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  1. Article: Antiretroviral drug-drug interactions in an era of polypharmacy.

    Back, David

    Germs

    2019  Volume 9, Issue 3, Page(s) 123–124

    Language English
    Publishing date 2019-09-02
    Publishing country Romania
    Document type Editorial
    ZDB-ID 2649305-6
    ISSN 2248-2997
    ISSN 2248-2997
    DOI 10.18683/germs.2019.1166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cardio-ankle vascular index predicts postoperative atrial fibrillation after cardiac surgery.

    Plunde, Oscar / Hupin, David / Franco-Cereceda, Anders / Bäck, Magnus

    European heart journal open

    2023  Volume 3, Issue 3, Page(s) oead042

    Language English
    Publishing date 2023-05-03
    Publishing country England
    Document type Journal Article
    ISSN 2752-4191
    ISSN (online) 2752-4191
    DOI 10.1093/ehjopen/oead042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Digitalisierung und Telerehabilitation.

    Pförringer, Dominik / Back, David

    Unfallchirurgie (Heidelberg, Germany)

    2022  

    Abstract: Digitalization and digitization are becoming increasingly more important in medicine. Processes are being optimized and data are being digitally recorded, analyzed and archived. Although there is still a comparatively large need to catch up in Germany, ... ...

    Title translation Digitalization and telerehabilitation.
    Abstract Digitalization and digitization are becoming increasingly more important in medicine. Processes are being optimized and data are being digitally recorded, analyzed and archived. Although there is still a comparatively large need to catch up in Germany, we are on a solid transformation path. The establishment of the European Health Data Space (EHDS) in Brussels represents a milestone for the secure exchange of data. Digitalization holds the potential for extensive process optimization. While a large part of the working time of physicians in German is currently consumed by bureaucracy, a relevant part of this can be solved digitally. The digitalization does not replace the physician but plays a supporting role for the benefit of the patient. Numerous routes and the associated transport and logistics costs can be avoided or addressed digitally through digital supplementation and new forms of treatment administration. This conserves resources, saves time and optimizes the care of patients. The openness and affinity of physicians and patients towards the topic significantly depends on digital health literacy, i.e. the understanding and knowledge on the topic. The goal for the coming years is to continually reduce fears and increase acceptance. In addition, relevant investments are needed for the basic technical equipment on the software and hardware side.
    Language German
    Publishing date 2022-12-13
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ISSN 2731-703X
    ISSN (online) 2731-703X
    DOI 10.1007/s00113-022-01257-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Digitalization in orthopaedics: a narrative review.

    Youssef, Yasmin / De Wet, Deana / Back, David A / Scherer, Julian

    Frontiers in surgery

    2024  Volume 10, Page(s) 1325423

    Abstract: Advances in technology and digital tools like the Internet of Things (IoT), artificial intelligence (AI), and sensors are shaping the field of orthopaedic surgery on all levels, from patient care to research and facilitation of logistic processes. ... ...

    Abstract Advances in technology and digital tools like the Internet of Things (IoT), artificial intelligence (AI), and sensors are shaping the field of orthopaedic surgery on all levels, from patient care to research and facilitation of logistic processes. Especially the COVID-19 pandemic, with the associated contact restrictions was an accelerator for the development and introduction of telemedical applications and digital alternatives to classical in-person patient care. Digital applications already used in orthopaedic surgery include telemedical support, online video consultations, monitoring of patients using wearables, smart devices, surgical navigation, robotic-assisted surgery, and applications of artificial intelligence in forms of medical image processing, three-dimensional (3D)-modelling, and simulations. In addition to that immersive technologies like virtual, augmented, and mixed reality are increasingly used in training but also rehabilitative and surgical settings. Digital advances can therefore increase the accessibility, efficiency and capabilities of orthopaedic services and facilitate more data-driven, personalized patient care, strengthening the self-responsibility of patients and supporting interdisciplinary healthcare providers to offer for the optimal care for their patients.
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2023.1325423
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Fulminant Heterotopic Ossification of the Lower Extremity After Gunshot Injury and Blunt Trauma: A Case Report.

    Estel, Katharina / Back, David Alexander / Scheuermann-Poley, Catharina / Willy, Christian

    Military medicine

    2024  

    Abstract: Traumatic heterotopic ossification (HO) of the lower extremity is relatively rare but is of major importance in clinical practice. They are defined as posttraumatic abnormal formations of bone within soft tissue outside of the skeletal system. This ... ...

    Abstract Traumatic heterotopic ossification (HO) of the lower extremity is relatively rare but is of major importance in clinical practice. They are defined as posttraumatic abnormal formations of bone within soft tissue outside of the skeletal system. This article describes the clinical case of a 31-year-old male patient who suffered 2 traumatic events within 12 months-a gunshot wound in the lumbar spine/gluteal region followed by a severe traumatic brain injury with intracranial hemorrhage in a traffic accident as a pedestrian. Clinically, the patient was bedridden because of complete stiffening of the lumbar spine, both hip joints, and the left knee joint. After preoperative diagnosis, 3 surgical ablations of the HO were performed on both the hip joints and the left knee joint. In addition, physiotherapeutic exercise, postoperative nonsteroidal anti-inflammatory drug administration (25 mg of indomethazine for 6 weeks, 3 times a day), and perioperative radiation with 7 Gy for each operation were advised. After 4 years of follow-up, the patient showed significant improvement. In HO treatment, prophylactic local radiotherapy (pre- and postoperative radiation with a local single dose of 7 Gy) and postoperative administration of nonsteroidal anti-inflammatory drugs are often recommended. For therapeutic purposes, surgical resection is still indicated for pronounced cases.
    Language English
    Publishing date 2024-04-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 391061-1
    ISSN 1930-613X ; 0026-4075
    ISSN (online) 1930-613X
    ISSN 0026-4075
    DOI 10.1093/milmed/usae109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: 2-Drug regimens in HIV treatment: pharmacological considerations.

    Back, David

    Germs

    2017  Volume 7, Issue 3, Page(s) 113–114

    Language English
    Publishing date 2017-09-01
    Publishing country Romania
    Document type Editorial
    ZDB-ID 2649305-6
    ISSN 2248-2997
    ISSN 2248-2997
    DOI 10.18683/germs.2017.1115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Kidney Diseases Associated with Human Immunodeficiency Virus Infection.

    Back, David J

    The New England journal of medicine

    2018  Volume 378, Issue 17, Page(s) 1654–1655

    MeSH term(s) HIV Infections ; Humans ; Kidney Diseases
    Language English
    Publishing date 2018--26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1800396
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Letter to the Editor:

    Schuler, Thilo / Currow, David / Clark, Katherine / Back, Michael

    Journal of palliative medicine

    2022  Volume 25, Issue 6, Page(s) 850–851

    MeSH term(s) Caregivers ; Humans ; Neoplasms/complications ; Sleep ; Sleep Wake Disorders/etiology
    Language English
    Publishing date 2022-05-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1427361-5
    ISSN 1557-7740 ; 1096-6218
    ISSN (online) 1557-7740
    ISSN 1096-6218
    DOI 10.1089/jpm.2022.0125
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Professional Social Media Use Among Orthopedic and Trauma Surgeons in Germany: Cross-Sectional Questionnaire-Based Study.

    Youssef, Yasmin / Gehlen, Tobias / Ansorg, Jörg / Back, David Alexander / Scherer, Julian

    JMIR formative research

    2024  Volume 8, Page(s) e53336

    Abstract: Background: Social media (SM) has been recognized as a professional communication tool in the field of orthopedic and trauma surgery that can enhance communication with patients and peers, and increase the visibility of research and offered services. ... ...

    Abstract Background: Social media (SM) has been recognized as a professional communication tool in the field of orthopedic and trauma surgery that can enhance communication with patients and peers, and increase the visibility of research and offered services. The specific purposes of professional SM use and the benefits and concerns among orthopedic and trauma surgeons, however, remain unexplored.
    Objective: This study aims to demonstrate the specific uses of different SM platforms among orthopedic and trauma surgeons in Germany as well as the advantages and concerns.
    Methods: A web-based questionnaire was developed on the use of SM in a professional context by considering the current literature and the authors' topics of interest. The final questionnaire consisted of 33 questions and was distributed among German orthopedic and trauma surgeons via the mail distributor of the Berufsverband für Orthopädie und Unfallchirurgie (Professional Association of Orthopaedic Surgeons in Germany). The study was conducted between June and July 2022. A subgroup analysis was performed for sex (male vs female), age (<60 years vs ≥60 years), and type of workplace (practice vs hospital).
    Results: A total of 208 participants answered the questionnaire (male: n=166, 79.8%; younger than 60 years: n=146, 70.2%). In total, all of the participants stated that they use SM for professional purposes. In contrast, the stated specific uses of SM were low. Overall, the most used platforms were employment-oriented SM, messenger apps, and Facebook. Instagram emerged as a popular choice among female participants and participants working in hospital settings. The highest specific use of SM was for professional networking, followed by receiving and sharing health-related information. The lowest specific use was for education and the acquisition of patients. Conventional websites occupied a dominating position, exceeding the use of SM across all specific uses. The key benefit of SM was professional networking. Under 50% of the participants stated that SM could be used to enhance communication with their patients, keep up-to-date, or increase their professional visibility. In total, 65.5% (112/171) of participants stated that SM use was time-consuming, 43.9% (76/173) stated that they lacked application knowledge, and 45.1% (78/173) stated that they did not know what content to post. Additionally, 52.9% (91/172) mentioned medicolegal concerns.
    Conclusions: Overall, SM did not seem to be used actively in the professional context among orthopedic and trauma surgeons in Germany. The stated advantages were low, while the stated concerns were high. Adequate education and information material are needed to elucidate the possible professional applications of SM and to address legal concerns.
    Language English
    Publishing date 2024-04-19
    Publishing country Canada
    Document type Journal Article
    ISSN 2561-326X
    ISSN (online) 2561-326X
    DOI 10.2196/53336
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The challenge of HIV treatment in an era of polypharmacy.

    Back, David / Marzolini, Catia

    Journal of the International AIDS Society

    2020  Volume 23, Issue 2, Page(s) e25449

    Abstract: Introduction: The availability of potent antiretroviral therapy has transformed HIV infection into a chronic disease such that people living with HIV (PLWH) have a near normal life expectancy. However, there are continuing challenges in managing HIV ... ...

    Abstract Introduction: The availability of potent antiretroviral therapy has transformed HIV infection into a chronic disease such that people living with HIV (PLWH) have a near normal life expectancy. However, there are continuing challenges in managing HIV infection, particularly in older patients, who often experience age-related comorbidities resulting in complex polypharmacy and an increased risk for drug-drug interactions. Furthermore, age-related physiological changes may affect the pharmacokinetics and pharmacodynamics of both antiretrovirals and comedications thereby predisposing elderly to adverse drug reactions. This review provides an overview of the therapeutic challenges when treating elderly PLWH (i.e. >65 years). Particular emphasis is placed on drug-drug interactions and other common prescribing issues (i.e. inappropriate drug use, prescribing cascade, drug-disease interaction) encountered in elderly PLWH.
    Discussion: Prescribing issues are common in elderly PLWH due to the presence of age-related comorbidities, organ dysfunction and physiological changes leading to a higher risk for drug-drug interactions, drugs dosage errors and inappropriate drug use.
    Conclusions: The high prevalence of prescribing issues in elderly PLWH highlights the need for ongoing education on prescribing principles and the optimal management of individual patients. The knowledge of adverse health outcomes associated with polypharmacy and inappropriate prescribing should ensure that there are interventions to prevent harm including medication reconciliation, medication review and medication prioritization according to the risks/benefits for each patient.
    MeSH term(s) Age Factors ; Aged ; Anti-HIV Agents/therapeutic use ; Drug Interactions ; HIV Infections/drug therapy ; Humans ; Inappropriate Prescribing ; Medication Reconciliation ; Polypharmacy
    Chemical Substances Anti-HIV Agents
    Language English
    Publishing date 2020-02-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2467110-1
    ISSN 1758-2652 ; 1758-2652
    ISSN (online) 1758-2652
    ISSN 1758-2652
    DOI 10.1002/jia2.25449
    Database MEDical Literature Analysis and Retrieval System OnLINE

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