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Artikel ; Online: Area-level excess mortality in times of COVID-19 in Switzerland: geographical, socioeconomic and political determinants.

Riou, Julien / Panczak, Radoslaw / Konstantinoudis, Garyfallos / Egger, Matthias

2024 Band 34, Heft 2, Seite(n) 415–417

Abstract: The coronavirus disease 2019 (COVID-19)-related excess mortality in Switzerland is well documented, but no study examined mortality at the small-area level. We analysed excess mortality in 2020 for 2141 Swiss municipalities using a Bayesian ... ...

Abstract	The coronavirus disease 2019 (COVID-19)-related excess mortality in Switzerland is well documented, but no study examined mortality at the small-area level. We analysed excess mortality in 2020 for 2141 Swiss municipalities using a Bayesian spatiotemporal model fitted to 2011-19 data. Areas most affected included the Ticino, the Romandie and the Northeast. Rural areas, municipalities within cross-border labour markets, of lower socioeconomic position and with less support for control measures in the popular vote on the COVID-19 Act had greater excess mortality. Particularly vulnerable municipalities require special efforts to mitigate the impact of pandemics.
Mesh-Begriff(e)	Humans ; COVID-19 ; Switzerland/epidemiology ; Bayes Theorem ; Cities ; Socioeconomic Factors ; Mortality
Sprache	Englisch
Erscheinungsdatum	2024-01-25
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	1129243-x
ISSN	1464-360X ; 1101-1262
ISSN (online)	1464-360X
ISSN	1101-1262
DOI	10.1093/eurpub/ckad230
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: The Swiss neighbourhood index of socioeconomic position: update and re-validation.

Panczak, Radoslaw / Berlin, Claudia / Voorpostel, Marieke / Zwahlen, Marcel / Egger, Matthias

Swiss medical weekly

2023 Band 153, Seite(n) 40028

Abstract: Background: The widely used Swiss neighbourhood index of socioeconomic position (Swiss-SEP 1) was based on data from the 2000 national census on rent, household head education and occupation, and crowding. It may now be out of date.: Methods: We ... ...

Abstract	Background: The widely used Swiss neighbourhood index of socioeconomic position (Swiss-SEP 1) was based on data from the 2000 national census on rent, household head education and occupation, and crowding. It may now be out of date. Methods: We created a new index (Swiss-SEP 2) based on the 2012-2015 yearly micro censuses that have replaced the decennial house-to-house census in Switzerland since 2010. We used principal component analysis on neighbourhood-aggregated variables and standardised the index. We also created a hybrid version (Swiss-SEP 3), with updated values for neighbourhoods centred on buildings constructed after the year 2000 and original values for the remaining neighbourhoods. Results: A total of 1.54 million neighbourhoods were included. With all three indices, the mean yearly equivalised household income increased from around 52,000 to 90,000 CHF from the lowest to the highest index decile. Analyses of mortality were based on 33.6 million person-years of follow-up. The age- and sex-adjusted hazard ratios of all-cause mortality comparing areas in the lowest Swiss-SEP decile with areas of the highest decile were 1.39 (95% confidence interval [CI] 1.36-1.41), 1.31 (1.29-1.33) and 1.34 (1.32-1.37) using the old, new and hybrid indices, respectively. Discussion: The Swiss-SEP indices capture area-based SEP at a high resolution and allow the study of SEP when individual-level SEP data are missing or area-level effects are of interest. The hybrid version (Swiss-SEP 3) maintains high spatial resolution while adding information on new neighbourhoods. The index will continue to be useful for Switzerland's epidemiological and public health research.
Mesh-Begriff(e)	Humans ; Switzerland ; Residence Characteristics ; Educational Status ; Public Health ; Socioeconomic Factors
Sprache	Englisch
Erscheinungsdatum	2023-01-12
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2036179-8
ISSN	1424-3997 ; 1424-7860
ISSN (online)	1424-3997
ISSN	1424-7860
DOI	10.57187/smw.2023.40028
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Large regional variation in cardiac closure procedures to prevent ischemic stroke in Switzerland a population-based small area analysis

Nina Stoller / Maria M. Wertli / Alan G. Haynes / Arnaud Chiolero / Nicolas Rodondi / Radoslaw Panczak / Drahomir Aujesky

PLoS ONE, Vol 19, Iss

2024 Band 1

Schlagwörter	Medicine ; R ; Science ; Q
Sprache	Englisch
Erscheinungsdatum	2024-01-01T00:00:00Z
Verlag	Public Library of Science (PLoS)
Dokumenttyp	Artikel ; Online
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Artikel ; Online: Regional variation and temporal trends in transcatheter and surgical aortic valve replacement in Switzerland: A population-based small area analysis.

Schenker, Carla / Wertli, Maria M / Räber, Lorenz / Haynes, Alan G / Chiolero, Arnaud / Rodondi, Nicolas / Panczak, Radoslaw / Aujesky, Drahomir

PloS one

2024 Band 19, Heft 1, Seite(n) e0296055

Abstract: Background: Aortic valve stenosis (AS) is the most common valvular heart disease and if severe, is treated with either transcatheter (TAVR) or surgical aortic valve replacement (SAVR). We assessed temporal trends and regional variation of these ... ...

Abstract	Background: Aortic valve stenosis (AS) is the most common valvular heart disease and if severe, is treated with either transcatheter (TAVR) or surgical aortic valve replacement (SAVR). We assessed temporal trends and regional variation of these interventions in Switzerland and examined potential determinants of geographic variation. Methods: We conducted a population-based analysis using patient discharge data from all Swiss public and private acute care hospitals from 2013 to 2018. We generated hospital service areas (HSAs) based on patient flows for TAVR. We calculated age-standardized mean procedure rates and variation indices (extremal quotient [EQ] and systematic component of variation [SCV]). Using multilevel regression, we calculated the influence of calendar year and regional demographics, socioeconomic factors (language, insurance status), burden of disease, and number of cardiologists/cardiovascular surgeons on geographic variation. Results: Overall, 8074 TAVR and 11,825 SAVR procedures were performed in 8 HSAs from 2013 to 2018. Whereas the age-/sex-standardized rate of TAVR increased from 12 to 22 procedures/100,000 persons, the SAVR rate decreased from 33 to 24 procedures during this period. After full adjustment, the predicted TAVR and SAVR rates varied from 12 to 22 and 20 to 35 per 100,000 persons across HSAs, respectively. The regional procedure variation was low to moderate over time, with a low overall variation in TAVR (EQ 1.9, SCV 3.9) and SAVR (EQ 1.6, SCV 2.2). In multilevel regression, TAVR rates increased annually by 10% and SAVR rates decreased by 5%. Determinants of higher TAVR rates were older age, male sex, living in a German speaking area, and higher burden of disease. A higher proportion of (semi)private insurance was also associated with higher TAVR and lower SAVR rates. After full adjustment, 10.6% of the variance in TAVR and 18.4% of the variance in SAVR remained unexplained. Most variance in TAVR and SAVR rates was explained by language region and insurance status. Conclusion: The geographic variation in TAVR and SAVR rates was low to moderate across Swiss regions and largely explained by differences in regional demographics and socioeconomic factors. The use of TAVR increased at the expense of SAVR over time.
Mesh-Begriff(e)	Humans ; Male ; Aortic Valve/surgery ; Switzerland/epidemiology ; Small-Area Analysis ; Aortic Valve Stenosis/surgery ; Insurance Coverage
Sprache	Englisch
Erscheinungsdatum	2024-01-08
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0296055
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Large regional variation in cardiac closure procedures to prevent ischemic stroke in Switzerland a population-based small area analysis.

Stoller, Nina / Wertli, Maria M / Haynes, Alan G / Chiolero, Arnaud / Rodondi, Nicolas / Panczak, Radoslaw / Aujesky, Drahomir

PloS one

2024 Band 19, Heft 1, Seite(n) e0291299

Abstract: Background: Percutaneous closure of a patent foramen ovale (PFO) or the left atrial appendage (LAA) are controversial procedures to prevent stroke but often used in clinical practice. We assessed the regional variation of these interventions and ... ...

Abstract	Background: Percutaneous closure of a patent foramen ovale (PFO) or the left atrial appendage (LAA) are controversial procedures to prevent stroke but often used in clinical practice. We assessed the regional variation of these interventions and explored potential determinants of such a variation. Methods: We conducted a population-based analysis using patient discharge data from all Swiss hospitals from 2013-2018. We derived hospital service areas (HSAs) using patient flows for PFO and LAA closure. We calculated age-standardized mean procedure rates and variation indices (extremal quotient [EQ] and systematic component of variation [SCV]). SCV values >5.4 indicate a high and >10 a very high variation. Because the evidence on the efficacy of PFO closure may differ in patients aged <60 years and ≥60 years, age-stratified analyses were performed. We assessed the influence of potential determinants of variation using multilevel regression models with incremental adjustment for demographics, cultural/socioeconomic, health, and supply factors. Results: Overall, 2574 PFO and 2081 LAA closures from 10 HSAs were analyzed. The fully adjusted PFO and LAA closure rates varied from 3 to 8 and from 1 to 9 procedures per 100,000 persons per year across HSAs, respectively. The regional variation was high with respect to overall PFO closures (EQ 3.0, SCV 8.3) and very high in patients aged ≥60 years (EQ 4.0, SCV 12.3). The variation in LAA closures was very high (EQ 16.2, SCV 32.1). In multivariate analysis, women had a 28% lower PFO and a 59% lower LAA closure rate than men. French/Italian language areas had a 63% lower LAA closure rate than Swiss German speaking regions and areas with a higher proportion of privately insured patients had a 86% higher LAA closure rate. After full adjustment, 44.2% of the variance in PFO closure and 30.3% in LAA closure remained unexplained. Conclusions: We found a high to very high regional variation in PFO closure and LAA closure rates within Switzerland. Several factors, including sex, language area, and insurance status, were associated with procedure rates. Overall, 30-45% of the regional procedure variation remained unexplained and most probably represents differing physician practices.
Mesh-Begriff(e)	Male ; Humans ; Female ; Ischemic Stroke/complications ; Switzerland/epidemiology ; Small-Area Analysis ; Stroke/epidemiology ; Stroke/prevention & control ; Stroke/complications ; Foramen Ovale, Patent/surgery ; Foramen Ovale, Patent/complications ; Treatment Outcome ; Cardiac Catheterization/methods
Sprache	Englisch
Erscheinungsdatum	2024-01-02
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0291299
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Survival among people hospitalized with COVID-19 in Switzerland: a nationwide population-based analysis.

Anderegg, Nanina / Panczak, Radoslaw / Egger, Matthias / Low, Nicola / Riou, Julien

BMC medicine

2022 Band 20, Heft 1, Seite(n) 164

Abstract: Background: Increasing age, male sex, and pre-existing comorbidities are associated with lower survival from SARS-CoV-2 infection. The interplay between different comorbidities, age, and sex is not fully understood, and it remains unclear if survival ... ...

Abstract	Background: Increasing age, male sex, and pre-existing comorbidities are associated with lower survival from SARS-CoV-2 infection. The interplay between different comorbidities, age, and sex is not fully understood, and it remains unclear if survival decreases linearly with higher ICU occupancy or if there is a threshold beyond which survival falls. Method: This national population-based study included 22,648 people who tested positive for SARS-CoV-2 infection and were hospitalized in Switzerland between February 24, 2020, and March 01, 2021. Bayesian survival models were used to estimate survival after positive SARS-CoV-2 test among people hospitalized with COVID-19 by epidemic wave, age, sex, comorbidities, and ICU occupancy. Two-way interactions between age, sex, and comorbidities were included to assess the differential risk of death across strata. ICU occupancy was modeled using restricted cubic splines to allow for a non-linear association with survival. Results: Of 22,648 people hospitalized with COVID-19, 4785 (21.1%) died. The survival was lower during the first epidemic wave than in the second (predicted survival at 40 days after positive test 76.1 versus 80.5%). During the second epidemic wave, occupancy among all available ICU beds in Switzerland varied between 51.7 and 78.8%. The estimated survival was stable at approximately 81.5% when ICU occupancy was below 70%, but worse when ICU occupancy exceeded this threshold (survival at 80% ICU occupancy: 78.2%; 95% credible interval [CrI] 76.1 to 80.1%). Periods with higher ICU occupancy (>70 vs 70%) were associated with an estimated number of 137 (95% CrI 27 to 242) excess deaths. Comorbid conditions reduced survival more in younger people than in older people. Among comorbid conditions, hypertension and obesity were not associated with poorer survival. Hypertension appeared to decrease survival in combination with cardiovascular disease. Conclusions: Survival after hospitalization with COVID-19 has improved over time, consistent with improved management of severe COVID-19. The decreased survival above 70% national ICU occupancy supports the need to introduce measures for prevention and control of SARS-CoV-2 transmission in the population well before ICUs are full.
Mesh-Begriff(e)	Aged ; Bayes Theorem ; COVID-19/epidemiology ; Hospitalization ; Humans ; Hypertension ; Male ; SARS-CoV-2 ; Switzerland/epidemiology
Sprache	Englisch
Erscheinungsdatum	2022-04-26
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2131669-7
ISSN	1741-7015 ; 1741-7015
ISSN (online)	1741-7015
ISSN	1741-7015
DOI	10.1186/s12916-022-02364-7
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Regional variation and temporal trends in transcatheter and surgical aortic valve replacement in Switzerland

Carla Schenker / Maria M Wertli / Lorenz Räber / Alan G Haynes / Arnaud Chiolero / Nicolas Rodondi / Radoslaw Panczak / Drahomir Aujesky

PLoS ONE, Vol 19, Iss 1, p e

A population-based small area analysis.

2024 Band 0296055

Abstract: Background Aortic valve stenosis (AS) is the most common valvular heart disease and if severe, is treated with either transcatheter (TAVR) or surgical aortic valve replacement (SAVR). We assessed temporal trends and regional variation of these ... ...

Abstract	Background Aortic valve stenosis (AS) is the most common valvular heart disease and if severe, is treated with either transcatheter (TAVR) or surgical aortic valve replacement (SAVR). We assessed temporal trends and regional variation of these interventions in Switzerland and examined potential determinants of geographic variation. Methods We conducted a population-based analysis using patient discharge data from all Swiss public and private acute care hospitals from 2013 to 2018. We generated hospital service areas (HSAs) based on patient flows for TAVR. We calculated age-standardized mean procedure rates and variation indices (extremal quotient [EQ] and systematic component of variation [SCV]). Using multilevel regression, we calculated the influence of calendar year and regional demographics, socioeconomic factors (language, insurance status), burden of disease, and number of cardiologists/cardiovascular surgeons on geographic variation. Results Overall, 8074 TAVR and 11,825 SAVR procedures were performed in 8 HSAs from 2013 to 2018. Whereas the age-/sex-standardized rate of TAVR increased from 12 to 22 procedures/100,000 persons, the SAVR rate decreased from 33 to 24 procedures during this period. After full adjustment, the predicted TAVR and SAVR rates varied from 12 to 22 and 20 to 35 per 100,000 persons across HSAs, respectively. The regional procedure variation was low to moderate over time, with a low overall variation in TAVR (EQ 1.9, SCV 3.9) and SAVR (EQ 1.6, SCV 2.2). In multilevel regression, TAVR rates increased annually by 10% and SAVR rates decreased by 5%. Determinants of higher TAVR rates were older age, male sex, living in a German speaking area, and higher burden of disease. A higher proportion of (semi)private insurance was also associated with higher TAVR and lower SAVR rates. After full adjustment, 10.6% of the variance in TAVR and 18.4% of the variance in SAVR remained unexplained. Most variance in TAVR and SAVR rates was explained by language region and insurance status. Conclusion The ...
Schlagwörter	Medicine ; R ; Science ; Q
Thema/Rubrik (Code)	333
Sprache	Englisch
Erscheinungsdatum	2024-01-01T00:00:00Z
Verlag	Public Library of Science (PLoS)
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Survival among people hospitalized with COVID-19 in Switzerland

Nanina Anderegg / Radoslaw Panczak / Matthias Egger / Nicola Low / Julien Riou

BMC Medicine, Vol 20, Iss 1, Pp 1-

a nationwide population-based analysis

2022 Band 11

Abstract: Abstract Background Increasing age, male sex, and pre-existing comorbidities are associated with lower survival from SARS-CoV-2 infection. The interplay between different comorbidities, age, and sex is not fully understood, and it remains unclear if ... ...

Abstract	Abstract Background Increasing age, male sex, and pre-existing comorbidities are associated with lower survival from SARS-CoV-2 infection. The interplay between different comorbidities, age, and sex is not fully understood, and it remains unclear if survival decreases linearly with higher ICU occupancy or if there is a threshold beyond which survival falls. Method This national population-based study included 22,648 people who tested positive for SARS-CoV-2 infection and were hospitalized in Switzerland between February 24, 2020, and March 01, 2021. Bayesian survival models were used to estimate survival after positive SARS-CoV-2 test among people hospitalized with COVID-19 by epidemic wave, age, sex, comorbidities, and ICU occupancy. Two-way interactions between age, sex, and comorbidities were included to assess the differential risk of death across strata. ICU occupancy was modeled using restricted cubic splines to allow for a non-linear association with survival. Results Of 22,648 people hospitalized with COVID-19, 4785 (21.1%) died. The survival was lower during the first epidemic wave than in the second (predicted survival at 40 days after positive test 76.1 versus 80.5%). During the second epidemic wave, occupancy among all available ICU beds in Switzerland varied between 51.7 and 78.8%. The estimated survival was stable at approximately 81.5% when ICU occupancy was below 70%, but worse when ICU occupancy exceeded this threshold (survival at 80% ICU occupancy: 78.2%; 95% credible interval [CrI] 76.1 to 80.1%). Periods with higher ICU occupancy (>70 vs 70%) were associated with an estimated number of 137 (95% CrI 27 to 242) excess deaths. Comorbid conditions reduced survival more in younger people than in older people. Among comorbid conditions, hypertension and obesity were not associated with poorer survival. Hypertension appeared to decrease survival in combination with cardiovascular disease. Conclusions Survival after hospitalization with COVID-19 has improved over time, consistent with improved management of severe COVID-19. The decreased survival above 70% national ICU occupancy supports the need to introduce measures for prevention and control of SARS-CoV-2 transmission in the population well before ICUs are full.
Schlagwörter	COVID-19 ; Survival ; SARS-CoV-2 ; Intensive care unit ; Medicine ; R
Thema/Rubrik (Code)	590
Sprache	Englisch
Erscheinungsdatum	2022-04-01T00:00:00Z
Verlag	BMC
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Correction

Radoslaw Panczak / Elin Charles-Edwards / Jonathan Corcoran

Humanities & Social Sciences Communications, Vol 7, Iss 1, Pp 1-

Estimating temporary populations: a systematic review of the empirical literature

2020 Band 1

Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

Abstract	An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Schlagwörter	History of scholarship and learning. The humanities ; AZ20-999 ; Social Sciences ; H
Sprache	Englisch
Erscheinungsdatum	2020-10-01T00:00:00Z
Verlag	Springer Nature
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Estimating temporary populations

Radoslaw Panczak / Elin Charles-Edwards / Jonathan Corcoran

Palgrave Communications, Vol 6, Iss 1, Pp 1-

a systematic review of the empirical literature

2020 Band 10

Abstract: Abstract The estimation of temporary populations is a well-established field, but despite growing interest they are yet to form part of the standard suite of official population statistics. This systematic review seeks to review the empirical literature ... ...

Abstract	Abstract The estimation of temporary populations is a well-established field, but despite growing interest they are yet to form part of the standard suite of official population statistics. This systematic review seeks to review the empirical literature on temporary population estimation and identify the contemporary “state of the art”. We identify a total of 96 studies that attempt to estimate or describe a method of estimation. Our findings reveal strong growth in the number of studies in recent decades that in part has been driven by the rise in both the type and availability of new sources of information, including mobile phone data. What emerges from this systematic review is the lack of any “gold standard” data source or methodology for temporary population estimation. The review points to a number of important challenges that remain for estimating temporary populations, both conceptually and practically. What remains is the need for clear definitions along with identification of appropriate data and methods that are able to robustly capture and measure the diverse array of spatial behaviours that drive temporary population dynamics. To our knowledge, this is the first review on this topic that brings together literature from various disciplines and collates methods used for estimation.
Schlagwörter	Social Sciences ; H
Thema/Rubrik (Code)	310
Sprache	Englisch
Erscheinungsdatum	2020-05-01T00:00:00Z
Verlag	Palgrave Macmillan
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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