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  1. Article: How Is CYP17A1 Activity Altered in Autism? A Pilot Study to Identify Potential Pharmacological Targets.

    Gasser, Benedikt Andreas / Kurz, Johann / Dick, Bernhard / Mohaupt, Markus Georg

    Life (Basel, Switzerland)

    2022  Volume 12, Issue 6

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-06-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life12060867
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  2. Article ; Online: Fusarium proliferatum secondary metabolite profile in vitro depends on the origin of the isolates and is clearly reduced in stored garlic

    Gasser, Katharina / Sulyok, Michael / Spangl, Bernhard / Krska, R. / Steinkellner, Siegrid / Hage-Ahmed, Karin

    Postharvest Biology and Technology. , p.112312-

    2023  , Page(s) 112312–

    Abstract: Fusarium proliferatum as well as F. oxysporum are pathogens with a broad host range that includes garlic (Allium sativum). The losses of garlic due to these pathogens increased over the last years. Especially F. proliferatum was identified several times ... ...

    Abstract Fusarium proliferatum as well as F. oxysporum are pathogens with a broad host range that includes garlic (Allium sativum). The losses of garlic due to these pathogens increased over the last years. Especially F. proliferatum was identified several times as the main cause of postharvest dry rot. This species is also known to produce mycotoxins, especially fumonisins. In this study, we aimed to identify and study the phylogeny of the Fusarium species diversity in garlic planting as well as stored material from two cultivars over two seasons. In addition, we surveyed the secondary metabolite production of the isolates obtained from this experimental design as well as in stored garlic intended for consumption. A total of 85 isolates were examined of which 84% were identified as F. proliferatum. The distribution of the two species was similar for both seasons. In the phylogeny, no influence of season, planting material or stored garlic or cultivar could be detected. In contrast, an influence of the origin of the isolates on the broad spectrum of secondary metabolites could be demonstrated. The isolates showed strong production of fumonisins and other Fusarium metabolites in vitro. 25% of the commercial garlic bulbs were contaminated with low levels of fumonisin, while 88% were contaminated with moniliformin. Our results might indicate, that moniliformin plays a role in pathogenesis.
    Keywords Allium sativum ; Fusarium proliferatum ; cultivars ; experimental design ; fumonisins ; garlic ; host range ; pathogenesis ; phylogeny ; secondary metabolites ; species diversity ; technology ; emerging mycotoxins ; dry rot ; Fusarium oxysporum
    Language English
    Publishing place Elsevier B.V.
    Document type Article ; Online
    Note Pre-press version
    ZDB-ID 1082798-5
    ISSN 1873-2356 ; 0925-5214
    ISSN (online) 1873-2356
    ISSN 0925-5214
    DOI 10.1016/j.postharvbio.2023.112312
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    In stock of ZB MED Bonn / Germany

    Z 5311: Show issues

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  3. Article ; Online: A reply to 'Alteration of steroidogenesis in boys with autism spectrum disorders'.

    Gasser, Benedikt Andreas / Kurz, Johann / Dick, Bernhard / Mohaupt, Markus Georg

    Translational psychiatry

    2021  Volume 11, Issue 1, Page(s) 278

    MeSH term(s) Autism Spectrum Disorder ; Humans ; Male ; Sex Factors
    Language English
    Publishing date 2021-05-10
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2609311-X
    ISSN 2158-3188 ; 2158-3188
    ISSN (online) 2158-3188
    ISSN 2158-3188
    DOI 10.1038/s41398-021-01393-9
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  4. Article ; Online: How Is CYP17A1 Activity Altered in Autism? A Pilot Study to Identify Potential Pharmacological Targets

    Benedikt Andreas Gasser / Johann Kurz / Bernhard Dick / Markus Georg Mohaupt

    Life, Vol 12, Iss 867, p

    2022  Volume 867

    Abstract: Background: Increasing evidence exists that higher levels of androgens can be found in individuals with autism. Evidence yields to a susceptible role of Cytochrome P450 17A1 (CYP17A1) with its catalyzation of the two distinct types of substrate oxidation ...

    Abstract Background: Increasing evidence exists that higher levels of androgens can be found in individuals with autism. Evidence yields to a susceptible role of Cytochrome P450 17A1 (CYP17A1) with its catalyzation of the two distinct types of substrate oxidation by a hydroxylase activity (17-alpha hydroxylase) and C17/20 lyase activity. However, to what extent steps are altered in affected children with autism versus healthy controls remains to be elucidated. Methods: Urine samples from 48 boys with autism (BMI 19.1 ± 0.6 kg/m 2 , age 14.2 ± 0.5 years) and a matched cohort of 48 healthy boys (BMI 18.6 ± 0.3 kg/m 2 , 14.3 ± 0.5 years) as well as 16 girls with autism (BMI 17.5 ± 0.7 kg/m 2 , age 13.8 ± 1.0 years) and a matched cohort of 16 healthy girls (BMI 17.2 ± 0.8 kg/m 2 , age 13.2 ± 0.8 years) were analyzed for steroid hormone metabolites by gas chromatography-mass spectrometry. Results: The activity of 17-alpha Hydroxylase increased by almost 50%, whereas activity of 17/20 Lyase activity increased by around 150% in affected children with autism. Furthermore, the concentration of Cortisol was higher as compared to the average increase of the three metabolites TH-Corticosterone, 5α-TH-Corticosterone and TH-11β-DH-Corticosterone, indicating, in addition, a stimulation by the CRH-ACTH system despite a higher enzymatic activity. Discussion: As it was shown that oxidative stress increases the 17/20-lyase activity via p38α, a link between higher steroid hormone levels and oxidative stress can be established. However, as glucocorticoid as well as androgen metabolites showed higher values in subjects affected with autism as compared to healthy controls, the data indicate, despite higher CYP17A1 activity, the presence of increased substrate availability in line with the Cholesterol theory of autism.
    Keywords DHEA ; androsterone ; etiocholanolone ; tetrahydrocorticosterone ; Science ; Q
    Subject code 333
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: A Luminescent NOTA-Based Terbium(III) "Turn-Off" Sensor for Copper.

    Clerc, Michèle / Heinemann, Franz / Spingler, Bernhard / Gasser, Gilles

    Inorganic chemistry

    2019  Volume 59, Issue 1, Page(s) 669–677

    Abstract: A bimacrocyclic luminescent terbium(III) sensor is reported for the selective "turn-off" detection of ... ...

    Abstract A bimacrocyclic luminescent terbium(III) sensor is reported for the selective "turn-off" detection of Cu
    Language English
    Publishing date 2019-12-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.9b02934
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  6. Article ; Online: Stand-off Hyperspectral Raman Imaging and Random Decision Forest Classification: A Potent Duo for the Fast, Remote Identification of Explosives.

    Gasser, Christoph / Göschl, Michael / Ofner, Johannes / Lendl, Bernhard

    Analytical chemistry

    2019  Volume 91, Issue 12, Page(s) 7712–7718

    Abstract: In this study, we present a stand-off hyperspectral Raman imager (HSRI) for the fast detection and classification of different explosives at a distance of 15 m. The hyperspectral image cube is created by using a liquid crystal tunable filter (LCTF) to ... ...

    Abstract In this study, we present a stand-off hyperspectral Raman imager (HSRI) for the fast detection and classification of different explosives at a distance of 15 m. The hyperspectral image cube is created by using a liquid crystal tunable filter (LCTF) to select a specific Raman shift and sequentially imaging spectral images onto an intensified CCD camera. The laser beam is expanded to illuminate the field of view of the HSRI and thereby improves large area scanning of suspicious surfaces. The collected hyperspectral image cube (HSI) is evaluated and classified using a random decision forest (RDF) algorithm. The RDF is trained with a training set of mg-amounts of different explosives, i.e., TNT, RDX, PETN, NaClO
    Language English
    Publishing date 2019-06-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.9b00890
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4033: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Steroid Metabolites Support Evidence of Autism as a Spectrum.

    Gasser, Benedikt Andreas / Kurz, Johann / Dick, Bernhard / Mohaupt, Markus Georg

    Behavioral sciences (Basel, Switzerland)

    2019  Volume 9, Issue 5

    Abstract: ... ...

    Abstract Objectives
    Language English
    Publishing date 2019-05-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651997-5
    ISSN 2076-328X
    ISSN 2076-328X
    DOI 10.3390/bs9050052
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  8. Article: Are Steroid Hormones Dysregulated in Autistic Girls?

    Gasser, Benedikt Andreas / Kurz, Johann / Dick, Bernhard / Mohaupt, Markus Georg

    Diseases (Basel, Switzerland)

    2020  Volume 8, Issue 1

    Abstract: Evidence of altered cholesterol and steroid hormones in autism is increasing. However, as boys are more often affected, evidence mainly relates to autistic males, whereas evidence for affected autistic girls is sparse. Therefore, a comprehensive gas ... ...

    Abstract Evidence of altered cholesterol and steroid hormones in autism is increasing. However, as boys are more often affected, evidence mainly relates to autistic males, whereas evidence for affected autistic girls is sparse. Therefore, a comprehensive gas chromatography mass spectrometry-based steroid hormone metabolite analysis was conducted from autistic girls. Results show increased levels of several steroid hormones, especially in the class of androgens in autistic girls such as testosterone or androstenediol. The increase of the majority of steroid hormones in autistic girls is probably best explained multifactorially by a higher substrate provision in line with the previously developed cholesterol hypothesis of autism.
    Language English
    Publishing date 2020-03-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720869-2
    ISSN 2079-9721
    ISSN 2079-9721
    DOI 10.3390/diseases8010006
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  9. Article: Stand-off Hyperspectral Raman Imaging and Random Decision Forest Classification: A Potent Duo for the Fast, Remote Identification of Explosives

    Gasser, Christoph / Göschl, Michael / Lendl, Bernhard / Ofner, Johannes

    Analytical chemistry. 2019 May 13, v. 91, no. 12

    2019  

    Abstract: In this study, we present a stand-off hyperspectral Raman imager (HSRI) for the fast detection and classification of different explosives at a distance of 15 m. The hyperspectral image cube is created by using a liquid crystal tunable filter (LCTF) to ... ...

    Abstract In this study, we present a stand-off hyperspectral Raman imager (HSRI) for the fast detection and classification of different explosives at a distance of 15 m. The hyperspectral image cube is created by using a liquid crystal tunable filter (LCTF) to select a specific Raman shift and sequentially imaging spectral images onto an intensified CCD camera. The laser beam is expanded to illuminate the field of view of the HSRI and thereby improves large area scanning of suspicious surfaces. The collected hyperspectral image cube (HSI) is evaluated and classified using a random decision forest (RDF) algorithm. The RDF is trained with a training set of mg-amounts of different explosives, i.e., TNT, RDX, PETN, NaClO3, and NH4NO3, on an artificial aluminum substrate. The resulting classification is validated, and variable importance is used to optimize the RDF using spectral descriptors, effectively reducing the dimensionality of the data set. Using the gained information, a faster acquisition and calculation mode can be designed, giving improved results in classification at a much higher repetition rate.
    Keywords algorithms ; aluminum ; ammonium nitrate ; cameras ; data collection ; explosives ; hyperspectral imagery ; liquid crystals ; Raman imaging ; sodium chlorate ; trinitrotoluene
    Language English
    Dates of publication 2019-0513
    Size p. 7712-7718.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.9b00890
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 4' 52/94: Show issues
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  10. Article ; Online: Are Steroid Hormones Dysregulated in Autistic Girls?

    Benedikt Andreas Gasser / Johann Kurz / Bernhard Dick / Markus Georg Mohaupt

    Diseases, Vol 8, Iss 1, p

    2020  Volume 6

    Abstract: Evidence of altered cholesterol and steroid hormones in autism is increasing. However, as boys are more often affected, evidence mainly relates to autistic males, whereas evidence for affected autistic girls is sparse. Therefore, a comprehensive gas ... ...

    Abstract Evidence of altered cholesterol and steroid hormones in autism is increasing. However, as boys are more often affected, evidence mainly relates to autistic males, whereas evidence for affected autistic girls is sparse. Therefore, a comprehensive gas chromatography mass spectrometry-based steroid hormone metabolite analysis was conducted from autistic girls. Results show increased levels of several steroid hormones, especially in the class of androgens in autistic girls such as testosterone or androstenediol. The increase of the majority of steroid hormones in autistic girls is probably best explained multifactorially by a higher substrate provision in line with the previously developed cholesterol hypothesis of autism.
    Keywords gas chromatography-mass spectrometry ; cholesterol ; 21-hydroxylase ; Medicine ; R
    Language English
    Publishing date 2020-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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