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  1. Book: Georg Schrimpf, Oskar Maria Graf, 1918

    Eschenburg, Barbara / Graf, Oskar Maria / Schrimpf, Georg

    (Patrimonia ; 48)

    1992  

    Institution Kulturstiftung der Länder
    Städtische Galerie im Lenbachhaus München
    Author's details Lenbachhaus München. [Red.: Barbara Eschenburg]
    Series title Patrimonia ; 48
    Language German
    Size 28 S., Ill., 28 cm
    Publisher Kulturstiftung der Länder
    Publishing place Berlin
    Document type Book
    Database Former special subject collection: coastal and deep sea fishing

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  2. Book ; Conference proceedings: Reden anläßlich der akademischen Feier der Baden-Württembergischen Rektorenkonferenz zum 60. Geburtstag des Ministerpräsidenten Kurt Georg Kiesinger am 7. April 1964 im Großen Senatssaal der Universität Tübingen

    Eschenburg, Theodor / Hommel, Hildebrecht / Kiesinger, Kurt Georg / Weise, Artur

    (Tübinger Universitätsreden ; 20)

    1964  

    Author's details von Theodor Eschenburg; Artur Weise; Hildebrecht Hommel
    Series title Tübinger Universitätsreden ; 20
    Language German
    Size 44 S., 8°
    Publisher Mohr
    Publishing place Tübingen
    Document type Book ; Conference proceedings
    Database ECONomics Information System

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  3. Book ; Conference proceedings: Reden anläßlich der akademischen Feier der Baden-Württembergischen Rektorenkonferenz zum 60. Geburtstag des Ministerpräsidenten Kurt Georg Kiesinger am 7. April 1964 im Großen Senatssaal der Universität Tübingen

    Eschenburg, Theodor / Hommel, Hildebrecht / Kiesinger, Kurt Georg / Weise, Artur

    (Tübinger Universitätsreden ; 20)

    1964  

    Author's details von Theodor Eschenburg; Artur Weise; Hildebrecht Hommel
    Series title Tübinger Universitätsreden ; 20
    Language German
    Size 44 S., 8°
    Publisher Mohr
    Publishing place Tübingen
    Document type Book ; Conference proceedings
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  4. Article ; Online: Vincristine resistance in relapsed neuroblastoma can be efficiently overcome by Smac mimetic LCL161 treatment.

    Frommann, Kristin / Appl, Birgit / Hundsdoerfer, Patrick / Reinshagen, Konrad / Eschenburg, Georg

    Journal of pediatric surgery

    2018  Volume 53, Issue 10, Page(s) 2059–2064

    Abstract: Purpose: In spite of good initial therapy response neuroblastomas often spread to distant organs or relapse after periods of remission. Dysregulation of apoptosis, a hallmark of cancer, is often effected by elevated levels of antiapoptotic signals ... ...

    Abstract Purpose: In spite of good initial therapy response neuroblastomas often spread to distant organs or relapse after periods of remission. Dysregulation of apoptosis, a hallmark of cancer, is often effected by elevated levels of antiapoptotic signals leading to resistance against chemotherapeutic drugs. Inhibitors of apoptosis proteins (IAPs) are crucial cellular apoptosis regulators. Targeting IAPs with Smac mimetics has been demonstrated as a promising strategy for treatment of neuroblastoma and other tumors.
    Methods: In paired neuroblastoma cell lines, obtained from the same patient at time of diagnosis (CHLA-15) and postchemotherapy during progressive disease (CHLA-20), expression of crucial IAPs was determined. Furthermore, effects of vincristine on viability, cytotoxicity, apoptosis induction and caspase-3/7 activation were determined.
    Results: Cellular IAP-1 (cIAP-1) and X-linked IAP (XIAP) expression was increased in cell line CHLA-20. Moreover, biological effects of vincristine were significantly lower in these cells. Treatment of cells with Smac mimetic LCL161 increased the effects of vincristine in CHLA-15 cells and more importantly was able to overcome vincristine resistance in CHLA-20 cells.
    Conclusions: These findings demonstrate the potential of Smac mimetics for the development of novel therapeutic approaches for the treatment of relapsed/resistant neuroblastoma.
    MeSH term(s) Apoptosis/drug effects ; Cell Line, Tumor ; Cell Survival/drug effects ; Drug Resistance, Neoplasm ; Humans ; Neoplasm Recurrence, Local ; Neuroblastoma ; Thiazoles/pharmacology ; Vincristine/pharmacology
    Chemical Substances LCL161 ; Thiazoles ; Vincristine (5J49Q6B70F)
    Language English
    Publishing date 2018-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80165-3
    ISSN 1531-5037 ; 0022-3468
    ISSN (online) 1531-5037
    ISSN 0022-3468
    DOI 10.1016/j.jpedsurg.2018.01.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 607: Show issues Location:
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  5. Article: A Novel Method to Achieve Precision and Reproducibility in Exposure Parameters for Low-Frequency Pulsed Magnetic Fields in Human Cell Cultures.

    Ronniger, Michael / Aguida, Blanche / Stacke, Christina / Chen, Yangmengfan / Ehnert, Sabrina / Erdmann, Niklas / Eschenburg, Georg / Falldorf, Karsten / Pooam, Marootpong / Wing, Anthony / Ahmad, Margaret

    Bioengineering (Basel, Switzerland)

    2022  Volume 9, Issue 10

    Abstract: The effects of extremely low-frequency electromagnetic field (ELF-MF) exposure on living systems have been widely studied at the fundamental level and also claimed as beneficial for the treatment of diseases for over 50 years. However, the underlying ... ...

    Abstract The effects of extremely low-frequency electromagnetic field (ELF-MF) exposure on living systems have been widely studied at the fundamental level and also claimed as beneficial for the treatment of diseases for over 50 years. However, the underlying mechanisms and cellular targets of ELF-MF exposure remain poorly understood and the field has been plagued with controversy stemming from an endemic lack of reproducibility of published findings. To address this problem, we here demonstrate a technically simple and reproducible EMF exposure protocol to achieve a standardized experimental approach which can be readily adopted in any lab. As an assay system, we chose a commercially available inflammatory model human cell line; its response to magnetic fields involves changes in gene expression which can be monitored by a simple colorimetric reporter gene assay. The cells were seeded and cultured in microplates and inserted into a custom-built, semi-automated incubation and exposure system which accurately controls the incubation (temperature, humidity, CO2) and magnetic-field exposure conditions. A specific alternating magnetic field (<1.0% spatial variance) including far-field reduction provided defined exposure conditions at the position of each well of the microplate. To avoid artifacts, all environmental and magnetic-field exposure parameters were logged in real time throughout the duration of the experiment. Under these extensively controlled conditions, the effect of the magnetic field on the cell cultures as assayed by the standardized operating procedure was highly reproducible between experiments. As we could fully define the characteristics (frequency, intensity, duration) of the pulsed magnetic field signals at the position of the sample well, we were, for the first time, able to accurately determine the effect of changing single ELF-MF parameters such as signal shape, frequency, intensity and duty cycle on the biological response. One signal in particular (10 Hz, 50% duty cycle, rectangular, bipolar, 39.6μT) provided a significant reduction in cytokine reporter gene expression by 37% in our model cell culture line. In sum, the accuracy, environmental control and data-logging capacity of the semi-automated exposure system should greatly facilitate research into fundamental cellular response mechanisms and achieve the consistency necessary to bring ELF-MF/PEMF research results into the scientific mainstream.
    Language English
    Publishing date 2022-10-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering9100595
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online ; Thesis: Mechanisms of B-cell arrest in acute lymphoblastic leukaemia (ALL) of childhood

    Eschenburg, Georg [Verfasser]

    the interplay between the essential early B-cell factor EBF1 and the multifunctional zinc finger protein OAZ

    2009  

    Author's details vorgelegt von Georg Eschenburg
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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  7. Article: Taurolidine cooperates with antineoplastic drugs in neuroblastoma cells.

    Eschenburg, Georg / Luckert, Christian / Reinshagen, Konrad / Bergholz, Robert

    Genes & cancer

    2014  Volume 5, Issue 11-12, Page(s) 460–469

    Abstract: Neuroblastoma is the most common extracranial tumor in childhood. Outcome of stage 4 disease remains poor and the development of novel therapeutic approaches is thus urgently needed. Taurolidine (TRD), originally invented to avoid catheter infections, ... ...

    Abstract Neuroblastoma is the most common extracranial tumor in childhood. Outcome of stage 4 disease remains poor and the development of novel therapeutic approaches is thus urgently needed. Taurolidine (TRD), originally invented to avoid catheter infections, has shown to exhibit antineoplastic activity in various cancers. The growth of neuroblastoma cell lines is inhibited by TRD as recently demonstrated. Further analysis disclosed a significant negative growth effect of TRD on the four neuroblastoma cell lines SH-EP TET21N, SK-N-AS, SK-N-BE(2)-M17 and SK-N-SH. Detected IC50 (51-274 μM; 48 h) are promising and correspond to clinically-achievable plasma levels. Apoptosis was induced (76-86%; 48 h) in a time-dependent manner mediated by a simultaneous activation of the intrinsic and extrinsic pathways. This was confirmed by cleavage of caspases -3, -8 and -9 and abrogation of apoptosis by pan-caspase inhibition. Application of TRD resulted in a significant enhancement of cytotoxic drugs vincristine/doxorubicin (2/3 of 4 cell lines) making TRD a promising candidate to be included in neuroblastoma therapy regimens in the future.
    Language English
    Publishing date 2014-12-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2538519-7
    ISSN 1947-6027 ; 1947-6019
    ISSN (online) 1947-6027
    ISSN 1947-6019
    DOI 10.18632/genesandcancer.36
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book: Dr. Karl Burney's Nachricht von Georg Friedrich Händel's Lebensumständen und der ihm zu London im Mai und Jun. 1784 angestellten Gedächtnißfeyer

    Burney, Charles / Eschenburg, Johann Joachim

    1965  

    Title translation Sketch of the life of Handel <dt.>
    Title variant Nachricht von Georg Friedrich Händel's Lebensumständen ; Gedächtnisfeier
    Author's details Aus dem Englischen übersetzt von Johann Joachim Eschenburg
    Language German
    Size [14] Bl., LII, 102 S., [2] Bl, Frontisp., Ill. (Kupferst.), quarto
    Publisher Dt. Verl. für Musik
    Publishing place Leipzig
    Document type Book
    Note In Fraktur
    Accompanying material 1 Beil.
    Database Former special subject collection: coastal and deep sea fishing

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  9. Article ; Online: X-linked inhibitor of apoptosis protein represents a promising therapeutic target for relapsed/refractory ALL.

    Carlet, Michela / Schmelz, Karin / Vergalli, Jenny / Herold, Tobias / Senft, Daniela / Jurinovic, Vindi / Hoffmann, Thomas / Proba, Jutta / Weichert, Nina / Junghanß, Christian / Roth, Mareike / Eschenburg, Georg / Barz, Malwine / Henze, Günter / Eckert, Cornelia / Eggert, Angelika / Zuber, Johannes / Hundsdoerfer, Patrick / Jeremias, Irmela

    EMBO molecular medicine

    2022  , Page(s) e14557

    Abstract: Acute lymphoblastic leukemia (ALL) represents the most frequent malignancy in children, and relapse/refractory (r/r) disease is difficult to treat, both in children and adults. In search for novel treatment options against r/r ALL, we studied inhibitor ... ...

    Abstract Acute lymphoblastic leukemia (ALL) represents the most frequent malignancy in children, and relapse/refractory (r/r) disease is difficult to treat, both in children and adults. In search for novel treatment options against r/r ALL, we studied inhibitor of apoptosis proteins (IAP) and Smac mimetics (SM). SM-sensitized r/r ALL cells towards conventional chemotherapy, even upon resistance against SM alone. The combination of SM and chemotherapy-induced cell death via caspases and PARP, but independent from cIAP-1/2, RIPK1, TNFα or NF-κB. Instead, XIAP was identified to mediate SM effects. Molecular manipulation of XIAP in vivo using microRNA-30 flanked shRNA expression in cell lines and patient-derived xenograft (PDX) models of r/r ALL mimicked SM effects and intermediate XIAP knockdown-sensitized r/r ALL cells towards chemotherapy-induced apoptosis. Interestingly, upon strong XIAP knockdown, PDX r/r ALL cells were outcompeted in vivo, even in the absence of chemotherapy. Our results indicate a yet unknown essential function of XIAP in r/r ALL and reveal XIAP as a promising therapeutic target for r/r ALL.
    Language English
    Publishing date 2022-11-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2467145-9
    ISSN 1757-4684 ; 1757-4676
    ISSN (online) 1757-4684
    ISSN 1757-4676
    DOI 10.15252/emmm.202114557
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6784: Show issues Location:
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  10. Book ; Thesis: Methodische Untersuchungen zur homologen Rekombination von Fusarium graminearum am Beispiel putativer Virulenzgene

    Eschenburg, Georg

    2004  

    Author's details von Georg Eschenburg
    Language German
    Size ii, III, 108 Bl, Ill., graph. Darst
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., FB Biologie, Diplomarbeit--Hamburg, 2004
    Database Former special subject collection: coastal and deep sea fishing

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