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  1. Book ; Online: On measuring inequalities in health / Michael Wolfson and Geoff Rowe ; A propos de la mesure des inégalités de santé

    Wolfson, Michael C / Rowe, Geoff

    résumé ; Sobre la medición de las desigualdades en salud : resumen

    2001  

    Abstract: Summaries in English, French and ... ...

    Abstract Summaries in English, French and Spanish
    Keywords Health status ; Socioeconomic factors ; Mortality ; Longevity ; Outcome assessment (Health care) ; Analysis of variance ; Longitudinal studies ; Models ; Statistical ; Epidemiology and Statistics ; trends
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Book ; Article ; Online: On measuring inequalities in health / Michael Wolfson and Geoff Rowe ; A propos de la mesure des inégalités de santé

    Wolfson, Michael C / Rowe, Geoff

    résumé ; Sobre la medición de las desigualdades en salud : resumen

    2001  

    Abstract: Summaries in English, French and ... ...

    Abstract Summaries in English, French and Spanish
    Keywords Health Status ; Socioeconomic Factors ; Mortality ; Longevity ; Outcome and Process Assessment ; Health Care ; Analysis of Variance ; Longitudinal Studies ; Models ; Statistical ; Epidemiology and Statistics ; trends
    Document type Book ; Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Management of the Pregnant Patient with Beta-Lactam Allergy.

    Wolfson, Anna R / Schatz, Michael X

    Current allergy and asthma reports

    2023  Volume 23, Issue 3, Page(s) 189–194

    Abstract: Purpose of review: We review the literature and discuss the logistics of testing pregnant patients for penicillin allergy.: Recent findings: As in the general population, pregnant patients commonly report a penicillin allergy, but most patients are ... ...

    Abstract Purpose of review: We review the literature and discuss the logistics of testing pregnant patients for penicillin allergy.
    Recent findings: As in the general population, pregnant patients commonly report a penicillin allergy, but most patients are able to tolerate penicillin. Avoidance of beta-lactams in pregnancy is associated with increased morbidity: longer hospitalizations, more frequent infections, and more complications. Penicillin allergy testing is safe in pregnant patients, and obstetricians are eager for allergists to offer this procedure to their patients. As allergists, we can improve our patients' health outcomes by offering penicillin allergy testing in our practices. The protocols for testing both with and without skin testing in pregnant patients have been studied, and future studies will continue to clarify the safety and efficacy of penicillin allergy delabeling in pregnant patients.
    MeSH term(s) Pregnancy ; Female ; Humans ; beta-Lactams ; Anti-Bacterial Agents/therapeutic use ; Penicillins ; Drug Hypersensitivity/epidemiology ; Skin Tests/methods ; Hypersensitivity/drug therapy
    Chemical Substances beta-Lactams ; Anti-Bacterial Agents ; Penicillins
    Language English
    Publishing date 2023-02-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057370-4
    ISSN 1534-6315 ; 1529-7322
    ISSN (online) 1534-6315
    ISSN 1529-7322
    DOI 10.1007/s11882-023-01069-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5548: Show issues Location:
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  4. Article ; Online: Ketamine Versus Opioids for Acute Pain in the Emergency Department.

    Duhaime, Michael J / Wolfson, Allan B

    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine

    2020  Volume 27, Issue 8, Page(s) 781–782

    Language English
    Publishing date 2020-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1329813-6
    ISSN 1553-2712 ; 1069-6563
    ISSN (online) 1553-2712
    ISSN 1069-6563
    DOI 10.1111/acem.13976
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    Zs.A 4479: Show issues Location:
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  5. Article ; Online: Bone Tunnel Management in Modern Revision Anterior Cruciate Ligament Reconstruction.

    Wolfson, Theodore S / Alaia, Michael J

    Bulletin of the Hospital for Joint Disease (2013)

    2020  Volume 78, Issue 1, Page(s) 53–64

    Abstract: Bone tunnel-related issues are frequently encountered during revision anterior cruciate ligament reconstruction. Tunnel malposition, widening, and interference pose unique challenges that may complicate surgery and compromise outcomes. Preoperative ... ...

    Abstract Bone tunnel-related issues are frequently encountered during revision anterior cruciate ligament reconstruction. Tunnel malposition, widening, and interference pose unique challenges that may complicate surgery and compromise outcomes. Preoperative planning is critical to identify and characterize bone tunnel pathology. Choice of technique, graft, and implant are influenced by numerous patientrelated and technical factors. Despite this complexity, a variety of strategies are available to help manage and navigate common bone tunnel problems. Among these include alternative techniques for reaming, bone grafting, and fixation. This review provides a modern evidence-based and practical guide to equip the orthopedic surgeon with a systematic approach to the evaluation and management of bone tunnel-related issues encountered during revision anterior cruciate ligament reconstruction.
    MeSH term(s) Anterior Cruciate Ligament Injuries/surgery ; Anterior Cruciate Ligament Reconstruction/methods ; Bone Transplantation/methods ; Humans ; Reoperation
    Language English
    Publishing date 2020-04-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 390411-8
    ISSN 2328-5273 ; 1936-9727 ; 1936-9719 ; 0018-5647 ; 0883-9344 ; 2328-4633
    ISSN (online) 2328-5273 ; 1936-9727
    ISSN 1936-9719 ; 0018-5647 ; 0883-9344 ; 2328-4633
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.233: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article: A Shining Light in Canada's Health Information System.

    Wolfson, Michael

    Healthcare policy = Politiques de sante

    2014  Volume 6, Issue Spec Issue, Page(s) 8–13

    Title translation Signaux lumineux dans le système d'information sur la santé au Canada.
    Language French
    Publishing date 2014-06-16
    Publishing country Canada
    Document type Editorial
    ZDB-ID 2481657-7
    ISSN 1715-6572
    ISSN 1715-6572
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Assessment of Aortic Characteristic Impedance and Arterial Compliance from Non-invasive Carotid Pressure Waveform in The Framingham Heart Study.

    Niroumandi, Soha / Alavi, Rashid / Wolfson, Aaron Michael / Vaidya, Ajay Shrikrishna / Pahlevan, Niema Mohammed

    The American journal of cardiology

    2023  Volume 204, Page(s) 195–199

    Abstract: The primary goal of this study was to test the hypothesis that a hybrid intrinsic frequency-machine learning (IF-ML) approach can accurately evaluate total arterial compliance (TAC) and aortic characteristic impedance (Zao) from a single noninvasive ... ...

    Abstract The primary goal of this study was to test the hypothesis that a hybrid intrinsic frequency-machine learning (IF-ML) approach can accurately evaluate total arterial compliance (TAC) and aortic characteristic impedance (Zao) from a single noninvasive carotid pressure waveform in both women and men with heart failure (HF). TAC and Zao are cardiovascular biomarkers with established clinical significance. TAC is lower and Zao is higher in women than in men, so women are more susceptible to the consequent deleterious effects of them. Although the principles of TAC and Zao are pertinent to a multitude of cardiovascular diseases, including HF, their routine clinical use is limited because of the requirement for simultaneous measurements of flow and pressure waveforms. For this study, the data were obtained from the Framingham Heart Study (n = 6,201, 53% women). The reference values of Zao and TAC were computed from carotid pressure and aortic flow waveforms. IF parameters of carotid pressure waveform were used in ML models. IF models were developed on n = 5,168 of randomly selected data and blindly tested the remaining data (n = 1,033). The final models were evaluated in patients with HF. Correlations between IF-ML and reference values in all HF and HF with preserved ejection fraction for TAC were 0.88 and 0.90, and for Zao were 0.82 and 0.80, respectively. The classification accuracy in all HF and HF with preserved ejection fraction for TAC were 0.9 and 0.93, and for Zao were 0.81 and 0.89, respectively. In conclusion, the IF-ML method provides an accurate estimation of TAC and Zao in all subjects with HF and in the general population.
    MeSH term(s) Male ; Humans ; Female ; Electric Impedance ; Aorta ; Longitudinal Studies ; Heart Failure ; Cardiovascular Diseases
    Language English
    Publishing date 2023-08-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2023.07.076
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    Ui IV Zs.73: Show issues Location:
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  8. Article ; Online: How to pay for national pharmacare.

    Wolfson, Michael C / Morgan, Steven G

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2018  Volume 190, Issue 47, Page(s) E1384–E1388

    MeSH term(s) Canada ; Financing, Government ; Health Policy ; Healthcare Financing ; Humans ; Income Tax ; Insurance, Pharmaceutical Services/economics ; Universal Health Insurance
    Language English
    Publishing date 2018-11-26
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.180897
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    Ua VI Zs.136: Show issues Location:
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  9. Article ; Online: Endoscopic third ventriculostomy and biopsy of a tectal lesion using flexible neuroendoscopy and urological cup forceps: illustrative case.

    Yang, Meredith / Wolfson, Daniel / LoPresti, Melissa A / Poland, Emma / Lam, Sandi / DeCuypere, Michael

    Journal of neurosurgery. Case lessons

    2023  Volume 5, Issue 16

    Abstract: Background: Tectal region tumors often clinically present as obstructive hydrocephalus due to mass effect on the outflow of the third ventricle and cerebral aqueduct. Pathology in this region varies; thus, biopsy can be of great value in the management ... ...

    Abstract Background: Tectal region tumors often clinically present as obstructive hydrocephalus due to mass effect on the outflow of the third ventricle and cerebral aqueduct. Pathology in this region varies; thus, biopsy can be of great value in the management decision making. Appropriate instrumentation remains an area of interest to further advance flexible neuroendoscopic techniques and applications.
    Observations: The authors report an illustrative case using flexible neuroendoscopy through a single burr hole for simultaneous endoscopic third ventriculostomy (ETV) and tectal tumor biopsy using urological cup forceps in a 13-year-old boy who had presented with obstructive hydrocephalus.
    Lessons: The authors demonstrate the feasibility of simultaneous ETV and tectal lesion biopsy via flexible neuroendoscopy to address obstructive hydrocephalus and obtain a tissue biopsy in a single-site procedure. They found that the use of flexible cup forceps designed for uroscopy is an important complement to flexible neuroendoscopy. Given the evolving applications of flexible neuroendoscopy, this has implications for instrumentation adaptation and future design.
    Language English
    Publishing date 2023-04-17
    Publishing country United States
    Document type Journal Article
    ISSN 2694-1902
    ISSN (online) 2694-1902
    DOI 10.3171/CASE22517
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Funneling modulatory peptide design with generative models: Discovery and characterization of disruptors of calcineurin protein-protein interactions.

    Tubiana, Jérôme / Adriana-Lifshits, Lucia / Nissan, Michael / Gabay, Matan / Sher, Inbal / Sova, Marina / Wolfson, Haim J / Gal, Maayan

    PLoS computational biology

    2023  Volume 19, Issue 2, Page(s) e1010874

    Abstract: Design of peptide binders is an attractive strategy for targeting "undruggable" protein-protein interfaces. Current design protocols rely on the extraction of an initial sequence from one known protein interactor of the target protein, followed by in- ... ...

    Abstract Design of peptide binders is an attractive strategy for targeting "undruggable" protein-protein interfaces. Current design protocols rely on the extraction of an initial sequence from one known protein interactor of the target protein, followed by in-silico or in-vitro mutagenesis-based optimization of its binding affinity. Wet lab protocols can explore only a minor portion of the vast sequence space and cannot efficiently screen for other desirable properties such as high specificity and low toxicity, while in-silico design requires intensive computational resources and often relies on simplified binding models. Yet, for a multivalent protein target, dozens to hundreds of natural protein partners already exist in the cellular environment. Here, we describe a peptide design protocol that harnesses this diversity via a machine learning generative model. After identifying putative natural binding fragments by literature and homology search, a compositional Restricted Boltzmann Machine is trained and sampled to yield hundreds of diverse candidate peptides. The latter are further filtered via flexible molecular docking and an in-vitro microchip-based binding assay. We validate and test our protocol on calcineurin, a calcium-dependent protein phosphatase involved in various cellular pathways in health and disease. In a single screening round, we identified multiple 16-length peptides with up to six mutations from their closest natural sequence that successfully interfere with the binding of calcineurin to its substrates. In summary, integrating protein interaction and sequence databases, generative modeling, molecular docking and interaction assays enables the discovery of novel protein-protein interaction modulators.
    MeSH term(s) Calcineurin/chemistry ; Calcineurin/genetics ; Calcineurin/metabolism ; Molecular Docking Simulation ; Peptides/chemistry ; Protein Binding
    Chemical Substances Calcineurin (EC 3.1.3.16) ; Peptides
    Language English
    Publishing date 2023-02-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2193340-6
    ISSN 1553-7358 ; 1553-734X
    ISSN (online) 1553-7358
    ISSN 1553-734X
    DOI 10.1371/journal.pcbi.1010874
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