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  1. Article ; Online: 'Damning' FDA inspection report undermines Alzheimer's drug.

    Piller, Charles

    Science (New York, N.Y.)

    2024  Volume 383, Issue 6688, Page(s) 1165–1166

    Abstract: Inspectors faulted analyses of clinical trial samples by Hoau-Yan Wang for drug developer Cassava Sciences. ...

    Abstract Inspectors faulted analyses of clinical trial samples by Hoau-Yan Wang for drug developer Cassava Sciences.
    MeSH term(s) Humans ; Alzheimer Disease/drug therapy ; Scientific Misconduct ; Spiro Compounds/therapeutic use ; United States ; United States Food and Drug Administration ; Clinical Trials as Topic
    Chemical Substances Simufilam (6NV440YIO0) ; Spiro Compounds
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type News
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.adp1964
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Probe of Alzheimer's studies finds 'egregious misconduct'.

    Piller, Charles

    Science (New York, N.Y.)

    2023  Volume 382, Issue 6668, Page(s) 251–252

    Abstract: Co-developer of biotech's drug couldn't supply original data. ...

    Abstract Co-developer of biotech's drug couldn't supply original data.
    MeSH term(s) Humans ; Alzheimer Disease/prevention & control ; Biotechnology ; Spiro Compounds ; Scientific Misconduct ; United States
    Chemical Substances Simufilam (6NV440YIO0) ; Spiro Compounds
    Language English
    Publishing date 2023-10-19
    Publishing country United States
    Document type News
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.adl4276
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Brain games?

    Piller, Charles

    Science (New York, N.Y.)

    2023  Volume 382, Issue 6672, Page(s) 754–759

    Abstract: Whistleblowers and former lab members suggest a star neuroscientist routinely manipulated data, compromising a planned NIH stroke trial and key Alzheimer's research. ...

    Abstract Whistleblowers and former lab members suggest a star neuroscientist routinely manipulated data, compromising a planned NIH stroke trial and key Alzheimer's research.
    MeSH term(s) Humans ; Alzheimer Disease/therapy ; Brain ; Stroke/therapy ; Whistleblowing ; Clinical Trials as Topic ; National Institutes of Health (U.S.) ; Scientific Misconduct
    Chemical Substances 3K3A-APC protein
    Language English
    Publishing date 2023-11-16
    Publishing country United States
    Document type News
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.adm9261
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Report on trial death stokes Alzheimer's drug fears.

    Piller, Charles

    Science (New York, N.Y.)

    2023  Volume 380, Issue 6641, Page(s) 122–123

    Abstract: Amyloid-clearing antibody lecanemab faces key FDA hearing in June. ...

    Abstract Amyloid-clearing antibody lecanemab faces key FDA hearing in June.
    MeSH term(s) Humans ; Alzheimer Disease/drug therapy ; Alzheimer Disease/mortality ; Amyloid beta-Peptides/immunology ; Antibodies, Monoclonal, Humanized/adverse effects ; Antibodies, Monoclonal, Humanized/therapeutic use ; Autopsy ; Brain/pathology ; Clinical Trials as Topic ; Fear ; United States Food and Drug Administration ; Female ; Aged
    Chemical Substances Amyloid beta-Peptides ; Antibodies, Monoclonal, Humanized ; lecanemab (12PYH0FTU9)
    Language English
    Publishing date 2023-04-13
    Publishing country United States
    Document type News
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.adi2242
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Failing the test.

    Piller, Charles

    Science (New York, N.Y.)

    2022  Volume 375, Issue 6580, Page(s) 484–489

    Abstract: Figure: see text]. ...

    Abstract [Figure: see text].
    Language English
    Publishing date 2022-02-03
    Publishing country United States
    Document type News
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.ada0801
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Controversial botanist cleared.

    Piller, Charles

    Science (New York, N.Y.)

    2022  Volume 376, Issue 6598, Page(s) 1145

    Abstract: Report sees "insufficient evidence" of misconduct. ...

    Abstract Report sees "insufficient evidence" of misconduct.
    Language English
    Publishing date 2022-06-09
    Publishing country United States
    Document type News
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.add3746
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Research backing experimental Alzheimer's drug was first target of suspicion.

    Piller, Charles

    Science (New York, N.Y.)

    2022  Volume 377, Issue 6604, Page(s) 363

    MeSH term(s) Alzheimer Disease/drug therapy ; Drugs, Investigational/therapeutic use ; Humans ; Scientific Misconduct ; Spiro Compounds/therapeutic use
    Chemical Substances Drugs, Investigational ; Spiro Compounds ; Simufilam (6NV440YIO0)
    Language English
    Publishing date 2022-07-21
    Publishing country United States
    Document type News
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.ade0181
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Research backing experimental Alzheimer's drug was first target of suspicion.

    Piller, Charles

    Science (New York, N.Y.)

    2022  Volume 377, Issue 6604, Page(s) 363

    MeSH term(s) Alzheimer Disease/drug therapy ; Drugs, Investigational/therapeutic use ; Humans ; Scientific Misconduct ; Spiro Compounds/therapeutic use
    Chemical Substances Drugs, Investigational ; Spiro Compounds ; Simufilam (6NV440YIO0)
    Language English
    Publishing date 2022-07-21
    Publishing country United States
    Document type News
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.ade0350
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Whistleblower finds possible misconduct in his own papers.

    Piller, Charles

    Science (New York, N.Y.)

    2022  Volume 378, Issue 6621, Page(s) 694–695

    Abstract: Matthew Schrag confronts a mentor after their joint work is flagged on the PubPeer website. ...

    Abstract Matthew Schrag confronts a mentor after their joint work is flagged on the PubPeer website.
    MeSH term(s) Humans ; Mentors ; Scientific Misconduct ; Whistleblowing ; Neurosciences/ethics ; Alzheimer Disease
    Language English
    Publishing date 2022-11-17
    Publishing country United States
    Document type News
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.adf8360
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Blots on a field?

    Piller, Charles

    Science (New York, N.Y.)

    2022  Volume 377, Issue 6604, Page(s) 358–363

    Abstract: A neuroscience image sleuth finds signs of fabrication in scores of Alzheimer's articles, threatening a reigning theory of the disease. ...

    Abstract A neuroscience image sleuth finds signs of fabrication in scores of Alzheimer's articles, threatening a reigning theory of the disease.
    MeSH term(s) Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/chemistry ; Amyloid beta-Peptides/metabolism ; Blotting, Western ; Humans ; Scientific Misconduct
    Chemical Substances Amyloid beta-Peptides
    Language English
    Publishing date 2022-07-21
    Publishing country United States
    Document type News
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.add9993
    Database MEDical Literature Analysis and Retrieval System OnLINE

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