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Article ; Online: In their own words: Interviews with Cell Cycle. Dr. Jiri Bartek on his highly cited paper published in Cell Cycle.

Bartek, Jiri

2010 Volume 9, Issue 11, Page(s) 2063–2064

MeSH term(s)	Ataxia Telangiectasia Mutated Proteins ; Cell Cycle Proteins/metabolism ; Checkpoint Kinase 2 ; DNA Breaks, Single-Stranded ; DNA Repair ; DNA-Binding Proteins/metabolism ; Histones/metabolism ; Humans ; Protein-Serine-Threonine Kinases/metabolism ; RNA Interference ; Tumor Suppressor Proteins/metabolism
Chemical Substances	Cell Cycle Proteins ; DNA-Binding Proteins ; Histones ; Tumor Suppressor Proteins ; Checkpoint Kinase 2 (EC 2.7.1.11) ; ATM protein, human (EC 2.7.11.1) ; Ataxia Telangiectasia Mutated Proteins (EC 2.7.11.1) ; CHEK2 protein, human (EC 2.7.11.1) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2010-06-01
Publishing country	United States
Document type	Comment ; Interview
ZDB-ID	2146183-1
ISSN	1551-4005 ; 1538-4101 ; 1554-8627
ISSN (online)	1551-4005
ISSN	1538-4101 ; 1554-8627
DOI	10.4161/cc.9.11.12365
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Article ; Online: The nexus of nuclear envelope dynamics, circular economy and cancer cell pathophysiology.

Keuper, Kristina / Bartek, Jiri / Maya-Mendoza, Apolinar

European journal of cell biology

2024 Volume 103, Issue 2, Page(s) 151394

Abstract: The nuclear envelope (NE) is a critical component in maintaining the function and structure of the eukaryotic nucleus. The NE and lamina are disassembled during each cell cycle to enable an open mitosis. Nuclear architecture construction and ... ...

Abstract	The nuclear envelope (NE) is a critical component in maintaining the function and structure of the eukaryotic nucleus. The NE and lamina are disassembled during each cell cycle to enable an open mitosis. Nuclear architecture construction and deconstruction is a prime example of a circular economy, as it fulfills a highly efficient recycling program bound to continuous assessment of the quality and functionality of the building blocks. Alterations in the nuclear dynamics and lamina structure have emerged as important contributors to both oncogenic transformation and cancer progression. However, the knowledge of the NE breakdown and reassembly is still limited to a fraction of participating proteins and complexes. As cancer cells contain highly diverse nuclei in terms of DNA content, but also in terms of nuclear number, size, and shape, it is of great interest to understand the intricate relationship between these nuclear features in cancer cell pathophysiology. In this review, we provide insights into how those NE dynamics are regulated, and how lamina destabilization processes may alter the NE circular economy. Moreover, we expand the knowledge of the lamina-associated domain region by using strategic algorithms, including Artificial Intelligence, to infer protein associations, assess their function and location, and predict cancer-type specificity with implications for the future of cancer diagnosis, prognosis and treatment. Using this approach we identified NUP98 and MECP2 as potential proteins that exhibit upregulation in Acute Myeloid Leukemia (LAML) patients with implications for early diagnosis.
Language	English
Publishing date	2024-02-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	391967-5
ISSN	1618-1298 ; 0070-2463 ; 0171-9335
ISSN (online)	1618-1298
ISSN	0070-2463 ; 0171-9335
DOI	10.1016/j.ejcb.2024.151394
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Article ; Online: Modern handläggning av intracerebralt hematom.

Mazya, Michael / Bartek, Jiri / Hansen, Björn

Lakartidningen

2023 Volume 120

Abstract: Intracerebral hemorrhage (ICH) carries the highest mortality and morbidity of all stroke types. Although small vessel disease accounts for the majority of ICH, there is a broad spectrum of other etiologies. Modern imaging techniques are a cornerstone of ... ...

Title translation	Treatment of intracerebral hemorrhage - An overview.
Abstract	Intracerebral hemorrhage (ICH) carries the highest mortality and morbidity of all stroke types. Although small vessel disease accounts for the majority of ICH, there is a broad spectrum of other etiologies. Modern imaging techniques are a cornerstone of the work-up process. The goals of acute management are to prevent hematoma expansion, stabilize and prevent failure of vital functions, and establish the cause of ICH. ICH expansion can be alleviated by rapid correction of any contributing coagulopathy and antihypertensive treatment. Early prognostication within 24 hours after onset is imprecise. For this reason, international guidelines recommend postponing decision-making on withdrawal or limitation of care until at least the second full day of hospitalization. Indications for intensive care differ from those for neurosurgical treatment and should be assessed separately. Neurosurgical treatment is commonly recommended to reduce mortality in the presence of hydrocephalus or infratentorial hematomas with significant mass effect. In deteriorating patients with supratentorial ICH, surgical treatment can be considered as a life-saving treatment on an individual basis, with consideration given to anatomical location, level of consciousness and medical history.
MeSH term(s)	Humans ; Antihypertensive Agents ; Cerebral Hemorrhage/diagnosis ; Cerebral Hemorrhage/etiology ; Cerebral Hemorrhage/surgery ; Hospitalization ; Neurosurgical Procedures
Chemical Substances	Antihypertensive Agents
Language	Swedish
Publishing date	2023-09-05
Publishing country	Sweden
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	391010-6
ISSN	1652-7518 ; 0023-7205
ISSN (online)	1652-7518
ISSN	0023-7205
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Article ; Online: 55-Year Follow-Up of the First Adult Patient With Craniopharyngioma Treated With Gamma Knife Radiosurgery.

Buwaider, Ali / Backlund, Erik-Olof / Almqvist, Per / Lippitz, Bodo / Fletcher-Sandersjöö, Alexander / Bartek, Jiri

Neurosurgery

2024

Abstract: In May 1968, Lars Leksell and Erik-Olof Backlund achieved a pioneering breakthrough by performing the first Gamma Knife radiosurgery (GKRS) on a craniopharyngioma (CP). Today, more than 50 years later, this patient remains under continuous monitoring, ... ...

Abstract	In May 1968, Lars Leksell and Erik-Olof Backlund achieved a pioneering breakthrough by performing the first Gamma Knife radiosurgery (GKRS) on a craniopharyngioma (CP). Today, more than 50 years later, this patient remains under continuous monitoring, providing the longest documented follow-up of a GKRS-treated CP. This case report provides a complete record of the patient's preoperative presentation, surgical assessment, GKRS, and an extensive long-term follow-up with multiple interventions. The investigation involved analysis of archived and digitalized patient records and radiological images. The patient was a 21-year-old female who presented with amenorrhea and low levels of gonadotropins. Pneumoencephalography showed a calcified 2 × 2.5 cm mass located in the suprasellar region, indicative of a CP. Subsequent stereotactic puncture confirmed a predominantly solid nature of the CP. Given the size and composition of the tumor, the surgical team opted for GKRS. Dose planning was performed manually, with coordinates determined using Leksell's stereotactic frame. The tumor was targeted with a total dose of 50 Gy using 179 beams of 60Co. Over the subsequent 55 years, the patient underwent radiological and clinical follow-ups. Throughout this period, 4 cystic tumor recurrences occurred and were managed by stereotactic puncture and Yttrium-90 instillation radiotherapy. The solid component remained stable without repeated GKRS. The patient suffered lateral quadrant anopsia and endocrinological deficits, necessitating pharmaceutical intervention. Despite these challenges, the patient is still living an active life at age 76 years. This case stands as historic evidence of long-term safety and efficacy of GKRS for CPs.
Language	English
Publishing date	2024-05-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	135446-2
ISSN	1524-4040 ; 0148-396X
ISSN (online)	1524-4040
ISSN	0148-396X
DOI	10.1227/neu.0000000000002973
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Article ; Online: [No title information]

Fletcher-Sandersjöö, Alexander / Skyrman, Simon / Thelin, Eric / Bartek, Jiri

Lakartidningen

2022 Volume 119

Title translation	ABC om Handläggning av patienter med kroniskt subduralhematom.
MeSH term(s)	Hematoma, Subdural, Chronic ; Humans ; Tomography, X-Ray Computed
Language	Swedish
Publishing date	2022-09-19
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	391010-6
ISSN	1652-7518 ; 0023-7205
ISSN (online)	1652-7518
ISSN	0023-7205
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Article ; Online: Super-sonic speed of DNA synthesis in medulloblastoma.

Maya-Mendoza, Apolinar / Bartek, Jiri

Nature cancer

2020 Volume 1, Issue 8, Page(s) 758–760

MeSH term(s)	Cerebellar Neoplasms/genetics ; DNA/genetics ; Hedgehog Proteins/genetics ; Humans ; Medulloblastoma/genetics
Chemical Substances	Hedgehog Proteins ; DNA (9007-49-2)
Language	English
Publishing date	2020-07-20
Publishing country	England
Document type	Journal Article ; Comment
ISSN	2662-1347
ISSN (online)	2662-1347
DOI	10.1038/s43018-020-0105-8
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Article ; Online: Laser interstitial thermal therapy using the Leksell Stereotactic System and a diagnostic MRI suite: how I do it.

Jensdottir, Margret / Sandvik, Ulrika / Fagerlund, Michael / Bartek, Jiri

Acta neurochirurgica

2022 Volume 165, Issue 2, Page(s) 549–554

Abstract: Background: Laser interstitial thermal therapy (LITT) is a stereotactic neurosurgical procedure used to treat neoplastic and epileptogenic lesions in the brain. A variety of advanced technological instruments such as frameless navigation systems, ... ...

Abstract	Background: Laser interstitial thermal therapy (LITT) is a stereotactic neurosurgical procedure used to treat neoplastic and epileptogenic lesions in the brain. A variety of advanced technological instruments such as frameless navigation systems, robotics, and intraoperative MRI are often described in this context, although the surgical procedure can also be performed using a standard stereotactic setup and a diagnostic MRI suite. Methods: We report on our experience and a surgical technique using a Leksell stereotactic frame and a diagnostic MRI suite to perform LITT. Conclusion: LITT can be safely performed using the Leksell frame and a diagnostic MRI suite, making the technique available even to neuro-oncology centers without advanced technological setup.
MeSH term(s)	Humans ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/surgery ; Laser Therapy/methods ; Neurosurgical Procedures/methods ; Magnetic Resonance Imaging/methods ; Lasers
Language	English
Publishing date	2022-12-31
Publishing country	Austria
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80010-7
ISSN	0942-0940 ; 0001-6268
ISSN (online)	0942-0940
ISSN	0001-6268
DOI	10.1007/s00701-022-05461-x
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Article ; Online: Drug-Drug Interactions of Cannabidiol with Standard-of-Care Chemotherapeutics.

Buchtova, Tereza / Lukac, David / Skrott, Zdenek / Chroma, Katarina / Bartek, Jiri / Mistrik, Martin

International journal of molecular sciences

2023 Volume 24, Issue 3

Abstract: Cannabidiol (CBD) is an easily accessible and affordable Marijuana ( ...

Abstract	Cannabidiol (CBD) is an easily accessible and affordable Marijuana (
MeSH term(s)	Humans ; Cannabidiol/pharmacology ; Cannabidiol/therapeutic use ; Cannabinoids/therapeutic use ; Cannabis ; Drug Interactions ; Neoplasms/drug therapy ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use
Chemical Substances	Cannabidiol (19GBJ60SN5) ; Cannabinoids ; Antineoplastic Agents
Language	English
Publishing date	2023-02-02
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24032885
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Article: Targeting Ribosome Biogenesis in Cancer: Lessons Learned and Way Forward.

Zisi, Asimina / Bartek, Jiri / Lindström, Mikael S

Cancers

2022 Volume 14, Issue 9

Abstract: Rapid growth and unrestrained proliferation is a hallmark of many cancers. To accomplish this, cancer cells re-wire and increase their biosynthetic and metabolic activities, including ribosome biogenesis (RiBi), a complex, highly energy-consuming process. ...

Abstract	Rapid growth and unrestrained proliferation is a hallmark of many cancers. To accomplish this, cancer cells re-wire and increase their biosynthetic and metabolic activities, including ribosome biogenesis (RiBi), a complex, highly energy-consuming process. Several chemotherapeutic agents used in the clinic impair this process by interfering with the transcription of ribosomal RNA (rRNA) in the nucleolus through the blockade of RNA polymerase I or by limiting the nucleotide building blocks of RNA, thereby ultimately preventing the synthesis of new ribosomes. Perturbations in RiBi activate nucleolar stress response pathways, including those controlled by p53. While compounds such as actinomycin D and oxaliplatin effectively disrupt RiBi, there is an ongoing effort to improve the specificity further and find new potent RiBi-targeting compounds with improved pharmacological characteristics. A few recently identified inhibitors have also become popular as research tools, facilitating our advances in understanding RiBi. Here we provide a comprehensive overview of the various compounds targeting RiBi, their mechanism of action, and potential use in cancer therapy. We discuss screening strategies, drug repurposing, and common problems with compound specificity and mechanisms of action. Finally, emerging paths to discovery and avenues for the development of potential biomarkers predictive of therapeutic outcomes across cancer subtypes are also presented.
Language	English
Publishing date	2022-04-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14092126
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Article ; Online: p53 at the crossroad of DNA replication and ribosome biogenesis stress pathways.

Lindström, Mikael S / Bartek, Jiri / Maya-Mendoza, Apolinar

Cell death and differentiation

2022 Volume 29, Issue 5, Page(s) 972–982

Abstract: Despite several decades of intense research focused on understanding function(s) and disease-associated malfunction of p53, there is no sign of any "mid-life crisis" in this rapidly advancing area of biomedicine. Firmly established as the hub of cellular ...

Abstract	Despite several decades of intense research focused on understanding function(s) and disease-associated malfunction of p53, there is no sign of any "mid-life crisis" in this rapidly advancing area of biomedicine. Firmly established as the hub of cellular stress responses and tumor suppressor targeted in most malignancies, p53's many talents continue to surprise us, providing not only fresh insights into cell and organismal biology, but also new avenues to cancer treatment. Among the most fruitful lines of p53 research in recent years have been the discoveries revealing the multifaceted roles of p53-centered pathways in the fundamental processes of DNA replication and ribosome biogenesis (RiBi), along with cellular responses to replication and RiBi stresses, two intertwined areas of cell (patho)physiology that we discuss in this review. Here, we first provide concise introductory notes on the canonical roles of p53, the key interacting proteins, downstream targets and post-translational modifications involved in p53 regulation. We then highlight the emerging involvement of p53 as a key component of the DNA replication Fork Speed Regulatory Network and the mechanistic links of p53 with cellular checkpoint responses to replication stress (RS), the driving force of cancer-associated genomic instability. Next, the tantalizing, yet still rather foggy functional crosstalk between replication and RiBi (nucleolar) stresses is considered, followed by the more defined involvement of p53-mediated monitoring of the multistep process of RiBi, including the latest updates on the RPL5/RPL11/5 S rRNA-MDM2-p53-mediated Impaired Ribosome Biogenesis Checkpoint (IRBC) pathway and its involvement in tumorigenesis. The diverse defects of RiBi and IRBC that predispose and/or contribute to severe human pathologies including developmental syndromes and cancer are then outlined, along with examples of promising small-molecule-based strategies to therapeutically target the RS- and particularly RiBi- stress-tolerance mechanisms to which cancer cells are addicted due to their aberrant DNA replication, repair, and proteo-synthesis demands.
MeSH term(s)	Cell Nucleolus/genetics ; Cell Nucleolus/metabolism ; DNA Replication ; Humans ; Neoplasms/genetics ; Neoplasms/metabolism ; Proto-Oncogene Proteins c-mdm2/genetics ; Proto-Oncogene Proteins c-mdm2/metabolism ; RNA, Ribosomal/metabolism ; Ribosomal Proteins/genetics ; Ribosomes/metabolism ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism
Chemical Substances	RNA, Ribosomal ; Ribosomal Proteins ; Tumor Suppressor Protein p53 ; Proto-Oncogene Proteins c-mdm2 (EC 2.3.2.27)
Language	English
Publishing date	2022-04-20
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1225672-9
ISSN	1476-5403 ; 1350-9047
ISSN (online)	1476-5403
ISSN	1350-9047
DOI	10.1038/s41418-022-00999-w
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