LIVIVO - Search results -

Search results

Result 1 - 10 of total 163

Search options

Article ; Online: WRNing for the right DNA repair pathway choice.

Lee, Jong-Hyuk / Croteau, Deborah L / Bohr, Vilhelm A

Aging

2022 Volume 14, Issue 11, Page(s) 4620–4621

MeSH term(s)	DNA Breaks, Double-Stranded ; DNA Repair ; RecQ Helicases/genetics ; RecQ Helicases/metabolism
Chemical Substances	RecQ Helicases (EC 3.6.4.12)
Language	English
Publishing date	2022-06-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.204120
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Early-Onset Hearing Loss in Mouse Models of Alzheimer's Disease and Increased DNA Damage in the Cochlea.

Park, Jae-Hyeon / Sahbaz, Burcin Duan / Pekhale, Komal / Chu, Xixia / Okur, Mustafa N / Grati, Mhamed / Isgrig, Kevin / Chien, Wade / Chrysostomou, Elena / Sullivan, Lauren / Croteau, Deborah L / Manor, Uri / Bohr, Vilhelm A

Aging Biology

2024 Volume 1

Abstract: There is considerable interest in whether sensory deficiency is associated with the development of Alzheimer's disease (AD). Notably, the relationship between hearing impairment and AD is of high relevance but still poorly understood. In this study, we ... ...

Abstract	There is considerable interest in whether sensory deficiency is associated with the development of Alzheimer's disease (AD). Notably, the relationship between hearing impairment and AD is of high relevance but still poorly understood. In this study, we found early-onset hearing loss in two AD mouse models, 3xTgAD and 3xTgAD/Polβ
Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Journal Article
DOI	10.59368/agingbio.20240025
Database	MEDical Literature Analysis and Retrieval System OnLINE

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Aquatic insect accumulation of uranium at spring outflows in the Grand Canyon region as influenced by aqueous and sediment geochemistry and biological factors: implications for monitoring.

Cain, Daniel J / Croteau, Marie-Noële / Fuller, Christopher C / Beisner, Kimberly R / Campbell, Kate M / Stoliker, Deborah L / Schenk, Edward R

Environmental monitoring and assessment

2023 Volume 195, Issue 7, Page(s) 841

Abstract: Potential adverse ecological effects of expanded uranium (U) mining within the Grand Canyon region motivated studies to better understand U exposure and risk to endemic species. This study documents U exposures and analyzes geochemical and biological ... ...

Abstract	Potential adverse ecological effects of expanded uranium (U) mining within the Grand Canyon region motivated studies to better understand U exposure and risk to endemic species. This study documents U exposures and analyzes geochemical and biological factors affecting U bioaccumulation at spring-fed systems within the Grand Canyon region. The principal objective was to determine if aqueous U was broadly indicative of U accumulated by insect larvae, a dominate fauna. Analyses focused on three widely distributed taxa: Argia sp. (a predatory damselfly), Culicidae (suspension feeding mosquitos), and Limnephilus sp. (a detritivorous caddisfly). The study showed that U accumulated by aquatic insects (and periphyton) generally correlated positively with total dissolved U, although correlations were strongest when based on modeled concentrations of the U-dicarbonato complex, UO
MeSH term(s)	Animals ; Uranium/analysis ; Insecta ; Biological Factors ; Environmental Monitoring ; Water/analysis
Chemical Substances	Uranium (4OC371KSTK) ; Biological Factors ; Water (059QF0KO0R)
Language	English
Publishing date	2023-06-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	782621-7
ISSN	1573-2959 ; 0167-6369
ISSN (online)	1573-2959
ISSN	0167-6369
DOI	10.1007/s10661-023-11254-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 5186: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Mitochondrial OGG1 expression reduces age-associated neuroinflammation by regulating cytosolic mitochondrial DNA.

Hussain, Mansoor / Chu, Xixia / Duan Sahbaz, Burcin / Gray, Samuel / Pekhale, Komal / Park, Jae-Hyeon / Croteau, Deborah L / Bohr, Vilhelm A

Free radical biology & medicine

2023 Volume 203, Page(s) 34–44

Abstract: Aging is accompanied by a decline in DNA repair efficiency, which leads to the accumulation of different types of DNA damage. Age-associated chronic inflammation and generation of reactive oxygen species exacerbate the aging process and age-related ... ...

Abstract	Aging is accompanied by a decline in DNA repair efficiency, which leads to the accumulation of different types of DNA damage. Age-associated chronic inflammation and generation of reactive oxygen species exacerbate the aging process and age-related chronic disorders. These inflammatory processes establish conditions that favor accumulation of DNA base damage, especially 8-oxo-7,8 di-hydroguanine (8-oxoG), which in turn contributes to various age associated diseases. 8-oxoG is repaired by 8-oxoG glycosylase1 (OGG1) through the base excision repair (BER) pathway. OGG1 is present in both the cell nucleus and in mitochondria. Mitochondrial OGG1 has been implicated in mitochondrial DNA repair and increased mitochondrial function. Using transgenic mouse models and cell lines that have been engineered to have enhanced expression of mitochondria-targeted OGG1 (mtOGG1), we show that elevated levels of mtOGG1 in mitochondria can reverse aging-associated inflammation and improve functions. Old male mtOGG1
MeSH term(s)	Animals ; Female ; Male ; Mice ; DNA Damage ; DNA Glycosylases/genetics ; DNA Glycosylases/metabolism ; DNA Repair ; DNA, Mitochondrial/genetics ; DNA, Mitochondrial/metabolism ; Inflammation/genetics ; Inflammation/metabolism ; Mice, Transgenic ; Mitochondria/genetics ; Mitochondria/metabolism ; Neuroinflammatory Diseases ; Oxidative Stress/genetics ; Humans
Chemical Substances	DNA Glycosylases (EC 3.2.2.-) ; DNA, Mitochondrial ; Ogg1 protein, mouse (EC 3.2.2.-) ; oxoguanine glycosylase 1, human (EC 3.2.2.-)
Language	English
Publishing date	2023-04-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	807032-5
ISSN	1873-4596 ; 0891-5849
ISSN (online)	1873-4596
ISSN	0891-5849
DOI	10.1016/j.freeradbiomed.2023.03.262
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2109: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: RecQ dysfunction contributes to social and depressive-like behavior and affects aldolase activity in mice.

Hou, Yujun / Park, Jae-Hyeon / Dan, Xiuli / Chu, Xixia / Yang, Beimeng / Hussain, Mansoor / Croteau, Deborah L / Bohr, Vilhelm A

Neurobiology of disease

2023 Volume 180, Page(s) 106092

Abstract: RecQ helicase family proteins play vital roles in maintaining genome stability, including DNA replication, recombination, and DNA repair. In human cells, there are five RecQ helicases: RECQL1, Bloom syndrome (BLM), Werner syndrome (WRN), RECQL4, and ... ...

Abstract	RecQ helicase family proteins play vital roles in maintaining genome stability, including DNA replication, recombination, and DNA repair. In human cells, there are five RecQ helicases: RECQL1, Bloom syndrome (BLM), Werner syndrome (WRN), RECQL4, and RECQL5. Dysfunction or absence of RecQ proteins is associated with genetic disorders, tumorigenesis, premature aging, and neurodegeneration. The biochemical and biological roles of RecQ helicases are rather well established, however, there is no systematic study comparing the behavioral changes among various RecQ-deficient mice including consequences of exposure to DNA damage. Here, we investigated the effects of ionizing irradiation (IR) on three RecQ-deficient mouse models (RecQ1, WRN and RecQ4). We find abnormal cognitive behavior in RecQ-deficient mice in the absence of IR. Interestingly, RecQ dysfunction impairs social ability and induces depressive-like behavior in mice after a single exposure to IR, suggesting that RecQ proteins play roles in mood and cognition behavior. Further, transcriptomic and metabolomic analyses revealed significant alterations in RecQ-deficient mice, especially after IR exposure. In particular, pathways related to neuronal and microglial functions, DNA damage repair, cell cycle, and reactive oxygen responses were downregulated in the RecQ4 and WRN mice. In addition, increased DNA damage responses were found in RecQ-deficient mice. Notably, two genes, Aldolase Fructose-Bisphosphate B (Aldob) and NADPH Oxidase 4 (Nox4), were differentially expressed in RecQ-deficient mice. Our findings suggest that RecQ dysfunction contributes to social and depressive-like behaviors in mice, and that aldolase activity may be associated with these changes, representing a potential therapeutic target.
MeSH term(s)	Animals ; Humans ; Mice ; RecQ Helicases/genetics ; RecQ Helicases/metabolism ; DNA Replication ; DNA Repair ; DNA Damage ; Genomic Instability ; Aldehyde-Lyases/genetics ; Aldehyde-Lyases/metabolism
Chemical Substances	RecQ Helicases (EC 3.6.4.12) ; Aldehyde-Lyases (EC 4.1.2.-) ; RECQL5 protein, human
Language	English
Publishing date	2023-03-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Intramural
ZDB-ID	1211786-9
ISSN	1095-953X ; 0969-9961
ISSN (online)	1095-953X
ISSN	0969-9961
DOI	10.1016/j.nbd.2023.106092
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4444: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Mitochondrial PARP1 regulates NAD

Lee, Jong-Hyuk / Hussain, Mansoor / Kim, Edward W / Cheng, Shang-Jung / Leung, Anthony K L / Fakouri, Nima Borhan / Croteau, Deborah L / Bohr, Vilhelm A

Experimental & molecular medicine

2022 Volume 54, Issue 12, Page(s) 2135–2147

Abstract: PARPs play fundamental roles in multiple DNA damage recognition and repair pathways. Persistent nuclear PARP activation causes cellular ... ...

Abstract	PARPs play fundamental roles in multiple DNA damage recognition and repair pathways. Persistent nuclear PARP activation causes cellular NAD
MeSH term(s)	Poly ADP Ribosylation ; NAD/metabolism ; Poly(ADP-ribose) Polymerase Inhibitors ; Mitochondria/metabolism ; DNA, Mitochondrial/genetics ; DNA, Mitochondrial/metabolism
Chemical Substances	NAD (0U46U6E8UK) ; Poly(ADP-ribose) Polymerase Inhibitors ; DNA, Mitochondrial
Language	English
Publishing date	2022-12-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1328915-9
ISSN	2092-6413 ; 1226-3613 ; 0378-8512
ISSN (online)	2092-6413
ISSN	1226-3613 ; 0378-8512
DOI	10.1038/s12276-022-00894-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4775: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Heterochromatin: an epigenetic point of view in aging.

Lee, Jong-Hyuk / Kim, Edward W / Croteau, Deborah L / Bohr, Vilhelm A

Experimental & molecular medicine

2020 Volume 52, Issue 9, Page(s) 1466–1474

Abstract: Aging is an inevitable process of life. Defined by progressive physiological and functional loss of tissues and organs, aging increases the risk of mortality for the organism. The aging process is affected by various factors, including genetic and ... ...

Abstract	Aging is an inevitable process of life. Defined by progressive physiological and functional loss of tissues and organs, aging increases the risk of mortality for the organism. The aging process is affected by various factors, including genetic and epigenetic ones. Here, we review the chromatin-specific epigenetic changes that occur during normal (chronological) aging and in premature aging diseases. Taking advantage of the reversible nature of epigenetic modifications, we will also discuss possible lifespan expansion strategies through epigenetic modulation, which was considered irreversible until recently.
MeSH term(s)	Age Factors ; Aging/genetics ; Animals ; Chromatin/genetics ; Chromatin/metabolism ; Epigenesis, Genetic ; Epigenomics/methods ; Gene Expression Regulation ; Heterochromatin/genetics ; Heterochromatin/metabolism ; Histones/metabolism ; Humans ; Longevity
Chemical Substances	Chromatin ; Heterochromatin ; Histones
Language	English
Publishing date	2020-09-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Review
ZDB-ID	1328915-9
ISSN	2092-6413 ; 1226-3613 ; 0378-8512
ISSN (online)	2092-6413
ISSN	1226-3613 ; 0378-8512
DOI	10.1038/s12276-020-00497-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4775: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Nicotinamide adenine dinucleotide supplementation drives gut microbiota variation in Alzheimer's mouse model.

Chu, Xixia / Hou, Yujun / Meng, Qiong / Croteau, Deborah L / Wei, Yong / De, Supriyo / Becker, Kevin G / Bohr, Vilhelm A

Frontiers in aging neuroscience

2022 Volume 14, Page(s) 993615

Abstract: Alzheimer's disease (AD) is the most common neurodegenerative disease. Growing evidence suggests an important role for gut dysbiosis and gut microbiota-host interactions in aging and neurodegeneration. Our previous works have demonstrated that ... ...

Abstract	Alzheimer's disease (AD) is the most common neurodegenerative disease. Growing evidence suggests an important role for gut dysbiosis and gut microbiota-host interactions in aging and neurodegeneration. Our previous works have demonstrated that supplementation with the nicotinamide adenine dinucleotide (NAD
Language	English
Publishing date	2022-09-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2558898-9
ISSN	1663-4365
ISSN	1663-4365
DOI	10.3389/fnagi.2022.993615
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Olfactory dysfunction in aging and neurodegenerative diseases.

Dan, Xiuli / Wechter, Noah / Gray, Samuel / Mohanty, Joy G / Croteau, Deborah L / Bohr, Vilhelm A

Ageing research reviews

2021 Volume 70, Page(s) 101416

Abstract: Alterations in olfactory functions are proposed to be early biomarkers for neurodegeneration. Many neurodegenerative diseases are age-related, including two of the most common, Parkinson's disease (PD) and Alzheimer's disease (AD). The establishment of ... ...

Abstract	Alterations in olfactory functions are proposed to be early biomarkers for neurodegeneration. Many neurodegenerative diseases are age-related, including two of the most common, Parkinson's disease (PD) and Alzheimer's disease (AD). The establishment of biomarkers that promote early risk identification is critical for the implementation of early treatment to postpone or avert pathological development. Olfactory dysfunction (OD) is seen in 90% of early-stage PD patients and 85% of patients with early-stage AD, which makes it an attractive biomarker for early diagnosis of these diseases. Here, we systematically review widely applied smelling tests available for humans as well as olfaction assessments performed in some animal models and the relationships between OD and normal aging, PD, AD, and other conditions. The utility of OD as a biomarker for neurodegenerative disease diagnosis and future research directions are also discussed.
MeSH term(s)	Aging ; Alzheimer Disease/diagnosis ; Animals ; Humans ; Neurodegenerative Diseases ; Olfaction Disorders/diagnosis ; Parkinson Disease ; Smell
Language	English
Publishing date	2021-07-27
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Review ; Systematic Review
ZDB-ID	2075672-0
ISSN	1872-9649 ; 1568-1637
ISSN (online)	1872-9649
ISSN	1568-1637
DOI	10.1016/j.arr.2021.101416
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5579: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Self-assembly of multi-component mitochondrial nucleoids via phase separation.

Feric, Marina / Demarest, Tyler G / Tian, Jane / Croteau, Deborah L / Bohr, Vilhelm A / Misteli, Tom

The EMBO journal

2021 Volume 40, Issue 6, Page(s) e107165

Abstract: Mitochondria contain an autonomous and spatially segregated genome. The organizational unit of their genome is the nucleoid, which consists of mitochondrial DNA (mtDNA) and associated architectural proteins. Here, we show that phase separation is the ... ...

Abstract	Mitochondria contain an autonomous and spatially segregated genome. The organizational unit of their genome is the nucleoid, which consists of mitochondrial DNA (mtDNA) and associated architectural proteins. Here, we show that phase separation is the primary physical mechanism for assembly and size control of the mitochondrial nucleoid (mt-nucleoid). The major mtDNA-binding protein TFAM spontaneously phase separates in vitro via weak, multivalent interactions into droplets with slow internal dynamics. TFAM and mtDNA form heterogenous, viscoelastic structures in vitro, which recapitulate the dynamics and behavior of mt-nucleoids in vivo. Mt-nucleoids coalesce into larger droplets in response to various forms of cellular stress, as evidenced by the enlarged and transcriptionally active nucleoids in mitochondria from patients with the premature aging disorder Hutchinson-Gilford Progeria Syndrome (HGPS). Our results point to phase separation as an evolutionarily conserved mechanism of genome organization.
MeSH term(s)	Cell Line ; Child ; Child, Preschool ; DNA, Mitochondrial/genetics ; DNA-Binding Proteins/metabolism ; Genome, Mitochondrial/genetics ; HEK293 Cells ; Humans ; Mitochondria/genetics ; Mitochondrial Proteins/metabolism ; Progeria/genetics ; Progeria/pathology ; Transcription Factors/metabolism
Chemical Substances	DNA, Mitochondrial ; DNA-Binding Proteins ; Mitochondrial Proteins ; TFAM protein, human ; Transcription Factors
Language	English
Publishing date	2021-02-23
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
ZDB-ID	586044-1
ISSN	1460-2075 ; 0261-4189
ISSN (online)	1460-2075
ISSN	0261-4189
DOI	10.15252/embj.2020107165
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1808: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 100: Show issues

Order via subito

Details ▾

To top

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito