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  1. Article: Neue S3-Leitlinie zur adjuvanten systemischen Antibiotikagabe bei subgingivaler Instrumentierung im Rahmen der systematischen Parodontitistherapie. Fachbeitrag von PD Dr. Yvonne Jockel-Schneider, Dr. Sonja Sälzer PhD, Prof. Dr. Benjamin Ehmke, Prof. Dr. Ulrich Schlagenhauf, Prof. Dr. Bernadette Pretzl

    Jockel-Schneider, Yvonne / Sälzer, Sonja / Ehmke, Benjamin / Schlagenhauf, Ulrich / Pretzl, Bernadette

    Teamwork

    2019  Volume 22, Issue 6, Page(s) 436

    Language German
    Document type Article
    ZDB-ID 1424340-4
    ISSN 1435-330X
    Database Current Contents Medicine

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  2. Article ; Online: Rainer Prohaska (1943-2022).

    Salzer, Ulrich / Mairhofer, Mario / De Franceschi, Lucia

    American journal of hematology

    2023  Volume 99, Issue 1, Page(s) 144–145

    Language English
    Publishing date 2023-10-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.27139
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  3. Article ; Online: TACI deficiency - a complex system out of balance.

    Salzer, Ulrich / Grimbacher, Bodo

    Current opinion in immunology

    2021  Volume 71, Page(s) 81–88

    Abstract: TACI promotes T-cell independent antibody responses and plasma cell differentiation and counteracts BAFF driven B-cell activation. Mutations in TNFRSF13B (encoding TACI) are associated with common variable immunodeficiency (CVID) but are also found in 1- ... ...

    Abstract TACI promotes T-cell independent antibody responses and plasma cell differentiation and counteracts BAFF driven B-cell activation. Mutations in TNFRSF13B (encoding TACI) are associated with common variable immunodeficiency (CVID) but are also found in 1-2% of the general population. Although not diseases causing, certain TNFRSF13B mutations predispose CVID patients to autoimmunity and lymphoproliferation. Recently, studies of TACI-deficient humans and murine models revealed novel aspects of TACI, especially its crosstalk with the TLR pathways, differential expression of TACI isoforms, and its role in the generation of autoreactive B-cells. Vice versa, these studies are instrumental for a better understanding of TACI deficiency in humans and suggest that gene dosage, mutation type, and additional clinical or laboratory abnormalities influence the relevance of TNFRSF13B variants in individual CVID patients. TACI is embedded in a complex and well-balanced system, which is vulnerable to genetic and possibly also environmental hits.
    MeSH term(s) Common Variable Immunodeficiency/genetics ; Common Variable Immunodeficiency/immunology ; Humans ; Transmembrane Activator and CAML Interactor Protein/deficiency ; Transmembrane Activator and CAML Interactor Protein/genetics ; Transmembrane Activator and CAML Interactor Protein/immunology
    Chemical Substances TNFRSF13B protein, human ; Transmembrane Activator and CAML Interactor Protein
    Language English
    Publishing date 2021-07-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2021.06.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Borderline-Störungen bei Jugendlichen

    Streeck-Fischer, Annette / Cropp, Carola / Streeck, Ulrich / Salzer, Simone

    die psychoanalytisch-interaktionelle Methode

    (Praxis der psychodynamischen Psychotherapie - analytische und tiefenpsychologisch fundierte Psychotherapie ; Band 10)

    2016  

    Author's details Annette Streeck-Fischer, Carola Cropp, Ulrich Streeck, Simone Salzer
    Series title Praxis der psychodynamischen Psychotherapie - analytische und tiefenpsychologisch fundierte Psychotherapie ; Band 10
    Collection
    Keywords Jugend ; Borderline-Persönlichkeitsstörung ; Psychoanalyse ; Interaktion
    Subject Interaktionsprozess ; Interaktives Verhalten ; Interpersonelle Interaktion ; Personale Interaktion ; Soziale Beziehung ; Soziale Interaktion ; Interaktionen ; Psychoanalytische Therapie ; Borderline-Syndrom ; Borderlinesyndrom ; Jugend ; Jugendalter ; Jugendlicher ; Teenager
    Language German
    Size VI, 123 Seiten
    Edition 1. Auflage
    Publisher hogrefe
    Publishing place Göttingen
    Publishing country Germany
    Document type Book
    HBZ-ID HT019074639
    ISBN 978-3-8017-2701-7 ; 3-8017-2701-7 ; 9783840927010 ; 9783844427011 ; 3840927013 ; 3844427015
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2016 A 2397 available for loan (reading room) Lesesaal EG

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  5. Article ; Online: Epigenetic immune cell quantification for diagnostic evaluation and monitoring of patients with inborn errors of immunity and secondary immune deficiencies.

    Ramirez, Neftali J / Schulze, Janika J / Walter, Steffi / Werner, Jeannette / Mrovecova, Pavla / Olek, Sven / Sachsenmaier, Christoph / Grimbacher, Bodo / Salzer, Ulrich

    Clinical immunology (Orlando, Fla.)

    2024  Volume 260, Page(s) 109920

    Abstract: Background: Early detection and monitoring of primary immunodeficiencies (PID) in humans require quantitative determination of immune cells from fresh blood analyzed by flow cytometry. However, epigenetic immune cell quantification allows analysis from ... ...

    Abstract Background: Early detection and monitoring of primary immunodeficiencies (PID) in humans require quantitative determination of immune cells from fresh blood analyzed by flow cytometry. However, epigenetic immune cell quantification allows analysis from fresh, frozen, or dried blood samples. We demonstrate the utility of epigenetic immune cell quantification for patients with PID.
    Methods: Epigenetic quantification of basic lymphocyte subpopulations of 259 samples from PID patients were compared to flow cytometric data. Epigenetic analysis was extended to T-cell subsets (Treg, Th17, Tfh, PD-1+, CCR6+) and memory B-cells and compared between venous EDTA and dried blood.
    Results: A high correlation of >0.9 was observed for basic T- and B-cell subsets. Extended epigenetic analysis showed quantitative trends within PID subgroups, but individually these varied substantially within these groups. Epigenetic analysis of dried blood samples was equivalent to EDTA blood.
    Conclusion: Epigenetic immune cell quantification is suitable for immune cell profiling in PID patients.
    MeSH term(s) Humans ; Edetic Acid ; T-Lymphocyte Subsets ; Lymphocyte Subsets ; Flow Cytometry ; Epigenesis, Genetic
    Chemical Substances Edetic Acid (9G34HU7RV0)
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2024.109920
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A Toolkit for Monitoring Immunoglobulin G Levels from Dried Blood Spots of Patients with Primary Immunodeficiencies.

    Haberstroh, Hanna / Hirsch, Aleksandra / Goldacker, Sigune / Zessack, Norbert / Warnatz, Klaus / Grimbacher, Bodo / Salzer, Ulrich

    Journal of clinical immunology

    2023  Volume 43, Issue 6, Page(s) 1185–1192

    Abstract: Purpose: This study assessed whether measuring immunoglobulin G (IgG) from dried blood spots (DBSs) using nephelometry is a suitable remote monitoring method for patients with primary immunodeficiencies (PID).: Methods: Patients receiving ... ...

    Abstract Purpose: This study assessed whether measuring immunoglobulin G (IgG) from dried blood spots (DBSs) using nephelometry is a suitable remote monitoring method for patients with primary immunodeficiencies (PID).
    Methods: Patients receiving immunoglobulin replacement therapy for PID were included in this non-interventional single-arm study (DRKS-ID: DRKS00020522) conducted in Germany from December 4, 2019, to December 22, 2020. Three blood samples, two capillary DBSs (one mail-transferred and the other direct-transferred to the laboratory), and one intravenous were collected from each patient. IgG levels were determined using nephelometry. IgG levels were summarized descriptively, and significant differences were assessed using Wilcoxon matched-pairs signed-rank tests. Correlation and agreement between IgG levels were assessed using Spearman correlation and Bland-Altman analyses, respectively.
    Results: Among 135 included patients, IgG levels measured from DBS samples were lower than those measured in serum (p < 0.0001). There was no significant difference between IgG levels in direct- and mail-transferred DBS samples. There was a high degree of correlation between IgG levels in serum samples and DBS samples (r = 0.94-0.95). Although there was a bias for higher levels of IgG in serum than in DBS samples, most samples were within the 95% interval of agreement. There was a high degree of correlation between IgG levels measured in direct- and mail-transferred DBS samples (r = 0.96) with no bias based on the shipment process and most samples within the 95% interval of agreement.
    Conclusion: Monitoring IgG levels from DBS samples is a suitable alternative to the standard method, and results are not substantially affected by mailing DBS cards.
    MeSH term(s) Humans ; Dried Blood Spot Testing/methods ; Immunoglobulin G ; Serum ; Germany
    Chemical Substances Immunoglobulin G
    Language English
    Publishing date 2023-03-21
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 779361-3
    ISSN 1573-2592 ; 0271-9142
    ISSN (online) 1573-2592
    ISSN 0271-9142
    DOI 10.1007/s10875-023-01464-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Low Prevalence of Anti-DFS70 Antibodies in Children With ANA-Associated Autoimmune Disease.

    Freudenhammer, Mirjam / Salzer, Ulrich / Heselich, Aileen / Hufnagel, Markus / Janda, Ales

    Frontiers in pediatrics

    2022  Volume 10, Page(s) 839928

    Abstract: Introduction: Anti-DFS70 antibodies occur in healthy individuals with various medical conditions. Unlike other anti-nuclear autoantibodies (ANA), they are not associated with systemic autoimmune disease in adult patients. To date, only a few studies ... ...

    Abstract Introduction: Anti-DFS70 antibodies occur in healthy individuals with various medical conditions. Unlike other anti-nuclear autoantibodies (ANA), they are not associated with systemic autoimmune disease in adult patients. To date, only a few studies have addressed the prevalence and/or clinical relevance of anti-DFS70 autoantibodies in children with and without autoimmune disease.
    Methods: Included in this retrospective cross-sectional mono-centric study were 308 pediatric patients with suspected or known autoimmune conditions who had a positive ANA in indirect immune fluorescence (IIF) screening and who were screened for anti-DFS70 antibodies by extractable nuclear antigen antibodies (ENA) immunoblot. Patients were assigned to four different diagnostic categories according to their diagnosis in the corresponding medical record: (a) absence of autoimmune or rheumatic disease (noARD,
    Results: The prevalence of anti-DFS70 antibodies in the overall cohort was 33.8%. Among children without ARD (46.6%, 54/116), prevalence was significantly higher than among children with ORD (23.7%, 27/115,
    Conclusion: As with adults, the higher prevalence of anti-DFS70 among children without autoimmune disease confirms the mutual exclusion for this autoantibody in the pathogenesis of ARD. Among ANA-positive children, monospecific anti-DFS70 antibodies may help to discriminate between AARD and not-AARD-related conditions.
    Language English
    Publishing date 2022-03-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2022.839928
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  8. Article ; Online: Flow Cytometry in the Diagnosis and Follow Up of Human Primary Immunodeficiencies.

    Salzer, Ulrich / Sack, Ulrich / Fuchs, Ilka

    EJIFCC

    2019  Volume 30, Issue 4, Page(s) 407–422

    Abstract: Primary immunodeficiencies (PID) comprise a group of more than 300 mostly monogenetic disorders of the immune system leading to infection susceptibility and a variety of associated clinical and immunological complications. In a majority of these ... ...

    Abstract Primary immunodeficiencies (PID) comprise a group of more than 300 mostly monogenetic disorders of the immune system leading to infection susceptibility and a variety of associated clinical and immunological complications. In a majority of these disorders the absence, disproportions or dysfunction of leucocyte subpopulations or of proteins expressed by these cells are observed. These distinctive features are studied by multicolour flow cytometry and the results are used for diagnosis, follow up, classification and therapy monitoring in patients with PIDs. Although a definite diagnosis almost always relies on genetic analysis in PIDs, the results of flow cytometric diagnostics are pivotal in the initial diagnostic assessment of suspected PID patients and often guide the treating physician to a more selective and efficient genetic diagnostic procedure, even in the era of next generation sequencing technology. Furthermore, phenotypic and functional flow cytometry tests allow to validate novel genetic variants and the mapping of complex disturbances of the immune system in individual patients in a personalized manner. In this review we give an overview on phenotypic, functional as well as disease/protein specific flow cytometric assays in the diagnosis of PID and highlight diagnostic strategies and specialties for several selected PIDs by way of example.
    Language English
    Publishing date 2019-11-25
    Publishing country Italy
    Document type Journal Article ; Review
    ISSN 1650-3414
    ISSN (online) 1650-3414
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Immundefizienz im Erwachsenenalter.

    Salzer, Ulrich / Warnatz, Klaus

    Deutsche medizinische Wochenschrift (1946)

    2017  Volume 142, Issue 11, Page(s) 829–832

    Title translation Primary Immunodeficiency in Adults.
    MeSH term(s) Adult ; Humans ; Immunologic Deficiency Syndromes/diagnosis ; Immunologic Deficiency Syndromes/genetics ; Immunologic Deficiency Syndromes/therapy
    Language German
    Publishing date 2017-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/s-0043-105094
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  10. Article ; Online: Susceptibility to infections and adaptive immunity in adults with heart failure.

    Salzer, Ulrich / Müller, Alisa / Zhou, Qian / Nieters, Alexandra / Grundmann, Sebastian / Wehr, Claudia

    ESC heart failure

    2022  Volume 9, Issue 2, Page(s) 1195–1205

    Abstract: Aims: Heart failure (HF) is a systemic inflammatory disorder with infections being an important cause of morbidity and mortality. We asked if HF patients have a higher susceptibility to infections compared with the general population and if a subtle ... ...

    Abstract Aims: Heart failure (HF) is a systemic inflammatory disorder with infections being an important cause of morbidity and mortality. We asked if HF patients have a higher susceptibility to infections compared with the general population and if a subtle secondary immunodeficiency facilitates infectious complications.
    Methods and results: In a cohort of 92 patients with HF with reduced ejection fraction, we analysed recirculating lymphocyte subpopulations, serum immunoglobulin levels, and specific antibody titres against pneumococcal antigens. We quantified susceptibility to infections of the respiratory tract with a validated questionnaire and compared it to the general population. Susceptibility to infections of the respiratory tract was comparable in HF patients and the general population. Hypogammaglobulinaemia was present in 16% of HF patients, but anti-pneumococcal titres showed no evidence of specific secondary antibody deficiency. Relative lymphopaenia in our HF cohort was due to B lymphocytopenia with a relative reduction in naive B-cells and expansion of memory B-cells while CD4+ and CD8+ T-lymphocytes as well as NK-cell counts were comparable between HF and healthy donors. The intake of the angiotensin receptor neprilysin (CD10) inhibitor (ARNI) sacubitril/valsartan was associated with increased B-lymphocyte counts, possibly by an increased output of CD10+ transitional B lymphocytes from the bone marrow.
    Conclusion: Despite a reduction of B lymphocytes in HF and mild hypogammaglobulinaemia, patients showed no evidence of secondary immunodeficiency or increased susceptibility to infections. The relevance of B-cell lymphopenia in HF patients and modulation of B-cell counts under ARNI treatment remains to be investigated.
    MeSH term(s) Adaptive Immunity ; Adult ; Aminobutyrates ; Angiotensin Receptor Antagonists ; Biphenyl Compounds ; Heart Failure ; Humans ; Stroke Volume ; Tetrazoles
    Chemical Substances Aminobutyrates ; Angiotensin Receptor Antagonists ; Biphenyl Compounds ; Tetrazoles ; sacubitril (17ERJ0MKGI)
    Language English
    Publishing date 2022-01-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2814355-3
    ISSN 2055-5822 ; 2055-5822
    ISSN (online) 2055-5822
    ISSN 2055-5822
    DOI 10.1002/ehf2.13793
    Database MEDical Literature Analysis and Retrieval System OnLINE

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