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  1. Article ; Online: Dealing with uncertainty after transplantation in times of COVID-19.

    Massey, Emma K / Forsberg, Anna

    Transplant international : official journal of the European Society for Organ Transplantation

    2020  Volume 33, Issue 10, Page(s) 1337–1338

    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/psychology ; Emotions ; Humans ; Life Style ; Medication Adherence ; Pandemics ; SARS-CoV-2 ; Social Support ; Transplant Recipients/psychology ; Uncertainty
    Keywords covid19
    Language English
    Publishing date 2020-08-17
    Publishing country England
    Document type Letter
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.1111/tri.13709
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2358: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Organoids: a systematic review of ethical issues.

    de Jongh, Dide / Massey, Emma K / Bunnik, Eline M

    Stem cell research & therapy

    2022  Volume 13, Issue 1, Page(s) 337

    Abstract: Organoids are 3D structures grown from pluripotent stem cells derived from human tissue and serve as in vitro miniature models of human organs. Organoids are expected to revolutionize biomedical research and clinical care. However, organoids are not seen ...

    Abstract Organoids are 3D structures grown from pluripotent stem cells derived from human tissue and serve as in vitro miniature models of human organs. Organoids are expected to revolutionize biomedical research and clinical care. However, organoids are not seen as morally neutral. For instance, tissue donors may perceive enduring personal connections with their organoids, setting higher bars for informed consent and patient participation. Also, several organoid sub-types, e.g., brain organoids and human-animal chimeric organoids, have raised controversy. This systematic review provides an overview of ethical discussions as conducted in the scientific literature on organoids. The review covers both research and clinical applications of organoid technology and discusses the topics informed consent, commercialization, personalized medicine, transplantation, brain organoids, chimeras, and gastruloids. It shows that further ethical research is needed especially on organoid transplantation, to help ensure the responsible development and clinical implementation of this technology in this field.
    MeSH term(s) Animals ; Biomedical Research ; Brain ; Humans ; Organoids ; Pluripotent Stem Cells ; Precision Medicine
    Language English
    Publishing date 2022-07-23
    Publishing country England
    Document type Journal Article ; Review ; Systematic Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2548671-8
    ISSN 1757-6512 ; 1757-6512
    ISSN (online) 1757-6512
    ISSN 1757-6512
    DOI 10.1186/s13287-022-02950-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Recommendations on How to Improve Medication Adherence Studies in the Field of Transplantation.

    Massey, Emma K

    Transplantation

    2016  Volume 100, Issue 1, Page(s) 12–13

    MeSH term(s) Drug Monitoring/instrumentation ; Electrical Equipment and Supplies ; Female ; Graft Rejection/prevention & control ; Graft Survival/drug effects ; Humans ; Immunosuppressive Agents/therapeutic use ; Kidney Transplantation ; Male ; Medication Adherence
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2016-01
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000000972
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 509: Show issues

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  5. Article ; Online: Clinical Translation of Bio-Artificial Pancreas Therapies: Ethical, Legal and Psychosocial Interdisciplinary Considerations and Key Recommendations.

    de Jongh, Dide / Thom, Rebecca L / Cronin, Antonia J / Bunnik, Eline M / Massey, Emma K

    Transplant international : official journal of the European Society for Organ Transplantation

    2023  Volume 36, Page(s) 11705

    Abstract: The field of regenerative medicine offers potential therapies for Type 1 Diabetes, whereby metabolically active cellular components are combined with synthetic medical devices. These therapies are sometimes referred to as "bioartificial pancreases." For ... ...

    Abstract The field of regenerative medicine offers potential therapies for Type 1 Diabetes, whereby metabolically active cellular components are combined with synthetic medical devices. These therapies are sometimes referred to as "bioartificial pancreases." For these emerging and rapidly developing therapies to be clinically translated to patients, researchers must overcome not just scientific hurdles, but also navigate complex legal, ethical and psychosocial issues. In this article, we first provide an introductory overview of the key legal, ethical and psychosocial considerations identified in the existing literature and identify areas where research is currently lacking. We then highlight two principal areas of concern in which these discrete disciplines significantly overlap: 1) individual autonomy and 2) access and equality. Using the example of beta-cell provenance, we demonstrate how, by harnessing an interdisciplinary approach we can address these key areas of concern. Moreover, we provide practical recommendations to researchers, clinicians, and policymakers which will help to facilitate the clinical translation of this cutting-edge technology for Type 1 Diabetes patients. Finally, we emphasize the importance of exploring patient perspectives to ensure their responsible and acceptable translation from bench to body.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 1/surgery ; Pancreas, Artificial ; Regenerative Medicine
    Language English
    Publishing date 2023-09-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.3389/ti.2023.11705
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2358: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Relinquishing Anonymity in Living Donor Kidney Transplantation: Lessons Learned From the UK Policy for Anonymous Donors.

    Pronk, Mathilde C / Burnapp, Lisa / Reinders, Marlies E J / Massey, Emma K

    Transplant international : official journal of the European Society for Organ Transplantation

    2022  Volume 35, Page(s) 10091

    Abstract: Anonymous living donor kidney transplantation (LDKT) is performed in many countries and policies on anonymity differ. The UK is the only European country with a conditional policy, allowing pairs to break anonymity post-transplant. There is little ... ...

    Abstract Anonymous living donor kidney transplantation (LDKT) is performed in many countries and policies on anonymity differ. The UK is the only European country with a conditional policy, allowing pairs to break anonymity post-transplant. There is little evidence on how contact after anonymous LDKT is experienced. In this cross-sectional study participants who donated or received a kidney through non-directed altruistic kidney donation or within the UK living kidney sharing scheme completed a questionnaire on their experiences with and attitudes towards anonymity. Non-parametric statistics were used to analyse the data. 207 recipients and 354 donors participated. Anonymity was relinquished among 11% of recipients and 8% of donors. Non-anonymous participants were generally content with non-anonymity. They reported positive experiences with contact/meeting the other party. Participants who remained anonymous were content with anonymity, however, 38% would have liked to meet post-transplant. If the other party would like to meet, this number increased to 64%. Although participants agreed with anonymity before surgery, they believe that, if desired, a meeting should be allowed after surgery. UK donors and recipients were satisfied with conditional anonymity and experiences with breaking anonymity were positive. These results support the expansion of conditional anonymity to other countries that allow anonymous LDKT.
    MeSH term(s) Confidentiality ; Cross-Sectional Studies ; Humans ; Kidney ; Kidney Transplantation/methods ; Living Donors ; Policy ; United Kingdom
    Language English
    Publishing date 2022-02-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.3389/ti.2022.10091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2358: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Dealing with uncertainty after transplantation in times of COVID‐19

    Massey, Emma K. / Forsberg, Anna

    Transplant International

    2020  Volume 33, Issue 10, Page(s) 1337–1338

    Keywords Transplantation ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.1111/tri.13709
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2358: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

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  8. Article ; Online: Dealing with uncertainty after transplantation in times of COVID-19

    Massey, Emma K. / Forsberg, Anna

    Transplant International; (2020) ; ISSN: 0934-0874

    2020  

    Keywords Public Health ; Global Health ; Social Medicine and Epidemiology ; covid19
    Language English
    Publishing date 2020-01-01
    Publisher Springer
    Publishing country se
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Reflections of unspecified anonymous kidney donors on their motivation and the impact of donation on their mental health

    Mathilde C. Pronk / Willij Zuidema / Willem Weimar / Jacqueline van de Wetering / Sohal Y. Ismail / Emma K. Massey

    SSM: Qualitative Research in Health, Vol 3, Iss , Pp 100272- (2023)

    A qualitative study

    2023  

    Keywords Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Early-Phase Clinical Trials of Bio-Artificial Organ Technology: A Systematic Review of Ethical Issues.

    de Jongh, Dide / Massey, Emma K / Cronin, Antonia J / Schermer, Maartje H N / Bunnik, Eline M

    Transplant international : official journal of the European Society for Organ Transplantation

    2022  Volume 35, Page(s) 10751

    Abstract: Regenerative medicine has emerged as a novel alternative solution to organ failure which circumvents the issue of organ shortage. In preclinical research settings bio-artificial organs are being developed. It is anticipated that eventually it will be ... ...

    Abstract Regenerative medicine has emerged as a novel alternative solution to organ failure which circumvents the issue of organ shortage. In preclinical research settings bio-artificial organs are being developed. It is anticipated that eventually it will be possible to launch first-in-human transplantation trials to test safety and efficacy in human recipients. In early-phase transplantation trials, however, research participants could be exposed to serious risks, such as toxicity, infections and tumorigenesis. So far, there is no ethical guidance for the safe and responsible design and conduct of early-phase clinical trials of bio-artificial organs. Therefore, research ethics review committees will need to look to related adjacent fields of research, including for example cell-based therapy, for guidance. In this systematic review, we examined the literature on early-phase clinical trials in these adjacent fields and undertook a thematic analysis of relevant ethical points to consider for early-phase clinical trials of transplantable bio-artificial organs. Six themes were identified: cell source, risk-benefit assessment, patient selection, trial design, informed consent, and oversight and accountability. Further empirical research is needed to provide insight in patient perspectives, as this may serve as valuable input in determining the conditions for ethically responsible and acceptable early clinical development of bio-artificial organs.
    MeSH term(s) Humans ; Ethics, Research ; Informed Consent ; Tissue and Organ Procurement ; Patient Selection ; Artificial Organs
    Language English
    Publishing date 2022-10-31
    Publishing country Switzerland
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.3389/ti.2022.10751
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2358: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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