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  1. Article ; Conference proceedings: Abstracts / International Symposium Advances in Transfusion Safety 2001

    Seitz, Rainer

    June 7 to 8, 2001, Paul-Ehrlich-Institut, Langen, Germany ; under the patronage of the German Federal Minister of Health

    2001  

    Title variant Advances in transfusion safety 2001
    Institution Paul-Ehrlich-Institut
    Event/congress International Symposium Advances in Transfusion Safety (2001, LangenHessen)
    Author's details guest ed.: Rainer Seitz
    Language English
    Publishing country Germany
    Document type Article ; Conference proceedings
    Note In: Infusion therapy and transfusion medicine. - ISSN 1424-5485. - 28 (2001),4, S. 228 - 247
    HBZ-ID HT013136912
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 959 -28- not available for loan Zeitschriften-Lesesaal

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  2. Article ; Online: "Thromboinflammation in COVID-19: can α2-macroglobulin help to control the fire?": Comment from Seitz et al.

    Seitz, Rainer / Gürtler, Lutz / Schramm, Wolfgang

    Journal of thrombosis and haemostasis : JTH

    2023  Volume 21, Issue 3, Page(s) 704–705

    MeSH term(s) Humans ; Pregnancy ; Female ; Pregnancy-Associated alpha 2-Macroglobulins ; Thromboinflammation ; COVID-19 ; Inflammation ; Thrombosis ; Enzyme Inhibitors ; Transcription Factors
    Chemical Substances Pregnancy-Associated alpha 2-Macroglobulins ; Enzyme Inhibitors ; Transcription Factors
    Language English
    Publishing date 2023-03-01
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1016/j.jtha.2023.01.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 295: Show issues

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  3. Article: Wie lassen sich Anti-Drug-Antikörper verhindern? EU-Forschungskonsortium mit Beteiligung des PEI

    Waibler, Zoe / Seitz, Rainer

    Bulletin zur Arzneimittelsicherheit, 2012(3):36-38

    2012  

    Abstract: Antikörper gegen Medikamente – sogenannte Anti-Drug-Antikörper – sind bei der Behandlung mit biologischen Arzneimitteln eine gefürchtete Komplikation. Bekannt ist das Auftreten solcher Antikörper beispielsweise bei der Behandlung von Patienten mit ... ...

    Institution Paul-Ehrlich-Institut
    Abstract Antikörper gegen Medikamente – sogenannte Anti-Drug-Antikörper – sind bei der Behandlung mit biologischen Arzneimitteln eine gefürchtete Komplikation. Bekannt ist das Auftreten solcher Antikörper beispielsweise bei der Behandlung von Patienten mit Hämophilie A (Faktor-VIII-Mangel), bei der Interferonbehandlung sowie bei der Behandlung mit monoklonalen Antikörpern. Im Forschungskonsortium ABIRISK – „Anti-Biopharmaceutical Immunization: Prediction and analysis of clinical relevance to minimize the RISK“ – wird die klinische Relevanz solcher Antikörper gegen biologische Arzneimittel untersucht und nach Möglichkeiten der Risikominimierung gesucht. Das Paul-Ehrlich-Institut (PEI) ist einer von insgesamt 37 europäischen Kooperationspartnern des von der „Innovative Medicines Initiative“ (IMI)1 geförderten Forschungskonsortiums. Im Folgenden werden das Forschungsprojekt und die Fragestellungen, die vom PEI bearbeitet werden, kurz vorgestellt.
    Keywords Antikörper ; Arzneimittelnebenwirkung
    Language German
    Document type Article
    DOI 10.4126/FRL01-006412557
    Database Repository for Life Sciences

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  4. Article ; Online: A Printing Strategy for Embedding Conductor Paths into FFF Printed Parts.

    Banko, Timo / Grünwald, Stefan / Kronberger, Rainer / Seitz, Hermann

    Polymers

    2023  Volume 15, Issue 17

    Abstract: A novel approach to manufacture components with integrated conductor paths involves embedding and sintering an isotropic conductive adhesive (ICA) during fused filament fabrication (FFF). However, the molten plastic is deposited directly onto the ... ...

    Abstract A novel approach to manufacture components with integrated conductor paths involves embedding and sintering an isotropic conductive adhesive (ICA) during fused filament fabrication (FFF). However, the molten plastic is deposited directly onto the adhesive path which causes an inhomogeneous displacement of the uncured ICA. This paper presents a 3D printing strategy to achieve a homogeneous cross-section of the conductor path. The approach involves embedding the ICA into a printed groove and sealing it with a wide extruded plastic strand. Three parameter studies are conducted to obtain a consistent cavity for uniform formation of the ICA path. Specimens made of polylactic acid (PLA) with embedded ICA paths are printed and evaluated. The optimal parameters include a groove printed with a layer height of 0.1 mm, depth of 0.4 mm, and sealed with a PLA strand of 700 µm diameter. This resulted in a conductor path with a homogeneous cross-section, measuring 660 µm ± 22 µm in width (relative standard deviation: 3.3%) and a cross-sectional area of 0.108 mm
    Language English
    Publishing date 2023-08-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym15173498
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Too Early to Abandon Convalescent Plasma for Supportive Treatment of COVID-19.

    Seitz, Rainer / Gürtler, Lutz / Vahlensieck, Ute / Hilger, Anneliese / Schramm, Wolfgang

    Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie

    2023  Volume 50, Issue 3

    Language English
    Publishing date 2023-04-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2100848-6
    ISSN 1660-3818 ; 1660-3796
    ISSN (online) 1660-3818
    ISSN 1660-3796
    DOI 10.1159/000530097
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: DIC in COVID-19: Implications for prognosis and treatment?

    Seitz, Rainer / Schramm, Wolfgang

    Journal of thrombosis and haemostasis : JTH

    2020  Volume 18, Issue 7, Page(s) 1798–1799

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; Prognosis ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-14
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/jth.14878
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    Zs.MO 295: Show issues

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  7. Book ; Online: Alkoholabhängigkeit

    Seitz, Helmut K. / Lesch, Otto-Michael / Spanagel, Rainer / Beutel, Martin / Redecker, Thomas Gerhard

    (Suchtmedizinische Reihe ; 1)

    2017  

    Institution Deutsche Hauptstelle für Suchtfragen
    Author's details DHS, Deutsche Hauptstelle für Suchtfragen e.V.. Verantwortlich für den Inhalt: Prof. Dr. med. Helmut K. Seitz, Prof. Dr. med. Otto M. Lesch, Prof. Dr. med. Rainer Spanagel, Dr. med. Martin Beutel, Dr. med. Thomas Redecker
    Series title Suchtmedizinische Reihe ; 1
    Collection
    Keywords Alkoholismus
    Subject Alkoholabhängigkeit ; Trunksucht ; Alkoholbedingte Krankheit ; Alkoholkrankheit ; Alkoholsucht ; Alkohol
    Language German
    Size 1 Online-Ressource (187 Seiten), Illustrationen
    Edition 7. Auflage
    Publisher Deutsche Hauptstelle für Suchtfragen e. V
    Publishing place Hamm
    Publishing country Germany
    Document type Book ; Online
    HBZ-ID HT019693000
    ISBN 978-3-937587-01-1 ; 3-937587-01-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Article ; Online: Cerebral venous thrombosis after COVID-19 vaccination: is the risk of thrombosis increased by intravascular application of the vaccine?

    Gürtler, Lutz / Seitz, Rainer / Schramm, Wolfgang

    Infection

    2021  Volume 49, Issue 5, Page(s) 1071–1074

    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Humans ; SARS-CoV-2 ; Thrombosis ; Vaccination ; Vaccines ; Venous Thrombosis/epidemiology ; Venous Thrombosis/etiology ; Venous Thrombosis/prevention & control
    Chemical Substances COVID-19 Vaccines ; Vaccines
    Language English
    Publishing date 2021-07-21
    Publishing country Germany
    Document type Letter
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-021-01658-x
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    Zs.MO 528: Show issues

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  10. Article: Chronic alcohol intake regulates expression of SARS-CoV2 infection-relevant genes in an organ-specific manner.

    Friske, Marion M / Giannone, Francesco / Senger, Mona / Seitz, Robin / Hansson, Anita C / Spanagel, Rainer

    Alcohol (Hanover, York County, Pa.)

    2023  Volume 47, Issue 1, Page(s) 76–86

    Abstract: Background: Chronic alcohol consumption and alcohol use disorder have a tremendous impact on the patient's psychological and physiological health. There is evidence that chronic alcohol consumption influences SARS-CoV2 infection risk, but so far, the ... ...

    Abstract Background: Chronic alcohol consumption and alcohol use disorder have a tremendous impact on the patient's psychological and physiological health. There is evidence that chronic alcohol consumption influences SARS-CoV2 infection risk, but so far, the molecular mechanism underlying such an effect is unknown.
    Methods: We generated the expression data of SARS-CoV2 infection-relevant genes (Ace2, Tmprss2, and Mas) in different organs in rat models of chronic alcohol exposure and alcohol dependence. Ace2 and Tmprss2 represent the virus entry point, whereas Mas activates the anti-inflammatory response once the cells are infected.
    Results: Across three different chronic alcohol test conditions, we found a consistent upregulation of Ace2 gene expression in the lung, which has been shown to be the most affected organ in COVID-19 patients. Other organs such as liver, ileum, kidney, heart, and brain also showed upregulation of Ace2 and Mas gene expression but less consistently across the different animal models, while Tmprss2 expression was unaffected in all conditions.
    Conclusions: We conclude that alcohol-induced upregulation of Ace2 gene expression can lead to an elevated stochastic probability of virus entry into cells and may thus confer a molecular risk for SARS-CoV2 infection.
    MeSH term(s) Rats ; Animals ; COVID-19 ; Angiotensin-Converting Enzyme 2 ; RNA, Viral ; SARS-CoV-2 ; Alcohol Drinking
    Chemical Substances Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; RNA, Viral
    Language English
    Publishing date 2023-02-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    DOI 10.1111/acer.14981
    Database MEDical Literature Analysis and Retrieval System OnLINE

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