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Article ; Online: Understanding the Raman enhancement of carbon nanohorns labelled with organic dyes.

Iglesias, Daniel / Martín, Raúl / Álvarez-Sánchez, Miguel Á / Badía-Domínguez, Irene / Vázquez, Ester / Carmen Ruiz Delgado, M / Prieto, Pilar / Antonia Herrero, M

Nanoscale

2023 Volume 15, Issue 29, Page(s) 12280–12286

Abstract: Carbon nanohorns have been non-covalently functionalized with two different benzothiadiazoloquinoxalines ... ...

Abstract	Carbon nanohorns have been non-covalently functionalized with two different benzothiadiazoloquinoxalines prepared
Language	English
Publishing date	2023-07-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/d3nr01357j
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Article ; Online: An ETFDH-driven metabolon supports OXPHOS efficiency in skeletal muscle by regulating coenzyme Q homeostasis.

Herrero Martín, Juan Cruz / Salegi Ansa, Beñat / Álvarez-Rivera, Gerardo / Domínguez-Zorita, Sonia / Rodríguez-Pombo, Pilar / Pérez, Belén / Calvo, Enrique / Paradela, Alberto / Miguez, David G / Cifuentes, Alejandro / Cuezva, José M / Formentini, Laura

Nature metabolism

2024 Volume 6, Issue 2, Page(s) 209–225

Abstract: Coenzyme Q (Q) is a key lipid electron transporter, but several aspects of its biosynthesis and redox homeostasis remain undefined. Various flavoproteins reduce ubiquinone (oxidized form of Q) to ubiquinol ( ... ...

Abstract	Coenzyme Q (Q) is a key lipid electron transporter, but several aspects of its biosynthesis and redox homeostasis remain undefined. Various flavoproteins reduce ubiquinone (oxidized form of Q) to ubiquinol (QH
MeSH term(s)	Animals ; Mice ; Ubiquinone/metabolism ; Ubiquinone/therapeutic use ; Oxidative Phosphorylation ; Electron-Transferring Flavoproteins/genetics ; Electron-Transferring Flavoproteins/metabolism ; Muscle, Skeletal/metabolism ; Lipids ; Homeostasis
Chemical Substances	Ubiquinone (1339-63-5) ; Electron-Transferring Flavoproteins ; Lipids
Language	English
Publishing date	2024-01-19
Publishing country	Germany
Document type	Journal Article
ISSN	2522-5812
ISSN (online)	2522-5812
DOI	10.1038/s42255-023-00956-y
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Article ; Online: Progression of myeloproliferative neoplasm with BCR::JAK2 fusion to acute leukemia of ambiguous lineage.

Suárez, Edwin Uriel / Piris, Miguel Ángel / Rodríguez-Pinilla, Socorro María / García, Juan F / López-Lorenzo, José Luis / Cornago-Navascués, Javier / Salgado-Sánchez, Rocío / Castaño-Bonilla, Tamara / Mata-Serna, Raquel / Alonso-Domínguez, Juan M / Llamas, Pilar

Annals of hematology

2024 Volume 103, Issue 5, Page(s) 1797–1799

MeSH term(s)	Humans ; Bone Marrow Neoplasms/genetics ; Janus Kinase 2/genetics ; Leukemia ; Mutation ; Myeloproliferative Disorders/genetics ; Oncogene Proteins, Fusion/genetics ; Proto-Oncogene Proteins c-bcr/genetics
Chemical Substances	JAK2 protein, human (EC 2.7.10.2) ; Janus Kinase 2 (EC 2.7.10.2) ; Oncogene Proteins, Fusion ; Proto-Oncogene Proteins c-bcr (EC 2.7.11.1)
Language	English
Publishing date	2024-02-03
Publishing country	Germany
Document type	Case Reports ; Letter
ZDB-ID	1064950-5
ISSN	1432-0584 ; 0939-5555 ; 0945-8077
ISSN (online)	1432-0584
ISSN	0939-5555 ; 0945-8077
DOI	10.1007/s00277-024-05647-6
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Article ; Online: The regulatory, evaluation, pricing and reimbursement pathway for medicines in the UK

Adriana M. IVAMA-BRUMMELL / Pilar PINILLA-DOMINGUEZ / Aline N. BIZ

Revista Brasileira de Farmácia Hospitalar e Serviços de Saúde, Vol 13, Iss

combining innovation and access

2022 Volume 2

Abstract: The United Kingdom has universal healthcare systems, the National Health System (NHS), in its four nations, with healthcare services provided free of charge at the point of delivery. Approximately 10.5% of the UK population has voluntary supplementary ... ...

Abstract	The United Kingdom has universal healthcare systems, the National Health System (NHS), in its four nations, with healthcare services provided free of charge at the point of delivery. Approximately 10.5% of the UK population has voluntary supplementary private health insurance. While the provision of inpatient medicines is free of charge, medicines provided in the outpatient setting have a dispensing fee in some of the nations, such as the case of England (co-payment). The UK marketing authorisation process is called product licensing and is overseen by the Medicines and Healthcare Products Regulatory Agency (MHRA). There are different licensing routes based on the intended market for launch. MHRA also offers early access schemes and pathways for products targeting unmet medical needs and promising technologies, that aim to accelerate and facilitate market and patient access to products in the UK. These schemes include the option for companies to engage early with regulators and other system partners such as health technology assessment (HTA) agencies. As soon as the technology is authorised, it is available at a list price. Prices for medicines are regulated in legislation and in schemes agreed between the industry association and the Department of Health and Social Care (DHSC). The prices for the NHS are negotiated between the government and the companies. Routine funding decisions in the NHS are guided by HTA evaluations informed by agencies such as the National Institute for Health and Care Excellence (NICE) in England, the Scottish Medicines Consortium (SMC) in Scotland, and the All Wales Medicines Strategy Group (AWMSG) in Wales. Many medicines and other technologies are subject to price negotiations in the NHS, sometimes with confidential price agreements. The NHS in England is legally mandated to routinely fund technologies recommended by NICE that have been evaluated by some of its programmes. The other UK nations have similar arrangements or recognise decisions made in England. The role and contribution ...
Keywords	Public aspects of medicine ; RA1-1270 ; Pharmacy and materia medica ; RS1-441 ; Therapeutics. Pharmacology ; RM1-950
Subject code	360
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Sociedade Brasileira de Farmácia Hospitalar e Serviços de Saúde
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Music Listening in Stem Cell Transplantation and Acute Myeloid Leukemia: A Randomized Clinical Trial.

Lázaro-García, Alberto / Láinez-González, Daniel / González-Rodríguez, Marta / Cano Alsua, Santiago / Suárez M, Edwin Uriel / Solán-Blanco, Laura / Cornago-Navascués, Javier / López-Lorenzo, José Luis / Llamas-Sillero, Pilar / Alonso-Domínguez, Juan Manuel

Journal of pain and symptom management

2024

Abstract: Context: Music listening (ML) has been shown to have a beneficial effect on patients with cancer. However, novel intervention approaches are needed.: Objectives: We aimed to determine whether ML based on the iso-principle, conducted using a mobile ... ...

Abstract	Context: Music listening (ML) has been shown to have a beneficial effect on patients with cancer. However, novel intervention approaches are needed. Objectives: We aimed to determine whether ML based on the iso-principle, conducted using a mobile application (GloMus), improves symptom burden, quality of life (QoL), anxiety, and depression in patients undergoing stem cell transplantation (SCT) and intensive induction chemotherapy for acute myeloid leukemia (AML). Methods: In this randomized controlled clinical trial, we assigned 71 patients to the ML or standard care (SC) groups, stratified by the reason for admission (AML, allogeneic-SCT, or inpatient/outpatient autologous-SCT). Upon admission, participants in the ML groups were invited to undergo daily ML sessions designed to change negative moods into positive ones (iso-principle). The intervention consisted of listening to pre-recorded classical music ordered by beats per minute and tonality. Symptom burden (Edmonton Symptom Assessment System-Revised) was assessed in the ML groups before and after each session. Anxiety, depression (Hospital Anxiety and Depression Scale), and QoL (Functional Assessment of Cancer Therapy-Bone Marrow Transplantation/Leukemia) were measured weekly in the ML and SC groups. Results: Symptom burden in both allogeneic- and inpatient autologous-SCT ML groups reduced after the intervention. In all experimental groups, clinically important improvements were observed after ML sessions. No differences were found between the groups (ML vs. SC) at different weeks of admission regarding anxiety, depression, and QoL. Conclusions: ML based on our innovative iso-principle strategy, conducted using GloMus, reduced the symptom burden in patients undergoing allogeneic- and inpatient autologous-SCT (ClinicalTrials.gov number, NCT05696457).
Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	639142-4
ISSN	1873-6513 ; 0885-3924
ISSN (online)	1873-6513
ISSN	0885-3924
DOI	10.1016/j.jpainsymman.2024.02.567
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Article ; Online: Flexible metallic core-shell nanostructured electrodes for neural interfacing.

Rodilla, Beatriz L / Arché-Núñez, Ana / Ruiz-Gómez, Sandra / Domínguez-Bajo, Ana / Fernández-González, Claudia / Guillén-Colomer, Clara / González-Mayorga, Ankor / Rodríguez-Díez, Noelia / Camarero, Julio / Miranda, Rodolfo / López-Dolado, Elisa / Ocón, Pilar / Serrano, María C / Pérez, Lucas / González, M Teresa

Scientific reports

2024 Volume 14, Issue 1, Page(s) 3729

Abstract: Electrodes with nanostructured surface have emerged as promising low-impedance neural interfaces that can avoid the charge-injection restrictions typically associated to microelectrodes. In this work, we propose a novel approximation, based on a two-step ...

Abstract	Electrodes with nanostructured surface have emerged as promising low-impedance neural interfaces that can avoid the charge-injection restrictions typically associated to microelectrodes. In this work, we propose a novel approximation, based on a two-step template assisted electrodeposition technique, to obtain flexible nanostructured electrodes coated with core-shell Ni-Au vertical nanowires. These nanowires benefit from biocompatibility of the Au shell exposed to the environment and the mechanical properties of Ni that allow for nanowires longer and more homogeneous in length than their only-Au counterparts. The nanostructured electrodes show impedance values, measured by electrochemical impedance spectroscopy (EIS), at least 9 times lower than those of flat reference electrodes. This ratio is in good accordance with the increased effective surface area determined both from SEM images and cyclic voltammetry measurements, evidencing that only Au is exposed to the medium. The observed EIS profile evolution of Ni-Au electrodes over 7 days were very close to those of Au electrodes and differently from Ni ones. Finally, the morphology, viability and neuronal differentiation of rat embryonic cortical cells cultured on Ni-Au NW electrodes were found to be similar to those on control (glass) substrates and Au NW electrodes, accompanied by a lower glial cell differentiation. This positive in-vitro neural cell behavior encourages further investigation to explore the tissue responses that the implantation of these nanostructured electrodes might elicit in healthy (damaged) neural tissues in vivo, with special emphasis on eventual tissue encapsulation.
MeSH term(s)	Rats ; Animals ; Electrodes ; Microelectrodes ; Nanostructures ; Neurons/physiology ; Nanowires ; Electric Impedance
Language	English
Publishing date	2024-02-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-53719-4
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Article ; Online: 'Why should I feel guilty? I always give my best'. Guilt in Spanish women caring for dependent relatives from a gender perspective.

Domínguez-Castillo, Pilar / Bonilla-Campos, Amparo / Izquierdo, MJesús

Aging & mental health

2022 Volume 27, Issue 9, Page(s) 1803–1811

Abstract: Objectives: The sense of guilt in informal caregivers has been associated with lower levels of overall life-satisfaction, an increase in feelings of overwork, stress, and health problems, including anxiety and depression. Even though women who care for ... ...

Abstract	Objectives: The sense of guilt in informal caregivers has been associated with lower levels of overall life-satisfaction, an increase in feelings of overwork, stress, and health problems, including anxiety and depression. Even though women who care for dependent relatives have higher levels of feelings of guilt than male caregivers, little research has been done on the dynamics of guilt from a gender perspective. This study examines the dynamics of this moral emotion in women caregivers' psychosocial health. Methods: This study is based on semi-structured interviews with nineteen Spanish women who are informal caregivers looking after dependent family members. The interviews were subsequently transcribed and subjected to thematic analysis. Results: Three themes emerged from qualitative analysis: first, doing more for the people being cared for than for oneself; secondly, being demanding on oneself; and thirdly, controlling one's own desires. Conclusion: The results show dynamics of self-control that seem to function as mechanisms for the women caregivers to avoid feelings of guilt, but at the price of taking on greater caring responsibilities, denying their own desires, and endangering their psychosocial health. We consider that intervention to help women reduce anticipatory guilt is essential, as these feelings put women caregivers' psychosocial health at risk.
Language	English
Publishing date	2022-10-19
Publishing country	England
Document type	Journal Article
ZDB-ID	1474804-6
ISSN	1364-6915 ; 1360-7863
ISSN (online)	1364-6915
ISSN	1360-7863
DOI	10.1080/13607863.2022.2135681
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Article ; Online: "Nursing (Her) Storytelling": An Ethnographic Fiction Proposal for Exploring Feminist Health Activism in Spain.

Alameda-Cuesta, Almudena / Blanco-Fuente, Irene / Bonilla-Campos, Amparo / Casado-Aparicio, Elena / Domínguez-Castillo, M Pilar / García-Dauder, Dau / Lara-Rodríguez, Ángel Luis / López-Sáez, Miguel Ángel / Velázquez-Berrio, Nerea / Romero-Bachiller, Carmen

ANS. Advances in nursing science

2023 Volume 47, Issue 1, Page(s) 29–42

Abstract: The aim of this article is to share theoretical and methodological reflections on a project on feminist epistemologies and health activism. Based on the analysis of 12 life stories and 1 group interview, an approach based on ethnographic fiction is ... ...

Abstract	The aim of this article is to share theoretical and methodological reflections on a project on feminist epistemologies and health activism. Based on the analysis of 12 life stories and 1 group interview, an approach based on ethnographic fiction is proposed through the creation of a serial story in podcast format. This approach helps in generating emotions to facilitate understanding and awareness of the issues raised and in showing everyday practices as ways of constructing knowledge. It also avoids turning life stories into academic artifacts with little transformational capacity.
MeSH term(s)	Female ; Humans ; Spain ; Feminism ; Communication ; Emotions
Language	English
Publishing date	2023-01-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	424430-8
ISSN	1550-5014 ; 0161-9268
ISSN (online)	1550-5014
ISSN	0161-9268
DOI	10.1097/ANS.0000000000000479
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Article ; Online: Virucidal Properties of Photocatalytic Coating on Glass against a Model Human Coronavirus.

Álvarez, Ángel L / Dalton, Kevin P / Nicieza, Inés / Abade Dos Santos, Fabio A / de la Peña, Pilar / Domínguez, Pedro / Martin-Alonso, José M / Parra, Francisco

Microbiology spectrum

2022 Volume 10, Issue 3, Page(s) e0026922

Abstract: The antimicrobial properties of photocatalysts have long been studied. However, most of the available literature describes their antibacterial properties, while knowledge of their antiviral activity is rather scarce. Since the outset of the coronavirus ... ...

Abstract	The antimicrobial properties of photocatalysts have long been studied. However, most of the available literature describes their antibacterial properties, while knowledge of their antiviral activity is rather scarce. Since the outset of the coronavirus disease 2019 (COVID-19) pandemic, an increasing body of research has suggested their antiviral potential and highlighted the need for further research in this area. In this study, we investigated the virucidal properties of a commercial TiO
MeSH term(s)	Antiviral Agents/pharmacology ; COVID-19/prevention & control ; Humans ; Pandemics ; SARS-CoV-2 ; Viruses
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2022-05-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.00269-22
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Article ; Online: Estimate of influenza cases using generalized linear, additive and mixed models.

Oviedo, Manuel / Domínguez, Ángela / Pilar Muñoz, M

Human vaccines & immunotherapeutics

2015 Volume 11, Issue 1, Page(s) 298–301

Abstract: We investigated the relationship between reported cases of influenza in Catalonia (Spain). Covariates analyzed were: population, age, data of report of influenza, and health region during 2010-2014 using data obtained from the SISAP program (Institut ... ...

Abstract	We investigated the relationship between reported cases of influenza in Catalonia (Spain). Covariates analyzed were: population, age, data of report of influenza, and health region during 2010-2014 using data obtained from the SISAP program (Institut Catala de la Salut - Generalitat of Catalonia). Reported cases were related with the study of covariates using a descriptive analysis. Generalized Linear Models, Generalized Additive Models and Generalized Additive Mixed Models were used to estimate the evolution of the transmission of influenza. Additive models can estimate non-linear effects of the covariates by smooth functions; and mixed models can estimate data dependence and variability in factor variables using correlations structures and random effects, respectively. The incidence rate of influenza was calculated as the incidence per 100 000 people. The mean rate was 13.75 (range 0-27.5) in the winter months (December, January, February) and 3.38 (range 0-12.57) in the remaining months. Statistical analysis showed that Generalized Additive Mixed Models were better adapted to the temporal evolution of influenza (serial correlation 0.59) than classical linear models.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Disease Transmission, Infectious ; Female ; Humans ; Incidence ; Influenza, Human/epidemiology ; Influenza, Human/transmission ; Male ; Middle Aged ; Models, Statistical ; Spain/epidemiology ; Young Adult
Language	English
Publishing date	2015
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2664176-8
ISSN	2164-554X ; 2164-5515
ISSN (online)	2164-554X
ISSN	2164-5515
DOI	10.4161/hv.36168
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