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Article: New respiratory therapies in cystic fibrosis.

Stableforth, D E

Journal of the Royal Society of Medicine

1994 Volume 87 Suppl 21, Page(s) 11–16

MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Anti-Inflammatory Agents/therapeutic use ; Cystic Fibrosis/complications ; Cystic Fibrosis/therapy ; Genetic Therapy ; Humans ; Lung Transplantation ; Respiratory Therapy ; Tissue and Organ Procurement
Chemical Substances	Anti-Bacterial Agents ; Anti-Inflammatory Agents
Language	English
Publishing date	1994
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	6731-3
ISSN	1758-1095 ; 0141-0768 ; 0035-9157
ISSN (online)	1758-1095
ISSN	0141-0768 ; 0035-9157
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Ua VI Zs.114: Show issues

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Article ; Online: A systematic review of the role of immunonutrition in patients undergoing surgery for head and neck cancer.

Stableforth, W D / Thomas, S / Lewis, S J

International journal of oral and maxillofacial surgery

2009 Volume 38, Issue 2, Page(s) 103–110

Abstract: Patients with head and neck cancer are often malnourished and have a high incidence of postoperative complications. Studies of patients with head and neck cancer receiving immunonutrition in the perioperative period have suggested, but not conclusively ... ...

Abstract	Patients with head and neck cancer are often malnourished and have a high incidence of postoperative complications. Studies of patients with head and neck cancer receiving immunonutrition in the perioperative period have suggested, but not conclusively demonstrated, benefit. This study reviews randomised trials comparing perioperative standard polymeric nutrition or no nutritional supplementation with immunonutrition in the treatment of head and neck cancer. Electronic databases were searched; reference lists checked and letters sent requesting details of further data. Data were combined to estimate the common relative risk of postoperative complications (wound infections, fistula formation, death and length of hospital stay), and associated 95% confidence intervals. Random effects models were used. 10 trials of polymeric nutritional supplementation with immunonutrition were identified; one compared two types of immunonutrition. There was little evidence of heterogeneity. Pooled estimates showed a reduction in length of hospital stay by 3.5 days (95% CI 0.7 to 6.3 day, P<0.01). No reductions in clinical complications were seen. Perioperative immunonutrition is associated with reduced length of hospital stay; the mechanism is unclear as other outcomes were not improved. Trials were small with incomplete reporting of outcomes. An adequately powered trial is required to substantiate benefit.
MeSH term(s)	Enteral Nutrition ; Head and Neck Neoplasms/drug therapy ; Head and Neck Neoplasms/immunology ; Head and Neck Neoplasms/surgery ; Humans ; Immunotherapy/methods ; Length of Stay ; Nutritional Support/methods ; Perioperative Care/methods ; Postoperative Complications/prevention & control ; Treatment Outcome
Language	English
Publishing date	2009-02
Publishing country	Denmark
Document type	Journal Article ; Review
ZDB-ID	353721-3
ISSN	1399-0020 ; 0901-5027
ISSN (online)	1399-0020
ISSN	0901-5027
DOI	10.1016/j.ijom.2008.12.008
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Zs.A 931: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 401: Show issues

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Article: Doctors and nuclear war.

Stableforth, D

The Practitioner

1987 Volume 231, Issue 1436, Page(s) 1249–1250

MeSH term(s)	Internationality ; Nuclear Warfare ; Physician's Role ; Role ; Social Responsibility
Language	English
Publishing date	1987-10-08
Publishing country	England
Document type	Journal Article
ZDB-ID	124095-x
ISSN	0032-6518
ISSN	0032-6518
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Zs.B 228: Show issues

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Article ; Online: Reducing the environmental footprint of gastrointestinal endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) and European Society of Gastroenterology and Endoscopy Nurses and Associates (ESGENA) Position Statement.

Rodríguez de Santiago, Enrique / Dinis-Ribeiro, Mario / Pohl, Heiko / Agrawal, Deepak / Arvanitakis, Marianna / Baddeley, Robin / Bak, Elzbieta / Bhandari, Pradeep / Bretthauer, Michael / Burga, Patricia / Donnelly, Leigh / Eickhoff, Axel / Hayee, Bu'Hussain / Kaminski, Michal F / Karlović, Katarina / Lorenzo-Zúñiga, Vicente / Pellisé, Maria / Pioche, Mathieu / Siau, Keith /

Siersema, Peter D / Stableforth, William / Tham, Tony C / Triantafyllou, Konstantinos / Tringali, Alberto / Veitch, Andrew / Voiosu, Andrei M / Webster, George J / Vienne, Ariane / Beilenhoff, Ulrike / Bisschops, Raf / Hassan, Cesare / Gralnek, Ian M / Messmann, Helmut

Endoscopy

2022 Volume 54, Issue 8, Page(s) 797–826

Abstract: Climate change and the destruction of ecosystems by human activities are among the greatest challenges of the 21st century and require urgent action. Health care activities significantly contribute to the emission of greenhouse gases and waste production, ...

Abstract	Climate change and the destruction of ecosystems by human activities are among the greatest challenges of the 21st century and require urgent action. Health care activities significantly contribute to the emission of greenhouse gases and waste production, with gastrointestinal (GI) endoscopy being one of the largest contributors. This Position Statement aims to raise awareness of the ecological footprint of GI endoscopy and provides guidance to reduce its environmental impact. The European Society of Gastrointestinal Endoscopy (ESGE) and the European Society of Gastroenterology and Endoscopy Nurses and Associates (ESGENA) outline suggestions and recommendations for health care providers, patients, governments, and industry. MAIN STATEMENTS 1: GI endoscopy is a resource-intensive activity with a significant yet poorly assessed environmental impact. 2: ESGE-ESGENA recommend adopting immediate actions to reduce the environmental impact of GI endoscopy. 3: ESGE-ESGENA recommend adherence to guidelines and implementation of audit strategies on the appropriateness of GI endoscopy to avoid the environmental impact of unnecessary procedures. 4: ESGE-ESGENA recommend the embedding of reduce, reuse, and recycle programs in the GI endoscopy unit. 5: ESGE-ESGENA suggest that there is an urgent need to reassess and reduce the environmental and economic impact of single-use GI endoscopic devices. 6: ESGE-ESGENA suggest against routine use of single-use GI endoscopes. However, their use could be considered in highly selected patients on a case-by-case basis. 7: ESGE-ESGENA recommend inclusion of sustainability in the training curricula of GI endoscopy and as a quality domain. 8: ESGE-ESGENA recommend conducting high quality research to quantify and minimize the environmental impact of GI endoscopy. 9: ESGE-ESGENA recommend that GI endoscopy companies assess, disclose, and audit the environmental impact of their value chain. 10: ESGE-ESGENA recommend that GI endoscopy should become a net-zero greenhouse gas emissions practice by 2050.
MeSH term(s)	Ecosystem ; Endoscopy, Gastrointestinal/methods ; Gastroenterology ; Humans
Language	English
Publishing date	2022-07-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/a-1859-3726
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Zs.A 669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 162: Show issues

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Article: The treatment of respiratory pseudomonas infection in cystic fibrosis: what drug and which way?

Banerjee, D / Stableforth, D

Drugs

2000 Volume 60, Issue 5, Page(s) 1053–1064

Abstract: Pseudomonas aeruginosa is a non-capsulate and non-sporing gram-negative bacillus that most commonly affects the lower respiratory system in humans. Burkholderia (previously Pseudomonas) cepacia has emerged as an important respiratory pathogen in patients ...

Abstract	Pseudomonas aeruginosa is a non-capsulate and non-sporing gram-negative bacillus that most commonly affects the lower respiratory system in humans. Burkholderia (previously Pseudomonas) cepacia has emerged as an important respiratory pathogen in patients with cystic fibrosis (CF). The ability of P. aeruginosa to persist and multiply in moist environments and equipment, such as humidifiers in hospital wards, bathrooms, sinks and kitchens, maybe of importance in cross-infection. P. aeruginosa infections of the lower respiratory tract can range in severity from colonisation (without an immunological response) to a severe necrotising bronchopneumonia. Infection is seen in patients with CF and other chronic lung diseases such as non-CF bronchiectasis. In patients with CF, once P. aeruginosa is established in the airways it is almost impossible to eradicate, but prior to this, aggressive treatment can delay the development of chronic infection. 30 to 40% of the present paediatric population with CF will have chronic pseudomonal infection. B. cepacia has a particular predisposition to infect patients with CF and may be distinguished from P. aeruginosa by accelerated lung disease in about one- third of patients. Overwhelming septicaemia and necrotising pneumonia are well described (cepacia syndrome); events that are rare with P. aeruginosa. With the propensity for social cross-infection, segregation policies have been accepted as means of controlling outbreaks. A number of antipseudomonal agents are available. The most commonly used are the extended-spectrum penicillins, aminoglycosides, cephalosporins, fluoroquinolones, polymixins and the monobactams. An aminoglycoside with a beta-lactam penicillin is usually considered to be the first line treatment. No trial has shown any significant clinical advantage of any particular combination regimen over another. The emergence of resistance continues to be a concern. Pipericillin, piperacillin/tazobactam and meropenem have good but equivalent antibacterial activity against P. aeruginosa. However, B. cepacia is characterised by in vitro resistance to colistin (colomycin), aminoglycosides and ciprofloxacin but better susceptibility to ceftazidime. Nebulised delivery of antipseudomonal antibiotics is thought to prevent recurrent exacerbations, reduce antibiotic usage and maintain lung function, particularly in patients with CF. Colistin, tobramycin and gentamicin are currently the most commonly prescribed nebulised antibiotics. Much effort is directed at treating chronic P. aeruginosa infection but as chronic infection is seldom if ever eradicated when first established, prevention is preferable. Early intensive treatment for P. aeruginosa infection is advocated in order to maintain pulmonary function and postpone the onset of chronic P. aeruginosa infection.
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Cystic Fibrosis/complications ; Cystic Fibrosis/microbiology ; Drug Resistance, Microbial ; Hospitalization ; Humans ; Lung/microbiology ; Lung/pathology ; Nebulizers and Vaporizers ; Pseudomonas Infections/drug therapy ; Pseudomonas Infections/epidemiology ; Pseudomonas Infections/etiology ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/pathogenicity ; Respiratory Tract Infections/drug therapy ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/etiology
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2000-11
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	120316-2
ISSN	1179-1950 ; 0012-6667
ISSN (online)	1179-1950
ISSN	0012-6667
DOI	10.2165/00003495-200060050-00006
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Article: Death from asthma.

Stableforth, D

Thorax

1983 Volume 38, Issue 11, Page(s) 801–805

MeSH term(s)	Adrenergic beta-Agonists/adverse effects ; Adult ; Asthma/diagnosis ; Asthma/mortality ; Asthma/therapy ; Child ; England ; Female ; Humans ; Male ; Middle Aged ; Respiratory Therapy ; Risk ; Wales
Chemical Substances	Adrenergic beta-Agonists
Language	English
Publishing date	1983-11
Publishing country	England
Document type	Editorial
ZDB-ID	204353-1
ISSN	1468-3296 ; 0040-6376
ISSN (online)	1468-3296
ISSN	0040-6376
DOI	10.1136/thx.38.11.801
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Ui III Zs.83: Show issues

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Article ; Online: Iatrogenic portobiliary fistula complicating endoscopic stenting of a pancreatic cyst, with possible carcinoma: a case report.

Stableforth, William D / Pathmakanthan, Shrikanth / Holt, Andrew / Haydon, Geoffery / Freshwater, Dennis / Mangat, Kamarjit

Gastrointestinal endoscopy

2011 Volume 73, Issue 3, Page(s) 630–632

MeSH term(s)	Aged ; Carcinoma/pathology ; Cholangiopancreatography, Endoscopic Retrograde ; Common Bile Duct Diseases/etiology ; Digestive System Fistula/etiology ; Hemorrhage/etiology ; Humans ; Male ; Pancreatic Cyst/pathology ; Pancreatic Cyst/therapy ; Pancreatic Neoplasms/pathology ; Portal Vein ; Stents/adverse effects ; Vascular Fistula/etiology
Language	English
Publishing date	2011-03
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	391583-9
ISSN	1097-6779 ; 0016-5107
ISSN (online)	1097-6779
ISSN	0016-5107
DOI	10.1016/j.gie.2010.07.043
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Zs.B 283: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 519: Show issues

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Article: Asthma mortality and physician competence.

Stableforth, D E

The Journal of allergy and clinical immunology

1987 Volume 80, Issue 3 Pt 2, Page(s) 463–466

MeSH term(s)	Asthma/mortality ; Clinical Competence ; Emergencies ; Humans ; Physicians/standards ; United Kingdom
Language	English
Publishing date	1987-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	121011-7
ISSN	1085-8725 ; 1097-6825 ; 0091-6749
ISSN (online)	1085-8725 ; 1097-6825
ISSN	0091-6749
DOI	10.1016/0091-6749(87)90076-5
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Uh III Zs.92: Show issues

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Article: Asthma deaths in the United Kingdom.

Stableforth, D E

New England and regional allergy proceedings

1986 Volume 7, Issue 5, Page(s) 435–438

Abstract: ... in the United Kingdom by Stewart and Nunn shows that the changes in the World Health Organisation I.C.D. coding of 1967 ...

Abstract	Mortality due to asthma was recognised by Thomas Willis in 1671 though it was not until the early 1960s that an epidemic of death raised major concern in the United Kingdom. Initially over-treatment with beta agonist aerosols was blamed as the cause both here and in Australia and New Zealand. Further studies in London, Cardiff and Birmingham suggested this was not the case, rather than under diagnosis, under appreciation and under treatment were a more common cause of asthma mortality. The British Thoracic Society's confidential survey in 1979 confirmed these findings and further suggested that wrong certification was a potential source of inaccuracy in older age groups. More recently the New Zealand Asthma Task Force have reported the results of a two year national survey of deaths, revealing similar results to the UK studies, also finding little evidence of beta agonist over usage, little effect of nebulized drug administration and no significant theophylline drug over usage. An examination of trends in Asthma Mortality in the United Kingdom by Stewart and Nunn shows that the changes in the World Health Organisation I.C.D. coding of 1967 and 1978 had little overall effect on asthma death certification in the 15-44 year old age group. When this is taken into account they found that asthma mortality has declined from 1958 to 1982 in females but that there has been no change in males despite therapeutic advances over the period. Asthma mortality date derived since; however, does suggest a small but significant annual incremental rise in the 15 to 44 year age group.(ABSTRACT TRUNCATED AT 250 WORDS)
MeSH term(s)	Age Factors ; Asthma/drug therapy ; Asthma/mortality ; Bronchodilator Agents/adverse effects ; Humans ; New Zealand ; United Kingdom
Chemical Substances	Bronchodilator Agents
Language	English
Publishing date	1986-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	604966-7
ISSN	0742-2814
ISSN	0742-2814
DOI	10.2500/108854186778984763
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Article: A political asylum seeker with an amoebic empyema in Birmingham.

Banerjee, D / Clamp, A / Stableforth, D

Hospital medicine (London, England : 1998)

2001 Volume 62, Issue 6, Page(s) 372–373

MeSH term(s)	Adult ; Animals ; Diagnosis, Differential ; Drainage/methods ; Empyema, Pleural/parasitology ; Entamoeba histolytica/isolation & purification ; Humans ; Liver Abscess, Amebic/complications ; Liver Abscess, Amebic/diagnosis ; Liver Abscess, Amebic/therapy ; Male ; Refugees ; Tomography, X-Ray Computed/methods
Language	English
Publishing date	2001-08-03
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	604229-6
ISSN	1462-3935 ; 0007-1064
ISSN	1462-3935 ; 0007-1064
DOI	10.12968/hosp.2001.62.6.1599
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Zs.A 651: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.A 1515: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)

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