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  1. Article ; Online: Microbiota-driven mechanisms at different stages of cancer development.

    Ivleva, Elena A / Grivennikov, Sergei I

    Neoplasia (New York, N.Y.)

    2022  Volume 32, Page(s) 100829

    Abstract: A myriad of microbes living together with the host constitutes the microbiota, and the microbiota exerts very diverse functions in the regulation of host physiology. Microbiota regulates cancer initiation, progression, metastasis, and responses to ... ...

    Abstract A myriad of microbes living together with the host constitutes the microbiota, and the microbiota exerts very diverse functions in the regulation of host physiology. Microbiota regulates cancer initiation, progression, metastasis, and responses to therapy. Here we review known pro-tumorigenic and anti-tumorigenic functions of microbiota, and mechanisms of how microbes can shape tumor microenvironment and affect cancer cells as well as activation and functionality of immune and stromal cells within the tumor. While some of these mechanisms are distal, often distinct members of microbiota travel with and establish colonization with the tumors in the distant organs. We further briefly describe recent findings regarding microbiota composition in metastasis and highlight important future directions and considerations for the manipulation of microbiota for cancer treatment.
    MeSH term(s) Carcinogenesis ; Humans ; Microbiota ; Neoplasms ; Tumor Microenvironment
    Language English
    Publishing date 2022-08-04
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1483840-0
    ISSN 1476-5586 ; 1522-8002
    ISSN (online) 1476-5586
    ISSN 1522-8002
    DOI 10.1016/j.neo.2022.100829
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Inflammation and Cancer: Triggers, Mechanisms, and Consequences.

    Greten, Florian R / Grivennikov, Sergei I

    Immunity

    2019  Volume 51, Issue 1, Page(s) 27–41

    Abstract: Inflammation predisposes to the development of cancer and promotes all stages of tumorigenesis. Cancer cells, as well as surrounding stromal and inflammatory cells, engage in well-orchestrated reciprocal interactions to form an inflammatory tumor ... ...

    Abstract Inflammation predisposes to the development of cancer and promotes all stages of tumorigenesis. Cancer cells, as well as surrounding stromal and inflammatory cells, engage in well-orchestrated reciprocal interactions to form an inflammatory tumor microenvironment (TME). Cells within the TME are highly plastic, continuously changing their phenotypic and functional characteristics. Here, we review the origins of inflammation in tumors, and the mechanisms whereby inflammation drives tumor initiation, growth, progression, and metastasis. We discuss how tumor-promoting inflammation closely resembles inflammatory processes typically found during development, immunity, maintenance of tissue homeostasis, or tissue repair and illuminate the distinctions between tissue-protective and pro-tumorigenic inflammation, including spatiotemporal considerations. Defining the cornerstone rules of engagement governing molecular and cellular mechanisms of tumor-promoting inflammation will be essential for further development of anti-cancer therapies.
    MeSH term(s) Animals ; Autoimmunity ; Carcinogenesis ; Chronic Disease ; Homeostasis ; Humans ; Infections/immunology ; Inflammation ; Neoplasms/immunology ; Neovascularization, Pathologic ; Tumor Microenvironment ; Wound Healing
    Language English
    Publishing date 2019-07-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2019.06.025
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  3. Article ; Online: Microbiota and cancer: a complex equation with a lot of exciting unknowns.

    Dmitrieva, Oxana / Grivennikov, Sergei I

    Seminars in immunology

    2018  Volume 32, Page(s) 1–2

    MeSH term(s) Animals ; Carcinogenesis ; Homeostasis ; Humans ; Inflammation/microbiology ; Microbiota/immunology ; Neoplasms/microbiology ; Tumor Microenvironment
    Language English
    Publishing date 2018-03-13
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1018141-6
    ISSN 1096-3618 ; 1044-5323
    ISSN (online) 1096-3618
    ISSN 1044-5323
    DOI 10.1016/j.smim.2017.10.003
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  4. Article ; Online: LTα, TNF, and ILC3 in Peyer's Patch Organogenesis.

    Gogoleva, Violetta S / Kuprash, Dmitry V / Grivennikov, Sergei I / Tumanov, Alexei V / Kruglov, Andrey A / Nedospasov, Sergei A

    Cells

    2022  Volume 11, Issue 12

    Abstract: TNF and LTα are structurally related cytokines of the TNF superfamily. Their genes are located in close proximity to each other and to ... ...

    Abstract TNF and LTα are structurally related cytokines of the TNF superfamily. Their genes are located in close proximity to each other and to the
    MeSH term(s) Animals ; Lymphoid Tissue ; Lymphotoxin-alpha ; Mice ; Mice, Knockout ; Organogenesis/genetics ; Peyer's Patches ; Tumor Necrosis Factors/metabolism
    Chemical Substances Lymphotoxin-alpha ; Tumor Necrosis Factors
    Language English
    Publishing date 2022-06-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11121970
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  5. Article ; Online: Microbiome in cancer progression and therapy.

    Andreeva, Natalia V / Gabbasova, Railia R / Grivennikov, Sergei I

    Current opinion in microbiology

    2020  Volume 56, Page(s) 118–126

    Abstract: A myriad of microbes living together with the host constitute microbiota, which possesses very diverse functions in regulation of host physiology. Recently, it has been unequivocally demonstrated that microbiota regulates cancer initiation, progression ... ...

    Abstract A myriad of microbes living together with the host constitute microbiota, which possesses very diverse functions in regulation of host physiology. Recently, it has been unequivocally demonstrated that microbiota regulates cancer initiation, progression and responses to therapy. Here we review known pro-tumorigenic and anti-tumorigenic function of microbiota and mechanisms how microbes can regulate cancer cells and immune and stromal cells within the tumor microenvironment.
    MeSH term(s) Animals ; Disease Progression ; Humans ; Immune System/immunology ; Microbiota ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/microbiology ; Neoplasms/therapy ; Tumor Microenvironment
    Language English
    Publishing date 2020-11-02
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 1418474-6
    ISSN 1879-0364 ; 1369-5274
    ISSN (online) 1879-0364
    ISSN 1369-5274
    DOI 10.1016/j.mib.2020.09.001
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    Zs.MG 51: Show issues

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  6. Article ; Online: IL-11: a prominent pro-tumorigenic member of the IL-6 family.

    Grivennikov, Sergei I

    Cancer cell

    2013  Volume 24, Issue 2, Page(s) 145–147

    Abstract: Cytokines have recently emerged as important players in tumor promotion and progression. In this issue of Cancer Cell, Putoczki and colleagues report the importance of interleukin 11 in a variety of gastrointestinal malignances and lay down a framework ... ...

    Abstract Cytokines have recently emerged as important players in tumor promotion and progression. In this issue of Cancer Cell, Putoczki and colleagues report the importance of interleukin 11 in a variety of gastrointestinal malignances and lay down a framework for its potential inhibition in a variety of human cancers.
    MeSH term(s) Animals ; Cell Transformation, Neoplastic/immunology ; Gastrointestinal Neoplasms/immunology ; Humans ; Interleukin-11/metabolism ; Interleukin-6/metabolism
    Chemical Substances Interleukin-11 ; Interleukin-6
    Language English
    Publishing date 2013-07-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2078448-X
    ISSN 1878-3686 ; 1535-6108
    ISSN (online) 1878-3686
    ISSN 1535-6108
    DOI 10.1016/j.ccr.2013.07.018
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    Zs.MG 104: Show issues

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  7. Article ; Online: LTα, TNF, and ILC3 in Peyer’s Patch Organogenesis

    Violetta S. Gogoleva / Dmitry V. Kuprash / Sergei I. Grivennikov / Alexei V. Tumanov / Andrey A. Kruglov / Sergei A. Nedospasov

    Cells, Vol 11, Iss 1970, p

    2022  Volume 1970

    Abstract: TNF and LTα are structurally related cytokines of the TNF superfamily. Their genes are located in close proximity to each other and to the Ltb gene within the TNF/LT locus inside MHC. Unlike Ltb , transcription of Tnf and of Lta is tightly controlled, ... ...

    Abstract TNF and LTα are structurally related cytokines of the TNF superfamily. Their genes are located in close proximity to each other and to the Ltb gene within the TNF/LT locus inside MHC. Unlike Ltb , transcription of Tnf and of Lta is tightly controlled, with the Tnf gene being an immediate early gene that is rapidly induced in response to various inflammatory stimuli. Genes of the TNF/LT locus play a crucial role in lymphoid tissue organogenesis, although some aspects of their specific contribution remain controversial. Here, we present new findings and discuss the distinct contribution of TNF produced by ILC3 cells to Peyer’s patch organogenesis.
    Keywords TNF ; lymphotoxin ; Peyer’s patches ; lymphoid tissue organogenesis ; innate lymphoid cells ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Inflammation and colorectal cancer: colitis-associated neoplasia.

    Grivennikov, Sergei I

    Seminars in immunopathology

    2012  Volume 35, Issue 2, Page(s) 229–244

    Abstract: Connection between inflammation and cancer is a rapidly developing field. Epidemiological data suggests that inflammation along with distinct arms of host immune system plays a very important role in the development and progression of many different ... ...

    Abstract Connection between inflammation and cancer is a rapidly developing field. Epidemiological data suggests that inflammation along with distinct arms of host immune system plays a very important role in the development and progression of many different cancers. Inflammatory bowel disease (IBD) is an important risk factor for the development of colon cancer, namely, colitis-associated cancer (CAC). The molecular mechanisms by which inflammation promotes cancer development are still being uncovered and may differ between CAC and other forms of colorectal cancer. Recent work has shed light on the role of distinct immune cells, cytokines, and other immune mediators in virtually all of the steps of colonic tumorigenesis, including tumor initiation and promotion as well as progression and metastasis. The close proximity of colonic tumors to the myriad of intestinal microbes, as well as instrumental role of microbiota in IBD, introduces microbes as new players capable of triggering inflammation and possibly promoting tumorigenesis. Various mechanisms of CAC tumorigenesis as well as new possible hints for the future approaches for prevention and therapy are discussed in this review.
    MeSH term(s) Animals ; Colitis/complications ; Colitis/metabolism ; Colitis/microbiology ; Colitis/pathology ; Colitis/therapy ; Colonic Neoplasms/etiology ; Colonic Neoplasms/metabolism ; Colonic Neoplasms/microbiology ; Colonic Neoplasms/pathology ; Colonic Neoplasms/prevention & control ; Humans ; Inflammatory Bowel Diseases/complications ; Inflammatory Bowel Diseases/metabolism ; Inflammatory Bowel Diseases/microbiology ; Inflammatory Bowel Diseases/pathology ; Inflammatory Bowel Diseases/therapy ; Rectal Neoplasms/etiology ; Rectal Neoplasms/metabolism ; Rectal Neoplasms/microbiology ; Rectal Neoplasms/pathology ; Rectal Neoplasms/prevention & control ; Risk Factors
    Language English
    Publishing date 2012-11-16
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2316828-6
    ISSN 1863-2300 ; 1863-2297
    ISSN (online) 1863-2300
    ISSN 1863-2297
    DOI 10.1007/s00281-012-0352-6
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  9. Article ; Online: Colitis-Associated and Sporadic Colon Cancers: Different Diseases, Different Mutations?

    Grivennikov, Sergei I / Cominelli, Fabio

    Gastroenterology

    2016  Volume 150, Issue 4, Page(s) 808–810

    MeSH term(s) Biomarkers, Tumor/genetics ; Cell Transformation, Neoplastic/genetics ; Colitis, Ulcerative/genetics ; Colorectal Neoplasms/genetics ; Crohn Disease/genetics ; DNA Mutational Analysis ; Exome ; Humans ; Mutation
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2016-02-26
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2016.02.062
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  10. Article: Loss of Pkd1 limits susceptibility to colitis and colorectal cancer.

    Nikonova, Anna S / Deneka, Alexander Y / Silva, Flaviane N / Pirestani, Shabnam / Tricarico, Rossella / Kiseleva, Anna A / Zhou, Yan / Nicolas, Emmanuelle / Flieder, Douglas B / Grivennikov, Sergei I / Golemis, Erica A

    Oncogenesis

    2023  Volume 12, Issue 1, Page(s) 40

    Abstract: Colorectal cancer (CRC) is one of the most common cancers, with an annual incidence of ~135,000 in the US, associated with ~50,000 deaths. Autosomal dominant polycystic kidney disease (ADPKD), associated with mutations disabling the PKD1 gene, affects as ...

    Abstract Colorectal cancer (CRC) is one of the most common cancers, with an annual incidence of ~135,000 in the US, associated with ~50,000 deaths. Autosomal dominant polycystic kidney disease (ADPKD), associated with mutations disabling the PKD1 gene, affects as many as 1 in 1000. Intriguingly, some studies have suggested that individuals with germline mutations in PKD1 have reduced incidence of CRC, suggesting a genetic modifier function. Using mouse models, we here establish that loss of Pkd1 greatly reduces CRC incidence and tumor growth induced by loss of the tumor suppressor Apc. Growth of Pkd1
    Language English
    Publishing date 2023-08-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2674437-5
    ISSN 2157-9024
    ISSN 2157-9024
    DOI 10.1038/s41389-023-00486-y
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