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  1. Article ; Online: The efficacy of intraarticular viscosupplementation after arthroscopic partial meniscectomy: a randomized controlled trial.

    Yoon, Kyoung Ho / Wan, Woo Seung / Kim, Yoon-Seok / Park, Jae-Young

    BMC musculoskeletal disorders

    2022  Volume 23, Issue 1, Page(s) 32

    Abstract: Background: This study aimed to evaluate the efficacy of viscosupplementation after arthroscopic partial meniscectomy.: Method: A randomized controlled trial of 47 patients who underwent arthroscopic partial meniscectomy was conducted between March ... ...

    Abstract Background: This study aimed to evaluate the efficacy of viscosupplementation after arthroscopic partial meniscectomy.
    Method: A randomized controlled trial of 47 patients who underwent arthroscopic partial meniscectomy was conducted between March 2020 and March 2021. Patients were randomized into two groups: a viscosupplementation group (n = 23) and a control group (n = 24). A single-dose intraarticular hyaluronic acid injection was used as viscosupplementation. The 100 mm visual analogue scale (VAS) for pain assessment was measured at baseline and at 1 day, 2 weeks, 6 weeks, and 3 months post-surgery. The International Knee Documentation Committee (IKDC), Tegner, Lysholm, and Western Ontario and McMaster University Osteoarthritis Index (WOMAC) scores and range of motion (ROM) of the knee were measured at baseline, 2 weeks, 6 weeks, and 3 months.
    Results: The 100 mm VAS score for pain was significantly lower in the viscosupplementation group at 2 weeks post-surgery (27.5 mm vs. 40.7 mm, P = 0.047). ROM was significantly greater in the viscosupplementation group than in the control group at 2 weeks (131.5° vs. 121.0°, P = 0.044) post-surgery. No significant differences were observed in the IKDC or in the Tegner, Lysholm, and WOMAC scores between the two groups.
    Conclusions: Viscosupplementation after arthroscopic partial meniscectomy significantly reduced pain at 2 weeks post-surgery and improved ROM of the knee at 2 weeks post-surgery. There might be some benefits in terms of pain and functional recovery of viscosupplementation after arthroscopic surgery.
    Study design: Randomized controlled trial; Level of evidence, 1.
    Trial registration: This randomized controlled trial was registered at cris.nih.go.kr # KCT0004921 .
    MeSH term(s) Arthroscopy ; Humans ; Knee Joint/diagnostic imaging ; Knee Joint/surgery ; Meniscectomy/adverse effects ; Osteoarthritis, Knee/drug therapy ; Osteoarthritis, Knee/surgery ; Treatment Outcome ; Viscosupplementation
    Language English
    Publishing date 2022-01-04
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ISSN 1471-2474
    ISSN (online) 1471-2474
    DOI 10.1186/s12891-021-04990-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Dead cell phagocytosis and innate immune checkpoint.

    Yoon, Kyoung Wan

    BMB reports

    2017  Volume 50, Issue 10, Page(s) 496–503

    Abstract: The human body loses several billions of cells daily. When cells die in vivo, the corpse of each dead cell is immediately cleared. Specifically, dead cells are efficiently recognized and cleared by multiple types of neighboring phagocytes. Early research ...

    Abstract The human body loses several billions of cells daily. When cells die in vivo, the corpse of each dead cell is immediately cleared. Specifically, dead cells are efficiently recognized and cleared by multiple types of neighboring phagocytes. Early research on cell death focused more on molecular mechanisms of cell death regulation while the cellular corpses were merely considered cellular debris. However, it has come to light that various biological stimuli following cell death are important for immune regulation. Clearance of normal dead cells occurs silently in immune tolerance. Exogenous or mutated antigens of malignant or infected cells can initiate adaptive immunity, thereby inducing immunogenicity by adjuvant signals. Several pathogens and cancer cells have strategies to limit the adjuvant signals and escape immune surveillance. In this review, we present an overview of the mechanisms of dead cell clearance and its immune regulations. [BMB Reports 2017; 50(10): 496-503].
    MeSH term(s) Animals ; Apoptosis/immunology ; Cell Death ; Cytophagocytosis/immunology ; Cytophagocytosis/physiology ; Humans ; Immune Tolerance ; Immunity, Innate/immunology ; Phagocytes/physiology ; Phagocytosis/immunology
    Language English
    Publishing date 2017-08-02
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2410389-5
    ISSN 1976-670X ; 1976-6696
    ISSN (online) 1976-670X
    ISSN 1976-6696
    DOI 10.5483/bmbrep.2017.50.10.147
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Current state of cytopathology residency training: a Korean national survey of pathologists.

    Cho, Uiju / Kim, Tae Jung / Kim, Wan Seop / Lee, Kyo Young / Yoon, Hye Kyoung / Choi, Hyun Joo

    Journal of pathology and translational medicine

    2023  Volume 57, Issue 2, Page(s) 95–101

    Abstract: Background: Although the Korean Society for Cytopathology has developed educational goals as guidelines for cytopathology education in Korea, there is still no systematic approach to cytopathology education status for pathology residents. Furthermore, ... ...

    Abstract Background: Although the Korean Society for Cytopathology has developed educational goals as guidelines for cytopathology education in Korea, there is still no systematic approach to cytopathology education status for pathology residents. Furthermore, satisfaction with cytopathology education and with the outcome of the current training/educational program has not been investigated in Korea. This study aimed to obtain comprehensive data on the current state of cytopathology education for residents and evaluate education outcomes.
    Methods: An online survey was conducted in December 2020 for the board-certified pathologists and training residents registered as members of the Korean Society for Cytopathology. The questionnaire comprised questions that investigated the current status of cytopathology at each training institution, the degree of satisfaction with the work and education related to cytopathology, outcomes of cytopathology training, and educational accomplishments.
    Results: Of the participants surveyed, 12.3% (132/1,075) completed the questionnaire, and 36.8% (32/87) of cytopathology residents participated. The mean overall satisfaction with cytopathology education was 3.1 points (on a 1- to 5-point scale, 5: very satisfied). The most frequent suggestion among the free description format responses was to expand educational opportunities, such as online education opportunities, outside of the individual institutions.
    Conclusions: Our results showed that cytopathology training in Korea needs further improvement. We expect that this study will inform systematic training of competent medical personnel armed with broad cytopathology knowledge and strong problem-solving abilities.
    Language English
    Publishing date 2023-03-14
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3022395-7
    ISSN 2383-7845 ; 2383-7837
    ISSN (online) 2383-7845
    ISSN 2383-7837
    DOI 10.4132/jptm.2023.01.06
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Health-related Quality of Life Outcomes of Adalimumab for Patients With Rheumatoid Arthritis in Korea.

    Lee, Myeung-Su / Lee, Chang Hoon / Lee, Hye Soon / Sung, Yoon-Kyoung / Choi, Jung Ran / Park, Kyungsu / Lim, Mi-Kyoung / Choi, Byoong Yong / Kim, Hyoun-Ah / Choi, Seung Won / Lee, Yusun / Yoo, Wan-Hee

    Journal of rheumatic diseases

    2023  Volume 28, Issue 2, Page(s) 68–75

    Abstract: Objective: Rheumatoid arthritis (RA) is a chronic, progressive, autoimmune disorder that impairs patients' overall health-related quality of life (HRQOL) In this study, we evaluated the effect of adalimumab in Korean patients with active RA on HRQOL.: ...

    Abstract Objective: Rheumatoid arthritis (RA) is a chronic, progressive, autoimmune disorder that impairs patients' overall health-related quality of life (HRQOL) In this study, we evaluated the effect of adalimumab in Korean patients with active RA on HRQOL.
    Methods: Patients included in the study had moderate to severe active RA that did not respond to conventional drugs with a Disease Activity Score of 28 joints >32 and were biologics-naïve All patients received adalimumab 40 mg subcutaneously every other week and were followed for 24 weeks The primary endpoint was the change in baseline Health Assessment Questionnaire Disability Index (HAQ-DI) score at week 24 Secondary endpoints were changes in the EuroQol 5-dimension 3-Level (EQ-5D-3L) baseline score and Short Form 36-Item Health Survey (SF-36) domain scores at weeks 12 and 24 and change in baseline HAQ-DI score at week 12.
    Results: In total, 91 Korean patients were included Ninety-three percent of patients were in high disease activity with a baseline mean DAS28 value of 61 within all patients The mean change from baseline in HAQ-DI scores were -046 at week 12 and∼067 at week 24 (p<00001) Additionally, EQ-5D-3L score at weeks 12 and 24 had significantly improved (p<00001) compared to baseline SF-36 at weeks 12 and 24 had significantly improved (p<00001, p=00001) compared to baseline.
    Conclusion: Treatment with adalimumab resulted in significant improvement in HAQ-DI, EQ-5D-3L, and SF-36 scores at 12 and 24 weeks in Korean RA patient.
    Language English
    Publishing date 2023-07-18
    Publishing country Korea (South)
    Document type Journal Article
    ISSN 2233-4718
    ISSN (online) 2233-4718
    DOI 10.4078/jrd.2021.28.2.68
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Hazardous characteristics of dust waste from metal manufacturing industries in South Korea.

    Yoon, Cheol-Woo / Yoon, Young-Sam / Hong, Su-Yeon / Jeon, Tea-Wan / Shin, Sun-Kyoung

    Waste management & research : the journal of the International Solid Wastes and Public Cleansing Association, ISWA

    2021  Volume 39, Issue 12, Page(s) 1471–1479

    Abstract: The Ministry of Environment, South Korea, is involved in efforts to reduce safety-related accidents that could occur during hazardous waste disposal and minimise the environmental impacts of waste disposal. To reach such goals, new factors have been ... ...

    Abstract The Ministry of Environment, South Korea, is involved in efforts to reduce safety-related accidents that could occur during hazardous waste disposal and minimise the environmental impacts of waste disposal. To reach such goals, new factors have been added that contribute to the hazardous characteristics of hazardous waste. The Ministry is also expanding regulations on inorganic and organic components present in hazardous waste for these factors and continues to correct the classification system to establish standards for waste components. Metallic dust, for example, is mostly generated during the operation of melting furnaces or precipitators and dangerous materials contained in this dust may cause accidents, such as explosions or fires. South Korean accident cases have confirmed that waste containing hazardous materials, such as Mg, Al and Mg-Al alloys, can cause such events. Therefore, this study analysed 28 dust samples collected from the dust accumulated in precipitators in 28 metal manufacturing facilities in South Korea. Nine samples were flammable and four samples were reactive to water. Two samples also exhibited leaching toxicities. The results applied to relevant laws in South Korea showed that the proportion of waste containing hazardous characteristics increased from 7.14% in the previous management category to 39.29% in the extended category, an overall increase of 32.15 percentage points.
    MeSH term(s) Dust/analysis ; Hazardous Waste ; Manufacturing Industry ; Refuse Disposal ; Republic of Korea
    Chemical Substances Dust ; Hazardous Waste
    Language English
    Publishing date 2021-03-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1480483-9
    ISSN 1096-3669 ; 1399-3070 ; 0734-242X
    ISSN (online) 1096-3669 ; 1399-3070
    ISSN 0734-242X
    DOI 10.1177/0734242X21996552
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Effects of Semi-Immersive Virtual Reality-Based Cognitive Training Combined with Locomotor Activity on Cognitive Function and Gait Ability in Community-Dwelling Older Adults.

    Hwang, Na-Kyoung / Choi, Jong-Bae / Choi, Dae-Kil / Park, Jae-Min / Hong, Chang-Wan / Park, Ji-Su / Yoon, Tae-Hyung

    Healthcare (Basel, Switzerland)

    2021  Volume 9, Issue 7

    Abstract: This study aimed to investigate the effects of semi-immersive virtual reality-based cognitive training (VRCT) combined with locomotor activity on cognitive function, balance, and gait ability in older adults. Eighteen community-dwelling older adults ... ...

    Abstract This study aimed to investigate the effects of semi-immersive virtual reality-based cognitive training (VRCT) combined with locomotor activity on cognitive function, balance, and gait ability in older adults. Eighteen community-dwelling older adults participated in this study. Subjects who met the selection criteria were assigned to an experimental group (
    Language English
    Publishing date 2021-06-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare9070814
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  7. Article: Promoting angiogenesis and diabetic wound healing through delivery of protein transduction domain-BMP2 formulated nanoparticles with hydrogel.

    Suh, Jae Wan / Lee, Kyoung-Mi / Ko, Eun Ae / Yoon, Dong Suk / Park, Kwang Hwan / Kim, Hyun Sil / Yook, Jong In / Kim, Nam Hee / Lee, Jin Woo

    Journal of tissue engineering

    2023  Volume 14, Page(s) 20417314231190641

    Abstract: Decreased angiogenesis contributes to delayed wound healing in diabetic patients. Recombinant human bone morphogenetic protein-2 (rhBMP2) has also been demonstrated to promote angiogenesis. However, the short half-lives of soluble growth factors, ... ...

    Abstract Decreased angiogenesis contributes to delayed wound healing in diabetic patients. Recombinant human bone morphogenetic protein-2 (rhBMP2) has also been demonstrated to promote angiogenesis. However, the short half-lives of soluble growth factors, including rhBMP2, limit their use in wound-healing applications. To address this limitation, we propose a novel delivery model using a protein transduction domain (PTD) formulated in a lipid nanoparticle (LNP). We aimed to determine whether a gelatin hydrogel dressing loaded with LNP-formulated PTD-BMP2 (LNP-PTD-BMP2) could enhance the angiogenic function of BMP2 and improve diabetic wound healing. In vitro, compared to the control and rhBMP2, LNP-PTD-BMP2 induced greater tube formation in human umbilical vein endothelial cells and increased the cell recruitment capacity of HaCaT cells. We inflicted large, full-thickness back skin wounds on streptozotocin-induced diabetic mice and applied gelatin hydrogel (GH) cross-linked by microbial transglutaminase containing rhBMP2, LNP-PTD-BMP2, or a control to these wounds. Wounds treated with LNP-PTD-BMP2-loaded GH exhibited enhanced wound closure, increased re-epithelialization rates, and higher collagen deposition than those with other treatments. Moreover, LNP-PTD-BMP2-loaded GH treatment resulted in more CD31- and α-SMA-positive cells, indicating greater neovascularization capacity than rhBMP2-loaded GH or GH treatments alone. Furthermore, in vivo near-infrared fluorescence revealed that LNP-PTD-BMP2 has a longer half-life than rhBMP2 and that BMP2 localizes around wounds. In conclusion, LNP-PTD-BMP2-loaded GH is a viable treatment option for diabetic wounds.
    Language English
    Publishing date 2023-08-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2573915-3
    ISSN 2041-7314
    ISSN 2041-7314
    DOI 10.1177/20417314231190641
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  8. Article ; Online: Clinical impact of clonal hematopoiesis on severe COVID- 19 patients without canonical risk factors.

    Kang, Chang Kyung / Choi, Baekgyu / Kim, Sugyeong / Sun, Choong Hyun / Yoon, Soon Ho / Kim, Kyukwang / Chang, Euijin / Jung, Jongtak / Choe, Pyoeng Gyun / Park, Wan Beom / Kim, Eu Suk / Kim, Hong Bin / Kim, Nam Joong / Oh, Myoung-Don / Im, Hogune / Kim, Joohae / Lee, Yong Hoon / Lee, Jaehee / Chun, Hyonho /
    Koh, Youngil / Lee, Ji Yeon / Moon, Joon Ho / Song, Kyoung-Ho / Jung, Inkyung

    Haematologica

    2023  Volume 108, Issue 1, Page(s) 257–260

    MeSH term(s) Humans ; Clonal Hematopoiesis ; COVID-19 ; Risk Factors ; Hematopoiesis ; Mutation
    Language English
    Publishing date 2023-01-01
    Publishing country Italy
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2022.280621
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Inhibitory Effect of Chemical Constituents Isolated from

    Lee, Yoon Kyoung / Hong, Eun Young / Whang, Wan Kyunn

    BioMed research international

    2017  Volume 2017, Page(s) 7375615

    Abstract: Blocking the polyol pathway plays an important role preventing diabetic complications. Therefore, aldose reductase (AR) and advanced glycation endproducts (AGEs) formation has significant effect on diabetic complications. ...

    Abstract Blocking the polyol pathway plays an important role preventing diabetic complications. Therefore, aldose reductase (AR) and advanced glycation endproducts (AGEs) formation has significant effect on diabetic complications.
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2017/7375615
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  10. Article ; Online: Severe Fever with Thrombocytopenia Syndrome Virus in Dogs, South Korea.

    Kang, Jun-Gu / Cho, Yoon-Kyoung / Jo, Young-Sun / Chae, Jeong-Byoung / Joo, Young-Hoon / Park, Kyoung-Wan / Chae, Joon-Seok

    Emerging infectious diseases

    2019  Volume 25, Issue 2, Page(s) 376–378

    Abstract: Of 103 serum samples collected from dogs in South Korea, 3 (2.9%) were positive for severe fever with thrombocytopenia syndrome virus (SFTSV) and 22 (21.4%) were positive for antibodies against SFTSV. A dog-derived isolate of SFTSV clustered with many ... ...

    Abstract Of 103 serum samples collected from dogs in South Korea, 3 (2.9%) were positive for severe fever with thrombocytopenia syndrome virus (SFTSV) and 22 (21.4%) were positive for antibodies against SFTSV. A dog-derived isolate of SFTSV clustered with many South Korea SFTSV strains in the Japanese clade.
    MeSH term(s) Animals ; Bunyaviridae Infections/veterinary ; Dog Diseases/epidemiology ; Dog Diseases/virology ; Dogs ; Phlebovirus/classification ; Phlebovirus/genetics ; Phlebovirus/isolation & purification ; Phylogeny ; RNA, Viral ; Republic of Korea/epidemiology
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2019-02-02
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2502.180859
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