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Book: Man han quan xi zhi man cai

Yang, Mei

(Man hua man han quan xi xi lie cong shu ; 漫画满汉全席系列丛书)

2010

Author's details	Yang mei man hua
Series title	Man hua man han quan xi xi lie cong shu 漫画满汉全席系列丛书
Language	Chinese
Size	161 p, Mainly ill.
Edition	Di 1 ban
Publisher	Dong fang chu ban zhong xin
Publishing place	Shanghai
Document type	Book
ISBN	9787547301029 ; 7547301029
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Transcriptome analysis reveals gene expression changes of the basidiomycetous yeast Apiotrichum mycotoxinivorans in response to ochratoxin A exposure

Zhi-Kai Yang / Xue-Ling Huang / Liang Peng

Ecotoxicology and Environmental Safety, Vol 246, Iss , Pp 114146- (2022)

2022

Abstract: Ochratoxin A (OTA) is one of the most common and deleterious mycotoxins found in food and feedstuffs worldwide; however, Apiotrichum mycotoxinivorans can detoxify OTA. Our results show that A. mycotoxinivorans GUM1709 efficiently degraded OTA, but it ... ...

Abstract	Ochratoxin A (OTA) is one of the most common and deleterious mycotoxins found in food and feedstuffs worldwide; however, Apiotrichum mycotoxinivorans can detoxify OTA. Our results show that A. mycotoxinivorans GUM1709 efficiently degraded OTA, but it caused the accumulation of intracellular reactive oxygen species. The main aim of this study was to identify potential OTA-detoxifying enzymes and to explore the effects of OTA on A. mycotoxinivorans GMU1709. RNA-seq data revealed that 1643 and 1980 genes were significantly upregulated and downregulated, respectively, after OTA exposure. Functional enrichment analyses indicated that OTA exposure enhanced defense capability, protein transport, endocytosis, and energy metabolism; caused ribosomal stress; suppressed DNA replication and transcription; inhibited cell growth and division; and promoted cell death. The integration of secretome, gene expression, and molecular docking analyses revealed that two carboxypeptidase homologues (members of the metallocarboxypeptidase family) were most likely responsible for the detoxification of both extracellular and intracellular OTA. Superoxide dismutase and catalase were the main genes activated in response to oxidative stress. In addition, analysis of key genes associated with cell division and apoptosis showed that OTA exposure inhibited mitosis and promoted cell death. This study revealed the possible OTA response and detoxification mechanisms in A. mycotoxinivorans.
Keywords	Transcriptome sequencing ; Apiotrichum mycotoxinivorans GMU1709 ; Ochratoxin A ; Detoxification gene ; Stress response ; Environmental pollution ; TD172-193.5 ; Environmental sciences ; GE1-350
Subject code	572
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Collaborative governance effects of carbon market on GHG and air pollutants emission reduction in 3E model —— analysis based on System Dynamics

Lan Yi / Zhi-peng Yang / Zhi-kai Zhang / Li Yang / Wei Deng

Heliyon, Vol 9, Iss 12, Pp e22684- (2023)

2023

Abstract: The carbon market is regarded as one of the important means to achieve China's dual carbon target. It has ancillary effect for reducing air pollution while regulating carbon emissions since climate change and air pollution share the same origin and ... ...

Abstract	The carbon market is regarded as one of the important means to achieve China's dual carbon target. It has ancillary effect for reducing air pollution while regulating carbon emissions since climate change and air pollution share the same origin and homology. Research on how to design the carbon market mechanism in order to maximize the synergistic effect of reducing greenhouse gas and air pollution will have a very important practical impact for China. This study conducts a theoretical analysis of the collaborative emission reduction path of China's carbon market, and constructs an Energy-Economy-Environment (3E) model of the collaborative emission reduction effect of carbon trading system based on System Dynamics. After analyzing the feedback path of the core cycle of the model and verifying its performance, three main policy factors in the carbon market are explored, and their effects under the dual objectives of emission control and economic development are comprehensively evaluated. This study suggests that the exploration of the potential of carbon market for collaborative governance should be accelerated, and ensure the orderly expansion of coverage and precise setting of limits, so as to ensure the smooth achievement of carbon reduction targets while guaranteeing the social and economic development.
Keywords	Carbon market ; Climate change ; Air pollution ; Synergistic management ; System dynamics ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	650
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Transcriptome analysis reveals gene expression changes of the basidiomycetous yeast Apiotrichum mycotoxinivorans in response to ochratoxin A exposure.

Yang, Zhi-Kai / Huang, Xue-Ling / Peng, Liang

Ecotoxicology and environmental safety

2022 Volume 246, Page(s) 114146

Abstract	Ochratoxin A (OTA) is one of the most common and deleterious mycotoxins found in food and feedstuffs worldwide; however, Apiotrichum mycotoxinivorans can detoxify OTA. Our results show that A. mycotoxinivorans GUM1709 efficiently degraded OTA, but it caused the accumulation of intracellular reactive oxygen species. The main aim of this study was to identify potential OTA-detoxifying enzymes and to explore the effects of OTA on A. mycotoxinivorans GMU1709. RNA-seq data revealed that 1643 and 1980 genes were significantly upregulated and downregulated, respectively, after OTA exposure. Functional enrichment analyses indicated that OTA exposure enhanced defense capability, protein transport, endocytosis, and energy metabolism; caused ribosomal stress; suppressed DNA replication and transcription; inhibited cell growth and division; and promoted cell death. The integration of secretome, gene expression, and molecular docking analyses revealed that two carboxypeptidase homologues (members of the metallocarboxypeptidase family) were most likely responsible for the detoxification of both extracellular and intracellular OTA. Superoxide dismutase and catalase were the main genes activated in response to oxidative stress. In addition, analysis of key genes associated with cell division and apoptosis showed that OTA exposure inhibited mitosis and promoted cell death. This study revealed the possible OTA response and detoxification mechanisms in A. mycotoxinivorans.
MeSH term(s)	DNA, Fungal/metabolism ; DNA, Fungal/pharmacology ; Molecular Docking Simulation ; Ochratoxins/toxicity ; Oxidative Stress/genetics ; Basidiomycota/metabolism ; Gene Expression Profiling ; Gene Expression
Chemical Substances	ochratoxin A (1779SX6LUY) ; DNA, Fungal ; Ochratoxins
Language	English
Publishing date	2022-10-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2022.114146
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Article: Collaborative governance effects of carbon market on GHG and air pollutants emission reduction in 3E model -- analysis based on System Dynamics.

Yi, Lan / Yang, Zhi-Peng / Zhang, Zhi-Kai / Yang, Li / Deng, Wei

Heliyon

2023 Volume 9, Issue 12, Page(s) e22684

Abstract	The carbon market is regarded as one of the important means to achieve China's dual carbon target. It has ancillary effect for reducing air pollution while regulating carbon emissions since climate change and air pollution share the same origin and homology. Research on how to design the carbon market mechanism in order to maximize the synergistic effect of reducing greenhouse gas and air pollution will have a very important practical impact for China. This study conducts a theoretical analysis of the collaborative emission reduction path of China's carbon market, and constructs an Energy-Economy-Environment (3E) model of the collaborative emission reduction effect of carbon trading system based on System Dynamics. After analyzing the feedback path of the core cycle of the model and verifying its performance, three main policy factors in the carbon market are explored, and their effects under the dual objectives of emission control and economic development are comprehensively evaluated. This study suggests that the exploration of the potential of carbon market for collaborative governance should be accelerated, and ensure the orderly expansion of coverage and precise setting of limits, so as to ensure the smooth achievement of carbon reduction targets while guaranteeing the social and economic development.
Language	English
Publishing date	2023-11-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e22684
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Preparation of (

Liu, Zhi-Kai / Yang, Ying / Zhan, Zhuang-Ping

The Journal of organic chemistry

2021 Volume 87, Issue 2, Page(s) 1589–1597

Abstract: A general and efficient palladium catalyzed hydroalkynylation of allenes was developed to produce synthetically versatile ( ...

Abstract	A general and efficient palladium catalyzed hydroalkynylation of allenes was developed to produce synthetically versatile (
MeSH term(s)	Alkadienes ; Catalysis ; Palladium ; Stereoisomerism
Chemical Substances	Alkadienes ; propadiene (4AV0LZ8QKB) ; Palladium (5TWQ1V240M)
Language	English
Publishing date	2021-12-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.1c02732
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Article ; Online: Oral vitamin D supplementation on the prevention of peritoneal dialysis-related peritonitis: A pilot randomised controlled trial.

Zhang, Yu-Hui / Xu, Xiao / Pi, Hai-Chen / Yang, Zhi-Kai / Johnson, David W / Dong, Jie

Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis

2023 Volume 44, Issue 1, Page(s) 27–36

Abstract: Objective: Peritoneal dialysis (PD)-related peritonitis is independently associated with low serum 25-hydroxy vitamin D [25(OH)D] levels. Our objective is to examine the feasibility of conducting a large, randomised controlled trial to determine the ... ...

Abstract	Objective: Peritoneal dialysis (PD)-related peritonitis is independently associated with low serum 25-hydroxy vitamin D [25(OH)D] levels. Our objective is to examine the feasibility of conducting a large, randomised controlled trial to determine the effects of vitamin D supplementation on the risk of PD-related peritonitis. Design: Pilot, prospective, open-label randomised controlled trial. Setting: Peking University First Hospital, China. Participants: Patients receiving PD who had recovered from a recent episode of peritonitis between 30 September 2017 and 28 May 2020. Interventions: Oral natural vitamin D supplementation (2000 IU per day) versus no vitamin D supplementation for 12 months. Primary and secondary outcome measures: Primary outcomes were feasibility (recruitment success, retention, adherence, safety) and fidelity (change in serum 25(OH)D level during follow-up) for a large, randomised controlled trial in the future to determine the effects of vitamin D on PD-related peritonitis. Secondary outcomes were time to peritonitis occurrence and outcome of subsequent peritonitis. Results: Overall, 60 among 151 patients were recruited (recruitment rate was 39.7%, 95% CI 31.9-47.5%, recruitment rate among eligible patients was 61.9%, 95% CI 52.2-71.5%). Retention and adherence rates were 100.0% (95% CI 100.0-100.0%) and 81.5% (95% CI 66.8-96.1%), respectively. During follow-up, serum 25(OH)D levels increased in the vitamin D (VD) group (from 19.25 ± 10.11 nmol/L to 60.27 ± 23.29 nmol/L after 6 months, Conclusions: A randomised controlled trial of the effect of vitamin D supplementation on peritonitis occurrence in patients receiving PD is feasible, safe and results in adequate serum 25(OH)D levels.
MeSH term(s)	Humans ; Prospective Studies ; Pilot Projects ; Peritoneal Dialysis/adverse effects ; Vitamin D ; Peritonitis/etiology ; Peritonitis/prevention & control ; Dietary Supplements ; Vitamin D Deficiency/etiology ; Double-Blind Method
Chemical Substances	Vitamin D (1406-16-2)
Language	English
Publishing date	2023-07-05
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	645010-6
ISSN	1718-4304 ; 0896-8608
ISSN (online)	1718-4304
ISSN	0896-8608
DOI	10.1177/08968608231182885
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Article ; Online: The systematic analysis of ultraconserved genomic regions in the budding yeast.

Yang, Zhi-Kai / Gao, Feng

Bioinformatics (Oxford, England)

2018 Volume 34, Issue 1, Page(s) 180

Language	English
Publishing date	2018--01
Publishing country	England
Document type	Journal Article ; Published Erratum
ZDB-ID	1422668-6
ISSN	1367-4811 ; 1367-4803
ISSN (online)	1367-4811
ISSN	1367-4803
DOI	10.1093/bioinformatics/btx751
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Article ; Online: Transcriptomic responses of the zearalenone (ZEN)-detoxifying yeast Apiotrichum mycotoxinivorans to ZEN exposure

Zhi-Kai Yang / Da-Wei Li / Liang Peng / Chen-Fei Liu / Zhi-Yuan Wang

Ecotoxicology and Environmental Safety, Vol 241, Iss , Pp 113756- (2022)

2022

Abstract: Zearalenone (ZEN) is a potent oestrogenic mycotoxin that is mainly produced by Fusarium species and is a serious environmental pollutant in animal feeds. Apiotrichum mycotoxinivorans has been widely used as a feed additive to detoxify ZEN. However, the ... ...

Abstract	Zearalenone (ZEN) is a potent oestrogenic mycotoxin that is mainly produced by Fusarium species and is a serious environmental pollutant in animal feeds. Apiotrichum mycotoxinivorans has been widely used as a feed additive to detoxify ZEN. However, the effects of ZEN on A. mycotoxinivorans and its detoxification mechanisms remain unclear. In this study, transcriptomic and bioinformatic analyses were used to investigate the molecular responses of A. mycotoxinivorans to ZEN exposure and the genetic basis of ZEN detoxification. We detected 1424 significantly differentially expressed genes (DEGs), of which 446 were upregulated and 978 were downregulated. Functional and enrichment analyses showed that ZEN-induced genes were significantly associated with xenobiotic metabolism, oxidative stress response, and active transport systems. However, ZEN-inhibited genes were mainly related to cell division, cell cycle, and fungal development. Subsequently, bioinformatic analysis identified candidate ZEN-detoxification enzymes. The Baeyer–Villiger monooxygenases and carboxylesterases, which are responsible for the formation and subsequent hydrolysis of a new ZEN lactone, respectively, were significantly upregulated. In addition, the expression levels of genes related to conjugation and transport involved in the xenobiotic detoxification pathway were significantly upregulated. Moreover, the expression levels of genes encoding enzymatic antioxidants and those related to growth and apoptosis were significantly upregulated and downregulated, respectively, which made it possible for A. mycotoxinivorans to survive in a highly toxic environment and efficiently detoxify ZEN. This is the first systematic report of ZEN tolerance and detoxification in A. mycotoxinivorans. We identified the metabolic enzymes that were potentially involved in detoxifying ZEN in the GMU1709 strain and found that ZEN-induced transcriptional regulation of genes is key to withstanding highly toxic environments. Hence, our results provide valuable information ...
Keywords	Transcriptome sequencing ; Apiotrichum mycotoxinivorans GMU1709 ; Zearalenone ; Detoxification gene ; Stress response ; Environmental pollution ; TD172-193.5 ; Environmental sciences ; GE1-350
Subject code	572
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Preparation of (E)-1,3-Enyne Derivatives through Palladium Catalyzed Hydroalkynylation of Allenes

Liu, Zhi-Kai / Yang, Ying / Zhan, Zhuang-Ping

Journal of organic chemistry. 2021 Dec. 30, v. 87, no. 2

2021

Abstract: A general and efficient palladium catalyzed hydroalkynylation of allenes was developed to produce synthetically versatile (E)-1,3-enyne derivatives with high regio- and stereoselectivity. This catalytic system proceeded under mild conditions and was ... ...

Abstract	A general and efficient palladium catalyzed hydroalkynylation of allenes was developed to produce synthetically versatile (E)-1,3-enyne derivatives with high regio- and stereoselectivity. This catalytic system proceeded under mild conditions and was compatible with a broad range of substrates, especially for allenes without electron-bias groups. This work further broadens the synthetic potential of these scaffolds in organic synthesis and medicinal chemistry.
Keywords	organic chemistry ; palladium ; stereoselectivity
Language	English
Dates of publication	2021-1230
Size	p. 1589-1597.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.1c02732
Database	NAL-Catalogue (AGRICOLA)

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