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Article ; Online: Performance evaluation of a novel platelet count parameter, hybrid platelet count, on the BC-780 automated hematology analyzer.

Prompetchara, Eakachai / Parnsamut, Chalisa / Chirapanuruk, Angkana / Ketloy, Chutitorn

Clinical chemistry and laboratory medicine

2023 Volume 62, Issue 4, Page(s) 690–697

Abstract: Objectives: Automated hematology analysis is expected to improve the performance of platelet counting. We evaluated the performance of a new platelet counting, hybrid (PLT-H) and also impedance (PLT-I) and optical (PLT-O) on the BC-780 automated ... ...

Abstract	Objectives: Automated hematology analysis is expected to improve the performance of platelet counting. We evaluated the performance of a new platelet counting, hybrid (PLT-H) and also impedance (PLT-I) and optical (PLT-O) on the BC-780 automated hematology analyzer compared to the international reference method (IRM) in blood samples with thrombocytopenic and platelet interference. Methods: The basic platelet count performance of the BC-780 automated hematology analyzer was evaluated according to the requirements of the Clinical Laboratory and Standards Institute (CLSI) Document H26-A2. Additionally, the thrombocytopenic (low PLT count) blood samples and the platelet interference blood samples including fragmented red blood cells (RBCs), microcytes or small RBCs, and giant platelets were determined with the BC-780 hematology analyzer compared to the IRM. Results: Blank counting and the carry-over contamination rate of platelet count using the BC-780 both met the manufacturers' claim. For both 123 thrombocytopenic and 232 platelet interference blood samples (72 fragmented RBCs, 91 microcytes and 51 giant platelets), all three platelet counting methods exhibited high comparability with the IRM (the lowest correlation (r)=0.916). Interestingly, the comparability of PLT-H (r=0.928-0.986) with the IRM was better than that of PLT-I (r=0.916-0.979). Conclusions: The performance of PLT-H in the BC-780 met the manufacturer's specifications. PLT-H exhibits better reproducibility than did PLT-I, correlates well with the PLT-O for thrombocytopenic samples and demonstrates good anti-interference ability. PLT-H counting is therefore recommended as a zero-cost alternative platelet counting method for platelet interference samples in clinical settings.
MeSH term(s)	Humans ; Platelet Count/methods ; Reproducibility of Results ; Hematology/methods ; Blood Platelets ; Agmatine/analogs & derivatives ; Oxamic Acid/analogs & derivatives
Chemical Substances	bis(agmatine)oxalamide (151368-32-0) ; Agmatine (70J407ZL5Q) ; Oxamic Acid (QU60N5OPLG)
Language	English
Publishing date	2023-10-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1418007-8
ISSN	1437-4331 ; 1434-6621 ; 1437-8523
ISSN (online)	1437-4331
ISSN	1434-6621 ; 1437-8523
DOI	10.1515/cclm-2023-1000
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Article: Inhibitory Effect of Isopanduratin A on Adipogenesis: A Study of Possible Mechanisms.

Rungsa, Prapenpuksiri / San, Htoo Tint / Sritularak, Boonchoo / Böttcher, Chotima / Prompetchara, Eakachai / Chaotham, Chatchai / Likhitwitayawuid, Kittisak

Foods (Basel, Switzerland)

2023 Volume 12, Issue 5

Abstract: ... The root ... ...

Abstract	The root of
Language	English
Publishing date	2023-02-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods12051014
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Article: Immunogenicity of a recombinant plant-produced respiratory syncytial virus F subunit vaccine in mice.

Pisuttinusart, Nuttapat / Shanmugaraj, Balamurugan / Srisaowakarn, Chanya / Ketloy, Chutitorn / Prompetchara, Eakachai / Thitithanyanont, Arunee / Phoolcharoen, Waranyoo

Biotechnology reports (Amsterdam, Netherlands)

2023 Volume 41, Page(s) e00826

Abstract: Respiratory syncytial virus (RSV) is a highly infectious respiratory virus that causes serious illness, particularly in young children, elderly people, and those with immunocompromised individuals. RSV infection is the leading cause of infant ... ...

Abstract	Respiratory syncytial virus (RSV) is a highly infectious respiratory virus that causes serious illness, particularly in young children, elderly people, and those with immunocompromised individuals. RSV infection is the leading cause of infant hospitalization and can lead to serious complications such as pneumonia and bronchiolitis. Currently, there is an RSV vaccine approved exclusively for the elderly population, but no approved vaccine specifically designed for infants or any other age groups. Therefore, it is crucial to continue the development of an RSV vaccine specifically tailored for these populations. In this study, the immunogenicity of the two plant-produced RSV-F Fc fusion proteins (Native construct and structural stabilized construct) were examined to assess them as potential vaccine candidates for RSV. The RSV-F Fc fusion proteins were transiently expressed in
Language	English
Publishing date	2023-12-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2801018-8
ISSN	2215-017X
ISSN	2215-017X
DOI	10.1016/j.btre.2023.e00826
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Article ; Online: Correction to Untapped Pharmaceutical Potential of 4,5,4'-Trihydroxy-3,3'-dimethoxybibenzyl for Regulating Obesity: A Cell-Based Study with a Focus on Terminal Differentiation in Adipogenesis.

Khine, Hnin Ei Ei / Sungthong, Rungroch / Sritularak, Boonchoo / Prompetchara, Eakachai / Chaotham, Chatchai

Journal of natural products

2022 Volume 85, Issue 9, Page(s) 2251

Language	English
Publishing date	2022-09-12
Publishing country	United States
Document type	Published Erratum
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/acs.jnatprod.2c00754
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Article ; Online: Erythrocyte sedimentation rate measurements using MIX-RATE® X20 and VISION A automated analyzers: Method validation and comparison study.

Prompetchara, Eakachai / Nowaratsopon, Sunudda / Wongkamchai, Suppakorn / Srieakpanit, Jittra / Ketloy, Chutitorn

International journal of laboratory hematology

2022 Volume 44, Issue 5, Page(s) 846–853

Abstract: Background: The Westergren method for erythrocyte sedimentation rate (ESR) measurement has a few drawbacks such as being a time-consuming process, poses a risk of biohazard exposure and requires high sample volume. Recent alternative methods and ... ...

Abstract	Background: The Westergren method for erythrocyte sedimentation rate (ESR) measurement has a few drawbacks such as being a time-consuming process, poses a risk of biohazard exposure and requires high sample volume. Recent alternative methods and analyzers were developed to overcome those limitations. In this study, we validated two automated ESR analyzers, MIX-RATE® X20 and VISION A, and assessed their analytical performance against the Westergren method. Methods: The analyzers were validated for inter-run and intra-run precision. Hemolysis interference and sensitivity to fibrinogen were also analysed. Analytical performance was performed using 177 patient samples spanning low (<40 mm/h), medium (40-80 mm/h), and high (>80 mm/h) ESR ranges. Method agreement and bias against the Westergren method were calculated. Results: The highest intra-run imprecision was seen in the low ESR range for both analyzers. They showed very high agreement with the Westergren method assessed by Spearmen rank correlation coefficient analysis, r = 1.000, p < .0001 for both analyzers. Bland-Altman analysis yielded overall insignificant mean biases for all comparisons. However, systematic positive and negative bias were observed at medium and high ESR levels analysed by MIX-RATE® X20 while negative bias was evidenced in the high ESR level measured by VISION A. Conclusions: Overall, results from both automated ESR analyzers showed comparable analytical performance with the Westergren method especially for low ESR levels. However, both positive and negative systematic bias were documented in the high levels. Thus, for clinical use, it must be assessed whether these biases could affect the cut-off for significant clinical values.
MeSH term(s)	Blood Sedimentation/instrumentation ; Fibrinogen ; Hemolysis ; Humans
Chemical Substances	Fibrinogen (9001-32-5)
Language	English
Publishing date	2022-06-16
Publishing country	England
Document type	Comparative Study ; Journal Article ; Validation Study
ZDB-ID	2268590-X
ISSN	1751-553X ; 1751-5521 ; 0141-9854
ISSN (online)	1751-553X
ISSN	1751-5521 ; 0141-9854
DOI	10.1111/ijlh.13914
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Article ; Online: Cisplatin-induced hydroxyl radicals mediate pro-survival autophagy in human lung cancer H460 cells.

Sumkhemthong, Somruethai / Prompetchara, Eakachai / Chanvorachote, Pithi / Chaotham, Chatchai

Biological research

2021 Volume 54, Issue 1, Page(s) 22

Abstract: Background: Accumulated evidence demonstrates cisplatin, a recommended chemotherapy, modulating pro-survival autophagic response that contributes to treatment failure in lung cancer patients. However, distinct mechanisms involved in cisplatin-induced ... ...

Abstract	Background: Accumulated evidence demonstrates cisplatin, a recommended chemotherapy, modulating pro-survival autophagic response that contributes to treatment failure in lung cancer patients. However, distinct mechanisms involved in cisplatin-induced autophagy in human lung cancer cells are still unclear. Results: Herein, role of autophagy in cisplatin resistance was indicated by a decreased cell viability and increased apoptosis in lung cancer H460 cells pre-incubated with wortmannin, an autophagy inhibitor, prior to treatment with 50 µM cisplatin for 24 h. The elevated level of hydroxyl radicals detected via flow-cytometry corresponded to autophagic response, as evidenced by the formation of autophagosomes and autolysosomes in cisplatin-treated cells. Interestingly, apoptosis resistance, autophagosome formation, and the alteration of the autophagic markers, LC3-II/LC3-I and p62, as well as autophagy-regulating proteins Atg7 and Atg3, induced by cisplatin was abrogated by pretreatment of H460 cells with deferoxamine, a specific hydroxyl radical scavenger. The modulations in autophagic response were also indicated in the cells treated with hydroxyl radicals generated via Fenton reaction, and likewise inhibited by pretreatment with deferoxamine. Conclusions: In summary, the possible role of hydroxyl radicals as a key mediator in the autophagic response to cisplatin treatment, which was firstly revealed in this study would benefit for the further development of novel therapies for lung cancer.
MeSH term(s)	Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Apoptosis ; Autophagy ; Cell Line, Tumor ; Cisplatin/pharmacology ; Cisplatin/therapeutic use ; Drug Resistance, Neoplasm ; Humans ; Hydroxyl Radical/pharmacology ; Hydroxyl Radical/therapeutic use ; Lung Neoplasms/drug therapy
Chemical Substances	Antineoplastic Agents ; Hydroxyl Radical (3352-57-6) ; Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2021-07-28
Publishing country	England
Document type	Journal Article
ZDB-ID	1138990-4
ISSN	0717-6287 ; 0716-9760
ISSN (online)	0717-6287
ISSN	0716-9760
DOI	10.1186/s40659-021-00346-2
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Article ; Online: Cisplatin-induced hydroxyl radicals mediate pro-survival autophagy in human lung cancer H460 cells

Somruethai Sumkhemthong / Eakachai Prompetchara / Pithi Chanvorachote / Chatchai Chaotham

Biological Research, Vol 54, Iss 1, Pp 1-

2021 Volume 15

Abstract: Abstract Background Accumulated evidence demonstrates cisplatin, a recommended chemotherapy, modulating pro-survival autophagic response that contributes to treatment failure in lung cancer patients. However, distinct mechanisms involved in cisplatin- ... ...

Abstract	Abstract Background Accumulated evidence demonstrates cisplatin, a recommended chemotherapy, modulating pro-survival autophagic response that contributes to treatment failure in lung cancer patients. However, distinct mechanisms involved in cisplatin-induced autophagy in human lung cancer cells are still unclear. Results Herein, role of autophagy in cisplatin resistance was indicated by a decreased cell viability and increased apoptosis in lung cancer H460 cells pre-incubated with wortmannin, an autophagy inhibitor, prior to treatment with 50 µM cisplatin for 24 h. The elevated level of hydroxyl radicals detected via flow-cytometry corresponded to autophagic response, as evidenced by the formation of autophagosomes and autolysosomes in cisplatin-treated cells. Interestingly, apoptosis resistance, autophagosome formation, and the alteration of the autophagic markers, LC3-II/LC3-I and p62, as well as autophagy-regulating proteins Atg7 and Atg3, induced by cisplatin was abrogated by pretreatment of H460 cells with deferoxamine, a specific hydroxyl radical scavenger. The modulations in autophagic response were also indicated in the cells treated with hydroxyl radicals generated via Fenton reaction, and likewise inhibited by pretreatment with deferoxamine. Conclusions In summary, the possible role of hydroxyl radicals as a key mediator in the autophagic response to cisplatin treatment, which was firstly revealed in this study would benefit for the further development of novel therapies for lung cancer.
Keywords	Cisplatin ; Autophagy ; Drug resistance ; Hydroxyl radicals ; Lung cancer ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
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Article ; Online: Untapped Pharmaceutical Potential of 4,5,4'-Trihydroxy-3,3'-dimethoxybibenzyl for Regulating Obesity: A Cell-Based Study with a Focus on Terminal Differentiation in Adipogenesis.

Khine, Hnin Ei Ei / Sungthong, Rungroch / Sritularak, Boonchoo / Prompetchara, Eakachai / Chaotham, Chatchai

Journal of natural products

2022 Volume 85, Issue 6, Page(s) 1591–1602

Abstract: Obesity and its global prevalence has become a threat to human health, while its pharmacotherapy via the application of natural products is still underdeveloped. Here, we probed how 4,5,4'-trihydroxy-3,3'-dimethoxybibenzyl (TDB) derived from an orchid ( ...

Abstract	Obesity and its global prevalence has become a threat to human health, while its pharmacotherapy via the application of natural products is still underdeveloped. Here, we probed how 4,5,4'-trihydroxy-3,3'-dimethoxybibenzyl (TDB) derived from an orchid (
MeSH term(s)	3T3-L1 Cells ; Adipogenesis ; Animals ; Bibenzyls/pharmacology ; Cell Differentiation ; Dendrobium/chemistry ; Glycogen Synthase Kinase 3 beta ; Humans ; Mice ; Obesity/drug therapy
Chemical Substances	Bibenzyls ; Glycogen Synthase Kinase 3 beta (EC 2.7.11.1)
Language	English
Publishing date	2022-06-09
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/acs.jnatprod.2c00213
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Article: Pinostrobin: An Adipogenic Suppressor from Fingerroot (

San, Htoo Tint / Khine, Hnin Ei Ei / Sritularak, Boonchoo / Prompetchara, Eakachai / Chaotham, Chatchai / Che, Chun-Tao / Likhitwitayawuid, Kittisak

Foods (Basel, Switzerland)

2022 Volume 11, Issue 19

Abstract: Obesity is a critical factor for chronic metabolic syndromes. The culinary plant fingerroot ( ...

Abstract	Obesity is a critical factor for chronic metabolic syndromes. The culinary plant fingerroot (
Language	English
Publishing date	2022-09-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods11193024
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Article: Immune responses in COVID-19 and potential vaccines: Lessons learned from SARS and MERS epidemic.

Prompetchara, Eakachai / Ketloy, Chutitorn / Palaga, Tanapat

Asian Pacific journal of allergy and immunology

2020 Volume 38, Issue 1, Page(s) 1–9

Abstract: As the world is witnessing the epidemic of COVID-19, a disease caused by a novel coronavirus, SARS-CoV-2, emerging genetics and clinical evidences suggest a similar path to those of SARS and MERS. The rapid genomic sequencing and open access data, ... ...

Abstract	As the world is witnessing the epidemic of COVID-19, a disease caused by a novel coronavirus, SARS-CoV-2, emerging genetics and clinical evidences suggest a similar path to those of SARS and MERS. The rapid genomic sequencing and open access data, together with advanced vaccine technology, are expected to give us more knowledge on the pathogen itself, including the host immune response as well as the plan for therapeutic vaccines in the near future. This review aims to provide a comparative view among SARS-CoV, MERS-CoV and the newly epidemic SARS-CoV-2, in the hope to gain a better understanding of the host-pathogen interaction, host immune responses, and the pathogen immune evasion strategies. This predictive view may help in designing an immune intervention or preventive vaccine for COVID-19 in the near future.
MeSH term(s)	Adaptive Immunity ; Betacoronavirus/immunology ; COVID-19 ; COVID-19 Vaccines ; Coronavirus Infections/immunology ; Coronavirus Infections/prevention & control ; Epidemics ; Host-Pathogen Interactions ; Humans ; Immune Evasion ; Immunity, Innate ; Middle East Respiratory Syndrome Coronavirus ; Pneumonia, Viral/immunology ; SARS Virus ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome ; Viral Vaccines/immunology
Chemical Substances	COVID-19 Vaccines ; Viral Vaccines
Keywords	covid19
Language	English
Publishing date	2020-02-27
Publishing country	Thailand
Document type	Journal Article ; Review
ZDB-ID	605782-2
ISSN	2228-8694 ; 0125-877X
ISSN (online)	2228-8694
ISSN	0125-877X
DOI	10.12932/AP-200220-0772
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