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Book ; Online: Efficacy, Safety, and Immunogenicity of Vaccines against Viruses: From Network Medicine to Clinical Experimentation

Guzzi, Pietro Hiram / Milano, Marianna / Das, Jayanta Kumar

2023

Keywords	Research & information: general ; Biology, life sciences ; Biochemistry ; monkeypox ; mpox ; MPXV ; universal vaccine ; multi-epitope mRNA vaccine ; immunoinformatics ; influenza ; H3N2 ; antigenic distance ; hemagglutinin ; attribute network embedding ; herpes simplex virus ; HSV-2 ; vaccine ; costimulation ; genital ; antibodies ; T cells ; MDV ; chickens ; Th17 cells ; IL-17A ; interferon-gamma and adaptive immunity ; adenoviral vector ; cell fusion ; human endogenous retrovirus type W (HERV-W) ; R-peptide ; Syncytin-1 ; HIV ; PLWH ; ART ; vaccination ; immune responses ; CD4 ; COVID-19 ; HPV ; respiratory syncytial virus ; RSV ; mucosal vaccine ; inactivated vaccine ; low-energy electron irradiation ; LEEI ; PC formulation ; PCLS ; binding antibody assay ; immune correlates of protection ; modified treatment policy ; neutralizing antibody assay ; principal stratification ; principal surrogate ; SARS-CoV-2 ; stochastic intervention ; stochastic interventional vaccine efficacy ; peste des petits ruminants ; ewes ; lambs ; passive immunity ; quadrivalent adjuvanted influenza vaccines ; toll-like receptors ; CVID ; azoximer bromide
Language	English
Size	1 electronic resource (204 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel
Document type	Book ; Online
Note	English
HBZ-ID	HT030645798
ISBN	9783036592329 ; 3036592326
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Online ; E-Book: Advances in nanotechnology-based drug delivery systems

Talukdar, Anupam Das / Sarker, Satyajit D. / Patra, Jayanta Kumar

(Nanotechnology in Biomedicine)

2022

Author's details	edited by Anupam Das Talukdar, Satyajit Dey Sarker, Jayanta Kumar Patra
Series title	Nanotechnology in Biomedicine
Keywords	Nanoparticles ; Drug delivery systems ; Nanotechnology
Subject code	615.6
Language	English
Dates of publication	2022-2022
Size	1 online resource (672 pages) :, illustrations
Publisher	Elsevier Inc
Publishing place	Amsterdam, Netherlands
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	0-323-90414-9 ; 9780323884501 ; 978-0-323-90414-8 ; 0323884504
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Online ; E-Book: Advances in Pharmaceutical Biotechnology

Patra, Jayanta Kumar / Shukla, Amritesh C. / Das, Gitishree

Recent Progress and Future Applications

2020

Abstract: This book explains both the basic science and the applications of biotechnology-derived pharmaceuticals, with special emphasis on their clinical uses. The foundations of pharmaceutical biotechnology lie mainly in the capability of plants, microorganism, ... ...

Author's details	edited by Jayanta Kumar Patra, Amritesh C. Shukla, Gitishree Das
Abstract	This book explains both the basic science and the applications of biotechnology-derived pharmaceuticals, with special emphasis on their clinical uses. The foundations of pharmaceutical biotechnology lie mainly in the capability of plants, microorganism, and animals to produce low and high molecular weight compounds useful as therapeutics. Pharmaceutical biotechnology has flourished since the advent of recombinant DNA technology and metabolic engineering, supported by the well-developed bioprocess technology. A large number of monoclonal antibodies and therapeutic proteins have been approved, delivering meaningful contributions to patients’ lives, and the techniques of biotechnology are also a driving force in modern drug discovery. Due to this rapid growth in the importance of biopharmaceuticals and the techniques of biotechnologies to modern medicine and the life sciences, the field of pharmaceutical biotechnology has become an increasingly important component in the education of pharmacists and pharmaceutical scientists. This book will serve as a complete one-stop source on the subject for undergraduate and graduate pharmacists, pharmaceutical science students, and pharmaceutical scientists in industry and academia.
Keywords	Pharmaceutical technology ; Biomedical engineering ; Pharmacotherapy ; Biotechnology ; Drug resistance ; Biochemistry ; Biotecnologia farmacèutica ; Quimioteràpia ; Pharmaceutical Sciences/Technology ; Biomedical Engineering/Biotechnology ; Drug Resistance ; Biochemistry, general
Subject code	615.19
Language	English
Size	1 online resource (xviii, 478 pages) ; 92 illustrations, 56 illustrations in colour
Edition	1st ed. 2020.
Publisher	Springer Singapore ; Imprint: Springer
Publishing place	Singapore
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	981-15-2195-6 ; 9789811521942 ; 9811521948 ; 978-981-15-2195-9
DOI	10.1007/978-981-15-2195-9
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Online ; E-Book: Green Nanoparticles

Patra, Jayanta Kumar / Fraceto, Leonardo F. / Das, Gitishree / Campos, Estefânia Vangelie Ramos

Synthesis and Biomedical Applications

(Nanotechnology in the Life Sciences,)

2020

Abstract: Nanotechnology is the application of science to control matter at the molecular level. It has become one of the most promising applied technologies in all areas of science. Nanoparticles have multi-functional properties and have created very interesting ... ...

Author's details	edited by Jayanta Kumar Patra, Leonardo F. Fraceto, Gitishree Das, Estefânia Vangelie Ramos Campos
Series title	Nanotechnology in the Life Sciences,
Abstract	Nanotechnology is the application of science to control matter at the molecular level. It has become one of the most promising applied technologies in all areas of science. Nanoparticles have multi-functional properties and have created very interesting applications in various fields such as medicine, nutrition, bioenergy, agriculture and the environment. But the biogenic syntheses of monodispersed nanoparticles with specific sizes and shapes have been a challenge in biomaterial science. Nanoparticles are of great interest due to their extremely small size and large surface-to-volume ratio, which lead to both chemical and physical differences in their properties (e.g., mechanical properties, biological and sterical properties, catalytic activity, thermal and electrical conductivity, optical absorption and melting point) compared to bulk of the same chemical composition. Recently, however, synthesizing metal nanoparticles using green technology via microorganisms, plants, viruses, and so on, has been extensively studied and has become recognized as a green and efficient way for further exploiting biological systems as convenient nanofactories. Thus the biological synthesis of nanoparticles is increasingly regarded as a rapid, ecofriendly, and easily scaled-up technology. Today researchers are developing new techniques and materials using nanotechnology that may be suitable for plants to boost their native functions. Recently, biological nanoparticles were found to be more pharmacologically active than physico-chemically synthesized nanoparticles. Various applications of biosynthesized nanoparticles have been discovered, especially in the field of biomedical research, such as applications to specific delivery of drugs, use for tumor detection, angiogenesis, genetic disease and genetic disorder diagnosis, photoimaging, and photothermal therapy. Further, iron oxide nanoparticles have been applied to cancer therapy, hyperthermia, drug delivery, tissue repair, cell labeling, targeting and immunoassays, detoxification of biological fluids, magnetic resonance imaging, and magnetically responsive drug delivery therapy. Nanoparticle synthesis for plant byproducts for biomedical applications has vast potential. This book offers researchers in plant science and biomedicine the latest research and opportunity to develop new tools for the synthesis of environmentally friendly and cost-effective nanoparticles for applications in biomedicine as well as other various fields.
Keywords	Plant biotechnology ; Nanotechnology ; Botanical chemistry ; Plants/Evolution ; Plants/Development ; Plant Biotechnology ; Plant Biochemistry ; Plant Evolution ; Plant Development
Subject code	615.19
Language	English
Size	1 online resource (395 pages).
Edition	1st ed. 2020.
Publisher	Springer International Publishing ; Imprint: Springer
Publishing place	Cham
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	3-030-39246-5 ; 3-030-39245-7 ; 978-3-030-39246-8 ; 978-3-030-39245-1
DOI	10.1007/978-3-030-39246-8
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Evaluation of Antibacterial Mechanism of Action, Tyrosinase Inhibition, and Photocatalytic Degradation Potential of Sericin-Based Gold Nanoparticles.

Das, Gitishree / Patra, Jayanta Kumar

International journal of molecular sciences

2023 Volume 24, Issue 11

Abstract: In recent times, numerous natural materials have been used for the fabrication of gold nanoparticles (AuNPs). Natural resources used for the synthesis of AuNPs are more environment friendly than chemical resources. Sericin is a silk protein that is ... ...

Abstract	In recent times, numerous natural materials have been used for the fabrication of gold nanoparticles (AuNPs). Natural resources used for the synthesis of AuNPs are more environment friendly than chemical resources. Sericin is a silk protein that is discarded during the degumming process for obtaining silk. The current research used sericin silk protein waste materials as the reducing agent for the manufacture of gold nanoparticles (SGNPs) by a one-pot green synthesis method. Further, the antibacterial effect and antibacterial mechanism of action, tyrosinase inhibition, and photocatalytic degradation potential of these SGNPs were evaluated. The SGNPs displayed positive antibacterial activity (8.45-9.58 mm zone of inhibition at 50 μg/disc) against all six tested foodborne pathogenic bacteria, namely,
MeSH term(s)	Gold/pharmacology ; Gold/chemistry ; Monophenol Monooxygenase ; Sericins/pharmacology ; Sericins/chemistry ; Metal Nanoparticles/chemistry ; Anti-Bacterial Agents/chemistry ; Bacteria ; Escherichia coli O157 ; Silk/pharmacology ; Microbial Sensitivity Tests
Chemical Substances	Gold (7440-57-5) ; Monophenol Monooxygenase (EC 1.14.18.1) ; Sericins ; Anti-Bacterial Agents ; Silk
Language	English
Publishing date	2023-05-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24119477
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Evaluation of Antibacterial Mechanism of Action, Tyrosinase Inhibition, and Photocatalytic Degradation Potential of Sericin-Based Gold Nanoparticles

Gitishree Das / Jayanta Kumar Patra

International Journal of Molecular Sciences, Vol 24, Iss 9477, p

2023 Volume 9477

Abstract	In recent times, numerous natural materials have been used for the fabrication of gold nanoparticles (AuNPs). Natural resources used for the synthesis of AuNPs are more environment friendly than chemical resources. Sericin is a silk protein that is discarded during the degumming process for obtaining silk. The current research used sericin silk protein waste materials as the reducing agent for the manufacture of gold nanoparticles (SGNPs) by a one-pot green synthesis method. Further, the antibacterial effect and antibacterial mechanism of action, tyrosinase inhibition, and photocatalytic degradation potential of these SGNPs were evaluated. The SGNPs displayed positive antibacterial activity (8.45–9.58 mm zone of inhibition at 50 μg/disc) against all six tested foodborne pathogenic bacteria, namely, Enterococcus feacium DB01, Staphylococcus aureus ATCC 13565, Listeria monocytogenes ATCC 33090, Escherichia coli O157:H7 ATCC 23514, Aeromonas hydrophila ATCC 7966, and Pseudomonas aeruginosa ATCC 27583. The SGNPs also exhibited promising tyrosinase inhibition potential, with 32.83% inhibition at 100 μg/mL concentration as compared to 52.4% by Kojic acid, taken as a reference standard compound. The SGNPs also displayed significant photocatalytic degradation effects, with 44.87% methylene blue dye degradation after 5 h of incubation. Moreover, the antibacterial mode of action of the SGNPs was also investigated against E. coli and E. feacium , and the results show that due to the small size of the nanomaterials, they could have adhered to the surface of the bacterial pathogens, and could have released more ions and dispersed in the bacterial cell wall surrounding environment, thereby disrupting the cell membrane and ROS production, and subsequently penetrating the bacterial cells, resulting in lysis or damage to the cell by the process of structural damage to the membrane, oxidative stress, and damage to the DNA and bacterial proteins. The overall outcome of the current investigation concludes the positive effects of ...
Keywords	gold nanoparticles ; sericin ; antibacterial activity ; mechanism of action ; tyrosinase inhibition ; photocatalytic degradation ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Hepaticojejunostomy Anastomosis Worm Obstruction and Its Laparoscopic Management: A Case Report and Review of Literature.

Das, Jayanta Kumar / Rangad, Gordon M

Cureus

2022 Volume 14, Issue 2, Page(s) e21968

Abstract: We report a surprising case of intraoperatively detected worm obstruction of a hepaticojejunostomy anastomosis. The patient presented with acute cholangitis including fever, abdominal pain, obstructive jaundice and sepsis. Six years earlier, she had ... ...

Abstract	We report a surprising case of intraoperatively detected worm obstruction of a hepaticojejunostomy anastomosis. The patient presented with acute cholangitis including fever, abdominal pain, obstructive jaundice and sepsis. Six years earlier, she had undergone open cholecystectomy with a right subcostal incision. Ultrasonography that night depicted the absence of the gall bladder and the presence of apparent stones in the common hepatic and common bile ducts. The patient was posted for laparoscopic exploration of common bile duct. Intraoperatively, worm obstruction was found in the hepaticojejunostomy anastomosis created during the previous operation. The obstruction was managed laparoscopically, and the patient recovered without any complications and was monitored for two years. In a search of PubMed and Google Scholar, we found reports of laparoscopy-assisted endoscopic retrograde cholangiopancreatography as an established method of relieving hepaticojejunostomy obstruction; however, we found no case of laparoscopic extraction of obstructing worms. Laparoscopic exploration of a hepaticojejunostomy anastomosis through the afferent Roux loop is a feasible and safe alternative to other advanced methods of endoscopic retrograde cholangiopancreatography, for which special technique, logistics, and training are required but may not be available in many parts of the world.
Language	English
Publishing date	2022-02-07
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.21968
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Torquoselective Thermal 6π-Electrocyclization Approach to 1,4-Cyclohexadienes via Solvent-Aided Proton Transfer: Experimental and Theoretical Studies.

Saha, Jayanta / Banerjee, Soumadip / Malo, Sidhartha / Das, Abhijit Kumar / Das, Indrajit

Chemistry (Weinheim an der Bergstrasse, Germany)

2024 Volume 30, Issue 16, Page(s) e202304009

Abstract: The thermal 6π-electrocyclization of hexatriene typically delivers 1,3-cyclohexadiene (1,3-CHD). However, there is only limited success in directly synthesizing 1,4-cyclohexadiene (1,4-CHD) using such an approach, probably due to the difficulty in ... ...

Abstract	The thermal 6π-electrocyclization of hexatriene typically delivers 1,3-cyclohexadiene (1,3-CHD). However, there is only limited success in directly synthesizing 1,4-cyclohexadiene (1,4-CHD) using such an approach, probably due to the difficulty in realizing thermally-forbidden 1,3-hydride shift after electrocyclic ring closure. The present study shows that by heating (2E,4E,6E)-hexatrienes bearing ester or ketone substituents at the C1-position in a mixture of toluene/MeOH or EtOH (2 : 1) solvents at 90-100 °C, 1,4-CHDs can be selectively synthesized. This is achieved through a torquoselective disrotatory 6π-electrocyclic ring closure followed by a proton-transfer process. The success of this method depends on the polar protic solvent-assisted intramolecular proton transfer from 1,3-CHD to 1,4-CHD, which has been confirmed by deuterium-labeling experiments. There are no reports to date for such a solvent-assisted isomerization. Density functional theory (DFT) studies have suggested that forming 1,3-CHD and subsequent isomerization is a thermodynamically feasible process, regardless of the functional groups involved. Two possible successive polar solvent-assisted proton-transfer pathways have been identified for isomerization.
Language	English
Publishing date	2024-01-24
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202304009
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Understanding flash flooding in the Himalayan Region: a case study.

Nagamani, Katukotta / Mishra, Anoop Kumar / Meer, Mohammad Suhail / Das, Jayanta

Scientific reports

2024 Volume 14, Issue 1, Page(s) 7060

Abstract: The Himalayan region, characterized by its substantial topographical scale and elevation, exhibits vulnerability to flash floods and landslides induced by natural and anthropogenic influences. The study focuses on the Himalayan region, emphasizing the ... ...

Abstract	The Himalayan region, characterized by its substantial topographical scale and elevation, exhibits vulnerability to flash floods and landslides induced by natural and anthropogenic influences. The study focuses on the Himalayan region, emphasizing the pivotal role of geographical and atmospheric parameters in flash flood occurrences. Specifically, the investigation delves into the intricate interactions between atmospheric and surface parameters to elucidate their collective contribution to flash flooding within the Nainital region of Uttarakhand in the Himalayan terrain. Pre-flood parameters, including total aerosol optical depth, cloud cover thickness, and total precipitable water vapor, were systematically analyzed, revealing a noteworthy correlation with flash flooding event transpiring on October 17th, 18th, and 19th, 2021. Which resulted in a huge loss of life and property in the study area. Contrasting the October 2021 heavy rainfall with the time series data (2000-2021), the historical pattern indicates flash flooding predominantly during June to September. The rare occurrence of October flash flooding suggests a potential shift in the area's precipitation pattern, possibly influenced by climate change. Robust statistical analyses, specifically employing non-parametric tests including the Autocorrelation function (ACF), Mann-Kendall (MK) test, Modified Mann-Kendall, and Sen's slope (q) estimator, were applied to discern extreme precipitation characteristics from 2000 to 201. The findings revealed a general non-significant increasing trend, except for July, which exhibited a non-significant decreasing trend. Moreover, the results elucidate the application of Meteosat-8 data and remote sensing applications to analyze flash flood dynamics. Furthermore, the research extensively explores the substantial roles played by pre and post-atmospheric parameters with geographic parameters in heavy rainfall events that resulted flash flooding, presenting a comprehensive discussion. The findings describe the role of real time remote sensing and satellite and underscore the need for comprehensive approaches to tackle flash flooding, including mitigation. The study also highlights the significance of monitoring weather patterns and rainfall trends to improve disaster preparedness and minimize the impact of flash floods in the Himalayan region.
Language	English
Publishing date	2024-03-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-53535-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Circulating renin-angiotensin systems mediated feedback controls over the mean-arterial pressure.

Thakuri, Bikash / Kumar Das, Jayanta / Kumar Roy, Amit / Chakraborty, Amit

Journal of theoretical biology

2023 Volume 572, Page(s) 111589

Abstract: The renin-angiotensin systems play pivotal role in cardiovascular physiology through its effects on regulating blood pressure and electrolyte homeostasis. Components of circulating RAS (cRAS) that include precursor angiotensinogen, two critical enzymes ( ... ...

Abstract	The renin-angiotensin systems play pivotal role in cardiovascular physiology through its effects on regulating blood pressure and electrolyte homeostasis. Components of circulating RAS (cRAS) that include precursor angiotensinogen, two critical enzymes (renin and angiotensin-converting enzyme, ACE), their bioactive products, angiotensin- I, II together with its receptors (AT1R and AT2R) essentially determine this homeostasis. Most classical studies, however, showed the deleterious role of cRAS in elevating the blood pressure. Contemporary discovery of non-canonical components of the RAS has challenged this classic hypothesis that it can only exert deleterious effects on the cardiovascular systems. Using the classic cRAS model, we have designed in-silico experiments to test the hypothesis that AT2R-mediated feedback effects play pivotal role for maintaining the normal variation of the mean-arterial pressure (MAP).Beside the AT2R-mediation of downstream singling pathways consisting of several non-canonical RAS components, this study first time illustrated AT2R mediated feedback controls over the blood pressure regulation: one that impedes AT1R activity, and the other that downregulates renin. It has been shown that relatively stronger suppression of renin activity significantly contributes in maintaining the normal MAP and that tight AT2R-mediated regulation is relaxed in hyper-and hypotension. This control mechanism is noted to be robustly maintained with the MAP variations through an established linear steady-state relationship among renin, angiotensin I and angiotensin II. This examination suggests that AT2R-mediated downregulation of renin activities potentially counteracts the AT1R-mediated deleterious actions of Ang II. This study, therefore, provides a solid ground for considering different AT2 receptor adaptor protein and direct agonism at AT2R that can cause greater effects along with contemporary approaches of blocking AT1R mediation to attenuate hypertension or other cardiovascular disorders.
MeSH term(s)	Renin/metabolism ; Feedback ; Arterial Pressure ; Renin-Angiotensin System/physiology ; Angiotensin II/metabolism
Chemical Substances	Renin (EC 3.4.23.15) ; Angiotensin II (11128-99-7)
Language	English
Publishing date	2023-07-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2972-5
ISSN	1095-8541 ; 0022-5193
ISSN (online)	1095-8541
ISSN	0022-5193
DOI	10.1016/j.jtbi.2023.111589
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