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Book ; Thesis: Risikostratifikation bei chronischer Herzinsuffizienz mittels Ergospirometrie

Gitt, Anselm Kai

die anaerobe Schwelle und die ventilatorische Effizienz als Indikatoren für eine hohe Frühmortalität innerhalb 6 Monaten

2002

Author's details	vorgelegt von Anselm Kai Gitt
Language	German
Size	120 Bl., graph. Darst., 30 cm
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Heidelberg, Univ., Diss., 2003
HBZ-ID	HT013725628
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Management of the COVID-19 pandemic in Rhineland-Palatinate hospitals of all levels of care : Results of the COVID-19 Registry RLP.

Gitt, Anselm K / Horack, Martin / Schneider, Steffen / Zeymer, Uwe / Zahn, Ralf

Herz

2023 Volume 48, Issue 3, Page(s) 184–189

Abstract: The COVID-19 pandemic placed a significant burden on the German healthcare system. Based on the experience of severe disease progression of the SARS-CoV‑2 infection from neighboring European countries in the early 2020s, with ICU overload and high ... ...

Title translation	Management der COVID-19-Pandemie in Rheinland-Pfalz Beteiligung von Krankenhäusern aller Versorgungsebenen : Ergebnisse des COVID-19-Registers RLP.
Abstract	The COVID-19 pandemic placed a significant burden on the German healthcare system. Based on the experience of severe disease progression of the SARS-CoV‑2 infection from neighboring European countries in the early 2020s, with ICU overload and high mortality rates, efforts were made in Germany to increase the capacity of available ICU beds. Subsequently, all documentation and reporting focused on the ICU capacities for COVID-19 patients. It was hypothesized that mainly a few large hospitals provided care for the majority of COVID-19 patients. The COVID-19 Registry RLP of Rhineland-Palatinate documented SARS-CoV‑2 inpatients from daily mandatory queries of all hospitals throughout the pandemic from April 2020 to March 2023, distinguishing between patients in ICUs and normal wards. In its 18th Corona Ordinance, the state government required all hospitals to participate in the care of SARS-CoV‑2 inpatients. We investigated the participation of hospitals at different levels of care in Rhineland-Palatinate in the management of the COVID-19 pandemic. Nine pandemic waves were documented during the pandemic and exemplary data on the respective pandemic peaks were evaluated. A distinction was made between the burden on hospitals at different levels of care: primary care hospitals, standard care hospitals, specialty hospitals, and maximal care hospitals. Analysis of the data showed that all hospital types participated equally in the care of SARS-CoV-2 patients. The requirement of the Ministry of Health of Rhineland-Palatinate to provide at least 20% of the available capacity was met by all levels of care and there were no disparities between hospitals of different levels of care in the management of the pandemic.Hospitals at all levels of care participated equally in the care of SARS-CoV‑2 inpatients and thus contributed significantly to the management of the pandemic in Rhineland-Palatinate.
MeSH term(s)	Humans ; COVID-19/epidemiology ; SARS-CoV-2 ; Pandemics ; Hospitals ; Registries
Language	English
Publishing date	2023-05-08
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	8262-4
ISSN	1615-6692 ; 0340-9937 ; 0946-1299
ISSN (online)	1615-6692
ISSN	0340-9937 ; 0946-1299
DOI	10.1007/s00059-023-05187-1
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Article ; Online: Hitting Hard and Early: A Novel Paradigm for Lipid Lowering in Primary Prevention.

Lautsch, Dominik / Gitt, Anselm K

Cardiology

2018 Volume 140, Issue 1, Page(s) 68–70

MeSH term(s)	Cholesterol, LDL/blood ; Coronary Disease/mortality ; Coronary Disease/prevention & control ; Humans ; Hypolipidemic Agents/therapeutic use ; Primary Prevention
Chemical Substances	Cholesterol, LDL ; Hypolipidemic Agents
Language	English
Publishing date	2018-06-06
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	80092-2
ISSN	1421-9751 ; 0008-6312
ISSN (online)	1421-9751
ISSN	0008-6312
DOI	10.1159/000488972
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Article: Hitting Hard and Early: A Novel Paradigm for Lipid Lowering in Primary Prevention

Lautsch, Dominik / Gitt, Anselm K.

Cardiology

2018 Volume 140, Issue 1, Page(s) 68–70

Institution	Merck & Co., Inc., Kenilworth, New Jersey, USA Cardiology, Herzzentrum Ludwigshafen, Ludwigshafen, Germany
Language	English
Publishing date	2018-06-06
Publisher	S. Karger AG
Publishing place	Basel, Switzerland
Document type	Article
Note	Editorial Comment
ZDB-ID	80092-2
ISSN	1421-9751 ; 0008-6312
ISSN (online)	1421-9751
ISSN	0008-6312
DOI	10.1159/000488972
Database	Karger publisher's database

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Article: Hypercholesterolemia Diagnosis, Treatment Patterns, and 12-Month Target Achievement in Clinical Practice in Germany in Patients with Familial Hypercholesterolemia.

Gitt, Anselm K / Laufs, Ulrich / März, Winfried / Paar, W Dieter / Bramlage, Peter / Marx, Nikolaus / Parhofer, Klaus G

Journal of clinical medicine

2022 Volume 11, Issue 13

Abstract: Background: Familial hypercholesterolemia (FH) is a highly prevalent disorder and a risk factor for early coronary artery disease. The objective of this registry was to document the clinical characteristics of patients with definite FH in Germany and to ... ...

Abstract	Background: Familial hypercholesterolemia (FH) is a highly prevalent disorder and a risk factor for early coronary artery disease. The objective of this registry was to document the clinical characteristics of patients with definite FH in Germany and to document lipid profiles, lipid-lowering therapy, and lipid target achievement during longitudinal follow-up. Methods: HYDRA-FH was a national, prospective, multicenter, non-interventional registry conducted in 35 centers in Germany. Consecutive adult patients with definite FH were included (n = 241). Results: In the cross-sectional analysis (n = 233), lipid-lowering therapy involved statins (82.0%), ezetimibe (31.8%), and PCSK9 antibodies (18.5%); 11.2% of patients were receiving no lipid-lowering drugs. Median lipid levels were: low-density lipoprotein cholesterol (LDL-C) 134 mg/dL (3.5 mmol/L), high-density lipoprotein cholesterol (HDL-C) 48 mg/dL (1.2 mmol/L), triglycerides 160 mg/dL (1.9 mmol/L), total cholesterol 211 mg/dL (5.5 mmol/L). Values were above the normal threshold (150 mg/dL) for LDL-C in 72.9%, total cholesterol in 29.7%, and triglycerides in 45.0% of patients. After the 12-month follow-up (n = 145), only 17.2% had LDL-C < 70 mg/dL, and 20.7% had either LDL-C < 70 mg/dL or a reduction of ≥50% versus baseline. Conclusion: This study provides insight into the clinical characteristics and current treatment status of patients with FH in Germany. Many patients with FH do not achieve recommended lipid levels.
Language	English
Publishing date	2022-06-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11133810
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Article ; Online: Hypercholesterolemia diagnosis, treatment patterns and target achievement in patients with acute coronary syndromes in Germany.

Gitt, Anselm K / Parhofer, Klaus G / Laufs, Ulrich / März, Winfried / Paar, W Dieter / Bramlage, Peter / Marx, Nikolaus

Clinical research in cardiology : official journal of the German Cardiac Society

2022 Volume 112, Issue 2, Page(s) 299–311

Abstract: Background: Patients who experience an acute coronary syndrome (ACS) are at high risk of further cardiovascular events. Long-term treatment of cardiovascular risk factors, such as hyperlipidemia, is critical to prevent progression of coronary heart ... ...

Abstract	Background: Patients who experience an acute coronary syndrome (ACS) are at high risk of further cardiovascular events. Long-term treatment of cardiovascular risk factors, such as hyperlipidemia, is critical to prevent progression of coronary heart disease. However, many patients do not reach recommended target levels for low-density lipoprotein (LDL) cholesterol, despite receiving lipid-lowering therapy. Objective: To obtain an insight into the current treatment situation for very high-risk patients after an initial ACS in Germany. Methods: The multicenter HYDRA-ACS registry study was initiated to document the clinical characteristics of very high-risk patients with ACS and hyperlipidemia in clinical practice. In addition, lipid profiles, lipid-lowering therapy, and lipid target achievement during treatment were documented over 1 year. Results: 353 patients who were documented had a mean age of 57.3 years, mean body mass index was 28.6 kg/m Conclusions: This study provides a contemporary picture of the treatment of hyperlipidemia after ACS in patients in Germany. Despite treatment with lipid-lowering therapy, many patients did not achieve recommended lipid targets by 12 months after an ACS event.
MeSH term(s)	Animals ; Male ; Humans ; Female ; Acute Coronary Syndrome/diagnosis ; Acute Coronary Syndrome/epidemiology ; Acute Coronary Syndrome/therapy ; Hypercholesterolemia/drug therapy ; Percutaneous Coronary Intervention ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Hyperlipidemias/chemically induced ; Hyperlipidemias/drug therapy ; Anticholesteremic Agents/therapeutic use ; Cholesterol ; Coronary Disease/diagnosis ; Germany/epidemiology ; Treatment Outcome
Chemical Substances	Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Anticholesteremic Agents ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2022-09-17
Publishing country	Germany
Document type	Multicenter Study ; Journal Article
ZDB-ID	2213295-8
ISSN	1861-0692 ; 1861-0684
ISSN (online)	1861-0692
ISSN	1861-0684
DOI	10.1007/s00392-022-02108-w
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Article ; Online: Hypercholesterolemia Diagnosis, Treatment Patterns, and 12-Month Target Achievement in Clinical Practice in Germany in Patients with Familial Hypercholesterolemia

Anselm K. Gitt / Ulrich Laufs / Winfried März / W. Dieter Paar / Peter Bramlage / Nikolaus Marx / Klaus G. Parhofer

Journal of Clinical Medicine, Vol 11, Iss 13, p

2022 Volume 3810

Abstract	Background: Familial hypercholesterolemia (FH) is a highly prevalent disorder and a risk factor for early coronary artery disease. The objective of this registry was to document the clinical characteristics of patients with definite FH in Germany and to document lipid profiles, lipid-lowering therapy, and lipid target achievement during longitudinal follow-up. Methods: HYDRA-FH was a national, prospective, multicenter, non-interventional registry conducted in 35 centers in Germany. Consecutive adult patients with definite FH were included ( n = 241). Results: In the cross-sectional analysis ( n = 233), lipid-lowering therapy involved statins (82.0%), ezetimibe (31.8%), and PCSK9 antibodies (18.5%); 11.2% of patients were receiving no lipid-lowering drugs. Median lipid levels were: low-density lipoprotein cholesterol (LDL-C) 134 mg/dL (3.5 mmol/L), high-density lipoprotein cholesterol (HDL-C) 48 mg/dL (1.2 mmol/L), triglycerides 160 mg/dL (1.9 mmol/L), total cholesterol 211 mg/dL (5.5 mmol/L). Values were above the normal threshold (150 mg/dL) for LDL-C in 72.9%, total cholesterol in 29.7%, and triglycerides in 45.0% of patients. After the 12-month follow-up ( n = 145), only 17.2% had LDL-C < 70 mg/dL, and 20.7% had either LDL-C < 70 mg/dL or a reduction of ≥50% versus baseline. Conclusion: This study provides insight into the clinical characteristics and current treatment status of patients with FH in Germany. Many patients with FH do not achieve recommended lipid levels.
Keywords	Familial hypercholesterolemia ; Germany ; lipid levels ; lipid-lowering therapy ; Medicine ; R
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: The COVID-19 Registry in Rhineland-Palatinate in the context of international registry activities documenting COVID-19 outcomes.

Gitt, Anselm K / Bernhardt, Alexandra / Zahn, Ralf / Zeymer, Uwe / Grau, Armin / Beutel, Manfred E / Werdan, Karl

Herz

2020 Volume 45, Issue 4, Page(s) 316–318

Title translation	Das COVID-19-Register in Rheinland-Pfalz im Kontext internationaler Registeraktivitäten zur Dokumentation der COVID-19-Komplikationen.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Germany/epidemiology ; Humans ; Outcome Assessment, Health Care ; Pandemics ; Pneumonia, Viral/epidemiology ; Registries ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-04-24
Publishing country	Germany
Document type	Letter
ZDB-ID	8262-4
ISSN	1615-6692 ; 0340-9937 ; 0946-1299
ISSN (online)	1615-6692
ISSN	0340-9937 ; 0946-1299
DOI	10.1007/s00059-020-04928-w
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Article ; Online: The COVID-19 Registry in Rhineland-Palatinate in the context of international registry activities documenting COVID-19 outcomes

Gitt, Anselm K. / Bernhardt, Alexandra / Zahn, Ralf / Zeymer, Uwe / Grau, Armin / Beutel, Manfred E. / Werdan, Karl

Herz

2020 Volume 45, Issue 4, Page(s) 316–318

Keywords	Cardiology and Cardiovascular Medicine ; covid19
Language	English
Publisher	Springer Science and Business Media LLC
Publishing country	us
Document type	Article ; Online
ZDB-ID	8262-4
ISSN	1615-6692 ; 0340-9937 ; 0946-1299
ISSN (online)	1615-6692
ISSN	0340-9937 ; 0946-1299
DOI	10.1007/s00059-020-04928-w
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Individualised treatment targets in patients with type-2 diabetes and hypertension.

Schmieder, Roland E / Tschöpe, Diethelm / Koch, Cornelia / Ouarrak, Taoufik / Gitt, Anselm K

Cardiovascular diabetology

2018 Volume 17, Issue 1, Page(s) 18

Abstract: Aim: Patients with type-2 diabetes mellitus (T2DM) are at high risk of cardiovascular events, accentuated in the presence of hypertension. At present, it is unclear to what extent the guidelines for the management of T2DM, advocating reduction in HbA1c ... ...

Abstract	Aim: Patients with type-2 diabetes mellitus (T2DM) are at high risk of cardiovascular events, accentuated in the presence of hypertension. At present, it is unclear to what extent the guidelines for the management of T2DM, advocating reduction in HbA1c levels to below target levels, are being adhered to in clinical practice. Methods: DIALOGUE was a prospective, observational, non-interventional registry performed across multiple centres in Germany. Patients aged 18 years or older who had T2DM and hypertension for whom the treating physician considered blood glucose lowering medication as inadequate and/or not safe/tolerable and chose to add a further oral drug or switch drug treatment were included. Patients were assigned a treatment target HbA1c value (≤ 6.5% [strict]; > 6.5 to ≤ 7.0% [intermediate]; > 7.0 to ≤ 7.5% [lenient]). Results: 8568 patients with T2DM and hypertension were enrolled. 6691 (78.1%) had 12-month follow-up. Patients who were assigned a strict HbA1c treatment target (n = 2644) were younger, had shorter diabetes duration, and less comorbidity in comparison to those with intermediate (n = 2912) or lenient targets (n = 1135). Only 53.1% of patients achieved their HbA1c treatment target (46.2% [strict], 56.8% [intermediate], 59.4% [lenient]). There was little sign of treatment intensification for patients that had not achieved their HbA1c target. Conclusions: Achievement of treatment targets was poor, leaving many patients with sub-optimal blood glucose levels. The apparent reluctance of physicians to intensify antidiabetic drug therapy is alarming, especially considering the evidence pointing to an association of hyperglycaemia and microvascular complications in patients with T2DM.
MeSH term(s)	Aged ; Biomarkers/blood ; Blood Glucose/drug effects ; Blood Glucose/metabolism ; Blood Pressure ; Clinical Decision-Making ; Comorbidity ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/epidemiology ; Drug Substitution ; Drug Therapy, Combination ; Female ; Germany/epidemiology ; Glycated Hemoglobin A/metabolism ; Guideline Adherence ; Humans ; Hypertension/diagnosis ; Hypertension/epidemiology ; Hypertension/physiopathology ; Hypoglycemic Agents/administration & dosage ; Hypoglycemic Agents/adverse effects ; Male ; Middle Aged ; Practice Guidelines as Topic ; Practice Patterns, Physicians' ; Prospective Studies ; Registries ; Risk Factors ; Time Factors ; Treatment Outcome
Chemical Substances	Biomarkers ; Blood Glucose ; Glycated Hemoglobin A ; Hypoglycemic Agents ; hemoglobin A1c protein, human
Language	English
Publishing date	2018-01-22
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
ISSN	1475-2840
ISSN (online)	1475-2840
DOI	10.1186/s12933-018-0661-8
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