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  1. Book: Clinical trials of genetic therapy with antisense DNA and DNA vectors

    Wickstrom, Eric

    1998  

    Author's details ed. by Eric Wickstrom
    Keywords Gene Therapy ; DNA, Antisense ; Genetic Vectors ; Clinical Trials ; Antisense-Nucleinsäuren ; Gentherapie ; Viren ; Vektor
    Subject Vektor-DNS ; Genetischer Vektor ; Klonierungsvektor ; Vektor-DNA ; Somatische Gentherapie ; Virus ; Antisense-Nukleinsäuren ; Antisense-Nucleotidsequenz ; Basenkomplimentäre-Nucleotidsequenz
    Language English
    Size XVII, 427 S. : Ill., graph. Darst.
    Publisher Dekker
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT009219418
    ISBN 0-8247-0085-6 ; 978-0-8247-0085-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1998 A 7517 order for loan Magazin

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  2. Article ; Online: DNA and RNA derivatives to optimize distribution and delivery.

    Wickstrom, Eric

    Advanced drug delivery reviews

    2015  Volume 87, Page(s) 25–34

    Abstract: Synthetic, complementary DNA single strands and short interfering RNA double strands have been found to inhibit the expression of animal, plant, and viral genes in cells, animals, and patients, in a dose dependent and sequence specific manner. DNAs and ... ...

    Abstract Synthetic, complementary DNA single strands and short interfering RNA double strands have been found to inhibit the expression of animal, plant, and viral genes in cells, animals, and patients, in a dose dependent and sequence specific manner. DNAs and RNAs, however, are readily digested in biological systems. Hence, chemists are obliged to design and synthesize nuclease-resistant analogs of normal DNA (Fig. 1).
    MeSH term(s) Animals ; DNA, Antisense/administration & dosage ; DNA, Antisense/chemistry ; DNA, Antisense/pharmacology ; Genetic Therapy ; Humans ; RNA Interference/drug effects ; RNA, Antisense/administration & dosage ; RNA, Antisense/chemistry ; RNA, Antisense/pharmacology
    Chemical Substances DNA, Antisense ; RNA, Antisense
    Language English
    Publishing date 2015-04-22
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 639113-8
    ISSN 1872-8294 ; 0169-409X
    ISSN (online) 1872-8294
    ISSN 0169-409X
    DOI 10.1016/j.addr.2015.04.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Book: Prospects for antisense nucleic acid therapy of cancer and AIDS

    Wickstrom, Eric

    1991  

    Author's details ed. Eric Wickstrom
    Keywords Acquired Immunodeficiency Syndrome / drug therapy ; Neoplasms / drug therapy ; Oligonucleotides, Antisense / therapeutic use ; Krebs ; Antisense-Nucleinsäuren ; Aids ; Nucleinsäuren ; Therapie
    Subject Nukleinsäuren ; Medizinische Behandlung ; Behandlung ; Krankenbehandlung ; Carcinom ; Malignom ; Maligner Tumor ; Neoplasma ; Karzinom ; Bösartiger Tumor ; Krebserkrankung ; Acquired immune deficiency syndrome ; Erworbenes Immundefektsyndrom ; Antisense-Nukleinsäuren ; Antisense-Nucleotidsequenz ; Basenkomplimentäre-Nucleotidsequenz
    Size XIV, 269 S. : Ill., graph. Darst.
    Publisher Wiley-Liss
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT004156369
    ISBN 0-471-56880-5 ; 978-0-471-56880-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1992 A 1716 order for loan Magazin

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  4. Article ; Online: International consensus recommendations for management of New Onset Refractory Status Epilepticus (NORSE) incl. Febrile Infection-Related Epilepsy Syndrome (FIRES): Statements and Supporting Evidence.

    Wickstrom, Ronny / Taraschenko, Olga / Dilena, Robertino / Payne, Eric T / Specchio, Nicola / Nabbout, Rima / Koh, Sookyong / Gaspard, Nicolas / Hirsch, Lawrence J

    Epilepsia

    2022  

    Abstract: Objective: To develop consensus-based recommendations for the management of adult and paediatric patients with NORSE/FIRES based on best evidence and experience.: Methods: The Delphi methodology was followed. A facilitator group of 9 experts was ... ...

    Abstract Objective: To develop consensus-based recommendations for the management of adult and paediatric patients with NORSE/FIRES based on best evidence and experience.
    Methods: The Delphi methodology was followed. A facilitator group of 9 experts was established, who defined the scope, users and suggestions for recommendations. Following a review of the current literature, recommendation statements concerning diagnosis, treatment and research directions were generated which were then voted on a scale of 1 (strongly disagree) to 9 (strongly agree) by a panel of 48 experts in the field. Consensus that a statement was appropriate was reached if the median score was greater or equal to 7, and inappropriate if the median score was less than or equal to 3. The analysis of evidence was mapped to the results of each statement included in the Delphi survey.
    Results: Overall, 85 recommendation statements achieved consensus. The recommendations are divided into five sections: 1) disease characteristics, 2) diagnostic testing and sampling, 3) acute treatment, 4) treatment in the post-acute phase, and 5) research, registries and future directions in NORSE/FIRES. The detailed results and discussion of all 85 statements are outlined herein. A corresponding summary of findings and practical flowsheets are presented in a companion article.
    Significance: This detailed analysis offers insight into the supporting evidence and the current gaps in the literature that are associated with expert consensus statements related to NORSE/FIRES. The recommendations generated by this consensus can be used as a guide for the diagnosis, evaluation, and management of patients with NORSE/FIRES, and for planning of future research.
    Language English
    Publishing date 2022-08-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 216382-2
    ISSN 1528-1167 ; 0013-9580
    ISSN (online) 1528-1167
    ISSN 0013-9580
    DOI 10.1111/epi.17397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Zs.MO 475: Show issues

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  5. Article ; Online: International consensus recommendations for management of New Onset Refractory Status Epilepticus (NORSE) including Febrile Infection-Related Epilepsy Syndrome (FIRES): Summary and Clinical Tools.

    Wickstrom, Ronny / Taraschenko, Olga / Dilena, Robertino / Payne, Eric T / Specchio, Nicola / Nabbout, Rima / Koh, Sookyong / Gaspard, Nicolas / Hirsch, Lawrence J

    Epilepsia

    2022  

    Abstract: Objective: To develop consensus-based recommendations for the management of adult and pediatric patients with NORSE/FIRES based on best available evidence and expert opinion.: Methods: The Delphi methodology was followed. A facilitator group of 9 ... ...

    Abstract Objective: To develop consensus-based recommendations for the management of adult and pediatric patients with NORSE/FIRES based on best available evidence and expert opinion.
    Methods: The Delphi methodology was followed. A facilitator group of 9 experts was established, who defined the scope, users and suggestions for recommendations. Following a review of the current literature, recommendation statements concerning diagnosis, treatment and research directions were generated which were then voted on a scale of 1 (strongly disagree) to 9 (strongly agree) by a panel of 48 experts in the field. Consensus that a statement was appropriate was reached if the median score was greater than or equal to 7, and inappropriate if the median score was less than or equal to 3.
    Results: Overall, 85 recommendation statements achieved consensus. The recommendations are divided into five sections: 1) disease characteristics, 2) diagnostic testing and sampling, 3) acute treatment, 4) treatment in the post-acute phase, and 5) research, registries and future directions in NORSE/FIRES. These are summarized in this article along with two practical clinical flowsheets: one for diagnosis and evaluation and one for acute treatment. A corresponding evidence-based analysis of all 85 recommendations alongside responses by the Delphi panel is presented in a companion article.
    Significance: The recommendations generated by this consensus can be used as a guide for the diagnosis, evaluation, and management of patients with NORSE/FIRES, and for planning of future research.
    Language English
    Publishing date 2022-08-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 216382-2
    ISSN 1528-1167 ; 0013-9580
    ISSN (online) 1528-1167
    ISSN 0013-9580
    DOI 10.1111/epi.17391
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  6. Article: Low-Cost Devices for Three-Dimensional Cell Aggregation, Real-Time Monitoring Microscopy, Microfluidic Immunostaining, and Deconvolution Analysis.

    Struber, Andreas / Auer, Georg / Fischlechner, Martin / Wickstrom, Cody / Reiter, Lisa / Lutsch, Eric / Simon-Nobbe, Birgit / Marozin, Sabrina / Lepperdinger, Günter

    Bioengineering (Basel, Switzerland)

    2022  Volume 9, Issue 2

    Abstract: The wide use of 3D-organotypic cell models is imperative for advancing our understanding of basic cell biological mechanisms. For this purpose, easy-to-use enabling technology is required, which should optimally link standardized assessment methods to ... ...

    Abstract The wide use of 3D-organotypic cell models is imperative for advancing our understanding of basic cell biological mechanisms. For this purpose, easy-to-use enabling technology is required, which should optimally link standardized assessment methods to those used for the formation, cultivation, and evaluation of cell aggregates or primordial tissue. We thus conceived, manufactured, and tested devices which provide the means for cell aggregation and online monitoring within a hanging drop. We then established a workflow for spheroid manipulation and immune phenotyping. This described workflow conserves media and reagent, facilitates the uninterrupted tracking of spheroid formation under various conditions, and enables 3D-marker analysis by means of 3D epifluorescence deconvolution microscopy. We provide a full description of the low-cost manufacturing process for the fluidic devices and microscopic assessment tools, and the detailed blueprints and building instructions are disclosed. Conclusively, the presented compilation of methods and techniques promotes a quick and barrier-free entry into 3D cell biology.
    Language English
    Publishing date 2022-02-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering9020060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Covalent Attachment of Daptomycin to Ti6Al4V Alloy Surfaces by a Thioether Linkage to Inhibit Colonization by

    Chen, Chang-Po / Jing, Rui-Yan / Wickstrom, Eric

    ACS omega

    2017  Volume 2, Issue 4, Page(s) 1645–1652

    Abstract: Infections are a devastating complication of titanium alloy orthopedic implants. Current therapies include antibiotic-impregnated bone cement and antibiotic-containing coatings. Daptomycin (DAP) ( ...

    Abstract Infections are a devastating complication of titanium alloy orthopedic implants. Current therapies include antibiotic-impregnated bone cement and antibiotic-containing coatings. Daptomycin (DAP) (
    Language English
    Publishing date 2017-04-26
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN 2470-1343
    DOI 10.1021/acsomega.6b00567
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Differentiating Imaging Features of Post-lobectomy Right Middle Lobe Torsion.

    Tamizuddin, Farah / Ocal, Selin / Toussie, Danielle / Azour, Lea / Wickstrom, Maj / Moore, William H / Kent, Amie / Babb, James / Fansiwala, Kush / Flagg, Eric / Ko, Jane P

    Journal of thoracic imaging

    2023  

    Abstract: Purpose: The purpose of this study was to identify differences in imaging features between patients with confirmed right middle lobe (RML) torsion compared to those suspected yet without torsion.: Materials and methods: This retrospective study ... ...

    Abstract Purpose: The purpose of this study was to identify differences in imaging features between patients with confirmed right middle lobe (RML) torsion compared to those suspected yet without torsion.
    Materials and methods: This retrospective study entailing a search of radiology reports from April 1, 2014, to April 15, 2021, resulted in 52 patients with suspected yet without lobar torsion and 4 with confirmed torsion, supplemented by 2 additional cases before the search period for a total of 6 confirmed cases. Four thoracic radiologists (1 an adjudicator) evaluated chest radiographs and computed tomography (CT) examinations, and Fisher exact and Mann-Whitney tests were used to identify any significant differences in imaging features (P<0.05).
    Results: A reversed halo sign was more frequent for all readers (P=0.001) in confirmed RML torsion than patients without torsion (83.3% vs. 0% for 3 readers, one the adjudicator). The CT coronal bronchial angle between RML bronchus and bronchus intermedius was larger (P=0.035) in torsion (121.28 degrees) than nontorsion cases (98.26 degrees). Patients with torsion had a higher percentage of ground-glass opacity in the affected lobe (P=0.031). A convex fissure towards the adjacent lobe on CT (P=0.009) and increased lobe volume on CT (P=0.001) occurred more often in confirmed torsion.
    Conclusion: A reversed halo sign, larger CT coronal bronchial angle, greater proportion of ground-glass opacity, fissural convexity, and larger lobe volume on CT may aid in early recognition of the rare yet highly significant diagnosis of lobar torsion.
    Language English
    Publishing date 2023-09-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632900-7
    ISSN 1536-0237 ; 0883-5993
    ISSN (online) 1536-0237
    ISSN 0883-5993
    DOI 10.1097/RTI.0000000000000736
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Imaging cancer gene activity in patients from outside the body.

    Wickstrom, Eric / Thakur, Mathew L

    Biotechnology healthcare

    2013  Volume 3, Issue 1, Page(s) 45–48

    Abstract: Is the lump malignant or benign? The investigators propose to answer this question by injecting a nuclear medicine gene probe into patients with suspicious lumps in their breasts. They then use scanning techniques to see if active cancer genes light up. ...

    Abstract Is the lump malignant or benign? The investigators propose to answer this question by injecting a nuclear medicine gene probe into patients with suspicious lumps in their breasts. They then use scanning techniques to see if active cancer genes light up.
    Language English
    Publishing date 2013-02-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2515820-X
    ISSN 1554-169X
    ISSN 1554-169X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Correspondence re: S. Heckl et al., Intracellular visualization of prostate cancer using magnetic resonance imaging. Cancer Res 2003;63:4766-72.

    Wickstrom, Eric

    Cancer research

    2004  Volume 64, Issue 7, Page(s) 2639; author reply 2639

    MeSH term(s) Animals ; Genes, myc/genetics ; Humans ; Magnetic Resonance Imaging ; Male ; Prostatic Neoplasms/genetics ; RNA, Messenger/analysis
    Chemical Substances RNA, Messenger
    Language English
    Publishing date 2004-03-29
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.can-03-3254
    Database MEDical Literature Analysis and Retrieval System OnLINE

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