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Article ; Online: Corrigendum to 'Performance of the Diasorin SARS-CoV-2 antigen detection assay on the LIAISON XL' [Journal of Clinical Virology 141 (2021) 104909].

Van der Moeren, N / Zwart, V F / Goderski, G / Rijkers, G T / van den Bijllaardt, W / Veenemans, J / Kluytmans, Jajw / Pas, S D / Meijer, A / Verweij, J J / Murk, Jlan / Stohr, Jjjm

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

2021 Volume 147, Page(s) 105028

Language	English
Publishing date	2021-11-30
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	1446080-4
ISSN	1873-5967 ; 1386-6532
ISSN (online)	1873-5967
ISSN	1386-6532
DOI	10.1016/j.jcv.2021.105028
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Article ; Online: Viral Evolution and Immunology of SARS-CoV-2 in a Persistent Infection after Treatment with Rituximab.

Van der Moeren, Nathalie / Selhorst, Philippe / Ha, My / Heireman, Laura / Van Gaal, Pieter-Jan / Breems, Dimitri / Meysman, Pieter / Laukens, Kris / Verstrepen, Walter / Van Gasse, Natasja / Ogunjimi, Benson / Arien, Kevin K / Naesens, Reinout

Viruses

2022 Volume 14, Issue 4

Abstract: ... clade 20B/GR, but rapidly accumulated a high number of mutations as well as deletions in the N-terminal ...

Abstract	Background: Prolonged shedding of SARS-CoV-2 in immunocompromised patients has been described. Furthermore, an accumulation of mutations of the SARS-CoV-2 genome in these patients has been observed. Methods: We describe the viral evolution, immunologic response and clinical course of a patient with a lymphoma in complete remission who had received therapy with rituximab and remained SARS-CoV-2 RT-qPCR positive for 161 days. Results: The patient remained hospitalised for 10 days, after which he fully recovered and remained asymptomatic. A progressive increase in Ct-value, coinciding with a progressive rise in lymphocyte count, was seen from day 137 onward. Culture of a nasopharyngeal swab on day 67 showed growth of SARS-CoV-2. Whole genome sequencing (WGS) demonstrated that the virus belonged to the wildtype SARS-CoV-2 clade 20B/GR, but rapidly accumulated a high number of mutations as well as deletions in the N-terminal domain of its spike protein. Conclusion: SARS-CoV-2 persistence in immunocompromised individuals has important clinical implications, but halting immunosuppressive therapy might result in a favourable clinical course. The long-term shedding of viable virus necessitates customized infection prevention measures in these individuals. The observed accelerated accumulation of mutations of the SARS-CoV-2 genome in these patients might facilitate the origin of new VOCs that might subsequently spread in the general community.
MeSH term(s)	COVID-19/drug therapy ; Humans ; Immunocompromised Host ; Male ; Persistent Infection ; Rituximab/therapeutic use ; SARS-CoV-2/genetics
Chemical Substances	Rituximab (4F4X42SYQ6)
Language	English
Publishing date	2022-04-03
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v14040752
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Article ; Online: De eerste 29 COVID-19-patiënten in de kliniek.

Van der Moeren, N / Talman, S / van den Bijllaardt, W / Kant, M / Heukels, P / Bentvelsen, R G / Loth, D W

Nederlands tijdschrift voor geneeskunde

2020 Volume 164

Abstract: The SARS-CoV-2 virus and COVID-19 disease is of pandemic proportions and reached the Netherlands on February 27 2020. Here we present the first Dutch cohort of 29 hospitalized patients during the first two weeks of the epidemic in the Netherlands. ... ...

Title translation	The first 29 COVID-19-patients in a clinic: early experiences from a Dutch hospital.
Abstract	The SARS-CoV-2 virus and COVID-19 disease is of pandemic proportions and reached the Netherlands on February 27 2020. Here we present the first Dutch cohort of 29 hospitalized patients during the first two weeks of the epidemic in the Netherlands. Demographic characteristics of patients, clinical presentation and course of disease up to the moment of analysis showed similarity with what has been described in Chinese and Italian literature. However the higher proportion of patients presenting with gastro-intestinal symptoms and the high number of patients with overweight and obesity stood out. Based on the experience in our hospital very early on in the epidemic COVID-19 impresses as a severe illness with risk of acute respiratory deterioration.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Ambulatory Care Facilities ; Betacoronavirus ; COVID-19 ; Comorbidity ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Female ; Gastrointestinal Diseases/epidemiology ; Gastrointestinal Diseases/virology ; Hospitals ; Humans ; Male ; Middle Aged ; Netherlands/epidemiology ; Obesity/epidemiology ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Young Adult
Keywords	covid19
Language	Dutch
Publishing date	2020-04-02
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	82073-8
ISSN	1876-8784 ; 0028-2162
ISSN (online)	1876-8784
ISSN	0028-2162
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Article: The first 29 COVID-19 patients in a clinic: Early experiences from a hospital in North Brabant

van der Moeren, N. / Talman, S. / van den Bijllaardt, W. / Kant, M. / Heukels, P. / Bentvelsen, R. G. / Loth, D. W.

Nederlands Tijdschrift voor Geneeskunde

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #590127
Database	COVID19

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Article ; Online: Evaluation of the test accuracy of a SARS-CoV-2 rapid antigen test in symptomatic community dwelling individuals in the Netherlands.

Van der Moeren, Nathalie / Zwart, Vivian F / Lodder, Esther B / Van den Bijllaardt, Wouter / Van Esch, Harald R J M / Stohr, Joep J J M / Pot, Joost / Welschen, Ineke / Van Mechelen, Petra M F / Pas, Suzan D / Kluytmans, Jan A J W

PloS one

2021 Volume 16, Issue 5, Page(s) e0250886

Abstract: ... qRT-PCR obtained at a MHS test center were eligible.: Findings: In part one (n = 352) SARS-CoV-2 ... In part two (n = 123) the sensitivity was 78·9% (95%CI: 70·6%-85·7%) overall, 89·4% (95% CI: 79·4%-95·6 ...

Abstract	Background: SARS-CoV-2 real-time reverse transcriptase polymerase chain reaction (qRT-PCR) is well suited for the diagnosis of clinically ill patients requiring treatment. Application for community testing of symptomatic individuals for disease control purposes however raises challenges. SARS-CoV-2 rapid antigen tests might offer an alternative, but quality evidence on their performance is limited. Methods: We conducted an evaluation of the test accuracy of the 'BD Veritor System for Rapid Detection of SARS-CoV-2' (VRD) compared to qRT-PCR on combined nose/throat swabs obtained from symptomatic individuals at Municipal Health Service (MHS) COVID-19 test centers in the Netherlands. In part one of the study, with the primary objective to evaluate test sensitivity and specificity, all adults presenting at one MHS test center were eligible for inclusion. In part two, with the objective to evaluate test sensitivity stratified by Ct (cycle threshold)-value and time since symptom onset, adults who had a positive qRT-PCR obtained at a MHS test center were eligible. Findings: In part one (n = 352) SARS-CoV-2 prevalence was 4.8%, overall specificity 100% (95%CI: 98·9%-100%) and sensitivity 94·1% (95%CI: 71·1%-100%). In part two (n = 123) the sensitivity was 78·9% (95%CI: 70·6%-85·7%) overall, 89·4% (95% CI: 79·4%-95·6%) for specimen obtained within seven days after symptom onset and 93% (95% CI: 86%-97.1%) for specimen with a Ct-value below 30. Interpretation: The VRD is a promising diagnostic for COVID-19 testing of symptomatic community-dwelling individuals within seven days after symptom onset in context of disease control. Further research on practical applicability and the optimal position within the testing landscape is needed.
MeSH term(s)	COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19 Serological Testing/economics ; COVID-19 Serological Testing/methods ; Humans ; Independent Living ; Netherlands/epidemiology ; Prospective Studies ; SARS-CoV-2/isolation & purification ; Sensitivity and Specificity ; Time Factors
Language	English
Publishing date	2021-05-13
Publishing country	United States
Document type	Evaluation Study ; Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0250886
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Performance of the Diasorin SARS-CoV-2 antigen detection assay on the LIAISON XL.

Van der Moeren, N / Zwart, V F / Goderski, G / Rijkers, G T / van den Bijllaardt, W / Veenemans, J / Kluytmans, J A J W / Pas, S D / Meijer, A / Verweij, J J / Murk, J L A N / Stohr, J J J M

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

2021 Volume 141, Page(s) 104909

Abstract: Background: The current reference standard to diagnose a SARS-CoV-2 infection is real-time reverse transcriptase polymerase chain reaction (RT-PCR). This test poses substantial challenges for large-scale community testing, especially with respect to the ...

Abstract	Background: The current reference standard to diagnose a SARS-CoV-2 infection is real-time reverse transcriptase polymerase chain reaction (RT-PCR). This test poses substantial challenges for large-scale community testing, especially with respect to the long turnaround times. SARS-CoV-2 antigen tests are an alternative, but typically use a lateral flow assay format rendering them less suitable for analysis of large numbers of samples. Methods: We conducted an evaluation of the Diasorin SARS-CoV-2 antigen detection assay (DAA) compared to real-time RT-PCR (Abbott). The study was performed on 248 (74 qRT-PCR positive, 174 qRT-PCR negative) clinical combined oro-nasopharyngeal samples of individuals with COVID-19-like symptoms obtained at a Municipal Health Service test centre. In addition, we evaluated the analytical performance of DAA with a 10-fold dilution series of SARS-CoV-2 containing culture supernatant and compared it with the lateral flow assay SARS-CoV-2 Roche/SD Biosensor Rapid Antigen test (RRA). Results: The DAA had an overall specificity of 100% (95%CI 97.9%-100%) and sensitivity of 73% (95%CI 61.3%-82.7%) for the clinical samples. Sensitivity was 86% (CI95% 74.6%-93.3%) for samples with Ct-value below 30. Both the DAA and RRA detected SARS-CoV-2 up to a dilution containing 5.2 × 10 Discussion: The DAA performed adequately for clinical samples with a Ct-value below 30. Test performance may be further optimised by lowering the relative light unit (RLU) threshold for positivity assuming the in this study used pre-analytical protocol . The test has potential for use as a diagnostic assay for symptomatic community-dwelling individuals early after disease onset in the context of disease control.
MeSH term(s)	COVID-19 ; Humans ; Nasopharynx ; SARS-CoV-2 ; Sensitivity and Specificity
Language	English
Publishing date	2021-07-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1446080-4
ISSN	1873-5967 ; 1386-6532
ISSN (online)	1873-5967
ISSN	1386-6532
DOI	10.1016/j.jcv.2021.104909
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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: De eerste 29 COVID-19-patiënten in de kliniek./ [The first 29 COVID-19-patients in a clinic: early experiences from a Dutch hospital]

Van der Moeren, N / Talman, S / van den Bijllaardt, W / Kant, M / Heukels, P / Bentvelsen, R G / Loth, D W

Ned. tijdschr. geneeskd

Abstract	The SARS-CoV-2 virus and COVID-19 disease is of pandemic proportions and reached the Netherlands on February 27 2020. Here we present the first Dutch cohort of 29 hospitalized patients during the first two weeks of the epidemic in the Netherlands. Demographic characteristics of patients, clinical presentation and course of disease up to the moment of analysis showed similarity with what has been described in Chinese and Italian literature. However the higher proportion of patients presenting with gastro-intestinal symptoms and the high number of patients with overweight and obesity stood out. Based on the experience in our hospital very early on in the epidemic COVID-19 impresses as a severe illness with risk of acute respiratory deterioration.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32391998
Database	COVID19

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Article: [The first 29 COVID-19-patients in a clinic: early experiences from a Dutch hospital]

Van der Moeren, N. / Talman, S. / van den Bijllaardt, W. / Kant, M. / Heukels, P. / Bentvelsen, R. G. / Loth, D. W.

Ned Tijdschr Geneeskd

Abstract: The SARS-CoV-2 virus and COVID-19 disease is of pandemic proportions and reached the Netherlands on February 27 2020 Here we present the first Dutch cohort of 29 hospitalized patients during the first two weeks of the epidemic in the Netherlands ... ...

Abstract	The SARS-CoV-2 virus and COVID-19 disease is of pandemic proportions and reached the Netherlands on February 27 2020 Here we present the first Dutch cohort of 29 hospitalized patients during the first two weeks of the epidemic in the Netherlands Demographic characteristics of patients, clinical presentation and course of disease up to the moment of analysis showed similarity with what has been described in Chinese and Italian literature However the higher proportion of patients presenting with gastro-intestinal symptoms and the high number of patients with overweight and obesity stood out Based on the experience in our hospital very early on in the epidemic COVID-19 impresses as a severe illness with risk of acute respiratory deterioration
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #234405
Database	COVID19

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Article ; Online: PERFORMANCE EVALUATION OF A SARS-COV-2 RAPID ANTIGENTEST: TEST PERFORMANCE IN THE COMMUNITY IN THE NETHERLANDS

Van der Moeren, N. / Zwart, V. / Lodder, E. / Van den Bijllaardt, W. / Van Esch, H. / Stohr, J. / Pot, J. / Welschen, I. / Van Mechelen, P. / Pas, S. / Kluytmans, J.

Abstract: Objectives: This study was primarily conducted to evaluate clinical sensitivity and specificity of the SARS-CoV-2 rapid antigen test BD Veritor System for Rapid Detection of SARS-CoV-2 (VRD) compared to real time reverse transcriptase polymerase chain ... ...

Abstract	Objectives: This study was primarily conducted to evaluate clinical sensitivity and specificity of the SARS-CoV-2 rapid antigen test BD Veritor System for Rapid Detection of SARS-CoV-2 (VRD) compared to real time reverse transcriptase polymerase chain reaction (qRT-PCR). Furthermore, the VRD sensitivity for different Ct-value groups (Ct <20; Ct 20-25, Ct 25-30 and Ct > 30) and different intervals since symptom onset (< 7 days; > 7 days) were examined. Design: Prospective performance evaluation study. Setting: Municipal Health Service (GGD) COVID-19 test centres in West-Brabant, the Netherlands Participants: In order to evaluate clinical specificity, 352 symptomatic adults (> 18 years) who presented at a participating GGD test centre for a COVID- 19 test between September 28 and October 7 2020 were included. In order to evaluate clinical sensitivity, 123 symptomatic adults (> 18 years) who were tested positive with qRT-PCR in a participating GGD test centre between September 26 and October 6 were included. Results: An overall clinical specificity of 100% (95%CI : 98.9%-100%) and sensitivity of 80.7% (95% CI: 73,2%-86,9%) was found for the VRD compared to qRT-PCR. Sensitivity was the highest for low Ct-value categories and for specimen obtained within the first days after disease onset. For specimen obtained within 7 days after onset of symptoms, the overall sensitivity was 91.0% (95%: CI 82,4%-96,3%) and 98,6% (95%: CI 92,3%-100%) for samples with qRT-PCR Ct-value beneath 30. Conclusion: The VRD is a promising diagnostic test for COVID-19 community screening for symptomatic individuals within 7 days after symptom onset in function of disease control. The clinical sensitivity was highest when viral load was high, which correlated with the duration of symptoms. Further research on practical applicability and the optimal position of the test within the current testing landscape is needed.
Keywords	covid19
Publisher	MedRxiv; WHO
Document type	Article ; Online
DOI	10.1101/2020.10.19.20215202
Database	COVID19

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Article ; Online: Performance of Various Lateral Flow SARS-CoV-2 Antigen Self Testing Methods in Healthcare Workers: a Multicenter Study.

Zwart, Vivian F / van der Moeren, Nathalie / Stohr, Joep J.J.M. / Feltkamp, Mariet C.W. / Bentvelsen, Robbert G. / Diederen, Bram M.W. / de Laat, Adrie C. / Mascini, Ellen M. / Schilders, Isabelle G.P. / Vlassak, Henk T.M. / Wertheim, Heiman F.L. / Murk, Jean-Luc A.N. / Kluytmans, Jan A.J.W. / van den Bijllaardt, Wouter

medRxiv

Abstract: Introduction: Rapid antigen detection tests (RDT) are suitable for large-scale testing for SARS-CoV-2 among the population and recent studies have shown that self-testing with RDT in the general population is feasible and yields acceptable sensitivities ... ...

Abstract	Introduction: Rapid antigen detection tests (RDT) are suitable for large-scale testing for SARS-CoV-2 among the population and recent studies have shown that self-testing with RDT in the general population is feasible and yields acceptable sensitivities with high specificity. We aimed to determine the accuracy of two different RDT, with two different sample collection methods for one of the RDT among healthcare workers (HCW). Secondary objectives were to determine the accuracy of RDT using a viral load cut-off as proxy of infectiousness and to identify predictors for a false negative RDT. Methods: Centers that participated were secondary care hospitals, academic teaching hospitals, and long-term care facilities. All HCW that met inclusion criteria were asked to perform a RDT self-test next to a regular SARS-CoV-2 nucleic acid amplification test (NAAT). Three study groups were created. Study group 1; Veritor™ System, Becton Dickinson, Franklin Lakes, USA (BD-RDT) with combined oropharyngeal - mid-turbinate nasal sampling, group 2; BD-RDT with mid-turbinate nasal sampling only and group 3; SD Biosensor SARS-CoV-2 Rapid Antigen Test, Roche, Basel, Switzerland (Roche-RDT) with combined oropharyngeal - mid-turbinate nasal sampling. RDT accuracy was calculated using NAAT as reference standard. For samples processed in the cobas® 6800/8800 platform (Roche Diagnostics, Basel, Switzerland), established cycle threshold values (Ct-values) could be converted into viral loads. A viral load cut-off of ≥5.2 log10 SARS-CoV-2 E gene copies/ml was used as proxy of infectiousness. Logistic regression analysis was performed to identify predictors for a false negative RDT. Results: In total, 7,196 HCW were included. Calculated sensitivities were 61.5% (95%CI 56.6%-66.3%), 50.3% (95%CI 42.8%-57.7%) and 74.2% (95%CI 66.4%-80.9%) for study groups 1, 2 and 3, respectively. After application of a viral load cut-off as a proxy for infectiousness for samples processed in the cobas® 6800/8800 platform sensitivities increased to 82.2% (95%CI 76.6-86.9%), 61.9% (95%CI 48.8%-73.9%) and 90.2% (95%CI 76.9%-97.3%) for group 1, group 2 and group 3, respectively. Multivariable regression analysis showed that use of Roche-RDT (p <0.01), combined oropharyngeal - mid-turbinate nasal sampling (p <0.05) and the presence of COVID-19 like symptoms at the time of testing (p <0.01) significantly reduced the likeliness of a false-negative RDT result. Conclusion: SARS-CoV-2 RDT has proven able to identify infectious individuals, especially when upper respiratory specimen is collected through combined oropharyngeal - mid-turbinate sampling. Reliability of self-testing with RDT among HCW seems to depend on the type of RDT, the sampling method and the presence of COVID-19 like symptoms at the time of testing.
Keywords	covid19
Language	English
Publishing date	2022-01-29
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2022.01.28.22269783
Database	COVID19

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