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  1. Article ; Online: Death from Covid-19 of 23 Health Care Workers in China.

    Zhan, Mingkun / Qin, Yaxun / Xue, Xiang / Zhu, Shuaijun

    The New England journal of medicine

    2020  Volume 382, Issue 23, Page(s) 2267–2268

    MeSH term(s) Adult ; Aged ; Betacoronavirus ; COVID-19 ; China/epidemiology ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Coronavirus Infections/mortality ; Coronavirus Infections/transmission ; Disease Progression ; Female ; Health Personnel/statistics & numerical data ; Humans ; Infectious Disease Transmission, Patient-to-Professional/prevention & control ; Infectious Disease Transmission, Patient-to-Professional/statistics & numerical data ; Male ; Medical Staff, Hospital/statistics & numerical data ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/mortality ; Pneumonia, Viral/transmission ; Respiratory Distress Syndrome/virology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-15
    Publishing country United States
    Document type Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2005696
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Genome-Wide Association Studies and Runs of Homozygosity to Identify Reproduction-Related Genes in Yorkshire Pig Population.

    Zhang, Lige / Zhang, Songyuan / Yuan, Meng / Zhan, Fengting / Song, Mingkun / Shang, Peng / Yang, Feng / Li, Xiuling / Qiao, Ruimin / Han, Xuelei / Li, Xinjian / Fang, Meiying / Wang, Kejun

    Genes

    2023  Volume 14, Issue 12

    Abstract: Reproductive traits hold considerable economic importance in pig breeding and production. However, candidate genes underpinning the reproductive traits are still poorly identified. In the present study, we executed a genome-wide association study (GWAS) ... ...

    Abstract Reproductive traits hold considerable economic importance in pig breeding and production. However, candidate genes underpinning the reproductive traits are still poorly identified. In the present study, we executed a genome-wide association study (GWAS) and runs of homozygosity (ROH) analysis using the PorcineSNP50 BeadChip array for 585 Yorkshire pigs. Results from the GWAS identified two genome-wide significant and eighteen suggestive significant single nucleotide polymorphisms (SNPs) associated with seven reproductive traits. Furthermore, we identified candidate genes, including
    MeSH term(s) Pregnancy ; Female ; Swine/genetics ; Male ; Animals ; Genome-Wide Association Study ; Semen ; Reproduction/genetics ; Homozygote ; Phenotype
    Language English
    Publishing date 2023-11-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14122133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Population Genetic Analysis of Six Chinese Indigenous Pig Meta-Populations Based on Geographically Isolated Regions.

    Zhang, Lige / Zhang, Songyuan / Zhan, Fengting / Song, Mingkun / Shang, Peng / Zhu, Fangxian / Li, Jiang / Yang, Feng / Li, Xiuling / Qiao, Ruimin / Han, Xuelei / Li, Xinjian / Liu, Gang / Wang, Kejun

    Animals : an open access journal from MDPI

    2023  Volume 13, Issue 8

    Abstract: The diversification of indigenous pig breeds in China has resulted from multiple climate, topographic, and human cultural influences. The numerous indigenous pig breeds can be geographically divided into six meta-populations; however, their genetic ... ...

    Abstract The diversification of indigenous pig breeds in China has resulted from multiple climate, topographic, and human cultural influences. The numerous indigenous pig breeds can be geographically divided into six meta-populations; however, their genetic relationships, contributions to genetic diversity, and genetic signatures remain unclear. Whole-genome SNP data for 613 indigenous pigs from the six Chinese meta-populations were obtained and analyzed. Population genetic analyses confirmed significant genetic differentiation and a moderate mixture among the Chinese indigenous pig meta-populations. The North China (NC) meta-population had the largest contribution to genetic and allelic diversity. Evidence from selective sweep signatures revealed that genes related to fat deposition and heat stress response (
    Language English
    Publishing date 2023-04-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13081396
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Robust Neutralization of SARS-CoV-2 Variants Including JN.1 and BA.2.87.1 by Trivalent XBB Vaccine-Induced Antibodies

    Wang, Xun / Jiang, Shujun / Ma, Wentai / Li, Chen / Liu, Changyi / Xie, Faren / Zhu, Jinsheng / Zhan, Yan / Jiang, Shibo / Li, Mingkun / Zhang, Yanliang / Wang, Pengfei

    bioRxiv

    Abstract: Newly emerged SARS-CoV-2 variants like JN.1, and more recently, the hypermutated BA.2.87.1, have raised global concern. We recruited two groups of participants who had BA.5/BF.7 breakthrough infection post three doses of inactivated vaccines: one group ... ...

    Abstract Newly emerged SARS-CoV-2 variants like JN.1, and more recently, the hypermutated BA.2.87.1, have raised global concern. We recruited two groups of participants who had BA.5/BF.7 breakthrough infection post three doses of inactivated vaccines: one group experienced subsequent XBB reinfection, while the other received the XBB-containing trivalent WSK-V102C vaccine. Our comparative analysis of their serum neutralization activities revealed that the WSK-V102C vaccine induced stronger antibody responses against a wide range of variants, notably including JN.1 and the highly escaped BA.2.87.1. Furthermore, our investigation into specific mutations revealed that fragment deletions in NTD significantly contribute to the immune evasion of the BA.2.87.1 variant. Our findings emphasize the necessity for ongoing vaccine development and adaptation to address the dynamic nature of SARS-CoV-2 variants.
    Keywords covid19
    Language English
    Publishing date 2024-02-16
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2024.02.16.580615
    Database COVID19

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  6. Article ; Online: Lesson learned from China regarding use of personal protective equipment.

    Zhan, Mingkun / Anders, Robert L / Lin, Bihua / Zhang, Min / Chen, Xiaosong

    American journal of infection control

    2020  Volume 48, Issue 12, Page(s) 1462–1465

    Abstract: Background: In Wuhan, China, in December 2019, the novel coronavirus was detected. The virus causing COVID-19 was related to a coronavirus named severe acute respiratory syndrome coronavirus (SARS-CoV). The virus caused an epidemic in China and was ... ...

    Abstract Background: In Wuhan, China, in December 2019, the novel coronavirus was detected. The virus causing COVID-19 was related to a coronavirus named severe acute respiratory syndrome coronavirus (SARS-CoV). The virus caused an epidemic in China and was quickly contained in 2003. Although coming from the same family of viruses and sharing certain transmissibility factors, the local health institutions in China had no experience with this new virus, subsequently named SARS-CoV-2.
    Methods: Based on their prior experience with the 2003 SARS epidemic, health authorities in China recognized the need for personal protective equipment (PPE). Existing PPE and protocols were limited and reflected early experience with SARS; however, as additional PPE supplies became available, designated COVID-19 hospitals in Hubei Province adopted the World Health Organization guidelines for Ebola to create a protocol specific for treating patients with COVID-19.
    Results: This article describes the PPE and protocol for its safe and effective deployment and the implementation of designated hospital units for COVID-19 patients. To date, only 2 nurses working in China who contracted SARS-CoV-2 have died from COVID-19 in the early period of the epidemic (February 11 and 14, 2020).
    Conclusions: The lessons learned by health care workers in China are shared in the hope of preventing future occupational exposure.
    MeSH term(s) COVID-19/prevention & control ; COVID-19/transmission ; China ; Humans ; Infectious Disease Transmission, Patient-to-Professional/prevention & control ; Occupational Exposure/prevention & control ; Personal Protective Equipment ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392362-9
    ISSN 1527-3296 ; 0196-6553
    ISSN (online) 1527-3296
    ISSN 0196-6553
    DOI 10.1016/j.ajic.2020.08.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Population Genetic Analysis of Six Chinese Indigenous Pig Meta-Populations Based on Geographically Isolated Regions

    Zhang, Lige / Zhang, Songyuan / Zhan, Fengting / Song, Mingkun / Shang, Peng / Zhu, Fangxian / Li, Jiang / Yang, Feng / Li, Xiuling / Qiao, Ruimin / Han, Xuelei / Li, Xinjian / Liu, Gang / Wang, Kejun

    Animals. 2023 Apr. 18, v. 13, no. 8

    2023  

    Abstract: The diversification of indigenous pig breeds in China has resulted from multiple climate, topographic, and human cultural influences. The numerous indigenous pig breeds can be geographically divided into six meta-populations; however, their genetic ... ...

    Abstract The diversification of indigenous pig breeds in China has resulted from multiple climate, topographic, and human cultural influences. The numerous indigenous pig breeds can be geographically divided into six meta-populations; however, their genetic relationships, contributions to genetic diversity, and genetic signatures remain unclear. Whole-genome SNP data for 613 indigenous pigs from the six Chinese meta-populations were obtained and analyzed. Population genetic analyses confirmed significant genetic differentiation and a moderate mixture among the Chinese indigenous pig meta-populations. The North China (NC) meta-population had the largest contribution to genetic and allelic diversity. Evidence from selective sweep signatures revealed that genes related to fat deposition and heat stress response (EPAS1, NFE2L2, VPS13A, SPRY1, PLA2G4A, and UBE3D) were potentially involved in adaptations to cold and heat. These findings from population genetic analyses provide a better understanding of indigenous pig characteristics in different environments and a theoretical basis for future work on the conservation and breeding of Chinese indigenous pigs.
    Keywords allelic variation ; climate ; cold ; genetic analysis ; heat ; heat shock response ; humans ; population genetics ; swine ; topography ; China
    Language English
    Dates of publication 2023-0418
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13081396
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: Large Doses of Propranolol for the Treatment of Infantile Cephalic and Facial Hemangiomas: A Clinical Report of 38 Cases.

    Jianguo, Ke / Xichun, Wang / Mingkun, Zhan / Qiaoling, Cai / Wenjin, Li

    The Journal of clinical pediatric dentistry

    2015  Volume 39, Issue 3, Page(s) 268–271

    Abstract: Objective: Infantile cephalic and facial hemangiomas (IHs) are common and histologically benign vascular lesions in infants. This study investigates the clinical effect of using large doses of Propranolol for the treatment of IHs.: Study design: This ...

    Abstract Objective: Infantile cephalic and facial hemangiomas (IHs) are common and histologically benign vascular lesions in infants. This study investigates the clinical effect of using large doses of Propranolol for the treatment of IHs.
    Study design: This study contains 38 patients with IHs. All patients received general screening before the treatment. The dosage of Propranolol was increased over the course of treatment, which initiated three days. 1mg/kg on the first day, then increased by 0.5 mg/kg each day. The daily dose was divided into two smaller doses, administered every 12 hours, half an hour after feeding. Patients were hospitalized for six days. In the absence of side effects, treatment was continued at home and patients were reevaluated every month. Generally, one course of treatment lasted six months.
    Results: With the treatment, the entire group had significant improvement. 6 of them had excellent results. 22 had a good response with considerable lesion reduction. Side effects were limited during or after the treatment.
    Conclusions: Large doses of oral Propranolol to treat severe IHs patients had great clinical results. The treatment can shorten the natural course of IHs, making it a possible first choice for treatment.
    MeSH term(s) Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/therapeutic use ; Blood Glucose/analysis ; Blood Pressure/drug effects ; Drug Administration Schedule ; Facial Neoplasms/drug therapy ; Female ; Follow-Up Studies ; Head and Neck Neoplasms/drug therapy ; Heart Rate/drug effects ; Hemangioma/drug therapy ; Humans ; Infant ; Male ; Propranolol/administration & dosage ; Propranolol/therapeutic use ; Remission Induction ; Skin Temperature/drug effects ; Treatment Outcome
    Chemical Substances Antineoplastic Agents ; Blood Glucose ; Propranolol (9Y8NXQ24VQ)
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1062408-9
    ISSN 1053-4628 ; 0145-5508
    ISSN 1053-4628 ; 0145-5508
    DOI 10.17796/1053-4628-39.3.268
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1444: Show issues Location:
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  9. Article: Lesson learned from China regarding use of personal protective equipment

    Zhan, Mingkun / Anders, Robert L / Lin, Bihua / Zhang, Min / Chen, Xiaosong

    Am. j. infect. control

    Abstract: BACKGROUND: In Wuhan, China, in December 2019, the novel coronavirus was detected. The virus causing COVID-19 was related to a coronavirus named severe acute respiratory syndrome coronavirus (SARS-CoV). The virus caused an epidemic in China and was ... ...

    Abstract BACKGROUND: In Wuhan, China, in December 2019, the novel coronavirus was detected. The virus causing COVID-19 was related to a coronavirus named severe acute respiratory syndrome coronavirus (SARS-CoV). The virus caused an epidemic in China and was quickly contained in 2003. Although coming from the same family of viruses and sharing certain transmissibility factors, the local health institutions in China had no experience with this new virus, subsequently named SARS-CoV-2. METHODS: Based on their prior experience with the 2003 SARS epidemic, health authorities in China recognized the need for personal protective equipment (PPE). Existing PPE and protocols were limited and reflected early experience with SARS; however, as additional PPE supplies became available, designated COVID-19 hospitals in Hubei Province adopted the World Health Organization guidelines for Ebola to create a protocol specific for treating patients with COVID-19. RESULTS: This article describes the PPE and protocol for its safe and effective deployment and the implementation of designated hospital units for COVID-19 patients. To date, only 2 nurses working in China who contracted SARS-CoV-2 have died from COVID-19 in the early period of the epidemic (February 11 and 14, 2020). CONCLUSIONS: The lessons learned by health care workers in China are shared in the hope of preventing future occupational exposure.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #707679
    Database COVID19

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  10. Article: [Combining eyebrow and inferior palpebral margin incision for the facial rejuvenation in the upper eyelid and midface region].

    Li, Ming / Xie, Yide / Zhan, Mingkun / Zhou, Yakuan / Huang, Chushan / Chen, Yanru / Wang, Limin

    Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery

    2016  Volume 32, Issue 3, Page(s) 166–170

    Abstract: Objective: To investigate a simple, minimally invasive and effective operative method for the facial rejuvenation in the upper eyelid and midface region.: Methods: Blepharoplasty was combined with suspending orbicularis oculi muscle flap and fixing ... ...

    Abstract Objective: To investigate a simple, minimally invasive and effective operative method for the facial rejuvenation in the upper eyelid and midface region.
    Methods: Blepharoplasty was combined with suspending orbicularis oculi muscle flap and fixing it on the periosteum underneath the eyebrow through eyebrow incision. Meanwhile, for midface rejuvenation, inferior palpebral margin incision was performed and prezygomatic interspace was separated completely under the orbicularis oculi muscle. The under-eye puffiness and tear trough deformity were corrected through releasing orbital fat, reposition and fastening orbital septum, and transposition of orbicularis oculi muscle flap. And the deep sulci nasolabialis and cheek anetoderma were relieved by dual lifting of malar fat pad and orbicularis oculi muscle flap. Follow-up was taken at the 1 week,3 months,6 months,1 year,2years and 3 years after operation. Each case was evaluated with postoperative effect, reprocessing time and postoperative complications and underwent photography.
    Results: From Feb.2010 to Oct.2014,190 patients (9 male,181 female, an average age of 49.03 ± 5.67 years) underwent this operation. Obvious improvement on the upper eyelid and midface region was achieved in all the patients after operation without serious or irreversible complication
    Conclusions: Combining eyebrow and inferior palpebral margin incision, through suspending the malar fat pad and orbicularis oculi muscle flap at the same time, as a simple, minimally invasive and reliable method, can strengthen the effect of the facial rejuvenation in the upper eyelid and midface region markedly.
    MeSH term(s) Adipose Tissue/surgery ; Adult ; Blepharoplasty/methods ; Cheek/surgery ; Eyebrows ; Eyelids/surgery ; Face/surgery ; Facial Muscles/surgery ; Female ; Humans ; Male ; Middle Aged ; Orbit/surgery ; Postoperative Complications/surgery ; Rejuvenation ; Rhytidoplasty/methods ; Surgical Flaps/surgery
    Language Chinese
    Publishing date 2016-05
    Publishing country China
    Document type Journal Article
    ZDB-ID 2019799-8
    ISSN 1009-4598 ; 1000-7806
    ISSN 1009-4598 ; 1000-7806
    Database MEDical Literature Analysis and Retrieval System OnLINE

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