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Article ; Online: Impulsive and compulsive reading comprehension in the prison population.

Muñoz-López, Lucas / Serrano, Francisca / López-Torrecillas, María Del Carmen / Sánchez-Barrera, María Blasa / Martín, Ignacio / López-Torrecillas, Francisca

BMC psychiatry

2024 Volume 24, Issue 1, Page(s) 45

Abstract: Background: Developmental dyslexia is characterized by reading and writing deficits that persist into adulthood. Dyslexia is strongly associated with academic underachievement, as well as impulsive, compulsive, and criminal behaviors. The aims of this ... ...

Abstract	Background: Developmental dyslexia is characterized by reading and writing deficits that persist into adulthood. Dyslexia is strongly associated with academic underachievement, as well as impulsive, compulsive, and criminal behaviors. The aims of this study were to investigate impulsive or compulsive reading comprehension, analyzing the differences in reading errors between two distinct groups -one with Antisocial Personality Disorder (ASPD) and another with Obsessive-Compulsive Personality Disorder (OCPD) and examine their correlation with criminal behavior within a prison population. Methods: We gathered data from 194 participants: 81 with ASPD and 113 with OCPD from a prison center. Participants took part in interviews to gather data on demographic, criminal, and behavioral data. Additionally, the participants underwent various assessments, including the International Examination for Personality Disorders; Symptom Inventory, and Battery for the Assessment of Reading Processes in Secondary and High School - Revised. Results: Our analysis revealed differences in reading skills between the ASPD and OCPD groups. Specifically, the OCPD group showed poorer performance on lexical selection, semantic categorization, grammar structures, grammatical judgements, and expository comprehension when compared with the ASPD group. Conversely, the OCPD group obtained higher scores on narrative comprehension relative to the ASPD group. Conclusions: The OCPD group showed slow lexical-phonological coding and phonological activation.
MeSH term(s)	Humans ; Obsessive-Compulsive Disorder/epidemiology ; Comprehension ; Prisons ; Language Disorders ; Spiperone/analogs & derivatives
Chemical Substances	4-aminospiroperidol (114442-96-5) ; Spiperone (4X6E73CJ0Q)
Language	English
Publishing date	2024-01-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2050438-X
ISSN	1471-244X ; 1471-244X
ISSN (online)	1471-244X
ISSN	1471-244X
DOI	10.1186/s12888-023-05372-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Resveratrol enhances A

Muñoz-López, Sonia / Sánchez-Melgar, Alejandro / Martín, Mairena / Albasanz, José Luis

Frontiers in endocrinology

2022 Volume 13, Page(s) 1007801

Abstract: Despite great efforts, effective treatment against cancer has not yet been found. However, natural compounds such as the polyphenol resveratrol have emerged as promising preventive agent in cancer therapy. The mode of action of resveratrol is still ... ...

Abstract	Despite great efforts, effective treatment against cancer has not yet been found. However, natural compounds such as the polyphenol resveratrol have emerged as promising preventive agent in cancer therapy. The mode of action of resveratrol is still poorly understood, but it can modulate many signaling pathways related to the initiation and progression of cancer. Adenosinergic signaling may be involved in the antitumoral action of resveratrol since resveratrol binds to the orthosteric binding site of adenosine A
MeSH term(s)	Humans ; Resveratrol/pharmacology ; Adenylyl Cyclases/metabolism ; Neuroblastoma ; Receptors, Purinergic P1/metabolism ; Adenosine/pharmacology
Chemical Substances	Resveratrol (Q369O8926L) ; Adenylyl Cyclases (EC 4.6.1.1) ; Receptors, Purinergic P1 ; Adenosine (K72T3FS567)
Language	English
Publishing date	2022-11-03
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2022.1007801
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Article ; Online: Immune System and Brain/Intestinal Barrier Functions in Psychiatric Diseases: Is Sphingosine-1-Phosphate at the Helm?

Martín-Hernández, David / Muñoz-López, Marina / Tendilla-Beltrán, Hiram / Caso, Javier R / García-Bueno, Borja / Menchén, Luis / Leza, Juan C

International journal of molecular sciences

2023 Volume 24, Issue 16

Abstract: Over the past few decades, extensive research has shed light on immune alterations and the significance of dysfunctional biological barriers in psychiatric disorders. The leaky gut phenomenon, intimately linked to the integrity of both brain and ... ...

Abstract	Over the past few decades, extensive research has shed light on immune alterations and the significance of dysfunctional biological barriers in psychiatric disorders. The leaky gut phenomenon, intimately linked to the integrity of both brain and intestinal barriers, may play a crucial role in the origin of peripheral and central inflammation in these pathologies. Sphingosine-1-phosphate (S1P) is a bioactive lipid that regulates both the immune response and the permeability of biological barriers. Notably, S1P-based drugs, such as fingolimod and ozanimod, have received approval for treating multiple sclerosis, an autoimmune disease of the central nervous system (CNS), and ulcerative colitis, an inflammatory condition of the colon, respectively. Although the precise mechanisms of action are still under investigation, the effectiveness of S1P-based drugs in treating these pathologies sparks a debate on extending their use in psychiatry. This comprehensive review aims to delve into the molecular mechanisms through which S1P modulates the immune system and brain/intestinal barrier functions. Furthermore, it will specifically focus on psychiatric diseases, with the primary objective of uncovering the potential of innovative therapies based on S1P signaling.
MeSH term(s)	Humans ; Immune System ; Mental Disorders/drug therapy ; Sphingosine ; Brain
Chemical Substances	sphingosine 1-phosphate (26993-30-6) ; Sphingosine (NGZ37HRE42)
Language	English
Publishing date	2023-08-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241612634
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Article: Antitumoral Action of Resveratrol Through Adenosinergic Signaling in C6 Glioma Cells.

Sánchez-Melgar, Alejandro / Muñoz-López, Sonia / Albasanz, José Luis / Martín, Mairena

Frontiers in neuroscience

2021 Volume 15, Page(s) 702817

Abstract: Gliomas are the most common and aggressive primary tumors in the central nervous system. The nucleoside adenosine is considered to be one major constituent within the tumor microenvironment. The adenosine level mainly depends on two enzymatic activities: ...

Abstract	Gliomas are the most common and aggressive primary tumors in the central nervous system. The nucleoside adenosine is considered to be one major constituent within the tumor microenvironment. The adenosine level mainly depends on two enzymatic activities: 5'-nucleotidase (5'NT or CD73) that synthesizes adenosine from AMP, and adenosine deaminase (ADA) that converts adenosine into inosine. Adenosine activates specific G-protein coupled receptors named A
Language	English
Publishing date	2021-09-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2021.702817
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Article ; Online: Anosmin 1 N-terminal domains modulate prokineticin receptor 2 activation by prokineticin 2.

Murcia-Belmonte, Verónica / Tercero-Díaz, María / Barrasa-Martín, Diego / López de la Vieja, Sandra / Muñoz-López, Marina / Esteban, Pedro F

Cellular signalling

2022 Volume 98, Page(s) 110417

Abstract: The X-linked form of Kallmann syndrome (KS), characterized by hypogonadotropic hypogonadism and anosmia, is due to mutations in the ANOS1 gene that encodes for the extracellular matrix (ECM) protein anosmin 1. Prokineticins (PKs) exert their biological ... ...

Abstract	The X-linked form of Kallmann syndrome (KS), characterized by hypogonadotropic hypogonadism and anosmia, is due to mutations in the ANOS1 gene that encodes for the extracellular matrix (ECM) protein anosmin 1. Prokineticins (PKs) exert their biological functions through the activation of the G protein-coupled receptors (GPCRs) prokineticin receptor 1 and 2 (PKR1, 2), and mutations in the PK2 and PKR2 genes are involved in the pathogenesis of KS. We have previously shown interaction between PKR2 and anosmin 1 in vitro. In the current report we present evidence of the modulation of PK2/PKR2 activity by anosmin 1, since this protein is able to enhance the activation of the ERK1/2 (extracellular signal-regulated kinase 1/2) pathway elicited by PK2 through PKR2. We also show that the N-terminal region of anosmin 1, capable of binding to the PK2-binding domain of PKR2, seems to be responsible for this effect. The whey acidic protein domain (WAP) is necessary for this modulatory activity, although data from GST pull-down (glutathione-S-transferase) and analysis of the N267K mutation in the fibronectin type III domain 1 (FnIII.1) suggest the cysteine-rich (CR) and the FnIII.1 domains could assist the WAP domain both in the binding to PKR2 and in the modulation of the activation of the receptor by PK2. Our data support the idea of a modulatory role of anosmin 1 in the biological effects controlled by the PK2/PKR2 system.
MeSH term(s)	Extracellular Matrix Proteins/metabolism ; Humans ; Kallmann Syndrome/genetics ; Kallmann Syndrome/metabolism ; Nerve Tissue Proteins/metabolism ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism
Chemical Substances	Extracellular Matrix Proteins ; Nerve Tissue Proteins ; Receptors, G-Protein-Coupled
Language	English
Publishing date	2022-07-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1002702-6
ISSN	1873-3913 ; 0898-6568
ISSN (online)	1873-3913
ISSN	0898-6568
DOI	10.1016/j.cellsig.2022.110417
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Article ; Online: Parents who spent more hours in intensive care units with their low birthweight newborn infant did not achieve autonomous care faster.

Piris-Borregas, Salvador / Bellón-Vaquerizo, Beatriz / Muñoz-López, Olga / Cuadrado-Obregón, Natalia / Melchor-Muñoz, Patricia / Niño-Díaz, Lidia / González-Mora, Francisco Javier / Barroso-Santiago, María / Martín-Arriscado, Cristina / Pallás-Alonso, Carmen Rosa

Acta paediatrica (Oslo, Norway : 1992)

2023 Volume 112, Issue 10, Page(s) 2104–2112

Abstract: Aim: We examined the correlation between how long it took the parents of very low birthweight infants, born weighing up to 1500 g, to provide different kinds of autonomous care in a neonatal intensive care unit (NICU).: Methods: This prospective ... ...

Abstract	Aim: We examined the correlation between how long it took the parents of very low birthweight infants, born weighing up to 1500 g, to provide different kinds of autonomous care in a neonatal intensive care unit (NICU). Methods: This prospective observational was conducted in the NICU of a Spanish hospital from 10 January 2020 to 3 May 2022. The unit had 11 beds single-family rooms and provided eight beds in an open bay room. The study examined breastfeeding, patient safety, participation in rounds, pain prevention and cleanliness. Results: We studied 96 patients and their parents and there was no correlation between any type of care and the time it took parents to provide it autonomously. Parents in the single-family room cohort spent a median of 9.5 h per day between them in the NICU, while the parents in the open bay room spent 7.0 h with their infants (p = 0.03). However, parents in the single-family room group were able to recognise pain faster (p = 0.02). Conclusion: Parents in single-family rooms spent more time in the NICU and recognised pain faster but did not achieve autonomous care faster than parents in the open bay group.
MeSH term(s)	Infant, Newborn ; Female ; Humans ; Infant ; Birth Weight ; Parents ; Intensive Care Units, Neonatal ; Breast Feeding ; Infant, Very Low Birth Weight
Language	English
Publishing date	2023-07-02
Publishing country	Norway
Document type	Observational Study ; Journal Article
ZDB-ID	203487-6
ISSN	1651-2227 ; 0365-1436 ; 0803-5253
ISSN (online)	1651-2227
ISSN	0365-1436 ; 0803-5253
DOI	10.1111/apa.16878
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Article: Use of the Therapy App Prescinde for Increasing Adherence to Smoking Cessation Treatment.

López-Torrecillas, Francisca / Ramírez-Uclés, Isabel / Rueda, María Del Mar / Cobo-Rodríguez, Beatriz / Castro-Martín, Luis / Urrea-Castaño, Sabina Arantxa / Muñoz-López, Lucas

Healthcare (Basel, Switzerland)

2023 Volume 11, Issue 24

Abstract: Tobacco use poses major health risks and is a major contributor to causes of death worldwide. Mobile phone-based cessation apps for this substance are gaining popularity, often used as a component of traditional interventions. This study aimed to analyze ...

Abstract	Tobacco use poses major health risks and is a major contributor to causes of death worldwide. Mobile phone-based cessation apps for this substance are gaining popularity, often used as a component of traditional interventions. This study aimed to analyze adherence to an intervention using a mobile phone application (App-therapy Prescinde (v1)) as a function of sociodemographic variables (age, gender, educational level, and profession) as well as the primary activities supported by the app (reducing tobacco or cannabis use and increasing physical exercise). The participants were recruited through the web pages of the Occupational Risk Prevention Service and the Psychology Clinic of the University of Granada during the COVID-19 confinement period. The application's contents include three components (self-report, motivational phrases, and goal setting). Our findings indicate that being male, being aged between 26 and 62, having a high school education, and being unemployed increase the likelihood of adherence to the Prescinde therapy app three months after usage. Our findings highlight the importance of developing new therapeutic approaches and conducting in-depth studies on the factors associated with adherence to tobacco cessation and cannabis cessation treatments via mobile phone applications.
Language	English
Publishing date	2023-12-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare11243121
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Article: Writing Abilities in Compulsive Prisoners.

Muñoz-López, Lucas / López-Torrecillas, Francisca / Martín, Ignacio / Sánchez-Barrera, María Blasa / López-Torrecillas, María Del Carmen / Serrano, Francisca

Frontiers in psychology

2021 Volume 12, Page(s) 701941

Abstract: Research has found links between academic failure and criminal offending and suggest that many incarcerated young people have experienced significant behavioral and learning problems in school, which could result in criminal outcomes and poor academic ... ...

Abstract	Research has found links between academic failure and criminal offending and suggest that many incarcerated young people have experienced significant behavioral and learning problems in school, which could result in criminal outcomes and poor academic performance. The objective of this study was to analyse writing disorders in impulsive and compulsive prisoners. The sample was composed of 194 male prisoners, of which 81 had been diagnosed with Antisocial Personality Disorder and 113 with Obsessive Compulsive Personality Disorder. Male participants were recruited at the Granada Prison Center. They completed the Demographic, Crime, and Institutional Behavior Interview; the International Personality Disorder Examination (IPDE); The Symptom Checklist (SCL-90-R) and Assessment Battery of Writing Processes (PROESC in its Spanish acronym). We found that prisoners with writing disorders generally have difficulties in the skills necessary to write properly due to impulsive and compulsive behavior.
Language	English
Publishing date	2021-08-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2021.701941
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Article ; Online: Neuroinflammation related to the blood-brain barrier and sphingosine-1-phosphate in a pre-clinical model of periodontal diseases and depression in rats.

Martín-Hernández, David / Martínez, María / Robledo-Montaña, Javier / Muñoz-López, Marina / Virto, Leire / Ambrosio, Nagore / Marín, Maria José / Montero, Eduardo / Herrera, David / Sanz, Mariano / Leza, Juan C / Figuero, Elena / García-Bueno, Borja

Journal of clinical periodontology

2023 Volume 50, Issue 5, Page(s) 642–656

Abstract: Aim: To explore the potential mechanisms of neuroinflammation (microglia, blood-brain barrier [BBB] permeability, and the sphingosine-1-phosphate [S1P] pathways) resulting from the association between periodontitis and depression in rats.: Materials ... ...

Abstract	Aim: To explore the potential mechanisms of neuroinflammation (microglia, blood-brain barrier [BBB] permeability, and the sphingosine-1-phosphate [S1P] pathways) resulting from the association between periodontitis and depression in rats. Materials and methods: This pre-clinical in vivo experimental study used Wistar rats, in which experimental periodontitis (P) was induced by using oral gavages with Porphyromonas gingivalis and Fusobacterium nucleatum. Then, a chronic mild stress (CMS) model was implemented to induce a depressive-like behaviour, resulting in four groups: P with CMS (P+CMS+), P without CMS (P+CMS-), CMS without P (P-CMS+), and control (P-CMS-). After harvesting brain samples, protein/mRNA expression analyses and fluorescence immunohistochemistry were performed in the frontal cortex (FC). Results were analysed by ANOVA. Results: CMS exposure increased the number of microglia (an indicator of neuroinflammation) in the FC. In the combined model (P+CMS+), there was a decrease in the expression of tight junction proteins (zonula occludens-1 [ZO-1], occludin) and an increase in intercellular and vascular cell adhesion molecules (ICAM-1, VCAM-1) and matrix metalloproteinase 9 (MMP9), suggesting a more severe disruption of the BBB. The enzymes and receptors of S1P were also differentially regulated. Conclusions: Microglia, BBB permeability, and S1P pathways could be relevant mechanisms explaining the association between periodontitis and depression.
MeSH term(s)	Rats ; Animals ; Blood-Brain Barrier/metabolism ; Rats, Wistar ; Neuroinflammatory Diseases ; Depression ; Periodontitis/metabolism
Chemical Substances	sphingosine 1-phosphate (26993-30-6)
Language	English
Publishing date	2023-01-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	188647-2
ISSN	1600-051X ; 0303-6979
ISSN (online)	1600-051X
ISSN	0303-6979
DOI	10.1111/jcpe.13780
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Zs.A 1003: Show issues

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Article ; Online: Suprahepatic vein cannulation as a complication of veno-venous ECMO with bicaval cannula: Ultrasound as part of multimodal management.

Muñoz Moreno, Juan Francisco / López Martín, Cristina / de la Torre-Capitán Pablos, Noelia

Medicina intensiva

2024 Volume 48, Issue 5, Page(s) 301–302

MeSH term(s)	Humans ; Cannula ; Catheterization ; Combined Modality Therapy ; Extracorporeal Membrane Oxygenation/methods ; Hepatic Veins/diagnostic imaging ; Ultrasonography ; Ultrasonography, Interventional ; Vena Cava, Inferior/diagnostic imaging
Language	English
Publishing date	2024-02-27
Publishing country	Spain
Document type	Letter ; Video-Audio Media
ISSN	2173-5727
ISSN (online)	2173-5727
DOI	10.1016/j.medine.2024.01.007
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