up streaks of blood in the sputum for the past 3 years. For the past few days before this presentation, he had multiple episodes of coughing up over a tablespoon of only blood. He was not on any anticoagulant agents. There were no risk factors for TB, nor was there a history of fevers, chills, shortness of breath, leg swelling, changes in his urine color and frequency or urgency, or unintended weight loss. On admission, he was noted to be breathing comfortably. Vital signs revealed a temperature of 36.6ºC, BP of 138/70 mm Hg, heart rate of 66 beats/min, respiratory of rate of 18 breaths/min, and a blood oxygen saturation level of 98% on room air. Physical examination was significant for decreased bilateral breath sounds with no wheezing, crackles, or rhonchi. Cardiovascular examination revealed normal cardiac rhythm without murmur, rubs, or gallops. There was no clubbing or edema on his extremities.
    MeSH term(s) Amyloidosis/diagnosis ; Biopsy ; Chronic Disease ; Comorbidity ; Diagnosis, Differential ; Diagnostic Imaging ; Hemoptysis ; Humans ; Lung Diseases/diagnosis ; Male ; Middle Aged ; Smokers
    Language English
    Publishing date 2021-04-30
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2020.12.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: In silico analysis, synthesis and biological evaluation of DHFR inhibitors.

    Lad, Chaitali / Panchal, Ishan / Patel, Ashish / Nagani, Afzal / Parikh, Vruti / Patel, Harnisha / Bhimani, Bhargav

    Folia medica

    2022  Volume 63, Issue 5, Page(s) 745–759

    Abstract: Introduction: Malaria is one of the varieties of fatal diseases caused by a protozoan parasite that is now considered to be the greatest global health challenge. A parasite of Plasmodium species triggers it transmitting the disease to humans by the ... ...

    Abstract Introduction: Malaria is one of the varieties of fatal diseases caused by a protozoan parasite that is now considered to be the greatest global health challenge. A parasite of Plasmodium species triggers it transmitting the disease to humans by the bites of female Anopheles mosquitoes.
    Aim: To screen out designed molecules by molecular docking analysis and assess their pharmacokinetic properties using SwissADME. To synthesize the designed compounds. To characterize the synthesized compounds by TLC, melting point, IR spectroscopy, mass spectrometry, 1H NMR, and 13C NMR. To evaluate the synthesized compounds for antimalarial activity.
    Materials and methods: In silico analysis was performed with SWISSADME, and molecular docking was performed by AutoDock Vina version 4.2. In vitro antimalarial activity study was performed.
    Results: In-vitro studies of synthesized molecules showed that compounds C2 (IC50 1.23), C6 (IC50 0.48), C10 (IC50 0.79), and C14 (IC50 0.19) possess good antimalarial activity.
    Conclusions: 7-chloroquinoline-piperazine derivatives exhibited potential antimalarial compounds for pf-DHFR inhibitors.
    MeSH term(s) Animals ; Antimalarials/pharmacology ; Female ; Humans ; Molecular Docking Simulation ; Plasmodium falciparum
    Chemical Substances Antimalarials
    Language English
    Publishing date 2022-07-18
    Publishing country Bulgaria
    Document type Journal Article
    ZDB-ID 300275-5
    ISSN 1314-2143 ; 0430-8638 ; 0204-8043
    ISSN (online) 1314-2143
    ISSN 0430-8638 ; 0204-8043
    DOI 10.3897/folmed.63.e56786
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Optimizing presurgical education for patients with head and neck cancer receiving laryngectomy and free flap surgery: A qualitative study.

    Mikhael, Marian / Kansara, Bhargav / Basta, Ameer / Hume, Emma / Nguyen, Oliver T / Reblin, Maija / Hong, Young-Rock / Tabriz, Amir Alishahi / Patel, Krupal / Magnuson, Jeffery Scott / Turner, Kea

    Head & neck

    2024  

    Abstract: Background: There has been limited study of oncology professionals' perspectives on optimizing delivery of presurgical education for individuals with head and neck cancer (HNC). Therefore, we assessed oncology professionals' perspectives about ... ...

    Abstract Background: There has been limited study of oncology professionals' perspectives on optimizing delivery of presurgical education for individuals with head and neck cancer (HNC). Therefore, we assessed oncology professionals' perspectives about presurgical education for laryngectomy and free flap surgeries, which have a significant impact on patients' quality of life.
    Methods: Interviews were conducted with 27 oncology professionals from an NCI-designated Comprehensive Cancer Center and a community oncology setting.
    Results: Participants identified six recommendations to improve presurgical education: (1) establishing preoperative consultations with allied health professionals; (2) educating patients and providers on the concept of team-based care; (3) optimizing education through multimodal strategies; (4) connecting patients with other HNC surgical patients; (5) preparing caregivers for their role; and (6) educating patients on insurance navigation.
    Conclusions: Study findings demonstrate gaps in the timing, content, and mode of delivery for presurgical education and suggest strategies for further evaluation in future studies.
    Language English
    Publishing date 2024-03-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.27729
    Database MEDical Literature Analysis and Retrieval System OnLINE

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