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Article ; Online: Abrupt onset of annular plaques and nodules in a young boy.

Robertson, Jake C / Rudzinski, Erin R / Boos, Markus D

2022 Volume 39, Issue 2, Page(s) 297–299

MeSH term(s)	Diagnosis, Differential ; Humans ; Male ; Skin Diseases/diagnosis
Language	English
Publishing date	2022-02-21
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	605539-4
ISSN	1525-1470 ; 0736-8046
ISSN (online)	1525-1470
ISSN	0736-8046
DOI	10.1111/pde.14895
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Article ; Online: The impact of the COVID-19 pandemic on US dermatology resident training and wellness.

Robertson, Jake C / Woodfin, Michael / Bonomo, Lauren / Feng, Shu / Shinohara, Michi M

International journal of dermatology

2021 Volume 60, Issue 9, Page(s) e338–e340

MeSH term(s)	COVID-19 ; Dermatology/education ; Humans ; Internship and Residency ; Pandemics ; SARS-CoV-2
Language	English
Publishing date	2021-04-26
Publishing country	England
Document type	Letter
ZDB-ID	412254-9
ISSN	1365-4632 ; 0011-9059 ; 1461-1244
ISSN (online)	1365-4632
ISSN	0011-9059 ; 1461-1244
DOI	10.1111/ijd.15572
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Article: Fatal Microangiopathic Hemolytic Anemia Due to Sézary Syndrome.

Robertson, Jake C / Jafry, Mustufa A / Soma, Lori / Shustov, Andrei / Shinohara, Michi M

Cureus

2021 Volume 13, Issue 6, Page(s) e15482

Abstract: Sézary syndrome (SS) is a form of cutaneous T-cell lymphoma (CTCL), demonstrating leukemic involvement of malignant T-cells. Known systemic sequelae of SS include hemophagocytic syndrome-induced anemia, normocytic anemia secondary to bone marrow ... ...

Abstract	Sézary syndrome (SS) is a form of cutaneous T-cell lymphoma (CTCL), demonstrating leukemic involvement of malignant T-cells. Known systemic sequelae of SS include hemophagocytic syndrome-induced anemia, normocytic anemia secondary to bone marrow infiltration, and pancytopenia. We report a patient with SS, initially demonstrating widespread morbilliform eruption, who presented with malignancy-related microangiopathic hemolytic anemia (MAHA). Our findings represent a novel presentation of SS that will inform the differential diagnosis and treatment of future SS patients presenting with anemia and thrombocytopenia.
Language	English
Publishing date	2021-06-06
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.15482
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Article: DICER1 Syndrome: DICER1 Mutations in Rare Cancers.

Robertson, Jake C / Jorcyk, Cheryl L / Oxford, Julia Thom

Cancers

2018 Volume 10, Issue 5

Abstract: DICER1 syndrome is a rare genetic disorder that predisposes individuals to multiple cancer types. Through mutations of the gene encoding the endoribonuclease, Dicer, DICER1 syndrome disrupts the biogenesis and processing of miRNAs with subsequent ... ...

Abstract	DICER1 syndrome is a rare genetic disorder that predisposes individuals to multiple cancer types. Through mutations of the gene encoding the endoribonuclease, Dicer, DICER1 syndrome disrupts the biogenesis and processing of miRNAs with subsequent disruption in control of gene expression. Since the first description of DICER1 syndrome, case reports have documented novel germline mutations of the
Language	English
Publishing date	2018-05-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers10050143
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Article ; Online: Barriers and job satisfaction among dermatology hospitalists.

Robertson, Jake C / Safaee, Maryam / Liu, Fan / Shinohara, Michi M

Cutis

2019 Volume 104, Issue 2, Page(s) 103–105

Abstract: Dermatology hospitalists (DHs) provide consultative care to inpatients with skin conditions. In this study, we surveyed current members of the Society for Dermatology Hospitalists (SDH) regarding barriers to care, current and ideal compensation models, ... ...

Abstract	Dermatology hospitalists (DHs) provide consultative care to inpatients with skin conditions. In this study, we surveyed current members of the Society for Dermatology Hospitalists (SDH) regarding barriers to care, current and ideal compensation models, and overall job satisfaction to evaluate the overall job satisfaction of DHs and further describe potential barriers to inpatient dermatology consultations.
MeSH term(s)	Dermatologists/organization & administration ; Dermatologists/psychology ; Dermatology/organization & administration ; Female ; Hospitalists/organization & administration ; Hospitalists/psychology ; Humans ; Job Satisfaction ; Male ; Surveys and Questionnaires
Language	English
Publishing date	2019-10-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	391840-3
ISSN	2326-6929 ; 0011-4162 ; 0151-9522
ISSN (online)	2326-6929
ISSN	0011-4162 ; 0151-9522
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Article ; Online: Systematic Review and Meta-Analysis on the Use of Photon-based Stereotactic Radiosurgery Versus Fractionated Stereotactic Radiotherapy for the Treatment of Uveal Melanoma.

Kosydar, Samuel / Robertson, Jake C / Woodfin, Michael / Mayr, Nina A / Sahgal, Arjun / Timmerman, Robert D / Lo, Simon S

American journal of clinical oncology

2020 Volume 44, Issue 1, Page(s) 32–42

Abstract: Purpose: The purpose of this report is to assess the efficacy and adverse event profile of photon-based stereotactic radiosurgery (SRS) compared with fractionated stereotactic radiotherapy (fSRT) for the treatment of uveal melanoma. Primary outcomes ... ...

Abstract	Purpose: The purpose of this report is to assess the efficacy and adverse event profile of photon-based stereotactic radiosurgery (SRS) compared with fractionated stereotactic radiotherapy (fSRT) for the treatment of uveal melanoma. Primary outcomes include incidence proportions of local control, enucleation, metastatic progression, disease-specific, and overall mortality. Treatment-related toxicities such as incidence proportions of radiation retinopathy, neovascular glaucoma, optic neuropathy, and cataract formation were examined as secondary outcomes. Five-year survival and 5-year local control rates were also assessed. Materials and methods: PubMed, Embase, Web of Science, Scopus, and 2 Cochrane databases were searched up to December 31, 2018. Random effects models were used to calculate pooled incidence proportions of outcome measures. Meta-regression was carried out to explore the potential impact of dose per fraction on local control. Results: Twenty-four articles with a total of 1745 patients were included in the meta-analysis. There were no statistically significant differences between photon-based fSRT and SRS for all primary, secondary and 5-year outcome measures, including local control (P=0.28), enucleation (P=0.51), and neovascular glaucoma (P=0.40). The 5-year local control rate was 90% (95% confidence interval: 76%, 96%) for fSRT and 89% (70%, 97%) for SRS. Conclusions: Our meta-analysis showed no difference in tumor control, survival and toxicities, as defined in this paper, between SRS and fSRT for uveal melanoma. Confounding biases remain an expected limitation in this study of novel treatment modalities deployed in rare tumors. Further investigation is needed to validate outcomes and compare stereotactic treatment techniques.
MeSH term(s)	Dose Fractionation, Radiation ; Humans ; Melanoma/mortality ; Melanoma/radiotherapy ; Photons ; Radiation Injuries/etiology ; Radiosurgery/adverse effects ; Radiosurgery/methods ; Treatment Outcome ; Uveal Neoplasms/mortality ; Uveal Neoplasms/radiotherapy
Language	English
Publishing date	2020-11-18
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	604536-4
ISSN	1537-453X ; 0277-3732
ISSN (online)	1537-453X
ISSN	0277-3732
DOI	10.1097/COC.0000000000000775
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Article ; Online: Adjuvant chemotherapy for adenocarcinoma arising from intraductal papillary mucinous neoplasia: multicentre ADENO-IPMN study.

Lucocq, James / Hawkyard, Jake / Haugk, Beate / Mownah, Omar / Menon, Krishna / Furukawa, Takaki / Inoue, Yosuke / Hirose, Yuki / Sasahira, Naoki / Feretis, Michael / Balakrishnan, Anita / Ceresa, Carlo / Davidson, Brian / Pande, Rupaly / Dasari, Bobby / Tanno, Lulu / Karavias, Dimitrios / Helliwell, Jack / Young, Alistair /

Nunes, Quentin / Urbonas, Tomas / Silva, Michael / Gordon-Weeks, Alex / Barrie, Jenifer / Gomez, Dhanny / Van Laarhoven, Stijn / Robertson, Francis / Nawara, Hossain / Doyle, Joseph / Bhogal, Ricky / Harrison, Ewen / Roalso, Marcus / Ciprani, Debora / Aroori, Somaiah / Ratnayake, Bathiya / Koea, Jonathan / Capurso, Gabriele / Bellotti, Ruben / Stättner, Stefan / Alsaoudi, Tareq / Bhardwaj, Neil / Rajesh, Srujan / Jeffery, Fraser / Connor, Saxon / Cameron, Andrew / Jamieson, Nigel / Sheen, Amy / Mittal, Anubhav / Samra, Jas / Gill, Anthony / Roberts, Keith / Søreide, Kjetil / Pandanaboyana, Sanjay

The British journal of surgery

2024 Volume 111, Issue 4

Abstract: ... association between adjuvant chemotherapy and overall recurrence (HR 0.89, 95% c.i. 0.57 to 1.40 ...

Abstract	Background: The clinical impact of adjuvant chemotherapy after resection for adenocarcinoma arising from intraductal papillary mucinous neoplasia is unclear. The aim of this study was to identify factors related to receipt of adjuvant chemotherapy and its impact on recurrence and survival. Methods: This was a multicentre retrospective study of patients undergoing pancreatic resection for adenocarcinoma arising from intraductal papillary mucinous neoplasia between January 2010 and December 2020 at 18 centres. Recurrence and survival outcomes for patients who did and did not receive adjuvant chemotherapy were compared using propensity score matching. Results: Of 459 patients who underwent pancreatic resection, 275 (59.9%) received adjuvant chemotherapy (gemcitabine 51.3%, gemcitabine-capecitabine 21.8%, FOLFIRINOX 8.0%, other 18.9%). Median follow-up was 78 months. The overall recurrence rate was 45.5% and the median time to recurrence was 33 months. In univariable analysis in the matched cohort, adjuvant chemotherapy was not associated with reduced overall (P = 0.713), locoregional (P = 0.283) or systemic (P = 0.592) recurrence, disease-free survival (P = 0.284) or overall survival (P = 0.455). Adjuvant chemotherapy was not associated with reduced site-specific recurrence. In multivariable analysis, there was no association between adjuvant chemotherapy and overall recurrence (HR 0.89, 95% c.i. 0.57 to 1.40), disease-free survival (HR 0.86, 0.59 to 1.30) or overall survival (HR 0.77, 0.50 to 1.20). Adjuvant chemotherapy was not associated with reduced recurrence in any high-risk subgroup (for example, lymph node-positive, higher AJCC stage, poor differentiation). No particular chemotherapy regimen resulted in superior outcomes. Conclusion: Chemotherapy following resection of adenocarcinoma arising from intraductal papillary mucinous neoplasia does not appear to influence recurrence rates, recurrence patterns or survival.
MeSH term(s)	Aged ; Female ; Humans ; Male ; Middle Aged ; Adenocarcinoma/pathology ; Adenocarcinoma/drug therapy ; Adenocarcinoma/mortality ; Adenocarcinoma/therapy ; Adenocarcinoma, Mucinous/pathology ; Adenocarcinoma, Mucinous/drug therapy ; Adenocarcinoma, Mucinous/therapy ; Adenocarcinoma, Mucinous/mortality ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Capecitabine/administration & dosage ; Capecitabine/therapeutic use ; Carcinoma, Pancreatic Ductal/pathology ; Carcinoma, Pancreatic Ductal/mortality ; Carcinoma, Pancreatic Ductal/drug therapy ; Carcinoma, Pancreatic Ductal/therapy ; Carcinoma, Pancreatic Ductal/surgery ; Chemotherapy, Adjuvant ; Gemcitabine ; Neoplasm Recurrence, Local/epidemiology ; Pancreatectomy ; Pancreatic Intraductal Neoplasms/pathology ; Pancreatic Intraductal Neoplasms/therapy ; Pancreatic Intraductal Neoplasms/mortality ; Pancreatic Intraductal Neoplasms/surgery ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/mortality ; Pancreatic Neoplasms/therapy ; Pancreatic Neoplasms/surgery ; Propensity Score ; Retrospective Studies
Chemical Substances	Capecitabine (6804DJ8Z9U) ; Gemcitabine
Language	English
Publishing date	2024-04-24
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	2985-3
ISSN	1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
ISSN (online)	1365-2168
ISSN	0263-1202 ; 0007-1323 ; 1355-7688
DOI	10.1093/bjs/znae100
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Article ; Online: Whole-genome characterization of lung adenocarcinomas lacking alterations in the RTK/RAS/RAF pathway

Jian Carrot-Zhang / Xiaotong Yao / Siddhartha Devarakonda / Aditya Deshpande / Jeffrey S. Damrauer / Tiago Chedraoui Silva / Christopher K. Wong / Hyo Young Choi / Ina Felau / A. Gordon Robertson / Mauro A.A. Castro / Lisui Bao / Esther Rheinbay / Eric Minwei Liu / Tuan Trieu / David Haan / Christina Yau / Toshinori Hinoue / Yuexin Liu /

Ofer Shapira / Kiran Kumar / Karen L. Mungall / Hailei Zhang / Jake June-Koo Lee / Ashton Berger / Galen F. Gao / Binyamin Zhitomirsky / Wen-Wei Liang / Meng Zhou / Sitapriya Moorthi / Alice H. Berger / Eric A. Collisson / Michael C. Zody / Li Ding / Andrew D. Cherniack / Gad Getz / Olivier Elemento / Christopher C. Benz / Josh Stuart / J.C. Zenklusen / Rameen Beroukhim / Jason C. Chang / Joshua D. Campbell / D. Neil Hayes / Lixing Yang / Peter W. Laird / John N. Weinstein / David J. Kwiatkowski / Ming S. Tsao / William D. Travis

Cell Reports, Vol 34, Iss 8, Pp 108784- (2021)

2021

Keywords	Biology (General) ; QH301-705.5
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Whole-genome characterization of lung adenocarcinomas lacking alterations in the RTK/RAS/RAF pathway.

Carrot-Zhang, Jian / Yao, Xiaotong / Devarakonda, Siddhartha / Deshpande, Aditya / Damrauer, Jeffrey S / Silva, Tiago Chedraoui / Wong, Christopher K / Choi, Hyo Young / Felau, Ina / Robertson, A Gordon / Castro, Mauro A A / Bao, Lisui / Rheinbay, Esther / Liu, Eric Minwei / Trieu, Tuan / Haan, David / Yau, Christina / Hinoue, Toshinori / Liu, Yuexin /

Shapira, Ofer / Kumar, Kiran / Mungall, Karen L / Zhang, Hailei / June-Koo Lee, Jake / Berger, Ashton / Gao, Galen F / Zhitomirsky, Binyamin / Liang, Wen-Wei / Zhou, Meng / Moorthi, Sitapriya / Berger, Alice H / Collisson, Eric A / Zody, Michael C / Ding, Li / Cherniack, Andrew D / Getz, Gad / Elemento, Olivier / Benz, Christopher C / Stuart, Josh / Zenklusen, J C / Beroukhim, Rameen / Chang, Jason C / Campbell, Joshua D / Hayes, D Neil / Yang, Lixing / Laird, Peter W / Weinstein, John N / Kwiatkowski, David J / Tsao, Ming S / Travis, William D / Khurana, Ekta / Berman, Benjamin P / Hoadley, Katherine A / Robine, Nicolas / Meyerson, Matthew / Govindan, Ramaswamy / Imielinski, Marcin

Cell reports

2021 Volume 34, Issue 8, Page(s) 108784

Language	English
Publishing date	2021-02-23
Publishing country	United States
Document type	Published Erratum
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2021.108784
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Article ; Online: MCAT: Motif Combining and Association Tool.

Yang, Yanshen / Robertson, Jeffrey A / Guo, Zhen / Martinez, Jake / Coghlan, Christy / Heath, Lenwood S

Journal of computational biology : a journal of computational molecular cell biology

2018 Volume 26, Issue 1, Page(s) 1–15

Abstract: De novo motif discovery in biological sequences is an important and computationally challenging problem. A myriad of algorithms have been developed to solve this problem with varying success, but it can be difficult for even a small number of these tools ...

Abstract	De novo motif discovery in biological sequences is an important and computationally challenging problem. A myriad of algorithms have been developed to solve this problem with varying success, but it can be difficult for even a small number of these tools to reach a consensus. Because individual tools can be better suited for specific scenarios, an ensemble tool that combines the results of many algorithms can yield a more confident and complete result. We present a novel and fast tool ensemble MCAT (Motif Combining and Association Tool) for de novo motif discovery by combining six state-of-the-art motif discovery tools (MEME, BioProspector, DECOD, XXmotif, Weeder, and CMF). We apply MCAT to data sets with DNA sequences that come from various species and compare our results with two well-established ensemble motif-finding tools, EMD and DynaMIT. The experimental results show that MCAT is able to identify exact match motifs in DNA sequences efficiently, and it has a significantly better performance in practice.
MeSH term(s)	Algorithms ; Animals ; Computational Biology/methods ; Humans ; Sequence Analysis, DNA/methods ; Software
Language	English
Publishing date	2018-11-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2030900-4
ISSN	1557-8666 ; 1066-5277
ISSN (online)	1557-8666
ISSN	1066-5277
DOI	10.1089/cmb.2018.0113
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