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Book ; Thesis: The role of beta-catenin/WNT signaling in Schwann cell development and myelination

Grigoryan, Tamara

2011

Author's details	von Tamara Grigoryan
Keywords	Mikroform
Subject	Fiche ; Mikrofiche ; Mikrofilm ; Microform ; Mikrobild ; Mikrodokumentation ; Mikrokopie ; Mikroformen
Language	English
Edition	[Mikrofiche-Ausg.]
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Berlin, Humboldt-Univ., Diss., 2011
HBZ-ID	HT016962763
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Histological and cytochemical analysis of the brain under conditions of hypobaric hypoxia-induced oxygen deficiency in albino rats.

Shushanyan, Ruzanna / Grigoryan, Anna / Abgaryan, Tamara / Karapetyan, Anna

Acta histochemica

2023 Volume 125, Issue 8, Page(s) 152114

Abstract: High altitude sickness is a life-threatening disease that occurs among acclimatized individuals working or living at a high altitude accompanied by hypobaric hypoxia exposure. The prolonged influence of hypobaric hypoxia on the brain may trigger neuronal ...

Abstract	High altitude sickness is a life-threatening disease that occurs among acclimatized individuals working or living at a high altitude accompanied by hypobaric hypoxia exposure. The prolonged influence of hypobaric hypoxia on the brain may trigger neuronal damage and cell death due to an oxygen deficiency. The purpose of the current study was to investigate the histomorphological changes in the hippocampus, cerebral cortex, cerebellar cortex, and striatum of the rat's brain following chronic hypobaric hypoxia. Fourteen albino rats were used for this investigation. The animals were exposed to chronic hypobaric hypoxia in the special decompression chamber at an altitude of 7000 m for 7 days. The histological analysis was conducted via toluidine staining and silver impregnation. DNA damage and cell apoptosis were assessed via Feulgen staining. The histochemical assessment revealed increased dark neurons in the hippocampus with cell swelling. Silver impregnation showed increased argyrophilic neurons in the cerebellar cortex, striatum, CA1 subfield of the hippocampus, and cerebral cortex. The cytochemical analysis determined the increased apoptotic cells with hyperchromatic condensation and pyknosis in the hippocampus subfields and cerebral cortex. In addition, it has been observed that hypoxia has resulted in small hemorrhages and perivascular edema within the cerebellar and cerebral cortex. The results indicate brain injury observed in the various parts of the brain towards hypobaric hypoxia, however, the hippocampus showed greater vulnerability against hypoxic exposure in comparison to the striatum, cerebellum, and cerebral cortex. These changes support our insights regarding brain intolerance under conditions of hypoxia-induced oxygen deficiency and its histomorphological manifestations.
MeSH term(s)	Rats ; Animals ; Silver/metabolism ; Hypoxia/metabolism ; Cerebral Cortex/metabolism ; Cerebral Cortex/pathology ; Hippocampus/metabolism ; Brain/pathology
Chemical Substances	Silver (3M4G523W1G)
Language	English
Publishing date	2023-11-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	77-2
ISSN	1618-0372 ; 0065-1281
ISSN (online)	1618-0372
ISSN	0065-1281
DOI	10.1016/j.acthis.2023.152114
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Article: Morphological abnormalities of peripheral blood cells among patients with COVID-19 disease.

Karapetyan, Anna / Niazyan, Lyudmila / Shushanyan, Ruzanna / Abgaryan, Tamara / Iritsyan, Sevan / Galechyan, Tehmine / Sargsyan, Knarik / Grigoryan, Anna

Heliyon

2024 Volume 10, Issue 2, Page(s) e24527

Abstract: Purpose: The hematological changes in COVID-19 patients continue to receive great attention, especially in the field of public health. To our knowledge, coronavirus disease may be identified based on the severity of illness, and the study of peripheral ... ...

Abstract	Purpose: The hematological changes in COVID-19 patients continue to receive great attention, especially in the field of public health. To our knowledge, coronavirus disease may be identified based on the severity of illness, and the study of peripheral blood smears may offer important information to facilitate the identification. Thus, we evaluated the morphological abnormalities (atypical and immature lymphocytes, lymphocytes with micronuclei, various nuclear abnormalities among erythrocytes) and quantitative changes in peripheral blood cells among 48 individuals with COVID-19 disease. Methods: The present study is a retrospective analysis of 48 individuals, including 24 hospitalized patients diagnosed with COVID-19 disease. The blood smears of all patients were subjected to a hematological examination to identify various morphological abnormalities in white and red blood cells. In addition, a micronucleus test was conducted to assess the incidence of chromosomal damage in lymphocytes. Furthermore, the complete blood count (CBC) was performed to evaluate changes in peripheral blood cells, particularly the differential total leukocyte count, which could indicate the immune response against viral infection in COVID-19 patients. Results: The findings of the hematological study conducted on patients diagnosed with COVID-19 disease revealed neutrophilia, eosinophilia, mild monocytosis, decreased hematocrit level, elevated erythrocyte sedimentation rate (ESR), and immature leukocytes. It was observed that patients who were infected with coronavirus demonstrated mild thrombocytopenia. Furthermore, the micronucleus test indicated the presence of immature cells with micronuclei among lymphocytes and numerous nuclear abnormalities in red blood cells. These results help to shed light on the hematological changes that occur in COVID-19 patients, and could potentially contribute to the development of more effective treatments for the disease. Conclusions: The examination of complete blood counts (CBCs) in conjunction with peripheral blood smears offers a potential means of identifying the impact of SARS-CoV-2 infection on the hematopoietic and immune systems, thereby providing early indications of inflammation. Based on a study, it has been suggested that SARS-CoV-2 may affect red and white blood cells causing morphological alterations thereby establishing a corresponding relationship with disease severity.
Language	English
Publishing date	2024-01-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e24527
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Article ; Online: Morphological abnormalities of peripheral blood cells among patients with COVID-19 disease

Anna Karapetyan / Lyudmila Niazyan / Ruzanna Shushanyan / Tamara Abgaryan / Sevan Iritsyan / Tehmine Galechyan / Knarik Sargsyan / Anna Grigoryan

Heliyon, Vol 10, Iss 2, Pp e24527- (2024)

2024

Abstract	Purpose: The hematological changes in COVID-19 patients continue to receive great attention, especially in the field of public health. To our knowledge, coronavirus disease may be identified based on the severity of illness, and the study of peripheral blood smears may offer important information to facilitate the identification. Thus, we evaluated the morphological abnormalities (atypical and immature lymphocytes, lymphocytes with micronuclei, various nuclear abnormalities among erythrocytes) and quantitative changes in peripheral blood cells among 48 individuals with COVID-19 disease. Methods: The present study is a retrospective analysis of 48 individuals, including 24 hospitalized patients diagnosed with COVID-19 disease. The blood smears of all patients were subjected to a hematological examination to identify various morphological abnormalities in white and red blood cells. In addition, a micronucleus test was conducted to assess the incidence of chromosomal damage in lymphocytes. Furthermore, the complete blood count (CBC) was performed to evaluate changes in peripheral blood cells, particularly the differential total leukocyte count, which could indicate the immune response against viral infection in COVID-19 patients. Results: The findings of the hematological study conducted on patients diagnosed with COVID-19 disease revealed neutrophilia, eosinophilia, mild monocytosis, decreased hematocrit level, elevated erythrocyte sedimentation rate (ESR), and immature leukocytes. It was observed that patients who were infected with coronavirus demonstrated mild thrombocytopenia. Furthermore, the micronucleus test indicated the presence of immature cells with micronuclei among lymphocytes and numerous nuclear abnormalities in red blood cells. These results help to shed light on the hematological changes that occur in COVID-19 patients, and could potentially contribute to the development of more effective treatments for the disease. Conclusions: The examination of complete blood counts (CBCs) in conjunction with ...
Keywords	Coronavirus ; Hematological abnormalities ; SARS-CoV-2 ; Hematopoesis ; Lymphocytes ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	610
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Molecular signaling mechanisms of axon-glia communication in the peripheral nervous system.

Grigoryan, Tamara / Birchmeier, Walter

BioEssays : news and reviews in molecular, cellular and developmental biology

2015 Volume 37, Issue 5, Page(s) 502–513

Abstract: In this article we discuss the molecular signaling mechanisms that coordinate interactions between Schwann cells and the neurons of the peripheral nervous system. Such interactions take place perpetually during development and in adulthood, and are ... ...

Abstract	In this article we discuss the molecular signaling mechanisms that coordinate interactions between Schwann cells and the neurons of the peripheral nervous system. Such interactions take place perpetually during development and in adulthood, and are critical for the homeostasis of the peripheral nervous system (PNS). Neurons provide essential signals to control Schwann cell functions, whereas Schwann cells promote neuronal survival and allow efficient transduction of action potentials. Deregulation of neuron-Schwann cell interactions often results in developmental abnormalities and diseases. Recent investigations have shown that during development, neuronally provided signals, such as Neuregulin, Jagged, and Wnt interact to fine-tune the Schwann cell lineage progression. In adult, the signal exchange between neurons and Schwann cells ensures proper nerve function and regeneration. Identification of the mechanisms of neuron-Schwann cell interactions is therefore essential for our understanding of the development, function and pathology of the peripheral nervous system as a whole.
MeSH term(s)	Animals ; Axons/metabolism ; Humans ; Neuroglia/cytology ; Neuroglia/metabolism ; Peripheral Nervous System/cytology ; Peripheral Nervous System/metabolism ; Signal Transduction/physiology ; Wnt Proteins/metabolism
Chemical Substances	Wnt Proteins
Language	English
Publishing date	2015-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	50140-2
ISSN	1521-1878 ; 0265-9247
ISSN (online)	1521-1878
ISSN	0265-9247
DOI	10.1002/bies.201400172
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Article ; Online: Prevalence of Pretreatment HIV-1 Drug Resistance in Armenia in 2017-2018 and 2020-2021 following a WHO Survey.

Kirichenko, Alina / Kireev, Dmitry / Lapovok, Ilya / Shlykova, Anastasia / Lopatukhin, Alexey / Pokrovskaya, Anastasia / Ladnaya, Natalya / Grigoryan, Trdat / Petrosyan, Arshak / Sarhatyan, Tatevik / Sargsyants, Narina / Hovsepyan, Tamara / Ghazaryan, Hovsep / Hovakimyan, Hermine / Martoyan, Siranush / Pokrovsky, Vadim

Viruses

2022 Volume 14, Issue 11

Abstract: The increased antiretroviral therapy (ART) coverage of patients in the absence of routine genotyping tests and in the context of active labor migration highlight the importance of HIV-1 drug resistance (DR) surveillance in Armenia. We conducted a two- ... ...

Abstract	The increased antiretroviral therapy (ART) coverage of patients in the absence of routine genotyping tests and in the context of active labor migration highlight the importance of HIV-1 drug resistance (DR) surveillance in Armenia. We conducted a two-phase pretreatment DR (PDR) study in 2017-2018 (phase I; 120 patients) and 2020-2021 (phase II; 133 patients) according to the WHO-approved protocol. The analysis of HIV-1 genetic variants showed high degrees of viral diversity, with the predominance of A6. The prevalence of any PDR was 9.2% in phase I and 7.5% in phase II. PDR to protease inhibitors was found only in 0.8% in phase II. PDR to efavirenz and nevirapine was found among 5.0% and 6.7% of patients in phase I, and 6.0% and 6.8% of patients in phase II, respectively. The prevalence of PDR to nucleoside reverse-transcriptase inhibitors decreased from 5.0% in phase I to 0.8% in phase II. In addition, we identified risk factors associated with the emergence of DR-male, MSM, subtype B, and residence in or around the capital of Armenia-and showed the active spread of HIV-1 among MSM in transmission clusters, i.e., harboring DR, which requires the immediate attention of public health policymakers for the prevention of HIV-1 DR spread in the country.
MeSH term(s)	Humans ; Male ; Pregnancy ; Female ; HIV-1/genetics ; Anti-HIV Agents/pharmacology ; Anti-HIV Agents/therapeutic use ; Drug Resistance, Viral/genetics ; Prevalence ; Homosexuality, Male ; Armenia/epidemiology ; Sexual and Gender Minorities ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; HIV Seropositivity ; World Health Organization ; Genotype ; Mutation
Chemical Substances	Anti-HIV Agents
Language	English
Publishing date	2022-10-22
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v14112320
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Article ; Online: [No title information]

Simonyan, Tamara / Papyan, Ruzanna / Danielyan, Samvel / Sargsyan, Lilit / Grigoryan, Varduhi / Topchyan, Hakob / Azaryan, Arpina / Tananyan, Armen / Muradyan, Armen / Tamamyan, Gevorg

Asian Pacific journal of cancer prevention : APJCP

2019 Volume 20, Issue 4, Page(s) 991–994

MeSH term(s)	Antineoplastic Agents/supply & distribution ; Armenia ; Child ; Developing Countries ; Drugs, Essential/supply & distribution ; Follow-Up Studies ; Health Services Accessibility ; Humans ; Neoplasms/drug therapy ; Neoplasms/pathology ; Pharmacies/statistics & numerical data ; Prognosis ; Surveys and Questionnaires
Chemical Substances	Antineoplastic Agents ; Drugs, Essential
Language	English
Publishing date	2019-04-29
Publishing country	Thailand
Document type	Journal Article
ZDB-ID	2218955-5
ISSN	2476-762X ; 1513-7368
ISSN (online)	2476-762X
ISSN	1513-7368
DOI	10.31557/APJCP.2019.20.4.991
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Article: Flavonoid Library Screening Reveals Kaempferol as a Potential Antiviral Agent Against African Swine Fever Virus.

Arabyan, Erik / Hakobyan, Astghik / Hakobyan, Tamara / Grigoryan, Rafaella / Izmailyan, Roza / Avetisyan, Aida / Karalyan, Zaven / Jackman, Joshua A / Ferreira, Fernando / Elrod, Charles C / Zakaryan, Hovakim

Frontiers in microbiology

2021 Volume 12, Page(s) 736780

Abstract: Naturally occurring plant flavonoids are a promising class of antiviral agents to inhibit African swine fever virus (ASFV), which causes highly fatal disease in pigs and is a major threat to the swine industry. Currently known flavonoids with anti-ASFV ... ...

Abstract	Naturally occurring plant flavonoids are a promising class of antiviral agents to inhibit African swine fever virus (ASFV), which causes highly fatal disease in pigs and is a major threat to the swine industry. Currently known flavonoids with anti-ASFV activity demonstrate a wide range of antiviral mechanisms, which motivates exploration of new antiviral candidates within this class. The objective of this study was to determine whether other flavonoids may significantly inhibit ASFV infection
Language	English
Publishing date	2021-10-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2021.736780
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Article: Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice.

Grigoryan, Tamara / Wend, Peter / Klaus, Alexandra / Birchmeier, Walter

Genes & development

2008 Volume 22, Issue 17, Page(s) 2308–2341

Abstract: Wnt signaling is one of a handful of powerful signaling pathways that play crucial roles in the animal life by controlling the genetic programs of embryonic development and adult homeostasis. When disrupted, these signaling pathways cause developmental ... ...

Abstract	Wnt signaling is one of a handful of powerful signaling pathways that play crucial roles in the animal life by controlling the genetic programs of embryonic development and adult homeostasis. When disrupted, these signaling pathways cause developmental defects, or diseases, among them cancer. The gateway of the canonical Wnt pathway, which contains >100 genes, is an essential molecule called beta-catenin (Armadillo in Drosophila). Conditional loss- and gain-of-function mutations of beta-catenin in mice provided powerful tools for the functional analysis of canonical Wnt signaling in many tissues and organs. Such studies revealed roles of Wnt signaling that were previously not accessible to genetic analysis due to the early embryonic lethality of conventional beta-catenin knockout mice, as well as the redundancy of Wnt ligands, receptors, and transcription factors. Analysis of conditional beta-catenin loss- and gain-of-function mutant mice demonstrated that canonical Wnt signals control progenitor cell expansion and lineage decisions both in the early embryo and in many organs. Canonical Wnt signaling also plays important roles in the maintenance of various embryonic or adult stem cells, and as recent findings demonstrated, in cancer stem cell types. This has opened new opportunities to model numerous human diseases, which have been associated with deregulated Wnt signaling. Our review summarizes what has been learned from genetic studies of the Wnt pathway by the analysis of conditional beta-catenin loss- and gain-of-function mice.
MeSH term(s)	Animals ; Bone and Bones/embryology ; Bone and Bones/metabolism ; Central Nervous System/embryology ; Central Nervous System/metabolism ; Extremities/embryology ; Gastrointestinal Tract/embryology ; Gastrointestinal Tract/metabolism ; Heart/embryology ; Hematopoiesis/physiology ; Humans ; Mice ; Mice, Mutant Strains ; Models, Animal ; Mutation ; Neural Crest/embryology ; Neural Crest/metabolism ; Organ Specificity ; Sense Organs/embryology ; Sense Organs/metabolism ; Signal Transduction ; Skin/embryology ; Skin/metabolism ; Wnt Proteins/genetics ; Wnt Proteins/physiology ; beta Catenin/genetics ; beta Catenin/metabolism
Chemical Substances	Wnt Proteins ; beta Catenin
Language	English
Publishing date	2008-09-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	806684-x
ISSN	1549-5477 ; 0890-9369
ISSN (online)	1549-5477
ISSN	0890-9369
DOI	10.1101/gad.1686208
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Article ; Online: E-cadherin is crucial for embryonic stem cell pluripotency and can replace OCT4 during somatic cell reprogramming.

Redmer, Torben / Diecke, Sebastian / Grigoryan, Tamara / Quiroga-Negreira, Angel / Birchmeier, Walter / Besser, Daniel

EMBO reports

2011 Volume 12, Issue 7, Page(s) 720–726

Abstract: We report new functions of the cell-adhesion molecule E-cadherin in murine pluripotent cells. E-cadherin is highly expressed in mouse embryonic stem cells, and interference with E-cadherin causes differentiation. During cellular reprogramming of mouse ... ...

Abstract	We report new functions of the cell-adhesion molecule E-cadherin in murine pluripotent cells. E-cadherin is highly expressed in mouse embryonic stem cells, and interference with E-cadherin causes differentiation. During cellular reprogramming of mouse fibroblasts by OCT4, SOX2, KLF4 and c-MYC, fully reprogrammed cells were exclusively observed in the E-cadherin-positive cell population and could not be obtained in the absence of E-cadherin. Moreover, reprogrammed cells could be established by viral E-cadherin in the absence of exogenous OCT4. Thus, reprogramming requires spatial cues that cross-talk with essential transcription factors. The cell-adhesion molecule E-cadherin has important functions in pluripotency and reprogramming.
MeSH term(s)	Animals ; Cadherins/genetics ; Cadherins/metabolism ; Cell Differentiation/genetics ; Cell Line ; Cellular Reprogramming/genetics ; Embryonic Stem Cells/metabolism ; Gene Deletion ; Gene Expression Regulation, Developmental ; Mice ; Mice, 129 Strain ; Mice, Inbred NOD ; Mice, SCID ; Octamer Transcription Factor-3/genetics ; Octamer Transcription Factor-3/metabolism ; Pluripotent Stem Cells/cytology ; Pluripotent Stem Cells/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
Chemical Substances	Cadherins ; Octamer Transcription Factor-3 ; Pou5f1 protein, mouse ; RNA, Messenger
Language	English
Publishing date	2011-07-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2020896-0
ISSN	1469-3178 ; 1469-221X
ISSN (online)	1469-3178
ISSN	1469-221X
DOI	10.1038/embor.2011.88
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