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  1. Article ; Online: Risk of pneumonia associated with proton pump inhibitor use.

    Watanabe, Kenta / Iijima, Katsunori

    Journal of gastroenterology

    2023  Volume 58, Issue 9, Page(s) 945–946

    MeSH term(s) Humans ; Proton Pump Inhibitors/adverse effects ; Pneumonia/epidemiology ; Pneumonia/etiology ; Anti-Ulcer Agents
    Chemical Substances Proton Pump Inhibitors ; Anti-Ulcer Agents
    Language English
    Publishing date 2023-07-16
    Publishing country Japan
    Document type Editorial
    ZDB-ID 1186495-3
    ISSN 1435-5922 ; 0944-1174
    ISSN (online) 1435-5922
    ISSN 0944-1174
    DOI 10.1007/s00535-023-02022-6
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  2. Article: Ceftriaxone-Induced Neutropenia Successfully Treated With Alternative β-Lactam Antibiotics: A Case Report and Review of the Literature.

    Satake, Kana / Iijima, Kenta

    Cureus

    2023  Volume 15, Issue 5, Page(s) e39176

    Abstract: Ceftriaxone-induced neutropenia is a rare and severe adverse effect of the drug. It usually resolves in one to three weeks following the cessation of ceftriaxone and the administration of granulocyte colony-stimulating factor (G-CSF). After neutrophil ... ...

    Abstract Ceftriaxone-induced neutropenia is a rare and severe adverse effect of the drug. It usually resolves in one to three weeks following the cessation of ceftriaxone and the administration of granulocyte colony-stimulating factor (G-CSF). After neutrophil recovery, patients are often treated with non-β-lactam antibiotics instead of ceftriaxone due to the possibility of cross-reactivity associated with β-lactam allergy. However, in some cases, β-lactam antibiotics are superior to non-β-lactam antibiotics. Few cases of the readministration of β-lactam antibiotics for patients who developed ceftriaxone-induced neutropenia have been reported so far. Moreover, its pathogenesis and management have still not been established. We describe a case of successful readministration of β-lactam antibiotics for a patient who had developed ceftriaxone-induced neutropenia. A 37-year-old man with a prosthetic aortic valve was admitted to our hospital with a fever. Blood culture on admission revealed methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia, and transesophageal echocardiography (TEE) showed aortic valve vegetation with multiple septic emboli seen on brain CT. We diagnosed MSSA infective endocarditis with central nervous complications. He underwent an operation and was treated with ceftriaxone. On admission day 28, he developed neutropenia (33/μL), and ceftriaxone-induced neutropenia was suspected. Vancomycin was started instead of ceftriaxone, and his neutrophil count recovered within two weeks with the administration of G-CSF. After recovery, on day 40 of admission, ampicillin sodium was administered instead of vancomycin. Although he developed mild eosinophilia, he did not exhibit neutropenia and was discharged with an amoxicillin prescription on day 60 of admission. Our report suggests the possibility that patients who develop ceftriaxone-induced neutropenia can be treated safely with an alternative β-lactam antibiotic, ampicillin sodium, without causing β-lactam cross-reactivity of neutropenia.
    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.39176
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  3. Article ; Online: Editorial: Comparisons of COVID-19-related disturbance in diagnosis of esophagogastric cancer between the Netherlands and Japan.

    Iijima, Katsunori / Watanabe, Kenta / Shimodaira, Yosuke

    Journal of gastroenterology

    2023  Volume 59, Issue 1, Page(s) 79–80

    MeSH term(s) Humans ; Esophageal Neoplasms/diagnosis ; Esophageal Neoplasms/epidemiology ; Japan/epidemiology ; Netherlands/epidemiology ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/epidemiology ; COVID-19 ; COVID-19 Testing
    Language English
    Publishing date 2023-11-16
    Publishing country Japan
    Document type Editorial
    ZDB-ID 1186495-3
    ISSN 1435-5922 ; 0944-1174
    ISSN (online) 1435-5922
    ISSN 0944-1174
    DOI 10.1007/s00535-023-02056-w
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  4. Article ; Online: The risk of antibiotics and enterocolitis for the development of inflammatory bowel disease: a Japanese administrative database analysis.

    Shimodaira, Yosuke / Watanabe, Kenta / Iijima, Katsunori

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 7604

    Abstract: Previous studies have shown that antibiotic use and enterocolitis increase the risk of developing inflammatory bowel disease (IBD) in western countries. However, these risk factors have not yet been identified in Asian populations. This study aimed to ... ...

    Abstract Previous studies have shown that antibiotic use and enterocolitis increase the risk of developing inflammatory bowel disease (IBD) in western countries. However, these risk factors have not yet been identified in Asian populations. This study aimed to investigate the risk of IBD development associated with antibiotic use and enterocolitis in Japan. A Japanese health insurance claims database was used to identify patients recently diagnosed with Crohn's disease (CD) and ulcerative colitis (UC) along with five matched participants without IBD. Episodes of antibiotic use and enterocolitis for 1 and 2 years before the date of diagnosis were analyzed using a conditional regression test. A total of 371 patients with CD and 2420 with UC were included. The adjusted odds ratio (AOR) increased in association with antibiotic use to 1.61 (95% confidence interval [CI] 1.26-2.05) and 1.20 (95% CI 1.09-1.31) and enterocolitis to 3.40 (95% CI 2.60-4.44) and 2.14 (95% CI 1.88-2.43) in 1 year in CD and UC, respectively. The risk associated with antibiotics was independent of the number or type of antibiotics, and the risk associated with enterocolitis did not differ with the pathogen that caused the disease. However, prior exposure to antibiotic use and enterocolitis was associated with an increased risk of developing IBD.
    MeSH term(s) Anti-Bacterial Agents/adverse effects ; Case-Control Studies ; Chronic Disease ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/epidemiology ; Crohn Disease/chemically induced ; Crohn Disease/drug therapy ; Crohn Disease/epidemiology ; Enterocolitis/chemically induced ; Enterocolitis/epidemiology ; Humans ; Inflammatory Bowel Diseases/chemically induced ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/epidemiology ; Japan/epidemiology ; Risk Factors
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-05-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-11646-2
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  5. Article ; Online: The risk of antibiotics and enterocolitis for the development of inflammatory bowel disease

    Yosuke Shimodaira / Kenta Watanabe / Katsunori Iijima

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    a Japanese administrative database analysis

    2022  Volume 8

    Abstract: Abstract Previous studies have shown that antibiotic use and enterocolitis increase the risk of developing inflammatory bowel disease (IBD) in western countries. However, these risk factors have not yet been identified in Asian populations. This study ... ...

    Abstract Abstract Previous studies have shown that antibiotic use and enterocolitis increase the risk of developing inflammatory bowel disease (IBD) in western countries. However, these risk factors have not yet been identified in Asian populations. This study aimed to investigate the risk of IBD development associated with antibiotic use and enterocolitis in Japan. A Japanese health insurance claims database was used to identify patients recently diagnosed with Crohn’s disease (CD) and ulcerative colitis (UC) along with five matched participants without IBD. Episodes of antibiotic use and enterocolitis for 1 and 2 years before the date of diagnosis were analyzed using a conditional regression test. A total of 371 patients with CD and 2420 with UC were included. The adjusted odds ratio (AOR) increased in association with antibiotic use to 1.61 (95% confidence interval [CI] 1.26–2.05) and 1.20 (95% CI 1.09–1.31) and enterocolitis to 3.40 (95% CI 2.60–4.44) and 2.14 (95% CI 1.88–2.43) in 1 year in CD and UC, respectively. The risk associated with antibiotics was independent of the number or type of antibiotics, and the risk associated with enterocolitis did not differ with the pathogen that caused the disease. However, prior exposure to antibiotic use and enterocolitis was associated with an increased risk of developing IBD.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Disproportionate cancer worries in ultra-short-segment Barrett's esophagus in Japan.

    Fukuda, Sho / Watanabe, Kenta / Takahashi, So / Yoshida, Tatsuki / Fujimori, Shusei / Komatsu, Taiga / Shimodaira, Yosuke / Matsuhashi, Tamotsu / Iijima, Katsunori

    DEN open

    2024  Volume 4, Issue 1, Page(s) e329

    Abstract: Objectives: Although Barrett's esophagus (BE), especially ultra-short-segment BE (USSBE), is very frequently diagnosed in Japan, how subjects feel about receiving a diagnosis of BE is unclear. We therefore prospectively investigated cancer worry in ... ...

    Abstract Objectives: Although Barrett's esophagus (BE), especially ultra-short-segment BE (USSBE), is very frequently diagnosed in Japan, how subjects feel about receiving a diagnosis of BE is unclear. We therefore prospectively investigated cancer worry in subjects who received a BE diagnosis.
    Methods: Self-administered questionnaires were sent to subjects who were diagnosed with BE at three health checkup institutes in Akita Prefecture, Japan. The cancer worry scale (CWS) was used to quantitatively assess the fear of developing cancer. The BE subjects were classified into USSBE <1 cm and non-USSBE ≥1 cm groups. Factors associated with the CWS were investigated using logistic regression analyses.
    Results: A total of 325 (31%) subjects, comprising 229 USSBE and 96 non-USSBE patients were included in this study. Compared with the USSBE group, the non-USSBE group had a significantly higher frequency of a history of a BE diagnosis and perception of carcinogenesis. However, the CWS was similar between the USSBE and non-USSBE groups, with a median CWS of 12.5 (3.75) versus 12.7 (3.65). A multivariate logistic regression analysis revealed that while positive reflux symptoms were significantly associated with a positive CWS, the BE length was not significantly associated with it, with an odds ratio (95% confidence interval) of 1.3 (0.75-2.2).
    Conclusions: A BE diagnosis promotes a similar level of worry about cancer among subjects, irrespective of the length of BE. In Japan, since USSBE poses a much lower cancer risk than non-USSBE, the former may frequently be associated with a disproportionate cancer worry relative to the latter. (UMIN000044010).
    Language English
    Publishing date 2024-01-13
    Publishing country Australia
    Document type Journal Article
    ISSN 2692-4609
    ISSN (online) 2692-4609
    DOI 10.1002/deo2.329
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  7. Article ; Online: Impact of Functional Status on Development of Clostridioides difficile Infection and Increase in Inhospital Mortality among Antibiotic Users.

    Watanabe, Kenta / Tsuji, Tsuyotoshi / Saruta, Yohei / Matsuzawa, Hisanori / Shimodaira, Yosuke / Iijima, Katsunori

    Digestion

    2023  Volume 105, Issue 2, Page(s) 131–139

    Abstract: Introduction: Functional status is one of the surrogates of advanced age, an established risk factor for Clostridioides difficile infection (CDI). We aimed to investigate the usefulness of functional status in the clinical management of CDI.: Methods!# ...

    Abstract Introduction: Functional status is one of the surrogates of advanced age, an established risk factor for Clostridioides difficile infection (CDI). We aimed to investigate the usefulness of functional status in the clinical management of CDI.
    Methods: We enrolled all hospitalized adult patients receiving antibiotics from a retrospective hospital-based cohort in Japan between 2016 and 2020. Using the Barthel index (BI), which is an objective scale of functional status, we investigated the association of BI with developing CDI and its impact on inhospital mortality in patients with CDI.
    Results: We enrolled 17,131 patients with 100 cases of CDI. Multivariable analysis revealed that lower BI (≤25) was an independent risk factor for developing CDI (adjusted odds ratio, 4.11; 95% confidence interval, 2.62-6.46). Furthermore, a combination of BI and Charlson comorbidity index (CCI) showed an adjusted odds ratio of 36.40 (95% confidence interval, 17.30-76.60) in the highest risk group. A high-risk group according to the combination of BI and CCI was estimated to have significantly higher inhospital mortality in patients with CDI using the Kaplan-Meier method (p = 0.017). A combination of lower BI and higher CCI was an independent predictor of inhospital mortality even in the multivariable Cox regression model (adjusted hazard ratio, 3.00; 95% confidence interval, 1.01-8.88).
    Conclusions: Assessment of functional status, especially combined with comorbidities, was significantly associated with developing CDI and may also be useful in predicting inhospital mortality.
    MeSH term(s) Adult ; Humans ; Anti-Bacterial Agents/therapeutic use ; Hospital Mortality ; Retrospective Studies ; Functional Status ; Clostridium Infections/epidemiology
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-11-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1712-7
    ISSN 1421-9867 ; 0012-2823
    ISSN (online) 1421-9867
    ISSN 0012-2823
    DOI 10.1159/000535306
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  8. Article ; Online: A Final Report on the Real Impact of the COVID-19 Pandemic on the Diagnosis of Gastrointestinal Cancer in Akita Prefecture, Japan in 2022.

    Iijima, Katsunori / Watanabe, Kenta / Shimodaira, Yosuke / Koizumi, Shigeto / Fukuda, Sho / Yoshida, Tatsuki / Ookubo, Ryo / Matsuhashi, Tamotsu / Jin, Mario / Miura, Masahito / Shibata, Hiroyuki

    The Tohoku journal of experimental medicine

    2024  

    Language English
    Publishing date 2024-04-25
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 123477-8
    ISSN 1349-3329 ; 0040-8727
    ISSN (online) 1349-3329
    ISSN 0040-8727
    DOI 10.1620/tjem.2024.J025
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  9. Article ; Online: Successful

    Takabayashi, Shuji / Iijima, Kenta / Tsujimura, Masumi / Aoshima, Takuya / Takagi, Hisayoshi / Aoto, Kazushi / Sato, Masahiro

    International journal of molecular sciences

    2022  Volume 23, Issue 18

    Abstract: Improved genome editing via oviductal nucleic acids delivery ( ...

    Abstract Improved genome editing via oviductal nucleic acids delivery (
    MeSH term(s) Animals ; CRISPR-Cas Systems ; Electroporation/methods ; Female ; Gene Editing/methods ; Gonads ; Humans ; Hyaluronoglucosaminidase/genetics ; Mammals/genetics ; Mice ; Nucleic Acids ; Oviducts ; Pregnancy ; Rats ; Ribonucleoproteins/genetics ; Zygote
    Chemical Substances Nucleic Acids ; Ribonucleoproteins ; Hyaluronoglucosaminidase (EC 3.2.1.35)
    Language English
    Publishing date 2022-09-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms231810678
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  10. Article: Rare-earth ions as antibacterial agents for woven wool fabric.

    Akioka, Shota / Hirai, Shinji / Iijima, Kenta / Hirai, Akihiro / Alharbi, Mohammed Abdullah Hamad

    Chemicke zvesti

    2022  Volume 76, Issue 6, Page(s) 3557–3567

    Abstract: Woven fabrics were bestowed with antibacterial property by the simple adsorption of rare-earth metal ions, and the underlying mechanism was investigated using electron spin resonance (ESR) spectroscopy. The adsorption of Ce: Supplementary information: ...

    Abstract Woven fabrics were bestowed with antibacterial property by the simple adsorption of rare-earth metal ions, and the underlying mechanism was investigated using electron spin resonance (ESR) spectroscopy. The adsorption of Ce
    Supplementary information: The online version contains supplementary material available at 10.1007/s11696-021-01999-9.
    Language English
    Publishing date 2022-02-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2252770-9
    ISSN 1336-9075 ; 0366-6352
    ISSN (online) 1336-9075
    ISSN 0366-6352
    DOI 10.1007/s11696-021-01999-9
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