Result 1 - 10 of total 67
(Methods in enzymology ; ...)
2008
| Author's details | ed. by Roya Khosravi-Far |
|---|---|
| Series title | Methods in enzymology ... |
| Language | English |
| Dates of publication | 2008-9999 |
| Publisher | Elsevier |
| Publishing place | Amsterdam u.a. |
| Publishing country | Netherlands |
| Document type | Book ; Collection (display volumes) |
| HBZ-ID | HT015697047 |
| Database | Catalogue ZB MED Medicine, Health |
Research square
2024
Abstract: The prediction of RNA secondary structures is essential for understanding its underlying principles and applications in diverse fields, including molecular diagnostics and RNA-based therapeutic strategies. However, the complexity of the search space ... ...
| Abstract | The prediction of RNA secondary structures is essential for understanding its underlying principles and applications in diverse fields, including molecular diagnostics and RNA-based therapeutic strategies. However, the complexity of the search space presents a challenge. This work proposes a Graph Convolutional Network (GCNfold) for predicting the RNA secondary structure. GCNfold considers an RNA sequence as graph-structured data and predicts posterior base-pairing probabilities given the prior base-pairing probabilities, calculated using McCaskill's partition function. The performance of GCNfold surpasses that of the state-of-the-art folding algorithms, as we have incorporated minimum free energy information into the richly parameterized network, enhancing its robustness in predicting non-homologous RNA secondary structures. A Symmetric Argmax Post-processing algorithm ensures that GCNfold formulates valid structures. To validate our algorithm, we applied it to the SARS-CoV-2 E gene and determined the secondary structure of the E-gene across the |
|---|---|
| Language | English |
| Publishing date | 2024-02-23 |
| Publishing country | United States |
| Document type | Preprint |
| DOI | 10.21203/rs.3.rs-3798842/v1 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
(Advances in experimental medicine and biology ; 615)
2008
| Author's details | Roya Khosravi-Far ; Eileen White |
|---|---|
| Series title | Advances in experimental medicine and biology ; 615 |
| Collection | |
| Language | English |
| Publisher | Springer |
| Publishing place | New York u.a. |
| Publishing country | United States |
| Document type | Book |
| HBZ-ID | HT015418803 |
| ISBN | 978-1-4020-6553-8 ; 9781402065545 ; 1-4020-6553-1 ; 140206554X |
| Database | Catalogue ZB MED Medicine, Health |
| Shelf mark | Loan status | Location |
|---|---|---|
| Zs A 3192 -615- | not available for loan | Zeitschriften-Lesesaal |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Archives of pathology & laboratory medicine
2020
| Keywords | covid19 |
|---|---|
| Language | English |
| Publishing date | 2020-04-16 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 194119-7 |
| ISSN | 1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985 |
| ISSN (online) | 1543-2165 |
| ISSN | 0363-0153 ; 0096-8528 ; 0003-9985 |
| DOI | 10.5858/arpa.2020-0175-LE |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Ud II Zs.36: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Arch. pathol. lab. med. (1976)
| Keywords | covid19 |
|---|---|
| Publisher | WHO |
| Document type | Article |
| Note | WHO #Covidence: #32298137 |
| Database | COVID19 |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
Indonesian Biomedical Journal, Vol 6, Iss 3, Pp 157-
2014 Volume 62
Abstract: BACKGROUND: Our previous report showed that phosphorylated-survivin at Ser81 induces survivin back loop to activate protein kinase A (PKA) in the cytoprotection mechanism. Activated PKA could possibly induce the cytoprotection via Phosphatydilinositol 3- ... ...
| Abstract | BACKGROUND: Our previous report showed that phosphorylated-survivin at Ser81 induces survivin back loop to activate protein kinase A (PKA) in the cytoprotection mechanism. Activated PKA could possibly induce the cytoprotection via Phosphatydilinositol 3-kinase (PI3K). Therefore our current study was conducted to investigate the possibility of survivin-PKA-PI3K signaling pathway. METHODS: Viral productions by BOSC23 cells of Survivin, Antisense Survivin (Survivin-AS) and Ser81Ala mutant (Survivin-S81A) in pMSCV-IRES-GFP vector with cytomegalovirus (CMV) promoter were conducted. L929 cells were pretreated with/without PKI 6-22 amide and infected with viral particle of Survivin, Survivin-AS, Survivin-S81A or vector only. Cells were harvested, lysed and immunoprecipitated with anti-PI3K (p85) antibody and immunoblotted to detect PI3K (p85) and phospho-(Tyr) p85 PI3K. To confirm PI3K activation, PI3K Activity Assay was conducted by using phosphoinositide fraction containing PtdIns(4,5)P2 and [32P]ATP. RESULTS: Immunoblot and PI3K activity results showed similar results. Upon infection of virus with survivin, a markedly increased level of tyrosine phosphorylation of p85 PI3K or PI3K activity in L929 cells was seen. Low levels of tyrosine phosphorylation of p85 PI3K or PI3K activity were observed for Survivin-AS and Survivin-S81A-viral-infected L929 cells. With higher concentrations of Survivin-viral-infection, levels of tyrosine phosphorylation of p85 PI3K or PI3K activity in L929 cells were gradually increased. However, when L929 cells were pretreated with PKI 6-22 amide, prior to Survivin-viral-infection, level of tyrosine phosphorylation level of p85 PI3K or PI3K activity was detected much lower. CONCLUSIONS: Our result suggest that Ser81 Survivin play role in inducing PI3K activation and the Survivin-PI3K signaling pathway was PKA-dependent. KEYWORDS: Ser81, Survivin, PKA, PI3K, L929. |
|---|---|
| Keywords | Medicine (General) ; R5-920 |
| Language | English |
| Publishing date | 2014-12-01T00:00:00Z |
| Publisher | Secretariat of The Indonesian Biomedical Journal |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
Biochimica et biophysica acta. Biomembranes
2019 Volume 1862, Issue 2, Page(s) 183107
Abstract: Host defense peptides selectively kill bacterial and cancer cells (including those that are drug-resistant) by perturbing the permeability of their membranes, without being significantly toxic to the host. Coulombic interactions between these cationic ... ...
| Abstract | Host defense peptides selectively kill bacterial and cancer cells (including those that are drug-resistant) by perturbing the permeability of their membranes, without being significantly toxic to the host. Coulombic interactions between these cationic and amphipathic peptides and the negatively charged membranes of pathogenic cells contribute to the selective toxicity. However, a positive charge is not sufficient for selectivity, which can be achieved only by a finely tuned balance of electrostatic and hydrophobic driving forces. A common property of amphipathic peptides is the formation of aggregated structures in solution, but the role of this phenomenon in peptide activity and selectivity has received limited attention. Our data on the anticancer peptide killerFLIP demonstrate that aggregation strongly increases peptide selectivity, by reducing the effective peptide hydrophobicity and thus the affinity towards membranes composed of neutral lipids (like the outer layer of healthy eukaryotic cell membranes). Aggregation is therefore a useful tool to modulate the selectivity of membrane active peptides and peptidomimetics. |
|---|---|
| MeSH term(s) | Antimicrobial Cationic Peptides/chemistry ; Antimicrobial Cationic Peptides/metabolism ; Antimicrobial Cationic Peptides/pharmacology ; Cell Membrane/drug effects ; Hydrophobic and Hydrophilic Interactions ; Liposomes/chemistry ; Protein Binding ; Protein Multimerization |
| Chemical Substances | Antimicrobial Cationic Peptides ; Liposomes |
| Language | English |
| Publishing date | 2019-10-31 |
| Publishing country | Netherlands |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 60-7 |
| ISSN | 1879-2642 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399 |
| ISSN (online) | 1879-2642 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2618 ; 1879-2650 |
| ISSN | 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399 |
| DOI | 10.1016/j.bbamem.2019.183107 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Uc I Zs.247: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
(Methods in enzymology ; 442)
2008
| Author's details | ed. by Roya Khosravi-Far |
|---|---|
| Series title | Methods in enzymology ; 442 |
| Language | English |
| Size | XLVIII, 493, [15] S., Ill., graph. Darst. |
| Document type | Book |
| ISBN | 9780123743121 ; 0123743125 |
| Database | Leibniz Institute of Plant Genetics and Crop Plant Research |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
(Methods in enzymology ; ...)
2008
| Author's details | ed. by Roya Khosravi-Far |
|---|---|
| Series title | Methods in enzymology ... |
| Language | English |
| Dates of publication | 2008-9999 |
| Publisher | Elsevier, Acad. Press |
| Publishing place | Amsterdam u.a. |
| Document type | Book |
| Database | Leibniz Institute of Plant Genetics and Crop Plant Research |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
(Methods in enzymology ; ...)
2008
| Author's details | ed. by Roya Khosravi-Far |
|---|---|
| Series title | Methods in enzymology ... |
| Language | English |
| Dates of publication | 2008-9999 |
| Publisher | Elsevier, Acad. Press |
| Publishing place | Amsterdam u.a. |
| Document type | Book |
| Database | Leibniz Institute of Plant Genetics and Crop Plant Research |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.