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Article: A comprehensive review on COVID-19 vaccines: development, effectiveness, adverse effects, distribution and challenges.

Rahman, Md Mijanur / Masum, Md Habib Ullah / Wajed, Shah / Talukder, Asma

2022 Volume 33, Issue 1, Page(s) 1–22

Abstract: ... The efficacy of the leading vaccines such as BNT162b2, mRNA-1273, Gam-Covid-Vac, Ad26.COV2.S, ChAdOx1 nCoV-19 ...

Abstract	The present SARS-CoV-2 induced COVID-19 pandemic is responsible for millions of deaths, illnesses, and economic loss worldwide. There are 21 COVID-19 vaccines from different platforms approved worldwide for emergency use until 13 August 2021. Later, BNT162b2 obtained full approval from the FDA. The efficacy of the leading vaccines such as BNT162b2, mRNA-1273, Gam-Covid-Vac, Ad26.COV2.S, ChAdOx1 nCoV-19, and BBIBP-CorV, against SARS-CoV-2 documented as 95%, 94.1%, 91.6%, 67%, 70.4%, and 78.1%, respectively. Moreover, against the Delta variant of SARS-CoV-2, BNT162b2, ChAdOx1 nCoV-19, and BBV152 showed 88%, 70%, and 65.2% efficacy, respectively. Apart from the common adverse effects such as fever, fatigue, headache, and pain in the injection site, Bell's palsy with BNT162b2, myocarditis and pericarditis with mRNA-1273, and thrombosis with ChAdOx1 nCoV-19 have been reported though seemed not alarming. Furthermore, global production and distribution of vaccines should be ensured in an equal and justifiable way that the immunity and protection against the virus would be optimum and persistent.
Language	English
Publishing date	2022-02-01
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2846993-8
ISSN	2347-3517 ; 2347-3584
ISSN (online)	2347-3517
ISSN	2347-3584
DOI	10.1007/s13337-022-00755-1
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Article ; Online: Elective splenectomy in patients with non-Hodgkin lymphoma: Does the size of the spleen affect surgical outcomes?

Di Mauro, Davide / Gelsomino, Mariannita / Fasano, Angelica / Wajed, Shahjehan / Manzelli, Antonio

Annals of hepato-biliary-pancreatic surgery

2022 Volume 26, Issue 2, Page(s) 144–148

Abstract: Backgrounds/aims: Splenectomy in patients with non-Hodgkin lymphoma (NHL) is performed to relieve abdominal symptoms, treat hypersplenism or confirm diagnosis. Excision of a very large spleen is technically challenging and data on outcomes of surgery in ...

Abstract	Backgrounds/aims: Splenectomy in patients with non-Hodgkin lymphoma (NHL) is performed to relieve abdominal symptoms, treat hypersplenism or confirm diagnosis. Excision of a very large spleen is technically challenging and data on outcomes of surgery in patients with NHL are scanty. The aim of study was to evaluate the impact of spleen size on the surgical outcome of splenectomy in patients with NHL. Methods: Patients with NHL who underwent splenectomy, between 2006 and 2017, were included and divided into two groups: group 1, spleen ≤ 20 cm; group 2, spleen > 20 cm. Surgical approach, operative time, postoperative morbidity, mortality, hospital stay and re-admission rates were retrospectively compared between groups. Non-parametric data were evaluated with the Mann-Whitney U test. Differences in frequencies were analyzed with Fisher's exact test. Results: Sixteen patients were included (group 1, 6; group 2, 10). Laparoscopy was successful in three patients of group 1, none of group 2 ( Conclusions: Spleen size does not affect the outcome of splenectomy in patients with NHL. If a mini-invasive approach is to be chosen, laparoscopy may not be feasible when the spleen size is > 20 cm.
Language	English
Publishing date	2022-02-07
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	3012179-6
ISSN	2508-5859 ; 2508-5778
ISSN (online)	2508-5859
ISSN	2508-5778
DOI	10.14701/ahbps.21-130
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Article ; Online: Coinfection of fungi with SARS-CoV-2 is a detrimental health risk for COVID-19 patients.

Baten, Nahida / Wajed, Shah / Talukder, Asma / Masum, Md Habib Ullah / Rahman, Md Mijanur

Beni-Suef University journal of basic and applied sciences

2022 Volume 11, Issue 1, Page(s) 64

Abstract: Background: Notable fungal coinfections with SARS-CoV-2 in COVID-19 patients have been reported worldwide in an alarming way. : Main body: Impaired CD4 + T cell response due to SARS-CoV-2 infection creates an opportunity for fungi to take over the ... ...

Abstract	Background: Notable fungal coinfections with SARS-CoV-2 in COVID-19 patients have been reported worldwide in an alarming way. Main body: Impaired CD4 + T cell response due to SARS-CoV-2 infection creates an opportunity for fungi to take over the host cells and, consequently, cause severe fungal coinfections, including candidiasis and candidemia, mucormycosis, invasive pulmonary aspergillosis (IPA), and COVID-19-associated pulmonary aspergillosis (CAPA). Among them, mucormycosis and CAPA have been reported with a mortality rate of 66% in India and 60% in Colombia. Moreover, IPA has been reported in Belgium, Netherlands, France, and Germany with a morbidity rate of 20.6%, 19.6%, 33.3%, and 26%, respectively. Several antifungal drugs have been applied to combat fungal coinfection in COVID-19 patients, including Voriconazole, Isavuconazole, and Echinocandins. Conclusion: SARS-CoV-2 deteriorates the immune system so that several fungi could take that opportunity and cause life-threatening health situations. To reduce the mortality and morbidity of fungal coinfections, it needs immunity boosting, proper hygiene and sanitation, and appropriate medication based on the diagnosis.
Language	English
Publishing date	2022-05-04
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2768279-1
ISSN	2314-8543 ; 2314-8535 ; 2314-8543
ISSN (online)	2314-8543
ISSN	2314-8535 ; 2314-8543
DOI	10.1186/s43088-022-00245-9
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Article ; Online: Routine examination of gallbladder specimens after cholecystectomy: a single-centre analysis of the incidence, clinical and histopathological aspects of incidental gallbladder carcinoma.

Di Mauro, Davide / Orabi, Amira / Myintmo, Aye / Reece-Smith, Alex / Wajed, Shahjehan / Manzelli, Antonio

Discover. Oncology

2021 Volume 12, Issue 1, Page(s) 4

Abstract: Background: Gallbladder carcinoma is often found incidentally on histopathologic examination after cholecystectomy-this is referred as incidental gallbladder carcinoma (IGC). Routine vs selective histopathological assessment of gallbladders is under ... ...

Abstract	Background: Gallbladder carcinoma is often found incidentally on histopathologic examination after cholecystectomy-this is referred as incidental gallbladder carcinoma (IGC). Routine vs selective histopathological assessment of gallbladders is under debate and this study evaluates the role of regular specimens' examination, based on a single-centre analysis of incidence, clinical and histopathological aspects of IGC. Methods: Patients who underwent cholecystectomy, between July 2010 and January 2020, were considered. Exclusion criteria were age under 18 and preoperative diagnosis of GB carcinoma. Demographic, clinical and histopathological data were retrospectively collected, continuous variables with a normal distribution were evaluated with Student's t-test and ANOVA. Results: Some 5779 patients were included. The female/male ratio was 2.5:1. Chronic cholecystitis (CC) was the most common finding on specimens (99.3%), IGC was found in six cases (0.1%). In the latter group, there were 5 women and patients were older than those with benign disease-73.7 [Formula: see text] 5.38 years vs 55.8 [Formula: see text] 0.79 years (p < 0.05). In all the cases, the GB was abnormal on intraoperative inspection and beside cancer, histopathology showed associated CC and/or dysplasia. Upon diagnosis, disease was at advanced stage-one stage II, one stage IIIA, one stage IIIB, three stage IVA. Two patients are alive, three died of disease progression-median survival was 7 months (range 2-14). Conclusions: In this series, ICG was rare, occurred most commonly in old adult women and was diagnosed at an advanced stage. In all the cases, the GB was abnormal intraoperatively, therefore macroscopic GB anomalies demand histopathological assessment of the specimen.
Language	English
Publishing date	2021-02-15
Publishing country	United States
Document type	Journal Article
ISSN	2730-6011
ISSN (online)	2730-6011
DOI	10.1007/s12672-021-00399-5
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Article ; Online: The mass effect of a slowly growing GIST.

Prakash, Deepali / Siragusa, Leandro / Wajed, Saj / Manzelli, Antonio

BMJ case reports

2018 Volume 2018

Abstract: Gastrointestinal stromal tumours (GISTs) are typically defined as solid masses arising from the GI tract, most commonly from the stomach and small intestine. They seldom present in a cystic form. Management of cystic masses arising from the GI tract may ... ...

Abstract	Gastrointestinal stromal tumours (GISTs) are typically defined as solid masses arising from the GI tract, most commonly from the stomach and small intestine. They seldom present in a cystic form. Management of cystic masses arising from the GI tract may pose a diagnostic predicament. We had one such case that presented itself with complaints of a slow growing intra-abdominal mass. An ultrasound scan demonstrated a thick-walled cystic lesion arising from the pelvis. Further imaging evaluations in the form of a CT scan revealed a complex large cystic mass arising from left upper quadrant (see Figure 1). Due to the uncertainty of origin of this mass and lack of invasion or lymphadenopathy, it was thought to be benign. After a multidisciplinary meeting, it was concluded that an urgent surgical excision of this benign mass was the best treatment. The surgical treatment of which entailed a 10 hours surgery to resect this 10 kg lesion, which comprised 7 L fluid and 3 kg solid mass. Histopathology aided in the diagnosis of this lesion as a CD117-positive and DOG1-positive GIST.
MeSH term(s)	Aged ; Biomarkers, Tumor ; Diagnosis, Differential ; Digestive System Surgical Procedures/methods ; Gastrointestinal Stromal Tumors/diagnostic imaging ; Gastrointestinal Stromal Tumors/pathology ; Gastrointestinal Stromal Tumors/surgery ; Humans ; Male ; Pancreas/diagnostic imaging ; Pancreas/surgery ; Splenectomy ; Splenic Artery/diagnostic imaging ; Splenic Artery/surgery ; Stomach Neoplasms/diagnostic imaging ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery ; Tomography, X-Ray Computed ; Treatment Outcome ; Ultrasonography
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2018-03-05
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2017-222556
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Article ; Online: Prenatal breastfeeding intervention program to increase breastfeeding duration among low income women

Wajed Hatamleh

Health, Vol 04, Iss 03, Pp 143-

2012 Volume 149

Abstract: ... through an intervention based on Den-nis’s Breastfeeding Self-Efficacy Theory. A quasi-Experimental design was used ...

Abstract	Extensive research confirms the nutritional, economic, biomedical, immunological, and psychological advantages of breast milk. Despite the clear benefits of breastfeeding to mother and infant, breastfeeding rates today continue to remain below the recommended levels in the United States, most notably among low-income mothers. One factor that plays a role in breast-feeding success and may be modifiable by nursing intervention is maternal self-efficacy. This study aimed to increase the breast-feeding du-ration through an intervention based on Den-nis’s Breastfeeding Self-Efficacy Theory. A quasi-Experimental design was used to test the effect of the intervention program on duration of breastfeeding. A convenience sample of 37 low-income women was recruited from two rural pre-natal clinics in the Midwest. Data were collected using the Breastfeeding Self-Efficacy Scale (BSES) and a demographic profile. Women were con-tacted by telephone at two and six weeks post-partum to determine if they were still breast-feeding and to complete the BSES. The women who were assigned to a breast-feeding self-efficacy intervention showed significantly greater increases in breast-feeding duration and self-efficacy than did the women in the control group. The results of this study suggest that the one-hour of breastfeeding intervention program during the prenatal period may increase the duration of breastfeeding in low-income women who intend to breastfeed. This study supports the literature which found that prenatal education and postpartum support are important to the out-come of breastfeeding.
Keywords	Breastfeeding ; Self-Efficacy ; Intervention ; Low Income ; Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	796
Language	English
Publishing date	2012-03-01T00:00:00Z
Publisher	Scientific Research Publishing
Document type	Article ; Online
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Article ; Online: Introduction into the NHS of magnetic sphincter augmentation: an innovative surgical therapy for reflux - results and challenges.

Prakash, D / Campbell, B / Wajed, S

Annals of the Royal College of Surgeons of England

2018 Volume 100, Issue 4, Page(s) 251–256

Abstract: Introduction Gastro-oesophageal reflux disease (GORD) is a common, chronic debilitating condition. Surgical management traditionally involves fundoplication. Magnetic sphincter augmentation (MSA) is a new definitive treatment. We describe our experience ... ...

Abstract	Introduction Gastro-oesophageal reflux disease (GORD) is a common, chronic debilitating condition. Surgical management traditionally involves fundoplication. Magnetic sphincter augmentation (MSA) is a new definitive treatment. We describe our experience of introducing this innovative therapy into NHS practice and report the early clinical outcomes. Methods MSA was introduced into NHS practice following successful acceptance of a cost-effective business plan and close observation of National Institute for Health and Care Excellence (NICE) recommendations for new procedures, including a carefully planned prospective data collection over a two-year follow-up period. Results Forty-seven patients underwent MSA over the 40-month period. Reflux health-related quality of life (GERD-HRQL) was significantly improved after the procedure and maintained at one- and two-year (P < 0.0001) follow-up. Drug dependency went from 100% at baseline to 2.6% and 8.7% after one and two years. High levels of patient satisfaction were reported. There were no adverse events. Conclusions MSA is highly effective in the treatment of uncomplicated GORD, with durable results and an excellent safety profile. This laparoscopic, minimally invasive procedure provides a good alternative for patients where surgical anatomy is unaltered. Our experience demonstrates that innovative technology can be incorporated into NHS practice with an acceptable business plan and compliance with NICE recommendations.
MeSH term(s)	Adult ; Cost-Benefit Analysis ; Digestive System Surgical Procedures/economics ; Digestive System Surgical Procedures/instrumentation ; Digestive System Surgical Procedures/methods ; Esophageal Sphincter, Lower/surgery ; Female ; Follow-Up Studies ; Gastroesophageal Reflux/surgery ; Humans ; Laparoscopy/economics ; Laparoscopy/instrumentation ; Laparoscopy/methods ; Magnets ; Male ; Middle Aged ; Patient Satisfaction ; Prospective Studies ; Prosthesis Implantation/economics ; Prosthesis Implantation/methods ; Quality of Life ; State Medicine
Language	English
Publishing date	2018-01-24
Publishing country	England
Document type	Journal Article
ZDB-ID	80044-2
ISSN	1478-7083 ; 0035-8843
ISSN (online)	1478-7083
ISSN	0035-8843
DOI	10.1308/rcsann.2017.0224
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Article ; Online: Can Preoperative Characteristics Predict the Outcomes of Laparoscopic Cholecystectomy?

Orabi, Amira / Di Mauro, Davide / Njere, Ikechukwu / Ratano, Marco / Thavakumar, Sankavi / Reece-Smith, Alex / Wajed, Shahjehan / Manzelli, Antonio

Journal of laparoendoscopic & advanced surgical techniques. Part A

2021 Volume 32, Issue 5, Page(s) 532–537

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Adult ; Body Mass Index ; Chi-Square Distribution ; Cholecystectomy, Laparoscopic/methods ; Female ; Humans ; Male ; Middle Aged ; Postoperative Complications/epidemiology ; Retrospective Studies
Language	English
Publishing date	2021-08-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	1381909-4
ISSN	1557-9034 ; 1092-6429
ISSN (online)	1557-9034
ISSN	1092-6429
DOI	10.1089/lap.2021.0398
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Article: A comprehensive review on COVID-19 vaccines: development, effectiveness, adverse effects, distribution and challenges

Rahman, Md. Mijanur / Masum, Md. Habib Ullah / Wajed, Shah / Talukder, Asma

Virusdisease. 2022 Mar., v. 33, no. 1

2022

Abstract: ... The efficacy of the leading vaccines such as BNT162b2, mRNA-1273, Gam-Covid-Vac, Ad26.COV2.S, ChAdOx1 nCoV-19 ... fatigue, headache, and pain in the injection site, Bell’s palsy with BNT162b2, myocarditis and ...

Abstract	The present SARS-CoV-2 induced COVID-19 pandemic is responsible for millions of deaths, illnesses, and economic loss worldwide. There are 21 COVID-19 vaccines from different platforms approved worldwide for emergency use until 13 August 2021. Later, BNT162b2 obtained full approval from the FDA. The efficacy of the leading vaccines such as BNT162b2, mRNA-1273, Gam-Covid-Vac, Ad26.COV2.S, ChAdOx1 nCoV-19, and BBIBP-CorV, against SARS-CoV-2 documented as 95%, 94.1%, 91.6%, 67%, 70.4%, and 78.1%, respectively. Moreover, against the Delta variant of SARS-CoV-2, BNT162b2, ChAdOx1 nCoV-19, and BBV152 showed 88%, 70%, and 65.2% efficacy, respectively. Apart from the common adverse effects such as fever, fatigue, headache, and pain in the injection site, Bell’s palsy with BNT162b2, myocarditis and pericarditis with mRNA-1273, and thrombosis with ChAdOx1 nCoV-19 have been reported though seemed not alarming. Furthermore, global production and distribution of vaccines should be ensured in an equal and justifiable way that the immunity and protection against the virus would be optimum and persistent.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; fever ; financial economics ; headache ; immunity ; injection site ; myocarditis ; pericarditis ; thrombosis ; viruses
Language	English
Dates of publication	2022-03
Size	p. 1-22.
Publishing place	Springer India
Document type	Article
Note	Review
ZDB-ID	2846993-8
ISSN	2347-3517 ; 2347-3584
ISSN (online)	2347-3517
ISSN	2347-3584
DOI	10.1007/s13337-022-00755-1
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Article ; Online: Diaphragmatic crural augmentation utilising cross-linked porcine dermal collagen biologic mesh (Permacol) in the repair of large and complex para-oesophageal herniation: a retrospective cohort study.

Travers, H C / Brewer, J O / Smart, N J / Wajed, S A

Hernia : the journal of hernias and abdominal wall surgery

2016 Volume 20, Issue 2, Page(s) 311–320

Abstract: Objective: To evaluate the safety, efficacy and durability of selective integration of porcine dermal collagen (Permacol) biologic mesh for crural re-construction in large or complex para-oesophageal hernia surgery.: Background: Surgical repair of ... ...

Abstract	Objective: To evaluate the safety, efficacy and durability of selective integration of porcine dermal collagen (Permacol) biologic mesh for crural re-construction in large or complex para-oesophageal hernia surgery. Background: Surgical repair of para-oesophageal herniation has been associated with high rates of failure. The utilisation of prosthetic mesh is controversial with complications including erosion and fistulation. Long-term outcomes for biologic mesh crural augmentation are unclear. Methods: A retrospective analysis of patients who underwent a biologic mesh (Permacol) augmented cruroplasty in the repair of large and/or complex para-oesophageal hernia was performed utilising the prospectively maintained oesophago-gastric database at the Royal Devon and Exeter Hospital between October 2004 and January 2013. This technique was selectively used for patients where the lateral extent of the diaphragmatic-crural defect prevented the fashioning of a sound, tension-free repair with sutures alone, or previous surgery had failed. Successful outcome was defined by resolution of symptoms and structural integrity of the repair. Results: Fifty one procedures were performed on 49 patients (15 male), median age 75 (range 25-91). Post-operative morbidity included 2 (3.9%) oesophageal injuries managed conservatively, and 2 (3.9%) patients who suffered early repair breakdown requiring immediate surgical re-intervention. Four patients (8%) required endoscopic dilatation due to dysphagia, one (2%) in the early post-operative phase. The median follow-up was 36 months (range 6-105). All patients reported initial symptomatic resolution. Two patients (4%) were demonstrated to have breakdown of their repair during the follow-up period, both of whom underwent revision mesh-augmented surgery and are re-incorporated in this series. Late-onset dysphagia in two (4%) patients may be mesh-related, but no other complications were observed and a Kaplan-Meier analysis of this series predicts a symptom-free rate of approximately 94% at 5 years. Conclusions: The selective integration of biologic mesh to augment the crural repair in para-oesophageal hernia with extensive diaphragmatic defects appears to be safe, effective and infers the potential of long-term satisfactory outcomes.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Animals ; Biocompatible Materials ; Collagen ; Diaphragm/surgery ; Female ; Hernia, Hiatal/surgery ; Herniorrhaphy/methods ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Surgical Mesh ; Swine
Chemical Substances	Biocompatible Materials ; Permacol ; Collagen (9007-34-5)
Keywords	covid19
Language	English
Publishing date	2016-04
Publishing country	France
Document type	Journal Article
ZDB-ID	1388125-5
ISSN	1248-9204 ; 1265-4906
ISSN (online)	1248-9204
ISSN	1265-4906
DOI	10.1007/s10029-015-1390-5
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