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  1. Article: Gut microbiome-immune crosstalk affects progression of cancer.

    Tilg, Herbert / Schmiderer, Andreas / Djanani, Angela

    Translational gastroenterology and hepatology

    2018  Volume 3, Page(s) 34

    Language English
    Publishing date 2018-06-19
    Publishing country China
    Document type Editorial ; Comment
    ISSN 2415-1289
    ISSN 2415-1289
    DOI 10.21037/tgh.2018.06.02
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  2. Article ; Online: Liver Transplantation after Successful Downstaging of a Locally Advanced Hepatocellular Carcinoma with Systemic Therapy.

    Schmiderer, Andreas / Zoller, Heinz / Niederreiter, Markus / Effenberger, Maria / Oberhuber, Georg / Krendl, Felix Julius / Oberhuber, Rupert / Schneeberger, Stefan / Tilg, Herbert / Djanani, Angela

    Digestive diseases (Basel, Switzerland)

    2023  Volume 41, Issue 4, Page(s) 641–644

    Abstract: Introduction: Liver transplantation (LT) is potentially curative for patients with cirrhosis and hepatocellular carcinoma (HCC). However, this procedure is usually reserved for patients with early tumor stages or after successful downstaging with local ... ...

    Abstract Introduction: Liver transplantation (LT) is potentially curative for patients with cirrhosis and hepatocellular carcinoma (HCC). However, this procedure is usually reserved for patients with early tumor stages or after successful downstaging with local regional therapies. In patients with locally advanced HCC, current guidelines recommend locoregional and palliative systemic therapies for tumor stages Barcelona Clinic Liver Cancer (BCLC) B and C, respectively.
    Case report: In this article, we describe a 63-year-old male patient with locally advanced HCC (BCLC C) and hepatitis C-associated cirrhosis. Following systemic treatment with the immune checkpoint inhibitor atezolizumab and the anti-VEGF antibody bevacizumab, significant downstaging to a tumor stage within the Milan criteria was achieved after which LT was successfully performed.
    Conclusion: As more effective systemic therapies become available, LT and potential curative treatment could become feasible for selected patients with locally advanced HCC.
    MeSH term(s) Male ; Humans ; Middle Aged ; Carcinoma, Hepatocellular/surgery ; Liver Neoplasms/surgery ; Liver Transplantation/adverse effects ; Neoplasm Staging ; Hepatitis C ; Treatment Outcome
    Language English
    Publishing date 2023-01-16
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 632798-9
    ISSN 1421-9875 ; 0257-2753
    ISSN (online) 1421-9875
    ISSN 0257-2753
    DOI 10.1159/000529023
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  3. Article: Das duktale Adenokarzinom des Pankreas

    Djanani, Angela / Niederreiter, Lukas / Niederreiter, Markus / Schmiderer, Andreas

    Wiener medizinische Wochenschrift : Skriptum : Kongressjournal

    2019  Volume 16, Issue 6, Page(s) 7

    Language German
    Document type Article
    ZDB-ID 2142526-7
    ISSN 1613-3803 ; 0043-5341
    Database Current Contents Medicine

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  4. Article ; Online: Decline in acute upper gastrointestinal bleeding during COVID-19 pandemic after initiation of lockdown in Austria.

    Schmiderer, Andreas / Schwaighofer, Hubert / Niederreiter, Lukas / Profanter, Christoph / Steinle, Hartmut / Ziachehabi, Alexander / Tilg, Herbert

    Endoscopy

    2020  Volume 52, Issue 11, Page(s) 1036–1038

    Abstract: Background: COVID-19 has spread rapidly around the world. The Austrian government implemented a lockdown on 16 March to contain further spread of the disease. We investigated the effects of lockdown on acute upper gastrointestinal (GI) bleeding in ... ...

    Abstract Background: COVID-19 has spread rapidly around the world. The Austrian government implemented a lockdown on 16 March to contain further spread of the disease. We investigated the effects of lockdown on acute upper gastrointestinal (GI) bleeding in Austria.
    Methods: We contacted 98 Austrian hospitals performing emergency endoscopies. The hospitals were asked to report upper GI endoscopies performed for recent hematemesis, melena, or both, and exhibiting endoscopically visible signs of bleeding. The study period was from 3 weeks before (calendar Week 9) to 3 weeks after (Week 14) initiation of the lockdown.
    Results: 61 % of Austrian hospitals, and importantly all major state hospitals, responded. A total of 575 upper GI bleedings occurred during the 3 weeks before and 341 during the 3 weeks after initiation of lockdown (40.7 % reduction). There was a 54.6 % decline in nonvariceal bleeding events at Week 14 compared with Week 9 (89 vs. 196), whereas rates of variceal hemorrhage did not change (15 vs. 17).
    Conclusions: National lockdown resulted in a dramatic decrease in upper GI bleeding events in Austrian hospitals.
    MeSH term(s) Austria ; Betacoronavirus ; COVID-19 ; Communicable Disease Control ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Endoscopy ; Esophageal and Gastric Varices/diagnosis ; Esophageal and Gastric Varices/epidemiology ; Esophageal and Gastric Varices/therapy ; Gastrointestinal Hemorrhage/diagnosis ; Gastrointestinal Hemorrhage/epidemiology ; Gastrointestinal Hemorrhage/therapy ; Humans ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; SARS-CoV-2 ; Social Isolation
    Keywords covid19
    Language English
    Publishing date 2020-07-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-1178-4656
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  5. Article ; Online: First evidence for the antitumor activity of nanoliposomal irinotecan with 5-fluorouracil and folinic acid in metastatic biliary tract cancer.

    Taghizadeh, Hossein / Unseld, Matthias / Schmiderer, Andreas / Djanani, Angela / Wilthoner, Klaus / Buchinger, Dieter / Prager, Gerald W

    Cancer chemotherapy and pharmacology

    2020  Volume 86, Issue 1, Page(s) 109–115

    Abstract: Background: Therapeutic options are limited for advanced, metastatic biliary tract cancer. The pivotal NAPOLI-1 trial demonstrated the superior clinical benefit of nanoliposomal irinotecan (Nal-IRI) in gemcitabine-pretreated patients with metastatic ... ...

    Abstract Background: Therapeutic options are limited for advanced, metastatic biliary tract cancer. The pivotal NAPOLI-1 trial demonstrated the superior clinical benefit of nanoliposomal irinotecan (Nal-IRI) in gemcitabine-pretreated patients with metastatic pancreatic ductal adenocarcinoma; however, the antitumor activity of Nal-IRI in biliary tract cancer is unknown. This is the first report describing the efficacy of Nal-IRI in biliary tract cancer.
    Methods: In this multicenter retrospective cohort analysis, we identified patients with metastatic biliary tract adenocarcinoma who were treated with Nal-IRI in combination with 5-fluorouracil and folinic acid following tumor progression under standard therapy at one of the study centers between May 2016 and January 2019. We assessed disease control rate (DCR), progression-free survival (PFS), and overall survival (OS).
    Results: There were 14 patients; the median age at the time of diagnosis and the median age at the initiation of Nal-IRI were 59.3 and 60.0 years, respectively. Nal-IRI in combination with 5-fluorouracil and folinic acid was administered as second-, third-, fourth-, and fifth-line treatment in 6 (43%), 5 (36%), 2 (14%), and 1 (7%) patient with metastatic disease, respectively. The objective DCR with Nal-IRI was 50% (7/14 patients). Six patients (43%) had partial response, and one patient (7%) had stable disease. Progressive disease was observed in seven patients. The median PFS and median OS following Nal-IRI initiation were 10.6 and 24.1 months, respectively.
    Conclusions: This retrospective analysis provides the first evidence that Nal-IRI might exhibit a clinical meaningful antitumor activity in metastatic biliary tract cancer.
    MeSH term(s) Adenocarcinoma/drug therapy ; Adenocarcinoma/mortality ; Adenocarcinoma/pathology ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biliary Tract Neoplasms/drug therapy ; Biliary Tract Neoplasms/mortality ; Biliary Tract Neoplasms/pathology ; Deoxycytidine/administration & dosage ; Deoxycytidine/analogs & derivatives ; Drug Carriers/administration & dosage ; Drug Carriers/chemistry ; Female ; Fluorouracil/administration & dosage ; Humans ; Irinotecan/administration & dosage ; Leucovorin/administration & dosage ; Liposomes/administration & dosage ; Male ; Middle Aged ; Nanoparticles/administration & dosage ; Nanoparticles/chemistry ; Retrospective Studies ; Treatment Outcome
    Chemical Substances Drug Carriers ; Liposomes ; Deoxycytidine (0W860991D6) ; Irinotecan (7673326042) ; gemcitabine (B76N6SBZ8R) ; Leucovorin (Q573I9DVLP) ; Fluorouracil (U3P01618RT)
    Language English
    Publishing date 2020-06-18
    Publishing country Germany
    Document type Journal Article ; Multicenter Study
    ZDB-ID 6820-2
    ISSN 1432-0843 ; 0344-5704 ; 0943-9404
    ISSN (online) 1432-0843
    ISSN 0344-5704 ; 0943-9404
    DOI 10.1007/s00280-020-04094-0
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  6. Article: Decline in acute upper gastrointestinal bleeding during COVID-19 pandemic after initiation of lockdown in Austria

    Schmiderer, Andreas / Schwaighofer, Hubert / Niederreiter, Lukas / Profanter, Christoph / Steinle, Hartmut / Ziachehabi, Alexander / Tilg, Herbert

    Endoscopy

    Abstract: BACKGROUND: COVID-19 has spread rapidly around the world. The Austrian government implemented a lockdown on 16 March to contain further spread of the disease. We investigated the effects of lockdown on acute upper gastrointestinal (GI) bleeding in ... ...

    Abstract BACKGROUND: COVID-19 has spread rapidly around the world. The Austrian government implemented a lockdown on 16 March to contain further spread of the disease. We investigated the effects of lockdown on acute upper gastrointestinal (GI) bleeding in Austria. METHODS: We contacted 98 Austrian hospitals performing emergency endoscopies. The hospitals were asked to report upper GI endoscopies performed for recent hematemesis, melena, or both, and exhibiting endoscopically visible signs of bleeding. The study period was from 3 weeks before (calendar Week 9) to 3 weeks after (Week 14) initiation of the lockdown. RESULTS: 61 % of Austrian hospitals, and importantly all major state hospitals, responded. A total of 575 upper GI bleedings occurred during the 3 weeks before and 341 during the 3 weeks after initiation of lockdown (40.7 % reduction). There was a 54.6 % decline in nonvariceal bleeding events at Week 14 compared with Week 9 (89 vs. 196), whereas rates of variceal hemorrhage did not change (15 vs. 17). CONCLUSIONS: National lockdown resulted in a dramatic decrease in upper GI bleeding events in Austrian hospitals.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #264811
    Database COVID19

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  7. Article: Decline in acute upper gastrointestinal bleeding during Covid-19 pandemic after lockdown in Austria

    Schmiderer, Andreas / Schwaighofer, Hubert / Niederreiter, Lukas / Profanter, Christoph / Steinle, Hartmut / Ziachehabi, Alexander / Tilg, Herbert

    Endoscopy

    Abstract: Background and study aims COVID-19 disease has rapidly spread all over the world. The Austrian government has implemented a lockdown to contain further spread of this disease on March 16th. We investigated the effects of lockdown on acute upper ... ...

    Abstract Background and study aims COVID-19 disease has rapidly spread all over the world. The Austrian government has implemented a lockdown to contain further spread of this disease on March 16th. We investigated the effects of lockdown on acute upper gastrointestinal (GI) bleeding in Austria. Patients and methods We contacted 98 Austrian hospitals performing emergency endoscopies. The hospitals were asked to report upper GI endoscopies performed because of recent hematemesis, melena, or both and exhibiting endoscopically visible signs of bleeding. Investigated time points included three weeks before and after lockdown. Results 61% of Austrian hospitals and importantly all major state hospitals responded. 575 upper GI bleedings occurred in the three weeks before and 341 after lockdown (40.7% reduction). When comparing the first and last calendar week of investigation we observed an almost 55% decline in nonvariceal bleeding events (calendar week 9 versus 14: 196 versus 89) whereas rates of variceal hemorrhage did not change (calendar week 9 versus 14: 17 versus 15). Conclusions National lockdown resulted in a dramatic decrease in upper gastrointestinal bleeding events.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32408356
    Database COVID19

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  8. Article: Decline in acute upper gastrointestinal bleeding during COVID-19 pandemic after initiation of lockdown in Austria

    Schmiderer, Andreas / Schwaighofer, Hubert / Niederreiter, Lukas / Profanter, Christoph / Steinle, Hartmut / Ziachehabi, Alexander / Tilg, Herbert

    Endoscopy

    2020  Volume 52, Issue 11, Page(s) 1036–1038

    Abstract: Background: COVID-19 has spread rapidly around the world. The Austrian government implemented a lockdown on 16 March to contain further spread of the disease. We investigated the effects of lockdown on acute upper gastrointestinal (GI) bleeding in ... ...

    Abstract Background: COVID-19 has spread rapidly around the world. The Austrian government implemented a lockdown on 16 March to contain further spread of the disease. We investigated the effects of lockdown on acute upper gastrointestinal (GI) bleeding in Austria.
    Methods: We contacted 98 Austrian hospitals performing emergency endoscopies. The hospitals were asked to report upper GI endoscopies performed for recent hematemesis, melena, or both, and exhibiting endoscopically visible signs of bleeding. The study period was from 3 weeks before (calendar Week 9) to 3 weeks after (Week 14) initiation of the lockdown.
    Results: 61 % of Austrian hospitals, and importantly all major state hospitals, responded. A total of 575 upper GI bleedings occurred during the 3 weeks before and 341 during the 3 weeks after initiation of lockdown (40.7 % reduction). There was a 54.6 % decline in nonvariceal bleeding events at Week 14 compared with Week 9 (89 vs. 196), whereas rates of variceal hemorrhage did not change (15 vs. 17).
    Conclusions: National lockdown resulted in a dramatic decrease in upper GI bleeding events in Austrian hospitals.
    Language English
    Publishing date 2020-05-14
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-1178-4656
    Database Thieme publisher's database

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  9. Article ; Online: Decline in acute upper gastrointestinal bleeding during COVID-19 pandemic after initiation of lockdown in Austria

    Schmiderer, Andreas / Schwaighofer, Hubert / Niederreiter, Lukas / Profanter, Christoph / Steinle, Hartmut / Ziachehabi, Alexander / Tilg, Herbert

    Endoscopy

    2020  Volume 52, Issue 11, Page(s) 1036–1038

    Abstract: Background COVID-19 has spread rapidly around the world. The Austrian government implemented a lockdown on 16 March to contain further spread of the disease. We investigated the effects of lockdown on acute upper gastrointestinal (GI) bleeding in Austria. ...

    Abstract Background COVID-19 has spread rapidly around the world. The Austrian government implemented a lockdown on 16 March to contain further spread of the disease. We investigated the effects of lockdown on acute upper gastrointestinal (GI) bleeding in Austria. Methods We contacted 98 Austrian hospitals performing emergency endoscopies. The hospitals were asked to report upper GI endoscopies performed for recent hematemesis, melena, or both, and exhibiting endoscopically visible signs of bleeding. The study period was from 3 weeks before (calendar Week 9) to 3 weeks after (Week 14) initiation of the lockdown. Results 61 % of Austrian hospitals, and importantly all major state hospitals, responded. A total of 575 upper GI bleedings occurred during the 3 weeks before and 341 during the 3 weeks after initiation of lockdown (40.7 % reduction). There was a 54.6 % decline in nonvariceal bleeding events at Week 14 compared with Week 9 (89 vs. 196), whereas rates of variceal hemorrhage did not change (15 vs. 17). Conclusions National lockdown resulted in a dramatic decrease in upper GI bleeding events in Austrian hospitals.
    Keywords Gastroenterology ; covid19
    Language English
    Publisher Georg Thieme Verlag KG
    Publishing country de
    Document type Article ; Online
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-1178-4656
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Faecal Biomarkers in Inflammatory Bowel Diseases: Calprotectin Versus Lipocalin-2-a Comparative Study.

    Zollner, Andreas / Schmiderer, Andreas / Reider, Simon J / Oberhuber, Georg / Pfister, Alexandra / Texler, Bernhard / Watschinger, Christina / Koch, Robert / Effenberger, Maria / Raine, Tim / Tilg, Herbert / Moschen, Alexander R

    Journal of Crohn's & colitis

    2020  Volume 15, Issue 1, Page(s) 43–54

    Abstract: Background and aims: Faecal biomarkers, particularly calprotectin [FCAL], have become important diagnostic and monitoring tools in inflammatory bowel diseases [IBD]. As FCAL is mainly produced by neutrophils, we hypothesised that faecal lipocalin-2 [ ... ...

    Abstract Background and aims: Faecal biomarkers, particularly calprotectin [FCAL], have become important diagnostic and monitoring tools in inflammatory bowel diseases [IBD]. As FCAL is mainly produced by neutrophils, we hypothesised that faecal lipocalin-2 [FLCN2], also expressed by intestinal epithelial cells [IEC], could be beneficial in specific clinical situations.
    Methods: We compared clinical and endoscopic activity-related correlations between FCAL and FLCN2, assayed from the same sample, in a cohort of 132 patients (72 Crohn's disease [CD]) and 40 controls. A detailed analysis of cellular origins was done by confocal microscopy and flow cytometry. To evaluate the potential to detect low-grade inflammation, we studied faecal and tissue concentrations in a cohort with clinical, endoscopic, and histological remission.
    Results: There was an excellent correlation between FCAL and FLCN2 [rS = 0.87, p <0.001] and comparable sensitivity and specificity to predict clinical and endoscopic disease activity, with optimal thresholds for endoscopic activity of 73.4 and 1.98 µg/g in ulcerative colitis [UC] and 78.4 and 0.56 µg/g in Crohn's disease for FCAL and FLCN2, respectively. Strong co-expression of both proteins was observed in granulocytes and macrophages. IECs expressed LCN2 but not CAL. In our IBD cohort in deep remission neither FCAL nor FLCN2 was different from controls; yet mucosal LCN2 but not CAL expressions remained elevated in the rectum of UC and the ileum of CD patients.
    Conclusions: This study corroborates the diagnostic equivalence of FLCN2 and FCAL in IBD. In remission, persistent mucosal overexpression renders LCN2 an attractive candidate for molecular inflammation warranting further investigation.
    MeSH term(s) Biomarkers/analysis ; Colitis, Ulcerative/immunology ; Colitis, Ulcerative/pathology ; Colitis, Ulcerative/therapy ; Colonoscopy/methods ; Crohn Disease/immunology ; Crohn Disease/pathology ; Crohn Disease/therapy ; Feces/chemistry ; Female ; Gene Expression Profiling/methods ; Humans ; Ileum/immunology ; Ileum/pathology ; Inflammation/metabolism ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Leukocyte L1 Antigen Complex/analysis ; Lipocalin-2/analysis ; Male ; Rectum/immunology ; Rectum/pathology ; Remission Induction ; Sensitivity and Specificity ; Severity of Illness Index
    Chemical Substances Biomarkers ; Leukocyte L1 Antigen Complex ; Lipocalin-2
    Language English
    Publishing date 2020-06-19
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 2390120-2
    ISSN 1876-4479 ; 1873-9946
    ISSN (online) 1876-4479
    ISSN 1873-9946
    DOI 10.1093/ecco-jcc/jjaa124
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