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  1. Article ; Online: Effectiveness of a comprehensive telemedicine intervention replacing standard care in gestational diabetes: a randomized controlled trial.

    Munda, Ana / Mlinaric, Zala / Jakin, Petra Ana / Lunder, Mojca / Pongrac Barlovic, Drazenka

    Acta diabetologica

    2023  Volume 60, Issue 8, Page(s) 1037–1044

    Abstract: Aims: Telemedicine improves glycemic and perinatal outcomes when used as an adjunct to standard care in gestational diabetes (GDM). Little is known about its effectiveness when used instead of standard care. We aimed to compare the outcomes of ... ...

    Abstract Aims: Telemedicine improves glycemic and perinatal outcomes when used as an adjunct to standard care in gestational diabetes (GDM). Little is known about its effectiveness when used instead of standard care. We aimed to compare the outcomes of telemedicine care and the standard care in women with GDM.
    Methods: In a single-center, parallel, randomized controlled trial, women were randomized to: (1) a telemedicine group, sending glucose readings via an application installed on a smartphone and monthly individual video calls replacing on-site visits or (2) standard care group with routine monthly on-site visits. The primary outcome was the effectiveness of glycemic control. The secondary outcomes were gestational weight gain (GWG) and perinatal data, including birth weight, gestational age, the incidence of the offspring large for gestational age, preterm birth, preeclampsia and cesarean section.
    Results: A total of 106 women were randomized to the telemedicine (n = 54) and the standard care group (n = 52). The telemedicine group demonstrated less postprandial measurements above the glycemic target (10.4% [3.9-17.9] vs. 14.6% [6.5-27.1]; p = 0.015), together with lower average postprandial glucose (5.6 ± 0.3 vs. 5.9 ± 0.4; p = 0.004). Percentage of cesarean section was lower in the telemedicine group (9 (17.3%) vs. 18 (35.3%); p = 0.038).
    Conclusions: Telemedicine offers an effective alternative to delivering care to women with GDM. Trial registration NCT05521893, ClinicalTrials.gov Identifier URL: https://www.
    Clinicaltrials: gov/ct2/show/NCT05521893?term=NCT05521893&draw=2&rank=1.
    MeSH term(s) Pregnancy ; Infant, Newborn ; Female ; Humans ; Diabetes, Gestational/therapy ; Cesarean Section ; Premature Birth/epidemiology ; Telemedicine ; Glucose
    Chemical Substances Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2023-04-25
    Publishing country Germany
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1097676-0
    ISSN 1432-5233 ; 0940-5429
    ISSN (online) 1432-5233
    ISSN 0940-5429
    DOI 10.1007/s00592-023-02099-8
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 611: Show issues Location:
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  2. Article: The Involvement of Peroxiporins and Antioxidant Transcription Factors in Breast Cancer Therapy Resistance.

    Milković, Lidija / Mlinarić, Monika / Lučić, Ivan / Čipak Gašparović, Ana

    Cancers

    2023  Volume 15, Issue 24

    Abstract: Breast cancer is still the leading cause of death in women of all ages. The reason for this is therapy resistance, which leads to the progression of the disease and the formation of metastases. Multidrug resistance (MDR) is a multifactorial process that ... ...

    Abstract Breast cancer is still the leading cause of death in women of all ages. The reason for this is therapy resistance, which leads to the progression of the disease and the formation of metastases. Multidrug resistance (MDR) is a multifactorial process that leads to therapy failure. MDR involves multiple processes and many signaling pathways that support each other, making it difficult to overcome once established. Here, we discuss cellular-oxidative-stress-modulating factors focusing on transcription factors NRF2, FOXO family, and peroxiporins, as well as their possible contribution to MDR. This is significant because oxidative stress is a consequence of radiotherapy, chemotherapy, and immunotherapy, and the activation of detoxification pathways could modulate the cellular response to therapy and could support MDR. These proteins are not directly responsible for MDR, but they support the survival of cancer cells under stress conditions.
    Language English
    Publishing date 2023-12-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15245747
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  3. Article ; Online: SAFETY CONSIDERATIONS IN RADIOTHERAPY.

    Budanec, Mirjana / Mrčela, Iva / Gregov, Marin / Mlinarić, Mihaela / Matanić, Ante / Fröbe, Ana

    Acta clinica Croatica

    2021  Volume 58, Issue Suppl 2, Page(s) 82–83

    Language English
    Publishing date 2021-12-17
    Publishing country Croatia
    Document type Journal Article ; Review
    ZDB-ID 1478635-7
    ISSN 1333-9451 ; 0353-9466
    ISSN (online) 1333-9451
    ISSN 0353-9466
    DOI 10.20471/acc.2019.58.s2.14
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5057: Show issues Location:
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  4. Article: Informed consent and ethics committee approval in laboratory medicine.

    Borovecki, Ana / Mlinaric, Ana / Horvat, Martina / Supak Smolcic, Vesna

    Biochemia medica

    2018  Volume 28, Issue 3, Page(s) 30201

    Abstract: Informed consent is a process in which a human subject who is to participate in research needs to give his or her consent after being properly informed of the expected benefits as well as the potential harm of the research that will be performed. The ... ...

    Abstract Informed consent is a process in which a human subject who is to participate in research needs to give his or her consent after being properly informed of the expected benefits as well as the potential harm of the research that will be performed. The function and purpose of the research ethics committee is to ensure that the research that will take place is in accordance with the relevant ethical standards. This means that the committee must assess the appropriateness of the design of the study reviewed. Research in the field of laboratory medicine has specific features,
    MeSH term(s) Clinical Laboratory Techniques/ethics ; Ethics, Medical ; Informed Consent
    Language English
    Publishing date 2018-11-14
    Publishing country Croatia
    Document type Journal Article ; Review
    ZDB-ID 1208725-7
    ISSN 1846-7482 ; 1330-0962
    ISSN (online) 1846-7482
    ISSN 1330-0962
    DOI 10.11613/BM.2018.030201
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4273: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Deciphering Common Traits of Breast and Ovarian Cancer Stem Cells and Possible Therapeutic Approaches

    Ivan Lučić / Matea Kurtović / Monika Mlinarić / Nikolina Piteša / Ana Čipak Gašparović / Maja Sabol / Lidija Milković

    International Journal of Molecular Sciences, Vol 24, Iss 10683, p

    2023  Volume 10683

    Abstract: Breast cancer (BC) and ovarian cancer (OC) are among the most common and deadly cancers affecting women worldwide. Both are complex diseases with marked heterogeneity. Despite the induction of screening programs that increase the frequency of earlier ... ...

    Abstract Breast cancer (BC) and ovarian cancer (OC) are among the most common and deadly cancers affecting women worldwide. Both are complex diseases with marked heterogeneity. Despite the induction of screening programs that increase the frequency of earlier diagnosis of BC, at a stage when the cancer is more likely to respond to therapy, which does not exist for OC, more than 50% of both cancers are diagnosed at an advanced stage. Initial therapy can put the cancer into remission. However, recurrences occur frequently in both BC and OC, which are highly cancer-subtype dependent. Therapy resistance is mainly attributed to a rare subpopulation of cells, named cancer stem cells (CSC) or tumor-initiating cells, as they are capable of self-renewal, tumor initiation, and regrowth of tumor bulk. In this review, we will discuss the distinctive markers and signaling pathways that characterize CSC, their interactions with the tumor microenvironment, and the strategies they employ to evade immune surveillance. Our focus will be on identifying the common features of breast cancer stem cells (BCSC) and ovarian cancer stem cells (OCSC) and suggesting potential therapeutic approaches.
    Keywords breast cancer ; ovarian cancer ; cancer stem cells (CSC) ; CSC markers ; signaling pathways ; tumor microenvironment ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Peroxiporins Are Induced upon Oxidative Stress Insult and Are Associated with Oxidative Stress Resistance in Colon Cancer Cell Lines.

    Čipak Gašparović, Ana / Milković, Lidija / Rodrigues, Claudia / Mlinarić, Monika / Soveral, Graça

    Antioxidants (Basel, Switzerland)

    2021  Volume 10, Issue 11

    Abstract: Oxidative stress can induce genetic instability and change cellular processes, resulting in colorectal cancer. Additionally, adaptation of oxidative defense causes therapy resistance, a major obstacle in successful cancer treatment. Peroxiporins are ... ...

    Abstract Oxidative stress can induce genetic instability and change cellular processes, resulting in colorectal cancer. Additionally, adaptation of oxidative defense causes therapy resistance, a major obstacle in successful cancer treatment. Peroxiporins are aquaporin membrane channels that facilitate H
    Language English
    Publishing date 2021-11-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10111856
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  7. Article: Novel Selective IDO1 Inhibitors with Isoxazolo[5,4-

    Dolšak, Ana / Bratkovič, Tomaž / Mlinarič, Larisa / Ogorevc, Eva / Švajger, Urban / Gobec, Stanislav / Sova, Matej

    Pharmaceuticals (Basel, Switzerland)

    2021  Volume 14, Issue 3

    Abstract: Indoleamine 2,3-dioxygenase 1 (IDO1) is a promising target in immunomodulation of several pathological conditions, especially cancers. Here we present the synthesis of a series of IDO1 inhibitors with the novel isoxazolo[5,4- ...

    Abstract Indoleamine 2,3-dioxygenase 1 (IDO1) is a promising target in immunomodulation of several pathological conditions, especially cancers. Here we present the synthesis of a series of IDO1 inhibitors with the novel isoxazolo[5,4-
    Language English
    Publishing date 2021-03-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph14030265
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  8. Article ; Online: Deciphering Common Traits of Breast and Ovarian Cancer Stem Cells and Possible Therapeutic Approaches.

    Lučić, Ivan / Kurtović, Matea / Mlinarić, Monika / Piteša, Nikolina / Čipak Gašparović, Ana / Sabol, Maja / Milković, Lidija

    International journal of molecular sciences

    2023  Volume 24, Issue 13

    Abstract: Breast cancer (BC) and ovarian cancer (OC) are among the most common and deadly cancers affecting women worldwide. Both are complex diseases with marked heterogeneity. Despite the induction of screening programs that increase the frequency of earlier ... ...

    Abstract Breast cancer (BC) and ovarian cancer (OC) are among the most common and deadly cancers affecting women worldwide. Both are complex diseases with marked heterogeneity. Despite the induction of screening programs that increase the frequency of earlier diagnosis of BC, at a stage when the cancer is more likely to respond to therapy, which does not exist for OC, more than 50% of both cancers are diagnosed at an advanced stage. Initial therapy can put the cancer into remission. However, recurrences occur frequently in both BC and OC, which are highly cancer-subtype dependent. Therapy resistance is mainly attributed to a rare subpopulation of cells, named cancer stem cells (CSC) or tumor-initiating cells, as they are capable of self-renewal, tumor initiation, and regrowth of tumor bulk. In this review, we will discuss the distinctive markers and signaling pathways that characterize CSC, their interactions with the tumor microenvironment, and the strategies they employ to evade immune surveillance. Our focus will be on identifying the common features of breast cancer stem cells (BCSC) and ovarian cancer stem cells (OCSC) and suggesting potential therapeutic approaches.
    MeSH term(s) Female ; Humans ; Breast/metabolism ; Breast Neoplasms/metabolism ; Neoplastic Stem Cells/metabolism ; Ovarian Neoplasms/metabolism ; Tumor Microenvironment
    Language English
    Publishing date 2023-06-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241310683
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  9. Article ; Online: AQP3-Dependent PI3K/Akt Modulation in Breast Cancer Cells.

    Mlinarić, Monika / Lučić, Ivan / Milković, Lidija / da Silva, Inês V / Tartaro Bujak, Ivana / Musani, Vesna / Soveral, Graça / Čipak Gašparović, Ana

    International journal of molecular sciences

    2023  Volume 24, Issue 9

    Abstract: Aquaporin 3 (AQP3) is a peroxiporin, a membrane protein that channels hydrogen peroxide in addition to water and glycerol. AQP3 expression also correlates with tumor progression and malignancy and is, therefore, a potential target in breast cancer ... ...

    Abstract Aquaporin 3 (AQP3) is a peroxiporin, a membrane protein that channels hydrogen peroxide in addition to water and glycerol. AQP3 expression also correlates with tumor progression and malignancy and is, therefore, a potential target in breast cancer therapy. In addition, epithelial growth factor receptor (EGFR) plays an important role in breast cancer. Therefore, we investigated whether disruption of the lipid raft harboring EGFR could affect AQP3 expression, and conversely, whether AQP3 silencing would affect the EGFR/phosphoinositide-3-kinase (PI3K)/Protein kinase B (PKB or Akt) signaling pathway in breast cancer cell lines with different malignant capacities. We evaluated H
    MeSH term(s) Female ; Humans ; Aquaporin 3/genetics ; Aquaporin 3/metabolism ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Cell Line, Tumor ; Epidermal Growth Factor/metabolism ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Hydrogen Peroxide/pharmacology ; Hydrogen Peroxide/metabolism ; Phosphatidylinositol 3-Kinase/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism
    Chemical Substances AQP3 protein, human ; Aquaporin 3 (158801-98-0) ; Epidermal Growth Factor (62229-50-9) ; ErbB Receptors (EC 2.7.10.1) ; Hydrogen Peroxide (BBX060AN9V) ; Phosphatidylinositol 3-Kinase (EC 2.7.1.137) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2023-05-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24098133
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  10. Article ; Online: Design and synthesis of amino-substituted

    Gobec, Martina / Obreza, Aleš / Jukič, Marko / Baumgartner, Ana / Mihelčič, Nja / Potočnik, Špela / Virant, Julija / Mlinarič, Irena / Stanislav, Raščan / Sosič, Gobec Izidor

    Acta pharmaceutica (Zagreb, Croatia)

    2023  Volume 73, Issue 3, Page(s) 441–456

    Abstract: The constitutive proteasome and the immunoproteasome represent validated targets for pharmacological intervention in the context of various diseases, such as cancer, inflammation, and autoimmune diseases. The development of novel chemical scaffolds of ... ...

    Abstract The constitutive proteasome and the immunoproteasome represent validated targets for pharmacological intervention in the context of various diseases, such as cancer, inflammation, and autoimmune diseases. The development of novel chemical scaffolds of non-peptidic nature, capable of inhibiting different catalytically active subunits of both isoforms, is a viable approach against these diseases. Such compounds are also useful as leads for the development of biochemical probes that enable the studies of the roles of both isoforms in various biological contexts. Here, we present a ligand-based computational design of (immuno)proteasome inhibitors, which resulted in the amino-substituted
    MeSH term(s) Humans ; Proteasome Endopeptidase Complex ; Autoimmune Diseases ; Inflammation ; Structure-Activity Relationship
    Chemical Substances Proteasome Endopeptidase Complex (EC 3.4.25.1)
    Language English
    Publishing date 2023-09-14
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 1111806-4
    ISSN 1846-9558 ; 1330-0075
    ISSN (online) 1846-9558
    ISSN 1330-0075
    DOI 10.2478/acph-2023-0032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1904: Show issues Location:
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