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Article ; Online: Nonalcoholic fatty liver disease: an update.

Bedogni, Giorgio / Palmese, Francesco / Foschi, Francesco Giuseppe

2023 Volume 34, Issue 3, Page(s) 114–118

Abstract: Purpose of review: We discuss two recent controversial issues in the research field of fatty liver: the proposal to replace nonalcoholic fatty liver disease (NAFLD) with metabolically associated fatty liver disease (MAFLD) and the suggestion to extend ... ...

Abstract	Purpose of review: We discuss two recent controversial issues in the research field of fatty liver: the proposal to replace nonalcoholic fatty liver disease (NAFLD) with metabolically associated fatty liver disease (MAFLD) and the suggestion to extend to primary care the noninvasive testing for liver fibrosis that was developed for secondary care. Recent findings: There is preliminary evidence that MAFLD-only patients are at greater risk of fibrosis than NAFLD-only patients. There are a large number of false positives associated with the downshift of noninvasive testing for liver fibrosis from secondary to primary care. Summary: More studies are needed to compare the MAFLD and NAFLD operational definitions. Noninvasive testing of liver fibrosis also needs further evaluation before it can be used in primary care or in the general population.
MeSH term(s)	Humans ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/diagnosis ; Liver Cirrhosis/diagnosis
Language	English
Publishing date	2023-02-22
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	1045394-5
ISSN	1473-6535 ; 0957-9672
ISSN (online)	1473-6535
ISSN	0957-9672
DOI	10.1097/MOL.0000000000000874
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Article: Relationship between Muscle Mass, Bone Density and Vascular Calcifications in Elderly People with SARS-CoV-2 Pneumonia.

Del Toro, Rossella / Palmese, Francesco / Feletti, Francesco / Zani, Gianluca / Minguzzi, Maria Teresa / Maddaloni, Ernesto / Napoli, Nicola / Bedogni, Giorgio / Domenicali, Marco

Journal of clinical medicine

2023 Volume 12, Issue 6

Abstract: Background: Little is known about the changes in organs and tissues that may make elder patients more vulnerable to acute stressors such as SARS-CoV-2 infection.: Methods: In 80 consecutive elderly patients with SARS-CoV-2 infection, we evaluated the ...

Abstract	Background: Little is known about the changes in organs and tissues that may make elder patients more vulnerable to acute stressors such as SARS-CoV-2 infection. Methods: In 80 consecutive elderly patients with SARS-CoV-2 infection, we evaluated the association between the descending thoracic aorta calcium score, L1 bone density and T12 skeletal muscle density measured on the same scan by high-resolution computed tomography. Results: At median regression, the ln-transformed DTA calcium score was inversely associated with L1 bone density (-0.02, 95%CI -0.04 to -0.01 ln-Agatston units for an increase of 1 HU) and with T12 muscle density (-0.03, -0.06 to -0.001 ln-Agatston units for an increase of 1 HU). At penalized logistic regression, an increase of 1 ln-Agatston unit of DTA calcium score was associated with an OR of death of 1.480 (1.022 to 2.145), one of 1 HU of bone density with an OR of 0.981 (0.966 to 0.996) and one of 1 HU of muscle density with an OR of 0.973 (0.948 to 0.999). These relationships disappeared after correction for age and age was the stronger predictor of body composition and death. Conclusions: Age has a big effect on the relationship between vascular calcifications, L1 bone density and T12 muscle density and on their relationship with the odds of dying.
Language	English
Publishing date	2023-03-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12062372
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Article ; Online: More than a "monstrous obesity"! Time to overcome the "anti-fat" bias.

Palmese, Francesco / Reggidori, Nicola / Pappas, Georgios / Gramenzi, Annagiulia

Clinical obesity

2020 Volume 11, Issue 1, Page(s) e12413

Abstract: A 54-years-old woman complained of unintentional important body weight gain associated with abdominal bloating. For this reason, she had consulted many different diet and nutritional professionals, general practitioners and a gastroenterology specialist, ...

Abstract	A 54-years-old woman complained of unintentional important body weight gain associated with abdominal bloating. For this reason, she had consulted many different diet and nutritional professionals, general practitioners and a gastroenterology specialist, but no one went beyond a simple diagnosis of "monstrous obesity". At our hospital division, based on physical examination, a computed tomography (CT) of the abdomen and pelvis was performed. It showed a voluminous intraperitoneal mass occupying the most part of the abdomen. The patient underwent laparotomy with resection of the abdomino-pelvic mass, originating from the left ovary, measuring 60 x 45 cm and weighing 46 kg. Histopathology examination revealed a tumor composed of three different areas, including a well-differentiated adenocarcinoma of intestinal-type. It is emblematic of a grotesque misdiagnosis generated by a non-comprehensive patient assessment and consequently by a too quick judgement related to the "anti-fat bias".
MeSH term(s)	Abdomen ; Female ; Humans ; Middle Aged ; Obesity/diagnosis ; Pelvis ; Tomography, X-Ray Computed
Language	English
Publishing date	2020-09-28
Publishing country	England
Document type	Case Reports
ZDB-ID	2625816-X
ISSN	1758-8111 ; 1758-8103
ISSN (online)	1758-8111
ISSN	1758-8103
DOI	10.1111/cob.12413
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Article ; Online: Relationship between Muscle Mass, Bone Density and Vascular Calcifications in Elderly People with SARS-CoV-2 Pneumonia

Rossella Del Toro / Francesco Palmese / Francesco Feletti / Gianluca Zani / Maria Teresa Minguzzi / Ernesto Maddaloni / Nicola Napoli / Giorgio Bedogni / Marco Domenicali

Journal of Clinical Medicine, Vol 12, Iss 2372, p

2023 Volume 2372

Abstract: Background: Little is known about the changes in organs and tissues that may make elder patients more vulnerable to acute stressors such as SARS-CoV-2 infection. Methods: In 80 consecutive elderly patients with SARS-CoV-2 infection, we evaluated the ... ...

Abstract	Background: Little is known about the changes in organs and tissues that may make elder patients more vulnerable to acute stressors such as SARS-CoV-2 infection. Methods: In 80 consecutive elderly patients with SARS-CoV-2 infection, we evaluated the association between the descending thoracic aorta calcium score, L1 bone density and T12 skeletal muscle density measured on the same scan by high-resolution computed tomography. Results: At median regression, the ln-transformed DTA calcium score was inversely associated with L1 bone density (−0.02, 95%CI −0.04 to −0.01 ln-Agatston units for an increase of 1 HU) and with T12 muscle density (−0.03, −0.06 to −0.001 ln-Agatston units for an increase of 1 HU). At penalized logistic regression, an increase of 1 ln-Agatston unit of DTA calcium score was associated with an OR of death of 1.480 (1.022 to 2.145), one of 1 HU of bone density with an OR of 0.981 (0.966 to 0.996) and one of 1 HU of muscle density with an OR of 0.973 (0.948 to 0.999). These relationships disappeared after correction for age and age was the stronger predictor of body composition and death. Conclusions: Age has a big effect on the relationship between vascular calcifications, L1 bone density and T12 muscle density and on their relationship with the odds of dying.
Keywords	frailty ; SARS-CoV-2 ; muscle mass ; bone density ; vascular calcifications ; mortality ; Medicine ; R
Subject code	616
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Biological Assay to Determine Gonadotropin Potency: From In Vivo to In Vitro Sustainable Method.

Nevelli, Francesco / Palmese, Angelo / Gleixner, Ralf / Peroglio, Flavio / D'Acunto, Cosimo-Walter / Dadone, Aurora / D'Hooghe, Thomas / Lispi, Monica

International journal of molecular sciences

2023 Volume 24, Issue 9

Abstract: Various preparations of follicle-stimulating hormone (FSH) are commercially available; however, they differ in glycoforms composition and purity owing to their respective sources. Additional chemical/physical changes can also be introduced during ... ...

Abstract	Various preparations of follicle-stimulating hormone (FSH) are commercially available; however, they differ in glycoforms composition and purity owing to their respective sources. Additional chemical/physical changes can also be introduced during manufacturing and can impact their biological activity (biopotency), which is routinely assessed using an in vivo bioassay (Steelman-Pohley). This study aimed to determine whether an in vitro bioassay could assess biopotency by distinguishing between r-hFSH chemical/physical variants with similar ability to the in vivo bioassay. The specific activity (units of biological activity per mg of product) of variants of r-hFSH generated through enrichment (acidic/basic), stress (oxidative/acidic pH) and enzymatic treatment (desialylation and desialylation/degalactosylation) was compared using the in vivo and in vitro bioassays. The in vitro bioassay reliably detected potential chemical/physical modifications in r-hFSH variants that may impact biopotency. Overall, the methods demonstrated a comparable ability to detect changes in specific activities due to chemical/physical differences in r-hFSH variants. These data indicate that the in vitro bioassay is suitable to replace the in vivo bioassay.
MeSH term(s)	Follicle Stimulating Hormone, Human ; Follicle Stimulating Hormone ; Biological Assay/methods ; In Vitro Techniques
Chemical Substances	Follicle Stimulating Hormone, Human ; Follicle Stimulating Hormone (9002-68-0)
Language	English
Publishing date	2023-04-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24098040
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Article ; Online: COVID-19-Related Death in Patients with Alcohol or Substance Use Disorders.

Pavarin, Raimondo Maria / Consonni, Dario / Lucchi, Fabio / Pandolfi, Paolo / Marani, Silvia / Palmese, Francesco / Domenicali, Marco

European addiction research

2022 Volume 29, Issue 1, Page(s) 67–70

Abstract: Background: People with substance or alcohol use disorders (SUDs/AUDs) are likely to be more vulnerable to COVID-19 infection than the general population, but the evidence of COVID-19-related mortality in these patients is unclear.: Objectives: The ... ...

Abstract	Background: People with substance or alcohol use disorders (SUDs/AUDs) are likely to be more vulnerable to COVID-19 infection than the general population, but the evidence of COVID-19-related mortality in these patients is unclear. Objectives: The aim of the study was to verify whether patients with AUD and SUD have a higher mortality rate for COVID-19-related mortality compared to the general population. Method: We performed a follow-up study to assess mortality in 2020 in a cohort of patients diagnosed for the first time with AUDs or SUDs at the Public Health Services in the metropolitan area of Bologna (Northern Italy) from 2009 to 2019. Results: SUDs/AUDs patients present an excess mortality with respect to the general population for all causes of death and for COVID-19-related mortality. Conclusions: Our data support the need for prevention strategies in SUDs/AUDs patients such as vaccinations.
MeSH term(s)	Humans ; Alcoholism/epidemiology ; Follow-Up Studies ; COVID-19 ; Substance-Related Disorders/epidemiology ; Italy/epidemiology
Language	English
Publishing date	2022-11-30
Publishing country	Switzerland
Document type	News
ZDB-ID	1215786-7
ISSN	1421-9891 ; 1022-6877
ISSN (online)	1421-9891
ISSN	1022-6877
DOI	10.1159/000527542
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Article ; Online: Development and internal validation of a multivariable model for the prediction of the probability of 1-year readmission to the emergency department for acute alcohol intoxication.

Palmese, Francesco / Bonavita, Maria Elena / Pompili, Enrico / Reggidori, Nicola / Migliano, Maria Teresa / Di Stefano, Cecilia / Grieco, Marta / Colazzo, Stefano / Baldassarre, Maurizio / Caraceni, Paolo / Foschi, Francesco Giuseppe / Giostra, Fabrizio / Farina, Gabriele / Del Toro, Rossella / Bedogni, Giorgio / Domenicali, Marco

Internal and emergency medicine

2023 Volume 19, Issue 3, Page(s) 823–829

Abstract: To develop and internally validate a multivariable logistic regression model (LRM) for the prediction of the probability of 1-year readmission to the emergency department (ED) in patients with acute alcohol intoxication (AAI). We developed and internally ...

Abstract	To develop and internally validate a multivariable logistic regression model (LRM) for the prediction of the probability of 1-year readmission to the emergency department (ED) in patients with acute alcohol intoxication (AAI). We developed and internally validated the LRM on a previously analyzed retrospective cohort of 3304 patients with AAI admitted to the ED of the Sant'Orsola-Malpighi Hospital (Bologna, Italy). The benchmark LRM employed readmission to the same ED for AAI within 1 year as the binary outcome, age as a continuous predictor, and sex, alcohol use disorder, substance use disorder, at least one previous admission for trauma, mental or behavioral disease, and homelessness as the binary predictors. Optimism correction was performed using the bootstrap on 1000 samples without replacement. The benchmark LRM was gradually simplified to get the most parsimonious LRM with similar optimism-corrected overall fit, discrimination and calibration. The 1-year readmission rate was 15.7% (95% CI 14.4-16.9%). A reduced LRM based on sex, age, at least one previous admission for trauma, mental or behavioral disease, and homelessness, performed nearly as well as the benchmark LRM. The reduced LRM had the following optimism-corrected metrics: scaled Brier score 17.0%, C-statistic 0.799 (95% CI 0.778 to 0.821), calibration in the large 0.000 (95% CI - 0.099 to 0.099), calibration slope 0.985 (95% CI 0.893 to 1.088), and an acceptably accurate calibration plot. An LRM based on sex, age, at least one previous admission for trauma, mental or behavioral disease, and homelessness can be used to estimate the probability of 1-year readmission to ED for AAI. To begin proving its clinical utility, this LRM should be validated in external cohorts.
MeSH term(s)	Humans ; Patient Readmission/statistics & numerical data ; Emergency Service, Hospital/statistics & numerical data ; Emergency Service, Hospital/organization & administration ; Male ; Female ; Adult ; Alcoholic Intoxication ; Middle Aged ; Retrospective Studies ; Italy ; Logistic Models ; Probability
Language	English
Publishing date	2023-12-14
Publishing country	Italy
Document type	Journal Article ; Validation Study
ZDB-ID	2454173-4
ISSN	1970-9366 ; 1828-0447
ISSN (online)	1970-9366
ISSN	1828-0447
DOI	10.1007/s11739-023-03490-7
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Article ; Online: Low haemoglobin level predicts early hospital readmission in patients with cirrhosis and acute decompensation.

Pompili, Enrico / Baldassarre, Maurizio / Zaccherini, Giacomo / Tufoni, Manuel / Iannone, Giulia / Pratelli, Dario / Palmese, Francesco / Vizioli, Luca / Faggiano, Chiara / Bedogni, Giorgio / Domenicali, Marco / Caraceni, Paolo

JHEP reports : innovation in hepatology

2023 Volume 5, Issue 5, Page(s) 100698

Abstract: Background & aims: Patients with decompensated cirrhosis present frequent hospitalisations with a relevant clinical and socio-economic impact. This study aims to characterise unscheduled readmissions up to 1-year follow-up and identify predictors of 30- ... ...

Abstract	Background & aims: Patients with decompensated cirrhosis present frequent hospitalisations with a relevant clinical and socio-economic impact. This study aims to characterise unscheduled readmissions up to 1-year follow-up and identify predictors of 30-day readmission after an index hospitalisation for acute decompensation (AD). Methods: We performed a secondary analysis of a prospectively collected cohort of patients admitted for AD. Laboratory and clinical data at admission and at discharge were collected. Timing and causes of unscheduled readmissions and mortality were recorded up to 1 year. Results: A total of 329 patients with AD were included in the analysis. Acute-on-chronic liver failure was diagnosed in 19% of patients at admission or developed in an additional 9% of patients during the index hospitalisation. During the 1-year follow-up, 182 patients (55%) were rehospitalised and 98 (30%) more than once. The most frequent causes of readmission were hepatic encephalopathy (36%), ascites (22%), and infection (21%). Cumulative incidence of readmission was 20% at 30 days, 39% at 90 days, and 63% at 1 year. Fifty-four patients were readmitted for emergent liver-related causes within 30 days. Early readmission was associated with a higher 1-year mortality (47 Conclusion: Besides MELD-Na, a low Hb level (Hb ≤8.7 g/dl) at discharge emerged as a new risk factor for early readmission, contributing to identification of patients who require closer surveillance after discharge. Impact and implications: Patients with decompensated cirrhosis face frequent hospitalisations. In the present study, type and causes of readmissions were analysed during 1-year follow-up in patients discharged after the index hospitalisation for an acute decompensation of the disease. Early (30-day) liver-related readmission was associated with higher 1-year mortality. The model for end-stage liver disease-sodium score and low haemoglobin at discharge were identified as independent risk factors for early readmissions. Haemoglobin emerged as a new easy-to-use parameter associated with early readmission warranting further investigation.
Language	English
Publishing date	2023-02-11
Publishing country	Netherlands
Document type	Journal Article
ISSN	2589-5559
ISSN (online)	2589-5559
DOI	10.1016/j.jhepr.2023.100698
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Article ; Online: Predictors of clinical trajectories of patients with acutely decompensated cirrhosis. An external validation of the PREDICT study.

Pompili, Enrico / Baldassarre, Maurizio / Bedogni, Giorgio / Zaccherini, Giacomo / Iannone, Giulia / De Venuto, Clara / Pratelli, Dario / Palmese, Francesco / Domenicali, Marco / Caraceni, Paolo

Liver international : official journal of the International Association for the Study of the Liver

2023 Volume 44, Issue 1, Page(s) 72–82

Abstract: Background and aims: The PREDICT study recently showed that acutely decompensated (AD) patients with cirrhosis can present three different clinical phenotypes in the 90 days after admission: (1) pre-ACLF, developing acute-on-chronic liver failure (ACLF); ...

Abstract	Background and aims: The PREDICT study recently showed that acutely decompensated (AD) patients with cirrhosis can present three different clinical phenotypes in the 90 days after admission: (1) pre-ACLF, developing acute-on-chronic liver failure (ACLF); (2) unstable decompensated cirrhosis (UDC), being re-admitted for AD without ACLF and (3) stable decompensated cirrhosis (SDC), not presenting readmission or ACLF. This study aimed to externally validate the existence of these three distinct trajectories and to identify predictors for the occurrence of each trajectory. Methods: Baseline data, 3-month ACLF and readmission incidence and 1-year survival were analysed in a prospective cohort of patients admitted for AD. A multinomial multivariable model was used to evaluate the association between baseline features and clinical trajectories. Results: Of the 311 patients enrolled, 55% met the criteria for SDC, 18% for UDC and 27% for pre-ACLF, presenting a significantly different 1-year mortality: pre-ACLF 65%, UDC 46%, SDC 21% (p < .001). The presence of hepatic encephalopathy (HE) was associated with UDC (p = .043), while the absence of ascites to SDC (p = .017). Among laboratory parameters, an increase in MELD-Na (p = .001) and C-reactive protein (p = .009) and a decrease in haemoglobin (p = .004) and albumin (p = .008) levels were associated with pre-ACLF. Conclusion: The present study confirms that AD patients have three different clinical trajectories with different mortality rates. Besides the severity of cirrhosis, the association with C-reactive protein supports the predominant role of systemic inflammation in ACLF pathophysiology. Finally, HE is associated with the UDC phenotype highlighting the need for better management of this complication after discharge.
MeSH term(s)	Humans ; Acute-On-Chronic Liver Failure/complications ; C-Reactive Protein ; Hepatic Encephalopathy/complications ; Inflammation ; Liver Cirrhosis ; Prognosis ; Prospective Studies
Chemical Substances	C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2023-09-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2102783-3
ISSN	1478-3231 ; 1478-3223
ISSN (online)	1478-3231
ISSN	1478-3223
DOI	10.1111/liv.15734
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Article ; Online: A comparison of simplified protocols of personalized dosimetry in NEN patients treated by radioligand therapy (RLT) with [

Pirozzi Palmese, Valentina / D'Ambrosio, Laura / Di Gennaro, Francesca / Maisto, Costantina / de Marino, Roberta / Morisco, Anna / Coluccia, Sergio / Di Gennaro, Piergiacomo / De Lauro, Francesco / Raddi, Marco / Gaballo, Paolo / Tafuto, Salvatore / Celentano, Egidio / Lastoria, Secondo

European journal of nuclear medicine and molecular imaging

2023 Volume 50, Issue 6, Page(s) 1753–1764

Abstract: The role of internal dosimetry is usually proposed for investigational purposes in patients treated by RLT, even if its application is not yet the standard method in clinical practice. This limited use is partially justified by several concomitant ... ...

Abstract	The role of internal dosimetry is usually proposed for investigational purposes in patients treated by RLT, even if its application is not yet the standard method in clinical practice. This limited use is partially justified by several concomitant factors that make calculations a complex process. Therefore, simplified dosimetry protocols are required. Methods: In our study, dosimetric evaluations were performed in thirty patients with NENs who underwent RLT with [ Results: The mean differences of the cumulative absorbed doses between M1 and M0 were - 10% for kidney, - 5% for spleen, + 34% for liver, + 13% for red marrow, and + 37% for tumor lesions. Conversely, differences lower than ± 10% were measured between M2 and M0. Conclusion: Cumulative absorbed doses obtained with the M2 protocol resembled the doses calculated by M0, while the M1 protocol overestimated the absorbed doses in all organs at risk, except for the spleen.
MeSH term(s)	Humans ; Octreotide/therapeutic use ; Radionuclide Imaging ; Positron-Emission Tomography ; Radiometry/methods
Chemical Substances	copper dotatate CU-64 ; Octreotide (RWM8CCW8GP)
Language	English
Publishing date	2023-01-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	8236-3
ISSN	1619-7089 ; 0340-6997 ; 1619-7070
ISSN (online)	1619-7089
ISSN	0340-6997 ; 1619-7070
DOI	10.1007/s00259-023-06112-8
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