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  1. Article ; Online: DNA Sequencing in Adults With Acute Myeloid Leukemia to Detect Residual Disease Prior to Hematopoietic Cell Transplant-Reply.

    Gui, Gege / Dillon, Laura W / Hourigan, Christopher S

    JAMA

    2023  Volume 330, Issue 2, Page(s) 190–191

    MeSH term(s) Adult ; Humans ; Base Sequence ; Hematopoietic Stem Cell Transplantation ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/therapy ; Neoplasm, Residual/diagnosis ; Neoplasm, Residual/genetics ; Sequence Analysis, DNA
    Language English
    Publishing date 2023-05-08
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2023.8653
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.88: Show issues Location:
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  2. Article: TP53

    Mukherjee, Devdeep / Lawal, Rialnat A / Fitzhugh, Courtney D / Hourigan, Christopher S / Dillon, Laura W

    medRxiv : the preprint server for health sciences

    2024  

    Abstract: There is increasing recognition of the risk of developing therapy-related myeloid malignancy, including after cellular therapy. While retrospective studies have implicated pre- ... ...

    Abstract There is increasing recognition of the risk of developing therapy-related myeloid malignancy, including after cellular therapy. While retrospective studies have implicated pre-existing
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.06.24302401
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Measurable residual disease in patients undergoing allogeneic transplant for acute myeloid leukemia.

    Wong, Zoë C / Dillon, Laura W / Hourigan, Christopher S

    Best practice & research. Clinical haematology

    2023  Volume 36, Issue 2, Page(s) 101468

    Abstract: The most common indication for allogeneic hematopoietic cell transplant (alloHCT) is maintenance of remission after initial treatment for patients with acute myeloid leukemia (AML). Loss of remission, relapse, remains however the most frequent cause of ... ...

    Abstract The most common indication for allogeneic hematopoietic cell transplant (alloHCT) is maintenance of remission after initial treatment for patients with acute myeloid leukemia (AML). Loss of remission, relapse, remains however the most frequent cause of alloHCT failure. There is strong evidence that detectable persistent disease burden ("measurable residual disease", MRD) in patients with AML in remission prior to alloHCT is associated with increased risk of post-transplant relapse. MRD status as a summative assessment of response to pre-transplant therapy may allow superior patient-personalized risk stratification compared with models solely incorporating pre-treatment variables. An optimal methodology for AML MRD detection has not yet been established, but molecular methods such as DNA-sequencing may have additional prognostic utility compared to current approaches. There is growing evidence that intervention on AML MRD positivity may improve post-transplant outcomes. New initiatives will generate actionable data on the clinical utility of AML MRD testing for patients undergoing alloHCT.
    MeSH term(s) Humans ; Hematopoietic Stem Cell Transplantation/methods ; Transplantation, Homologous ; Recurrence ; Leukemia, Myeloid, Acute/diagnosis ; Leukemia, Myeloid, Acute/therapy ; Neoplasm, Residual/diagnosis ; Neoplasm, Residual/therapy ; Allografts
    Language English
    Publishing date 2023-04-18
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, N.I.H., Intramural
    ZDB-ID 2048027-1
    ISSN 1532-1924 ; 1521-6926
    ISSN (online) 1532-1924
    ISSN 1521-6926
    DOI 10.1016/j.beha.2023.101468
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  4. Article ; Online: Measurable Residual Disease Before Reduced-Intensity Allogeneic Transplantation in Patients With Myeloid Malignancy.

    Gui, Gege / Dillon, Laura W / Hourigan, Christopher S

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2021  Volume 39, Issue 21, Page(s) 2413–2415

    MeSH term(s) Adult ; Aged ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Leukemia, Myeloid, Acute/complications ; Middle Aged ; Neoplasm, Residual/etiology ; Neoplasm, Residual/pathology ; Transplantation Conditioning/methods ; Transplantation, Homologous/methods ; Young Adult
    Language English
    Publishing date 2021-05-05
    Publishing country United States
    Document type Letter
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.21.00255
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    Zs.A 1847: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 650: Show issues

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  5. Article ; Online: Persistent IDH mutations are not associated with increased relapse or death in patients with IDH-mutated acute myeloid leukemia undergoing allogeneic hematopoietic cell transplant with post-transplant cyclophosphamide.

    Ravindra, Niveditha / Dillon, Laura W / Gui, Gege / Smith, Matthew / Gondek, Lukasz P / Jones, Richard J / Corner, Adam / Hourigan, Christopher S / Ambinder, Alexander J

    Bone marrow transplantation

    2024  Volume 59, Issue 3, Page(s) 428–430

    MeSH term(s) Humans ; Hematopoietic Stem Cell Transplantation ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/therapy ; Cyclophosphamide/therapeutic use ; Chronic Disease ; Recurrence ; Mutation ; Retrospective Studies ; Graft vs Host Disease
    Chemical Substances Cyclophosphamide (8N3DW7272P)
    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Letter
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-023-02189-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2168: Show issues Location:
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  6. Article ; Online: Prediction of HLA genotypes from single-cell transcriptome data.

    Solomon, Benjamin D / Zheng, Hong / Dillon, Laura W / Goldman, Jason D / Hourigan, Christopher S / Heath, James R / Khatri, Purvesh

    Frontiers in immunology

    2023  Volume 14, Page(s) 1146826

    Abstract: The human leukocyte antigen (HLA) locus plays a central role in adaptive immune function and has significant clinical implications for tissue transplant compatibility and allelic disease associations. Studies using bulk-cell RNA sequencing have ... ...

    Abstract The human leukocyte antigen (HLA) locus plays a central role in adaptive immune function and has significant clinical implications for tissue transplant compatibility and allelic disease associations. Studies using bulk-cell RNA sequencing have demonstrated that HLA transcription may be regulated in an allele-specific manner and single-cell RNA sequencing (scRNA-seq) has the potential to better characterize these expression patterns. However, quantification of allele-specific expression (ASE) for HLA loci requires sample-specific reference genotyping due to extensive polymorphism. While genotype prediction from bulk RNA sequencing is well described, the feasibility of predicting HLA genotypes directly from single-cell data is unknown. Here we evaluate and expand upon several computational HLA genotyping tools by comparing predictions from human single-cell data to gold-standard, molecular genotyping. The highest 2-field accuracy averaged across all loci was 76% by arcasHLA and increased to 86% using a composite model of multiple genotyping tools. We also developed a highly accurate model (AUC 0.93) for predicting
    MeSH term(s) Humans ; Transcriptome ; Sequence Analysis, DNA ; HLA Antigens/genetics ; Histocompatibility Antigens Class I/genetics ; Genotype ; Histocompatibility Antigens Class II/genetics
    Chemical Substances HLA Antigens ; Histocompatibility Antigens Class I ; Histocompatibility Antigens Class II
    Language English
    Publishing date 2023-04-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1146826
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  7. Article ; Online: Increased incidence of hematologic malignancies in SCD after HCT in adults with graft failure and mixed chimerism.

    Lawal, Rialnat A / Mukherjee, Devdeep / Limerick, Emily M / Coles, Wynona / Hsieh, Matthew M / Dillon, Laura W / Hourigan, Christopher S / Fitzhugh, Courtney D

    Blood

    2022  Volume 140, Issue 23, Page(s) 2514–2518

    MeSH term(s) Humans ; Chimerism ; Hematologic Neoplasms/epidemiology ; Hematologic Neoplasms/therapy
    Language English
    Publishing date 2022-08-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2022017960
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  8. Article ; Online: Quantification of measurable residual disease using duplex sequencing in adults with acute myeloid leukemia.

    Dillon, Laura W / Higgins, Jake / Nasif, Hassan / Othus, Megan / Beppu, Lan / Smith, Thomas H / Schmidt, Elizabeth / Valentine Iii, Charles C / Salk, Jesse J / Wood, Brent L / Erba, Harry P / Radich, Jerald P / Hourigan, Christopher S

    Haematologica

    2024  Volume 109, Issue 2, Page(s) 401–410

    Abstract: The presence of measurable residual disease (MRD) is strongly associated with treatment outcomes in acute myeloid leukemia (AML). Despite the correlation with clinical outcomes, MRD assessment has yet to be standardized or routinely incorporated into ... ...

    Abstract The presence of measurable residual disease (MRD) is strongly associated with treatment outcomes in acute myeloid leukemia (AML). Despite the correlation with clinical outcomes, MRD assessment has yet to be standardized or routinely incorporated into clinical trials and discrepancies have been observed between different techniques for MRD assessment. In 62 patients with AML, aged 18-60 years, in first complete remission after intensive induction therapy on the randomized phase III SWOG-S0106 clinical trial (clinicaltrials gov. Identifier: NCT00085709), MRD detection by centralized, high-quality multiparametric flow cytometry was compared with a 29-gene panel utilizing duplex sequencing (DS), an ultrasensitive next-generation sequencing method that generates double-stranded consensus sequences to reduce false positive errors. MRD as defined by DS was observed in 22 (35%) patients and was strongly associated with higher rates of relapse (68% vs. 13%; hazard ratio [HR] =8.8; 95% confidence interval [CI]: 3.2-24.5; P<0.001) and decreased survival (32% vs. 82%; HR=5.6; 95% CI: 2.3-13.8; P<0.001) at 5 years. DS MRD strongly outperformed multiparametric flow cytometry MRD, which was observed in ten (16%) patients and marginally associated with higher rates of relapse (50% vs. 30%; HR=2.4; 95% CI: 0.9-6.7; P=0.087) and decreased survival (40% vs. 68%; HR=2.5; 95% CI: 1.0-6.3; P=0.059) at 5 years. Furthermore, the prognostic significance of DS MRD status at the time of remission for subsequent relapse was similar on both randomized arms of the trial. These findings suggest that next-generation sequencing-based AML MRD testing is a powerful tool that could be developed for use in patient management and for early anti-leukemic treatment assessment in clinical trials.
    MeSH term(s) Adult ; Humans ; Leukemia, Myeloid, Acute/diagnosis ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/therapy ; Treatment Outcome ; Hematopoietic Stem Cell Transplantation ; Prognosis ; Recurrence ; Neoplasm, Residual/diagnosis ; Flow Cytometry/methods
    Language English
    Publishing date 2024-02-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2023.283520
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  9. Article: Persistent

    Ravindra, Niveditha / Dillon, Laura W / Gui, Gege / Smith, Matthew / Gondek, Lukasz P / Jones, Richard J / Corner, Adam / Hourigan, Christopher S / Ambinder, Alexander J

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: The presence of measurable residual disease (MRD) prior to an allogeneic hematopoietic transplant (alloHCT) in Acute Myeloid Leukemia (AML) has been shown to be associated with an increased risk of post-transplant relapse. Since the Isocitrate ... ...

    Abstract The presence of measurable residual disease (MRD) prior to an allogeneic hematopoietic transplant (alloHCT) in Acute Myeloid Leukemia (AML) has been shown to be associated with an increased risk of post-transplant relapse. Since the Isocitrate Dehydrogenase genes (
    Language English
    Publishing date 2023-08-21
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.08.14.23294087
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  10. Article ; Online: Next-generation sequencing for measurable residual disease detection in acute myeloid leukaemia.

    Ghannam, Jack / Dillon, Laura W / Hourigan, Christopher S

    British journal of haematology

    2019  Volume 188, Issue 1, Page(s) 77–85

    Abstract: Acute myeloid leukaemia (AML) is a blood cancer characterized by acquired genetic mutations. There is great interest in accurately establishing measurable residual disease (MRD) burden in AML patients in remission after treatment but at risk of relapse. ... ...

    Abstract Acute myeloid leukaemia (AML) is a blood cancer characterized by acquired genetic mutations. There is great interest in accurately establishing measurable residual disease (MRD) burden in AML patients in remission after treatment but at risk of relapse. However, inter- and intrapatient genetic diversity means that, unlike in the chronic myeloid and acute promyelocytic leukaemias, no single genetic abnormality is pathognomonic for all cases of AML MRD. Next-generation sequencing offers the opportunity to test broadly and deeply for potential genetic evidence of residual AML, and while not currently accepted for such use clinically, is likely to be increasingly used for AML MRD testing in the future.
    MeSH term(s) Hematologic Neoplasms/genetics ; Hematologic Neoplasms/therapy ; High-Throughput Nucleotide Sequencing ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/therapy ; Leukemia, Promyelocytic, Acute/genetics ; Leukemia, Promyelocytic, Acute/therapy ; Neoplasm, Residual
    Language English
    Publishing date 2019-12-05
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.16362
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    Uh III Zs.182: Show issues Location:
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