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  1. Article ; Online: Ergometrine stimulates histamine H

    Jacob, Hannes / Braekow, Pauline / Hofmann, Britt / Kirchhefer, Uwe / Forster, Lisa / Mönnich, Denise / Humphrys, Laura J / Pockes, Steffen / Neumann, Joachim / Gergs, Ulrich

    Naunyn-Schmiedeberg's archives of pharmacology

    2023  Volume 396, Issue 12, Page(s) 3809–3822

    Abstract: Ergometrine (6aR,9R)-N-((S)-1-hydroxypropan-2-yl)-7-methyl-4,6,6a,7,8,9-hexa-hydro-indolo-[4,3-fg]chinolin-9-carboxamide or lysergide acid β-ethanolamide or ergonovine) activates several types of serotonin and histamine receptors in the animal heart. We ... ...

    Abstract Ergometrine (6aR,9R)-N-((S)-1-hydroxypropan-2-yl)-7-methyl-4,6,6a,7,8,9-hexa-hydro-indolo-[4,3-fg]chinolin-9-carboxamide or lysergide acid β-ethanolamide or ergonovine) activates several types of serotonin and histamine receptors in the animal heart. We thus examined whether ergometrine can activate human serotonin 5-HT
    MeSH term(s) Humans ; Mice ; Animals ; Serotonin/pharmacology ; Histamine ; Atrial Fibrillation ; Myocardial Contraction ; Heart Atria ; Mice, Transgenic ; Serine/pharmacology ; Receptors, Histamine H2
    Chemical Substances Serotonin (333DO1RDJY) ; Histamine (820484N8I3) ; Serine (452VLY9402) ; Receptors, Histamine H2
    Language English
    Publishing date 2023-06-24
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 121471-8
    ISSN 1432-1912 ; 0028-1298
    ISSN (online) 1432-1912
    ISSN 0028-1298
    DOI 10.1007/s00210-023-02573-8
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  2. Article ; Online: Histamine H

    Schrammel, Jasper Carsten / König, Martin / Frommer, Miriam / Andersen, Kaya Saskia / Kirsten, Marla / Seifert, Roland / Neumann, Detlef / Schirmer, Bastian

    Naunyn-Schmiedeberg's archives of pharmacology

    2023  Volume 396, Issue 12, Page(s) 3683–3693

    Abstract: In previous studies, we demonstrated the involvement of H ...

    Abstract In previous studies, we demonstrated the involvement of H
    MeSH term(s) Humans ; Mice ; Animals ; Histamine/pharmacology ; Histamine/metabolism ; Receptors, Histamine H1/genetics ; Receptors, Histamine H1/metabolism ; Receptors, Histamine H4 ; Caco-2 Cells ; Receptors, Histamine/genetics ; Receptors, Histamine/metabolism ; Colon/metabolism ; Inflammatory Bowel Diseases ; RNA, Messenger
    Chemical Substances Histamine (820484N8I3) ; Receptors, Histamine H1 ; Receptors, Histamine H4 ; Receptors, Histamine ; RNA, Messenger
    Language English
    Publishing date 2023-06-10
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 121471-8
    ISSN 1432-1912 ; 0028-1298
    ISSN (online) 1432-1912
    ISSN 0028-1298
    DOI 10.1007/s00210-023-02565-8
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  3. Article ; Online: Initial Characterization of a Transgenic Mouse with Overexpression of the Human H

    Rayo Abella, Lina Maria / Jacob, Hannes / Keller, Max / Schindler, Lisa / Pockes, Steffen / Pitzl, Sebastian / Klimas, Jan / Hadova, Katarína / Schneider, Sarah / Buchwalow, Igor B / Jin, CongYu / Panula, Pertti / Kirchhefer, Uwe / Neumann, Joachim / Gergs, Ulrich

    The Journal of pharmacology and experimental therapeutics

    2024  Volume 389, Issue 2, Page(s) 174–185

    Abstract: There is a debate on whether H ...

    Abstract There is a debate on whether H
    MeSH term(s) Humans ; Mice ; Animals ; Mice, Transgenic ; Histamine/pharmacology ; Pyrilamine/pharmacology ; Myocardial Contraction ; Heart ; Receptors, Histamine ; Heart Atria ; Heart Rate ; Receptors, Histamine H1/genetics ; Mammals
    Chemical Substances Histamine (820484N8I3) ; Pyrilamine (HPE317O9TL) ; Receptors, Histamine ; Receptors, Histamine H1
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3106-9
    ISSN 1521-0103 ; 0022-3565
    ISSN (online) 1521-0103
    ISSN 0022-3565
    DOI 10.1124/jpet.123.002060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Lysergic acid diethylamide stimulates cardiac human H

    Gergs, Ulrich / Jacob, Hannes / Braekow, Pauline / Hofmann, Britt / Pockes, Steffen / Humphrys, Laura J / Kirchhefer, Uwe / Fehse, Charlotte / Neumann, Joachim

    Naunyn-Schmiedeberg's archives of pharmacology

    2023  Volume 397, Issue 1, Page(s) 221–236

    Abstract: Lysergic acid diethylamide (LSD) is an artificial hallucinogenic drug. Thus, we hypothesized that LSD might act 5- ... ...

    Abstract Lysergic acid diethylamide (LSD) is an artificial hallucinogenic drug. Thus, we hypothesized that LSD might act 5-HT
    MeSH term(s) Humans ; Mice ; Animals ; Serotonin/pharmacology ; Lysergic Acid Diethylamide/pharmacology ; Histamine/pharmacology ; Receptors, Serotonin, 5-HT4/genetics ; Heart Atria ; Mice, Transgenic ; Receptors, Serotonin ; Receptors, Histamine ; Myocardial Contraction ; Receptors, Histamine H2/genetics
    Chemical Substances Serotonin (333DO1RDJY) ; Lysergic Acid Diethylamide (8NA5SWF92O) ; Histamine (820484N8I3) ; Receptors, Serotonin, 5-HT4 (158165-40-3) ; Receptors, Serotonin ; Receptors, Histamine ; Receptors, Histamine H2
    Language English
    Publishing date 2023-07-04
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 121471-8
    ISSN 1432-1912 ; 0028-1298
    ISSN (online) 1432-1912
    ISSN 0028-1298
    DOI 10.1007/s00210-023-02591-6
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  5. Article: Function and Role of Histamine H

    Neumann, Joachim / Hofmann, Britt / Kirchhefer, Uwe / Dhein, Stefan / Gergs, Ulrich

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 5

    Abstract: ... at least four heptahelical receptors: H ...

    Abstract Histamine can change the force of cardiac contraction and alter the beating rate in mammals, including humans. However, striking species and regional differences have been observed. Depending on the species and the cardiac region (atrium versus ventricle) studied, the contractile, chronotropic, dromotropic, and bathmotropic effects of histamine vary. Histamine is present and is produced in the mammalian heart. Thus, histamine may exert autocrine or paracrine effects in the mammalian heart. Histamine uses at least four heptahelical receptors: H
    Language English
    Publishing date 2023-05-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16050734
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The Roles of Cardiovascular H

    Neumann, Joachim / Kirchhefer, Uwe / Dhein, Stefan / Hofmann, Britt / Gergs, Ulrich

    Frontiers in pharmacology

    2021  Volume 12, Page(s) 732842

    Abstract: This review addresses pharmacological, structural and functional relationships among H ...

    Abstract This review addresses pharmacological, structural and functional relationships among H
    Language English
    Publishing date 2021-12-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.732842
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  7. Article ; Online: Clonidine stimulates force of contraction via histamine H

    Neumann, Joachim / Pockes, Steffen / Humphrys, Laura J / Mönnich, Denise / Forster, Lisa / Kirchhefer, Uwe / Hofmann, Britt / Gergs, Ulrich

    Naunyn-Schmiedeberg's archives of pharmacology

    2023  Volume 397, Issue 1, Page(s) 617–626

    Abstract: Clonidine has various clinical effects mediated by agonism of ... ...

    Abstract Clonidine has various clinical effects mediated by agonism of α
    MeSH term(s) Humans ; Mice ; Animals ; Guinea Pigs ; Histamine/pharmacology ; Clonidine/pharmacology ; Heart Atria ; Receptors, Histamine H2/genetics ; Cimetidine ; Myocardial Contraction ; Receptors, Histamine H1
    Chemical Substances Histamine (820484N8I3) ; Clonidine (MN3L5RMN02) ; Receptors, Histamine H2 ; Cimetidine (80061L1WGD) ; Receptors, Histamine H1
    Language English
    Publishing date 2023-07-25
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 121471-8
    ISSN 1432-1912 ; 0028-1298
    ISSN (online) 1432-1912
    ISSN 0028-1298
    DOI 10.1007/s00210-023-02635-x
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  8. Article ; Online: Human histamine H

    Gergs, U / Weisgut, J / Griethe, K / Mißlinger, N / Kirchhefer, U / Neumann, Joachim

    Naunyn-Schmiedeberg's archives of pharmacology

    2021  Volume 394, Issue 9, Page(s) 1963–1973

    Abstract: ... has hitherto not been available but might be useful to study the mechanism(s) of H ...

    Abstract Histamine is known to lead to arrhythmias in the human heart. A mouse model to mimic these effects has hitherto not been available but might be useful to study the mechanism(s) of H
    MeSH term(s) Animals ; Arrhythmias, Cardiac/physiopathology ; Cimetidine/pharmacology ; Dimaprit/pharmacology ; Disease Models, Animal ; Heart Atria/metabolism ; Heart Ventricles/metabolism ; Histamine/metabolism ; Humans ; Mice ; Mice, Transgenic ; Receptors, Histamine H2/genetics ; Receptors, Histamine H2/metabolism ; Signal Transduction/physiology
    Chemical Substances Receptors, Histamine H2 ; Cimetidine (80061L1WGD) ; Histamine (820484N8I3) ; Dimaprit (ZZQ699148P)
    Language English
    Publishing date 2021-06-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 121471-8
    ISSN 1432-1912 ; 0028-1298
    ISSN (online) 1432-1912
    ISSN 0028-1298
    DOI 10.1007/s00210-021-02098-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Correction to: Functional interaction of H

    Neumann, Joachim / Schwarzer, Denise / Fehse, Charlotte / Schwarz, Rebecca / Marusakova, Margareta / Kirchhefer, Uwe / Hofmann, Britt / Gergs, Ulrich

    Naunyn-Schmiedeberg's archives of pharmacology

    2021  Volume 394, Issue 12, Page(s) 2475–2476

    Language English
    Publishing date 2021-11-05
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 121471-8
    ISSN 1432-1912 ; 0028-1298
    ISSN (online) 1432-1912
    ISSN 0028-1298
    DOI 10.1007/s00210-021-02167-2
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  10. Article ; Online: Functional interaction of H

    Neumann, Joachim / Schwarzer, Denise / Fehse, Charlotte / Schwarz, Rebecca / Marusakova, Margareta / Kirchhefer, Uwe / Hofmann, Britt / Gergs, Ulrich

    Naunyn-Schmiedeberg's archives of pharmacology

    2021  Volume 394, Issue 12, Page(s) 2401–2418

    Abstract: In the past, we generated transgenic mice that overexpress the human histamine 2 (H ...

    Abstract In the past, we generated transgenic mice that overexpress the human histamine 2 (H
    MeSH term(s) Adenylyl Cyclases/metabolism ; Aged ; Animals ; Atrial Function/physiology ; GTP-Binding Proteins/metabolism ; Heart Atria/metabolism ; Histamine/metabolism ; Humans ; Mice ; Mice, Transgenic ; Middle Aged ; Receptors, Serotonin, 5-HT2/genetics ; Receptors, Serotonin, 5-HT2/metabolism ; Receptors, Serotonin, 5-HT4/genetics ; Receptors, Serotonin, 5-HT4/metabolism ; Serotonin/metabolism ; Species Specificity
    Chemical Substances Receptors, Serotonin, 5-HT2 ; Receptors, Serotonin, 5-HT4 (158165-40-3) ; Serotonin (333DO1RDJY) ; Histamine (820484N8I3) ; GTP-Binding Proteins (EC 3.6.1.-) ; Adenylyl Cyclases (EC 4.6.1.1)
    Language English
    Publishing date 2021-09-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 121471-8
    ISSN 1432-1912 ; 0028-1298
    ISSN (online) 1432-1912
    ISSN 0028-1298
    DOI 10.1007/s00210-021-02145-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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