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  1. Article: Dad 'never said much' but… Young Men and Great War Veterans in Day-to-Day-Life in Interwar Britain.

    Morley, Joel

    20 century British history

    2018  Volume 29, Issue 2, Page(s) 199–224

    Abstract: This article explores whether, how, and what young men in interwar Britain heard about the Great War from its veterans. Oral histories are used to enable the first detailed examination of the hitherto largely unexplored topic of the intergenerational ... ...

    Abstract This article explores whether, how, and what young men in interwar Britain heard about the Great War from its veterans. Oral histories are used to enable the first detailed examination of the hitherto largely unexplored topic of the intergenerational transmission of representations of the Great War in interwar Britain. It shows that although many veterans were reticent about their war experiences, young men heard about Great War experiences from veterans more frequently than has previously been acknowledged. What they heard was heterogeneous, like representations in popular culture, but tended to emphasize positive and rewarding elements of wartime service rather than disillusion. While veterans' narratives could be fleeting and ephemeral, this examination of their character shows they should be considered an important component of the wider body of representations of the Great War in interwar popular culture through which young men might 'know' about the Great War. As well as examining what young men heard, consideration is given to alternative ways that young men learned about familial service, and to what triggered veterans' narratives and why some remained silent. Reasons for the trope of the silent veteran are suggested, and its strength in contemporary popular memory is illustrated in discussion of the 'discomposure' it could cause some interviewees.
    Language English
    Publishing date 2018-06-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2077480-1
    ISSN 1477-4674 ; 0955-2359
    ISSN (online) 1477-4674
    ISSN 0955-2359
    DOI 10.1093/tcbh/hwx063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: 129:oral What are commissioners’ experiences of implementing a national programme seeking to reduce non-evidence-based healthcare in the NHS during the COVID-19 pandemic?

    Leila Rooshenas / William Hollingworth / Tim Jones / Joel Glynn / Nicola Farrar / Carmel Conefrey / Josie Morley

    BMJ Global Health, Vol 7, Iss Suppl

    2022  Volume 2

    Keywords Medicine (General) ; R5-920 ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: A method for long-term retention of pop-up satellite archival tags (PSATs) on small migratory fishes.

    Naisbett-Jones, Lewis C / Branham, Creed / Birath, Shayla / Paliotti, Savannah / McMains, Andrew R / Joel Fodrie, Frederick / Morley, James W / Buckel, Jeffrey A / Lohmann, Kenneth J

    Journal of fish biology

    2023  Volume 102, Issue 5, Page(s) 1029–1039

    Abstract: Achieving long-term retention of pop-up satellite archival tags (PSATs) has proven difficult for all fishes but is particularly challenging for small migrant species due to the relatively large size of tags. In this study, the authors tested the latest ... ...

    Abstract Achieving long-term retention of pop-up satellite archival tags (PSATs) has proven difficult for all fishes but is particularly challenging for small migrant species due to the relatively large size of tags. In this study, the authors tested the latest and smallest PSAT model on the market, the mark-report satellite tag (mrPAT), and developed a simple, cost-effective method of tag attachment on sheepshead Archosargus probatocephalus (Walbaum 1792), a small marine fish. During laboratory trials, the method of tag attachment used in this study outperformed the existing methods with two c. 40 cm fish retaining their tags for 3 months (the duration of the laboratory study). During field deployments, data were successfully obtained for 17 of the 25 tagged fish [37-50 cm fork length (FL)]. Of these, 14 tags (82%) remained on the fish until the pre-programmed release date resulting in tag retention times of up to 172 days (mean: 140 days). The investigation represents the first extensive study into the feasibility of PSATs for monitoring fishes in this size range. The authors demonstrate that their method of attachment and this latest PSAT model are feasible for c. 5-month deployments on fishes that are relatively small (c. 45 cm FL). These results with A. probatocephalus represent a potentially significant advance in PSAT methodology for fishes of this size. Future investigations are needed to determine if this method is transferrable to other species in the same size range.
    MeSH term(s) Animals ; Animal Migration ; Fishes
    Language English
    Publishing date 2023-03-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 410564-3
    ISSN 1095-8649 ; 0022-1112
    ISSN (online) 1095-8649
    ISSN 0022-1112
    DOI 10.1111/jfb.15351
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Longitudinal Evaluation of a Deprescribing Protocol in Skilled Nursing Facilities.

    Morley, Christopher P / Schad, Laura A / Cerio, Halle / McNamara, Sarah E / Wojtowycz, Martha A / Smith, Nancy H / Noviasky, John A / Ulen, Kelly R / Townsend, Kimberly / Amidon, Joel / Brangman, Sharon A

    The Senior care pharmacist

    2022  Volume 37, Issue 10, Page(s) 523–531

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Deprescriptions ; Diuretics ; Humans ; New York ; Retrospective Studies ; Skilled Nursing Facilities
    Chemical Substances Diuretics
    Language English
    Publishing date 2022-09-28
    Publishing country United States
    Document type Journal Article
    ISSN 2639-9636
    ISSN 2639-9636
    DOI 10.4140/TCP.n.2022.523
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Did the evidence-based intervention (EBI) programme reduce inappropriate procedures, lessen unwarranted variation or lead to spill-over effects in the National Health Service?

    Glynn, Joel / Jones, Timothy / Bell, Mike / Blazeby, Jane / Burton, Christopher / Conefrey, Carmel / Donovan, Jenny L / Farrar, Nicola / Morley, Josie / McNair, Angus / Owen-Smith, Amanda / Rule, Ellen / Thornton, Gail / Tucker, Victoria / Williams, Iestyn / Rooshenas, Leila / Hollingworth, William

    PloS one

    2023  Volume 18, Issue 9, Page(s) e0290996

    Abstract: Background: Health systems are under pressure to maintain services within limited resources. The Evidence-Based Interventions (EBI) programme published a first list of guidelines in 2019, which aimed to reduce inappropriate use of interventions within ... ...

    Abstract Background: Health systems are under pressure to maintain services within limited resources. The Evidence-Based Interventions (EBI) programme published a first list of guidelines in 2019, which aimed to reduce inappropriate use of interventions within the NHS in England, reducing potential harm and optimising the use of limited resources. Seventeen procedures were selected in the first round, published in April 2019.
    Methods: We evaluated changes in the trends for each procedure after its inclusion in the EBI's first list of guidelines using interrupted time series analysis. We explored whether there was any evidence of spill-over effects onto related or substitute procedures, as well as exploring changes in geographical variation following the publication of national guidance.
    Results: Most procedures were experiencing downward trends in the years prior to the launch of EBI. We found no evidence of a trend change in any of the 17 procedures following the introduction of the guidance. No evidence of spill-over increases in substitute or related procedures was found. Geographic variation in the number of procedures performed across English CCGs remained at similar levels before and after EBI.
    Conclusions: The EBI programme had little success in its aim to further reduce the use of the 17 procedures it deemed inappropriate in all or certain circumstances. Most procedure rates were already decreasing before EBI and all continued with a similar trend afterwards. Geographical variation in the number of procedures remained at a similar level post EBI. De-adoption of inappropriate care is essential in maintaining health systems across the world. However, further research is needed to explore context specific enablers and barriers to effective identification and de-adoption of such inappropriate health care to support future de-adoption endeavours.
    MeSH term(s) State Medicine ; Behavior Therapy ; England ; Geography ; Evidence-Based Medicine
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0290996
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A method for long‐term retention of pop‐up satellite archival tags (PSATs) on small migratory fishes

    Naisbett‐Jones, Lewis C. / Branham, Creed / Birath, Shayla / Paliotti, Savannah / McMains, Andrew R. / Joel Fodrie, Frederick / Morley, James W. / Buckel, Jeffrey A. / Lohmann, Kenneth J.

    Journal of Fish Biology. 2023 May, v. 102, no. 5 p.1029-1039

    2023  

    Abstract: Achieving long‐term retention of pop‐up satellite archival tags (PSATs) has proven difficult for all fishes but is particularly challenging for small migrant species due to the relatively large size of tags. In this study, the authors tested the latest ... ...

    Abstract Achieving long‐term retention of pop‐up satellite archival tags (PSATs) has proven difficult for all fishes but is particularly challenging for small migrant species due to the relatively large size of tags. In this study, the authors tested the latest and smallest PSAT model on the market, the mark‐report satellite tag (mrPAT), and developed a simple, cost‐effective method of tag attachment on sheepshead Archosargus probatocephalus (Walbaum 1792), a small marine fish. During laboratory trials, the method of tag attachment used in this study outperformed the existing methods with two c. 40 cm fish retaining their tags for 3 months (the duration of the laboratory study). During field deployments, data were successfully obtained for 17 of the 25 tagged fish [37–50 cm fork length (FL)]. Of these, 14 tags (82%) remained on the fish until the pre‐programmed release date resulting in tag retention times of up to 172 days (mean: 140 days). The investigation represents the first extensive study into the feasibility of PSATs for monitoring fishes in this size range. The authors demonstrate that their method of attachment and this latest PSAT model are feasible for c. 5‐month deployments on fishes that are relatively small (c. 45 cm FL). These results with A. probatocephalus represent a potentially significant advance in PSAT methodology for fishes of this size. Future investigations are needed to determine if this method is transferrable to other species in the same size range.
    Keywords Archosargus probatocephalus ; cost effectiveness ; marine fish ; markets ; migratory behavior ; models ; satellites
    Language English
    Dates of publication 2023-05
    Size p. 1029-1039.
    Publishing place Blackwell Publishing Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 410564-3
    ISSN 1095-8649 ; 0022-1112
    ISSN (online) 1095-8649
    ISSN 0022-1112
    DOI 10.1111/jfb.15351
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: High-resolution imaging of protein secretion at the single-cell level using plasmon-enhanced FluoroDOT assay.

    Seth, Anushree / Mittal, Ekansh / Luan, Jingyi / Kolla, Samhitha / Mazer, Monty B / Joshi, Hemant / Gupta, Rohit / Rathi, Priya / Wang, Zheyu / Morrissey, Jeremiah J / Ernst, Joel D / Portal-Celhay, Cynthia / Morley, Sharon Celeste / Philips, Jennifer A / Singamaneni, Srikanth

    Cell reports methods

    2022  Volume 2, Issue 8, Page(s) 100267

    Abstract: Secreted proteins mediate essential physiological processes. With conventional assays, it is challenging to map the spatial distribution of proteins secreted by single cells, to study cell-to-cell heterogeneity in secretion, or to detect proteins of low ... ...

    Abstract Secreted proteins mediate essential physiological processes. With conventional assays, it is challenging to map the spatial distribution of proteins secreted by single cells, to study cell-to-cell heterogeneity in secretion, or to detect proteins of low abundance or incipient secretion. Here, we introduce the "FluoroDOT assay," which uses an ultrabright nanoparticle plasmonic-fluor that enables high-resolution imaging of protein secretion. We find that plasmonic-fluors are 16,000-fold brighter, with nearly 30-fold higher signal-to-noise compared with conventional fluorescence labels. We demonstrate high-resolution imaging of different secreted cytokines in the single-plexed and spectrally multiplexed FluoroDOT assay that revealed cellular heterogeneity in secretion of multiple proteins simultaneously. Using diverse biochemical stimuli, including
    MeSH term(s) Humans ; Cytokines/metabolism ; Tuberculosis/metabolism ; Macrophages ; T-Lymphocytes/metabolism
    Chemical Substances Cytokines
    Language English
    Publishing date 2022-08-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 2667-2375
    ISSN (online) 2667-2375
    DOI 10.1016/j.crmeth.2022.100267
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Dietary lipids inhibit mitochondria transfer to macrophages to divert adipocyte-derived mitochondria into the blood.

    Borcherding, Nicholas / Jia, Wentong / Giwa, Rocky / Field, Rachael L / Moley, John R / Kopecky, Benjamin J / Chan, Mandy M / Yang, Bin Q / Sabio, Jessica M / Walker, Emma C / Osorio, Omar / Bredemeyer, Andrea L / Pietka, Terri / Alexander-Brett, Jennifer / Morley, Sharon Celeste / Artyomov, Maxim N / Abumrad, Nada A / Schilling, Joel / Lavine, Kory /
    Crewe, Clair / Brestoff, Jonathan R

    Cell metabolism

    2022  Volume 34, Issue 10, Page(s) 1499–1513.e8

    Abstract: Adipocytes transfer mitochondria to macrophages in white and brown adipose tissues to maintain metabolic homeostasis. In obesity, adipocyte-to-macrophage mitochondria transfer is impaired, and instead, adipocytes release mitochondria into the blood to ... ...

    Abstract Adipocytes transfer mitochondria to macrophages in white and brown adipose tissues to maintain metabolic homeostasis. In obesity, adipocyte-to-macrophage mitochondria transfer is impaired, and instead, adipocytes release mitochondria into the blood to induce a protective antioxidant response in the heart. We found that adipocyte-to-macrophage mitochondria transfer in white adipose tissue is inhibited in murine obesity elicited by a lard-based high-fat diet, but not a hydrogenated-coconut-oil-based high-fat diet, aging, or a corn-starch diet. The long-chain fatty acids enriched in lard suppress mitochondria capture by macrophages, diverting adipocyte-derived mitochondria into the blood for delivery to other organs, such as the heart. The depletion of macrophages rapidly increased the number of adipocyte-derived mitochondria in the blood. These findings suggest that dietary lipids regulate mitochondria uptake by macrophages locally in white adipose tissue to determine whether adipocyte-derived mitochondria are released into systemic circulation to support the metabolic adaptation of distant organs in response to nutrient stress.
    MeSH term(s) Adipocytes/metabolism ; Adipose Tissue, White/metabolism ; Animals ; Antioxidants/metabolism ; Diet, High-Fat ; Fatty Acids/metabolism ; Macrophages/metabolism ; Mice ; Mitochondria/metabolism ; Obesity/metabolism ; Starch/metabolism
    Chemical Substances Antioxidants ; Fatty Acids ; Starch (9005-25-8)
    Language English
    Publishing date 2022-09-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2022.08.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Examining an Evidence-Based Medicine Culture in Residency Education.

    Epling, John W / Heidelbaugh, Joel J / Woolever, Donald / Castelli, Gregory / Mi, Misa / Mader, Emily M / Morley, Christopher P

    Family medicine

    2018  Volume 50, Issue 10, Page(s) 751–755

    Abstract: Background and objectives: Reports of innovations in evidence-based medicine (EBM) training have focused on curriculum design and knowledge gained. Little is known about the educational culture and environment for EBM training and the extent to which ... ...

    Abstract Background and objectives: Reports of innovations in evidence-based medicine (EBM) training have focused on curriculum design and knowledge gained. Little is known about the educational culture and environment for EBM training and the extent to which those environments exist in family medicine residencies in the United States.
    Methods: A literature review on this topic identified a validated EBM environment scale intended for learner use. This scale was adapted for completion by family medicine residency program directors (PDs) and administered through an omnibus survey. Responses to this scale were analyzed descriptively with program and PD demographics. An EBM culture score was calculated for each program and the results were regressed with the correlated demographics.
    Results: In our adapted survey, family medicine PDs generally rated their residencies high on the EBM culture scale, but admitted to challenges with faculty feedback to residents about EBM skills, ability to protect time for EBM instruction, and clinician skepticism about EBM. In linear regression analysis, the mean summary score on the EBM scale was lower for female PDs and in programs with a higher proportion of international medical school graduates.
    Conclusions: To improve the culture for EBM teaching, family medicine residency programs should focus on faculty engagement and support and the allocation of sufficient time for EBM education.
    MeSH term(s) Evidence-Based Medicine/organization & administration ; Evidence-Based Medicine/standards ; Family Practice/education ; Humans ; Internship and Residency/organization & administration ; Learning ; Organizational Culture ; Socioeconomic Factors ; Time Factors ; United States
    Language English
    Publishing date 2018-12-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639374-3
    ISSN 1938-3800 ; 0742-3225
    ISSN (online) 1938-3800
    ISSN 0742-3225
    DOI 10.22454/FamMed.2018.576501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Sensitive Detection of SARS-CoV-2-Specific Antibodies in Dried Blood Spot Samples.

    Morley, Gabriella L / Taylor, Stephen / Jossi, Sian / Perez-Toledo, Marisol / Faustini, Sian E / Marcial-Juarez, Edith / Shields, Adrian M / Goodall, Margaret / Allen, Joel D / Watanabe, Yasunori / Newby, Maddy L / Crispin, Max / Drayson, Mark T / Cunningham, Adam F / Richter, Alex G / O'Shea, Matthew K

    Emerging infectious diseases

    2020  Volume 26, Issue 12, Page(s) 2970–2973

    Abstract: Dried blood spot (DBS) samples can be used for the detection of severe acute respiratory syndrome coronavirus 2 spike antibodies. DBS sampling is comparable to matched serum samples with a relative 98.1% sensitivity and 100% specificity. Thus, DBS ... ...

    Abstract Dried blood spot (DBS) samples can be used for the detection of severe acute respiratory syndrome coronavirus 2 spike antibodies. DBS sampling is comparable to matched serum samples with a relative 98.1% sensitivity and 100% specificity. Thus, DBS sampling offers an alternative for population-wide serologic testing in the coronavirus pandemic.
    MeSH term(s) Antibodies, Viral/immunology ; COVID-19/diagnosis ; COVID-19 Serological Testing/methods ; Case-Control Studies ; Dried Blood Spot Testing/economics ; Dried Blood Spot Testing/methods ; Humans ; Predictive Value of Tests ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/immunology ; Spike Glycoprotein, Coronavirus/isolation & purification
    Chemical Substances Antibodies, Viral ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-09-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2612.203309
    Database MEDical Literature Analysis and Retrieval System OnLINE

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