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  1. Article ; Online: Association Between Trimethylamine N-oxide and Adverse Kidney Outcomes and Overall Mortality in Type 2 Diabetes Mellitus.

    Yu, Ping-Shaou / Wu, Ping-Hsun / Hung, Wei-Wen / Lin, Ming-Yen / Zhen, Yen-Yi / Hung, Wei-Chun / Chang, Jer-Ming / Tsai, Jong-Rung / Chiu, Yi-Wen / Hwang, Shang-Jyh / Tsai, Yi-Chun

    The Journal of clinical endocrinology and metabolism

    2024  

    Abstract: Context: Type 2 diabetes (T2D) is the major contributor to chronic kidney disease and end-stage kidney disease (ESKD). The influence of trimethylamine N-oxide (TMAO) on kidney outcomes in T2D remains unclear.: Objective: To examine the association ... ...

    Abstract Context: Type 2 diabetes (T2D) is the major contributor to chronic kidney disease and end-stage kidney disease (ESKD). The influence of trimethylamine N-oxide (TMAO) on kidney outcomes in T2D remains unclear.
    Objective: To examine the association between fasting serum TMAO levels and adverse kidney outcomes in patients with T2D.
    Methods: Between October 2016 and June 2020, patients with T2D were recruited and monitored every 3 months until December 2021. Serum TMAO levels were assessed using liquid chromatography-mass spectrometry. The primary kidney outcomes were doubling of serum creatinine levels or progression to ESKD necessitating dialysis; the secondary kidney outcome was a rapid 30% decline in estimated glomerular filtration rate within 2 years. All-cause mortality was also evaluated.
    Results: Among the 440 enrolled patients with T2D, those in the highest serum TMAO tertile (≥0.88 μM) were older, had a longer diabetes duration, elevated blood urea nitrogen, and lower estimated glomerular filtration rate. Over a median follow-up period of 4 years, 26 patients (5.9%) had a doubling of serum creatinine level or progression to ESKD. After propensity score weighting, the patients in the highest serum TMAO tertile had a 6.45-fold increase in the risk of doubling of serum creatinine levels or progression to ESKD and 5.86-fold elevated risk of rapid decline in kidney function compared with those in the lowest tertile. Additionally, the stepwise increase in serum TMAO was associated with all-cause mortality.
    Conclusion: Patients with T2D with elevated circulating TMAO levels are at higher risk of doubling serum creatinine, progressing to ESKD, and mortality. TMAO is a potential biomarker for kidney function progression and mortality in patients with T2D.
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgae009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Decline in invasive pneumococcus diseases while combating the COVID-19 pandemic in Taiwan.

    Tsai, Jong-Rung / Yang, Chih-Jen / Huang, Wei-Ling / Chen, Yen-Hsu

    The Kaohsiung journal of medical sciences

    2020  Volume 36, Issue 7, Page(s) 572–573

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Disinfection ; Hand Disinfection ; Humans ; Masks ; Pandemics/prevention & control ; Patient Isolation ; Personal Protective Equipment ; Pneumococcal Infections/epidemiology ; Pneumococcal Infections/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; SARS-CoV-2 ; Taiwan/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-05-26
    Publishing country China (Republic : 1949- )
    Document type Letter
    ZDB-ID 639302-0
    ISSN 2410-8650 ; 0257-5655
    ISSN (online) 2410-8650
    ISSN 0257-5655
    DOI 10.1002/kjm2.12233
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Decline in invasive pneumococcus diseases while combating the COVID‐19 pandemic in Taiwan

    Jong‐Rung Tsai / Chih‐Jen Yang / Wei‐Ling Huang / Yen‐Hsu Chen

    Kaohsiung Journal of Medical Sciences, Vol 36, Iss 7, Pp 572-

    2020  Volume 573

    Keywords Medicine (General) ; R5-920 ; covid19
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Toward Evaluating Critical Factors of Extubation Outcome with XCSR-Generated Rules.

    Huang, Po-Hsun / Chen, Lian-Yu / Chung, Wei-Chan / Sheu, Chau-Chyun / Hsiao, Tzu-Chien / Tsai, Jong-Rung

    Bioengineering (Basel, Switzerland)

    2022  Volume 9, Issue 11

    Abstract: Predicting the correct timing for extubation is pivotal for critically ill patients with mechanical ventilation support. Evidence suggests that extubation failure occurs in approximately 15-20% of patients, despite their passing of the extubation ... ...

    Abstract Predicting the correct timing for extubation is pivotal for critically ill patients with mechanical ventilation support. Evidence suggests that extubation failure occurs in approximately 15-20% of patients, despite their passing of the extubation evaluation, necessitating reintubation. For critically ill patients, reintubation invariably increases mortality risk and medical costs. The numerous parameters that have been proposed for extubation decision-making, which constitute the key predictors of successful extubation, remains unclear. In this study, an extended classifier system capable of processing real-value inputs was proposed to select features of successful extubation. In total, 40 features linked to clinical information and variables acquired during spontaneous breathing trial (SBT) were used as the environmental inputs. According to the number of "don't care" rules in a population set, Prob
    Language English
    Publishing date 2022-11-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering9110701
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Is the asynchronous phase of thoracoabdominal movement a novel feature of successful extubation? A preliminary result.

    Huang, Po-Hsun / Chung, Wei-Chan / Sheu, Chau-Chyun / Tsai, Jong-Rung / Hsiao, Tzu-Chien

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

    2021  Volume 2021, Page(s) 752–756

    Abstract: Mechanical ventilation is necessary to maintain patients' life in intensive care units. However, too early or too late extubation may injure the muscles or lead to respiratory failure. Therefore, the spontaneous breathing trial (SBT) is applied for ... ...

    Abstract Mechanical ventilation is necessary to maintain patients' life in intensive care units. However, too early or too late extubation may injure the muscles or lead to respiratory failure. Therefore, the spontaneous breathing trial (SBT) is applied for testing whether the patients can spontaneously breathe or not. However, previous evidence still reported 15%~20% of the rate of extubation fail. The monitor only considers the ventilation variables during SBT. Therefore, this study measures the asynchronization between thoracic and abdomen wall movement (TWM and AWM) by using instantaneous phase difference method (IPD) during SBT for 120 minutes. The respiratory inductive plethysmography were used for TWM and AWM measurement. The preliminary result recruited 31 signals for further analysis. The result showed that in successful extubation group can be classified into two groups, IPD increase group, and IPD decrease group; but in extubation fail group, the IPD value only increase. Therefore, the IPD decrease group can almost perfectly be discriminated with extubation fail group, especially after 70 minutes (Area under curve of operating characteristic curve was 1). These results showed IPD is an important key factor to find whether the patient is suitable for extubation or not. These finding suggest that the asynchronization between TWM and AWM should be considered as a predictor of extubation outcome. In future work, we plan to recruit 150 subjects to validate the result of this preliminary result. In addition, advanced machine learning method is considered to apply for building effective models to discriminate the IPD increase group and extubation fail group.Clinical Relevance- The finding of this study is that the patients whose average IPD of 95 to 100 minutes was smaller than average IPD of first 5 minutes of SBT could be 100% successful extubation. In addition, ability of discrimination of average IPD after 70 minutes presents AUC 1.
    MeSH term(s) Airway Extubation ; Humans ; Prospective Studies ; Respiration, Artificial ; Respiratory Insufficiency ; Ventilator Weaning
    Language English
    Publishing date 2021-12-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2694-0604
    ISSN (online) 2694-0604
    DOI 10.1109/EMBC46164.2021.9629920
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Establishing Quality of Life in Southern Taiwan COPD Patients Using Long-Acting Bronchodilator.

    Chin, Pik-Qi / Sheu, Chau-Chyun / Tsai, Jong-Rung / Chang, Hsu-Liang / Lee, Li-Yao / Chen, Chung-Yu

    Patient preference and adherence

    2022  Volume 16, Page(s) 875–886

    Abstract: Background: To assess the health-related quality of life (HRQoL) of Taiwan patients with different stages of chronic obstructive pulmonary disease (COPD) and using different combination therapies and to explore the factors affecting HRQoL in these ... ...

    Abstract Background: To assess the health-related quality of life (HRQoL) of Taiwan patients with different stages of chronic obstructive pulmonary disease (COPD) and using different combination therapies and to explore the factors affecting HRQoL in these patients.
    Methods: This cross-sectional study included outpatient participants aged 35 years old and older who were receiving long-acting bronchodilator treatment in one of two hospitals in Southern Taiwan. Participants were categorized according to their Global Initiative for Obstructive Lung Disease (GOLD) classification as either their COPD group, based on symptoms and exacerbation risk, or their COPD stage, based on spirometry results. Patients' HRQoL was assessed using the St. George's Respiratory Questionnaire score (SGRQ), World Health Organization Quality of Life Quality of Life-BREF (WHOQOL-BREF), and EQ-5D-5L. The total scores of the SGRQ, WHOQOL-BREF, EQ-5D utility index, and EQ-VAS were presented as mean ± standard deviation (SD) among different combination treatments. Univariate and multivariate analyses were used to explore the association of patients' baseline characteristics and environmental factors with HRQoL.
    Results: A total of 218 patients were enrolled in the study. The distribution of patients using GOLD group classification were as follows: 73.39% in group A, 20.19% group B, 1.83% group C and 4.59% group D. Triple therapy patients mostly showed a lower quality of life than other combination therapies, regardless of the GOLD classification system. However, only the SGRQ scores of GOLD groups A and B were significantly different when using different drug combinations (p-value = 0.0072 and 0.0430, respectively). The COPD assessment test (CAT) score, a questionnaire to assess impact of COPD on health status, was found to be associated with all the questionnaires.
    Conclusion: The HRQoL is impaired in patients with COPD, and it deteriorates with an increase of severity. The CAT was the strongest predictor of HRQoL.
    Language English
    Publishing date 2022-04-05
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2455848-5
    ISSN 1177-889X
    ISSN 1177-889X
    DOI 10.2147/PPA.S355023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Decline in invasive pneumococcus diseases while combating the COVID ‐19 pandemic in Taiwan

    Tsai, Jong‐Rung / Yang, Chih‐Jen / Huang, Wei‐Ling / Chen, Yen‐Hsu

    The Kaohsiung Journal of Medical Sciences

    2020  Volume 36, Issue 7, Page(s) 572–573

    Keywords General Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2248033-X
    ISSN 1607-551X ; 0257-5655
    ISSN 1607-551X ; 0257-5655
    DOI 10.1002/kjm2.12233
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Corrigendum to "Novel mechanical ventilator weaning predictive model"[Kaohsiung J Med Sci. 2020;36(10):841-849].

    Chung, Wei-Chan / Sheu, Chau-Chyun / Hung, Jen-Yu / Hsu, Tuan-Jung / Yang, Ssu-Han / Tsai, Jong-Rung

    The Kaohsiung journal of medical sciences

    2020  Volume 36, Issue 11

    Language English
    Publishing date 2020-11-10
    Publishing country China (Republic : 1949- )
    Document type Published Erratum
    ZDB-ID 639302-0
    ISSN 2410-8650 ; 0257-5655
    ISSN (online) 2410-8650
    ISSN 0257-5655
    DOI 10.1002/kjm2.12321
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Corrigendum to “Novel mechanical ventilator weaning predictive model”[Kaohsiung J Med Sci. 2020;36(10):841‐849]

    Wei‐Chan Chung / Chau‐Chyun Sheu / Jen‐Yu Hung / Tuan‐Jung Hsu / Ssu‐Han Yang / Jong‐Rung Tsai

    Kaohsiung Journal of Medical Sciences, Vol 36, Iss 11, Pp n/a-n/a (2020)

    2020  

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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