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  1. Article ; Online: A prescription for fair housing during the COVID-19 pandemic.

    Hussaini, Syed M Qasim

    The Lancet. Infectious diseases

    2021  Volume 21, Issue 7, Page(s) 903–905

    MeSH term(s) COVID-19/economics ; Housing/economics ; Humans ; Pandemics/economics ; Poverty/economics ; Racism/economics
    Language English
    Publishing date 2021-05-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(21)00257-7
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    Zs.A 5743: Show issues Location:
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  2. Article ; Online: Dearth of infectious diseases physicians as the USA faces a global pandemic.

    Hussaini, Syed M Qasim

    The Lancet. Infectious diseases

    2020  Volume 20, Issue 6, Page(s) 648–649

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Global Health ; Humans ; Infectious Disease Medicine ; Pandemics/prevention & control ; Physicians/supply & distribution ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Reimbursement Mechanisms ; SARS-CoV-2 ; United States/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-05-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(20)30377-7
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  4. Article ; Online: Oncology Physician Workforce Diversity: Rationale, Trends, Barriers, and Solutions.

    Deville, Curtiland / Charles-Obi, Kenechukwu / Santos, Patricia Mae G / Mattes, Malcolm D / Hussaini, Syed M Qasim

    Cancer journal (Sudbury, Mass.)

    2023  Volume 29, Issue 6, Page(s) 301–309

    Abstract: Abstract: This chapter will discuss (1) the rationale for physician workforce diversity and inclusion in oncology; (2) current and historical physician workforce demographic trends in oncology, including workforce data at various training and career ... ...

    Abstract Abstract: This chapter will discuss (1) the rationale for physician workforce diversity and inclusion in oncology; (2) current and historical physician workforce demographic trends in oncology, including workforce data at various training and career levels, such as graduate medical education and as academic faculty or practicing physicians; (3) reported barriers and challenges to diversity and inclusion in oncology, such as exposure, access, preparation, mentorship, socioeconomic burdens, and interpersonal, structural, systemic bias; and (4) potential interventions and evidence-based solutions to increase diversity, equity, and inclusion and mitigate bias in the oncology physician workforce.
    MeSH term(s) Humans ; Physicians ; Medical Oncology ; Workforce
    Language English
    Publishing date 2023-11-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2018400-1
    ISSN 1540-336X ; 1528-9117 ; 1081-4442
    ISSN (online) 1540-336X
    ISSN 1528-9117 ; 1081-4442
    DOI 10.1097/PPO.0000000000000687
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  5. Article ; Online: The United States Postal Service: an Essential Public Health Agency?

    Hussaini, Syed M Qasim / Alexander, G Caleb

    Journal of general internal medicine

    2020  Volume 35, Issue 12, Page(s) 3699–3701

    MeSH term(s) Humans ; Postal Service ; Public Health ; United States/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-10-02
    Publishing country United States
    Document type Editorial
    ZDB-ID 639008-0
    ISSN 1525-1497 ; 0884-8734
    ISSN (online) 1525-1497
    ISSN 0884-8734
    DOI 10.1007/s11606-020-06275-2
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  6. Article ; Online: Estimated out-of-pocket costs for cancer-directed and supportive care medications for older adults with advanced pancreatic cancer.

    Desai, Nidhi / Besaw, Robert J / Sedhom, Ramy / Qasim Hussaini, Syed M / Blaes, Anne H / Dusetzina, Stacie B / Gupta, Arjun

    Journal of geriatric oncology

    2022  Volume 13, Issue 5, Page(s) 754–757

    MeSH term(s) Aged ; Health Care Costs ; Health Expenditures ; Humans ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms
    Language English
    Publishing date 2022-02-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2556813-9
    ISSN 1879-4076 ; 1879-4068
    ISSN (online) 1879-4076
    ISSN 1879-4068
    DOI 10.1016/j.jgo.2022.02.003
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  7. Article ; Online: sFRP3 inhibition improves age-related cellular changes in BubR1 progeroid mice.

    Cho, Chang Hoon / Yoo, Ki Hyun / Oliveros, Alfredo / Paulson, Summer / Hussaini, Syed Mohammed Qasim / van Deursen, Jan M / Jang, Mi-Hyeon

    Aging cell

    2019  Volume 18, Issue 2, Page(s) e12899

    Abstract: Wnt signaling is a well-known molecular pathway in age-related pathogenesis and therapy of disease. While prior studies have mainly focused on Wnt ligands or Wnt activators, the in vivo functions of naturally secreted Wnt inhibitors are not clear, ... ...

    Abstract Wnt signaling is a well-known molecular pathway in age-related pathogenesis and therapy of disease. While prior studies have mainly focused on Wnt ligands or Wnt activators, the in vivo functions of naturally secreted Wnt inhibitors are not clear, especially in brain aging. Using BubR1
    MeSH term(s) Animals ; Brain/metabolism ; Brain/pathology ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cellular Senescence ; Intracellular Signaling Peptides and Proteins/antagonists & inhibitors ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Mice ; Mice, Mutant Strains ; Progeria/metabolism ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; Wnt Signaling Pathway
    Chemical Substances Bub1b protein, mouse ; Cell Cycle Proteins ; Intracellular Signaling Peptides and Proteins ; WD repeat containing planar cell polarity effector ; Protein-Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2019-01-04
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2113083-8
    ISSN 1474-9726 ; 1474-9718
    ISSN (online) 1474-9726
    ISSN 1474-9718
    DOI 10.1111/acel.12899
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    Zs.A 6581: Show issues Location:
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  8. Article ; Online: Trainee-Led Quality Improvement Project to Improve Fertility Preservation Counseling for Patients With Cancer.

    Sena, Laura A / Sedhom, Ramy / Scott, Susan / Kagan, Amanda / Marple, Andrew H / Canzoniero, Jenna V / Hsu, Melinda / Qasim Hussaini, Syed M / Herati, Amin S / Reschke, Lauren / Antero, Maria Facadio / Christianson, Mindy S / Binder, Adam F / Chen, Allen R / Donehower, Ross C / Marrone, Kristen A / Gupta, Arjun

    JCO oncology practice

    2021  Volume 18, Issue 3, Page(s) e403–e411

    Abstract: Purpose: Oncofertility counseling regarding the reproductive risks associated with cancer therapy is essential for quality cancer care. We aimed to increase the rate of oncofertility counseling for patients of reproductive age (18-40 years) with cancer ... ...

    Abstract Purpose: Oncofertility counseling regarding the reproductive risks associated with cancer therapy is essential for quality cancer care. We aimed to increase the rate of oncofertility counseling for patients of reproductive age (18-40 years) with cancer who were initiating systemic therapy at the Johns Hopkins Cancer Center from a baseline rate of 37% (25 of 68, June 2019-January 2020) to 70% by February 2021.
    Methods: We formed an interprofessional, multidisciplinary team as part of the ASCO Quality Training Program. We obtained data from the electronic medical record and verified data with patients by phone. We surveyed patients, oncologists, and fertility specialists to identify barriers. After considering a prioritization matrix, we implemented Plan-Do-Study-Act (PDSA) cycles.
    Results: We identified the following improvement opportunities: (1) oncologist self-reported lack of knowledge about counseling and local fertility preservation options and (2) lack of a standardized referral mechanism to fertility services. During the first PDSA cycle (February 2020-August 2020, disrupted by COVID-19), we introduced the initiative to increase oncofertility counseling at faculty meetings. From September 2020 to November 2020, we implemented a second PDSA cycle: (1) educating and presenting the initiative at Oncology Grand Rounds, (2) distributing informative pamphlets to oncologists and patients, and (3) implementing an electronic medical record order set. In the third PDSA cycle (December 2020-February 2021), we redesigned the order set to add information (eg, contact information for fertility coordinator) to the patient after-visit summary. Postimplementation (September 2020-February 2021), counseling rates increased from 37% to 81% (38 of 47).
    Conclusion: We demonstrate how a trainee-led, patient-centered initiative improved oncofertility care. Ongoing work focuses on ensuring sustainability and assessing the quality of counseling.
    MeSH term(s) Adolescent ; Adult ; COVID-19 ; Counseling ; Fertility Preservation ; Humans ; Neoplasms/complications ; Neoplasms/therapy ; Quality Improvement ; SARS-CoV-2 ; Young Adult
    Language English
    Publishing date 2021-09-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3028198-2
    ISSN 2688-1535 ; 2688-1527
    ISSN (online) 2688-1535
    ISSN 2688-1527
    DOI 10.1200/OP.21.00479
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    Zs.A 7198: Show issues Location:
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  9. Article ; Online: Pulmonary blastomycosis presenting as primary lung cancer.

    Hussaini, Syed Mohammed Qasim / Madut, Deng / Tong, Betty C / Pavlisko, Elizabeth N / Schell, Wiley A / Perfect, John R / Thielman, Nathan M

    BMC infectious diseases

    2018  Volume 18, Issue 1, Page(s) 336

    Abstract: Background: Blastomycosis is an endemic mycosis in North America that is caused by the dimorphic fungus Blastomyces dermatitidis. The illness is a systemic disease with a wide variety of pulmonary and extra-pulmonary manifestations. The initial ... ...

    Abstract Background: Blastomycosis is an endemic mycosis in North America that is caused by the dimorphic fungus Blastomyces dermatitidis. The illness is a systemic disease with a wide variety of pulmonary and extra-pulmonary manifestations. The initial presentation of blastomycosis may easily be mistaken for other infectious or non-infectious etiologies.
    Case presentation: We present the case of a 52-year-old African-American male and former smoker that presented to his primary care provider with a 2-week history of non-productive cough, night sweats and weight loss. Initially diagnosed with primary lung malignancy, the patient was subsequently found to have pulmonary blastomycosis mimicking lung cancer. The patient underwent a successful course of treatment with posaconazole.
    Conclusions: Chronic blastomycosis can present with clinical and radiographic features indistinguishable from thoracic malignancies. There is no clinical syndrome specific for blastomycosis, thus a high degree of suspicion is required for early diagnosis. In this case report, we review recent evidence in radiographic features, diagnostic considerations and treatment of the disease.
    MeSH term(s) Antifungal Agents/therapeutic use ; Blastomyces/genetics ; Blastomyces/isolation & purification ; Blastomycosis/diagnosis ; Blastomycosis/drug therapy ; Blastomycosis/microbiology ; DNA, Fungal/genetics ; DNA, Fungal/metabolism ; Diagnosis, Differential ; Humans ; Lung/pathology ; Lung Neoplasms/diagnosis ; Male ; Middle Aged ; Positron Emission Tomography Computed Tomography ; Tomography, X-Ray Computed ; Triazoles/therapeutic use
    Chemical Substances Antifungal Agents ; DNA, Fungal ; Triazoles ; posaconazole (6TK1G07BHZ)
    Language English
    Publishing date 2018-07-18
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1471-2334
    ISSN (online) 1471-2334
    DOI 10.1186/s12879-018-3244-0
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  10. Article ; Online: Age-related decline in BubR1 impairs adult hippocampal neurogenesis.

    Yang, Zhongxi / Jun, Heechul / Choi, Chan-Ii / Yoo, Ki Hyun / Cho, Chang Hoon / Hussaini, Syed Mohammed Qasim / Simmons, Ambrosia J / Kim, Seonhee / van Deursen, Jan M / Baker, Darren J / Jang, Mi-Hyeon

    Aging cell

    2017  Volume 16, Issue 3, Page(s) 598–601

    Abstract: Aging causes significant declines in adult hippocampal neurogenesis and leads to cognitive disability. Emerging evidence demonstrates that decline in the mitotic checkpoint kinase BubR1 level occurs with natural aging and induces progeroid features in ... ...

    Abstract Aging causes significant declines in adult hippocampal neurogenesis and leads to cognitive disability. Emerging evidence demonstrates that decline in the mitotic checkpoint kinase BubR1 level occurs with natural aging and induces progeroid features in both mice and children with mosaic variegated aneuploidy syndrome. Whether BubR1 contributes to age-related deficits in hippocampal neurogenesis is yet to be determined. Here we report that BubR1 expression is significantly reduced with natural aging in the mouse brain. Using established progeroid mice expressing low amounts of BubR1, we demonstrate these mice exhibit deficits in neural progenitor proliferation and maturation, leading to reduction in new neuron production. Collectively, our identification of BubR1 as a new and critical factor controlling sequential steps across neurogenesis raises the possibility that BubR1 may be a key mediator regulating aging-related hippocampal pathology. Targeting BubR1 may represent a novel therapeutic strategy for age-related cognitive deficits.
    MeSH term(s) Aging/genetics ; Aging/metabolism ; Aging/pathology ; Animals ; Cell Cycle Proteins/antagonists & inhibitors ; Cell Cycle Proteins/deficiency ; Cell Cycle Proteins/genetics ; Cell Differentiation ; Disease Models, Animal ; Gene Expression Regulation, Developmental ; Hippocampus/metabolism ; Hippocampus/pathology ; Humans ; Mice ; Mice, Transgenic ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/metabolism ; Minichromosome Maintenance Complex Component 2/genetics ; Minichromosome Maintenance Complex Component 2/metabolism ; Neural Stem Cells/metabolism ; Neural Stem Cells/pathology ; Neurogenesis/genetics ; Neuronal Plasticity/genetics ; Neurons/metabolism ; Neurons/pathology ; Neuropeptides/genetics ; Neuropeptides/metabolism ; Progeria/genetics ; Progeria/metabolism ; Progeria/pathology ; Protein-Serine-Threonine Kinases/antagonists & inhibitors ; Protein-Serine-Threonine Kinases/deficiency ; Protein-Serine-Threonine Kinases/genetics ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism
    Chemical Substances Bub1b protein, mouse ; Cell Cycle Proteins ; Mcm2 protein, mouse ; Microtubule-Associated Proteins ; Neuropeptides ; RNA, Small Interfering ; doublecortin protein ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; Minichromosome Maintenance Complex Component 2 (EC 3.6.4.12)
    Language English
    Publishing date 2017-04-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2113083-8
    ISSN 1474-9726 ; 1474-9718
    ISSN (online) 1474-9726
    ISSN 1474-9718
    DOI 10.1111/acel.12594
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