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  1. Article ; Online: ABO discrepancy due to the para-Bombay phenotype

    Ying Lin / Rongcang Chen / Xingzhong Hu

    Journal of Men's Health, Vol 19, Iss 11, Pp 116-

    a case report

    2023  Volume 119

    Abstract: In this study, we aimed to determine and analyze the genetic differences of the FUT1 and FUT2 genes within an individual exhibiting the Para-Bombay phenotype. Standard serological tests were conducted to analyze the ABO phenotype. The amplification of ... ...

    Abstract In this study, we aimed to determine and analyze the genetic differences of the FUT1 and FUT2 genes within an individual exhibiting the Para-Bombay phenotype. Standard serological tests were conducted to analyze the ABO phenotype. The amplification of FUT1 and FUT2 genes was conducted by polymerase chain reaction and amplicons were sequenced. The determination of the ABO genotype was conducted by sequencing exons 1 to 7 of the ABO gene. The Lewis phenotype was defined as Le(a−b+); Despite this, red blood cells (RBCs) did not show signs of A, B and H antigens using the serological method utilized in this study. However, Analyses of sequencing and cloning demonstrated the existence of a FUT1 mutation at position c.658C>T and an inactive allele FUT1*01N.06 (c.551_552delAG). Genetic testing for ABO blood types was subsequently determined to be ABO*B.01/ABO*B.01 (c.297A>G; c.526C>G; c.657C>T; c.703G>A; c.796C>A; c.803G>C; c.930G>A). Heterozygosity for indel and missense mutation within the coding region of FUT1 are likely to be responsible for development of the Para-Bombay phenotype.
    Keywords abo discrepancy ; para-bombay ; fut1 ; fut2 ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher MRE Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Increased levels of circulating oxidized mitochondrial DNA contribute to chronic inflammation in metabolic syndrome, and MitoQ-based antioxidant therapy alleviates this DNA-induced inflammation.

    Ye, Wei / Wen, Chaowei / Zeng, Aibing / Hu, Xingzhong

    Molecular and cellular endocrinology

    2022  Volume 560, Page(s) 111812

    Abstract: Here, the aim was to investigate the role of circulating oxidized mitochondrial DNA (ox-mtDNA) in metabolic syndrome (MetS)-associated chronic inflammation and evaluate the effect of Mito-Quinone (MitoQ)-based antioxidant therapy on inflammation. A total ...

    Abstract Here, the aim was to investigate the role of circulating oxidized mitochondrial DNA (ox-mtDNA) in metabolic syndrome (MetS)-associated chronic inflammation and evaluate the effect of Mito-Quinone (MitoQ)-based antioxidant therapy on inflammation. A total of 112 MetS patients and 111 healthy control individuals (HCs) were recruited. Peripheral blood was collected, and mononuclear cells (PBMCs) were separated. In a preclinical study, MitoQ, a mitochondrial-targeted antioxidant, was administered to Sprague-Dawley (SD) rats fed a high-fat diet (HFD). In vitro, H
    MeSH term(s) Rats ; Animals ; DNA, Mitochondrial/genetics ; DNA, Mitochondrial/metabolism ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Metabolic Syndrome/drug therapy ; Metabolic Syndrome/metabolism ; NF-kappa B/metabolism ; Toll-Like Receptor 9/metabolism ; Cell-Free Nucleic Acids ; Hydrogen Peroxide ; Rats, Sprague-Dawley ; Inflammation/drug therapy ; Inflammation/metabolism ; Ubiquinone/pharmacology ; Ubiquinone/therapeutic use
    Chemical Substances DNA, Mitochondrial ; Antioxidants ; mitoquinone (47BYS17IY0) ; NF-kappa B ; Toll-Like Receptor 9 ; Cell-Free Nucleic Acids ; Hydrogen Peroxide (BBX060AN9V) ; Ubiquinone (1339-63-5) ; quinone (3T006GV98U)
    Language English
    Publishing date 2022-11-02
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 187438-x
    ISSN 1872-8057 ; 0303-7207
    ISSN (online) 1872-8057
    ISSN 0303-7207
    DOI 10.1016/j.mce.2022.111812
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1127: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Androgen receptor contributes to microglial/macrophage activation in rats with intracranial hemorrhage by mediating the JMJD3/Botch/Notch1 axis.

    Chen, Maohua / Chen, Xiaoxiang / Hu, Xingzhong / Dai, Junxia / Sun, Jun

    Neuroscience letters

    2021  Volume 765, Page(s) 136283

    Abstract: Intracerebral hemorrhage (ICH) is a leading medical problem and has no effective treatment approach up until now. The transcription factor androgen receptor (AR) has been indicated in the cerebrovascular function recently. However, its participation in ... ...

    Abstract Intracerebral hemorrhage (ICH) is a leading medical problem and has no effective treatment approach up until now. The transcription factor androgen receptor (AR) has been indicated in the cerebrovascular function recently. However, its participation in ICH remains unclear. The present study aims to expound the regulation of AR in microglia/macrophage phenotypes and the secondary brain injury in a rat model with ICH, and to discuss the involved pathway. Following the induction of ICH in rats, we found that ICH led to increased mNSS score, enhanced microglial activity, and promoted levels of inflammatory factors and apoptosis of brain cells. Using microarray analysis, AR was found to be significantly overexpressed in ICH rat brain tissues. AR repressed the transcription of Jumonji d3 (JMJD3, histone 3 demethylase). JMJD3 inhibited the methylation of Botch and promoted the activity of Notch1. JMJD3 hampered microglial activity and ameliorated secondary brain injury in rats, whereas upregulation of AR or downregulation of Botch reversed the protective effects of JMJD3. In conclusion, we found that AR promoted microglial activation and secondary brain injury via transcriptionally repressing JMJD3 and mediating the subsequent Botch/Notch1 pathway, which may provide novel insights into therapeutic options for the treatment of ICH.
    MeSH term(s) Animals ; Intracranial Hemorrhages/metabolism ; Jumonji Domain-Containing Histone Demethylases/metabolism ; Macrophage Activation/physiology ; Macrophages/metabolism ; Male ; Microglia/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptor, Notch1/metabolism ; Receptors, Androgen/metabolism ; Signal Transduction/physiology ; gamma-Glutamylcyclotransferase/metabolism
    Chemical Substances Notch1 protein, rat ; Receptor, Notch1 ; Receptors, Androgen ; Jumonji Domain-Containing Histone Demethylases (EC 1.14.11.-) ; Kdm6b protein, rat (EC 1.14.11.-) ; gamma-Glutamylcyclotransferase (EC 4.3.2.9)
    Language English
    Publishing date 2021-10-12
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 194929-9
    ISSN 1872-7972 ; 0304-3940
    ISSN (online) 1872-7972
    ISSN 0304-3940
    DOI 10.1016/j.neulet.2021.136283
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1166: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Enhanced photocatalytic destruction of pollutants by surface W vacancies in V

    Wang, Zhiqiang / Zhang, Lili / Zhang, Xiao / Hu, Chun / Wang, Liang / Shi, Baoyou / Cao, Xingzhong

    Journal of colloid and interface science

    2020  Volume 576, Page(s) 385–393

    Abstract: W vacancies containing ... ...

    Abstract W vacancies containing Bi
    Language English
    Publishing date 2020-05-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2020.05.047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 71/707: Show issues

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  5. Article ; Online: Bi-Deficiency Leading to High-Performance in Mg

    Li, Jing-Wei / Liu, Weishu / Xu, Wei / Zhuang, Hua-Lu / Han, Zhijia / Jiang, Feng / Zhang, Peng / Hu, Haihua / Gao, Hanbin / Jiang, Yilin / Cai, Bowen / Pei, Jun / Su, Bin / Li, Qian / Hayashi, Kei / Li, Hezhang / Miyazaki, Yuzuru / Cao, Xingzhong / Zheng, Qiang /
    Li, Jing-Feng

    Advanced materials (Deerfield Beach, Fla.)

    2023  Volume 35, Issue 23, Page(s) e2209119

    Abstract: ... ...

    Abstract Mg
    Language English
    Publishing date 2023-04-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1474949-X
    ISSN 1521-4095 ; 0935-9648
    ISSN (online) 1521-4095
    ISSN 0935-9648
    DOI 10.1002/adma.202209119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Systematic and meta-based evaluation of the relationship between the built environment and physical activity behaviors among older adults.

    You, Yanwei / Chen, Yuquan / Zhang, Qi / Hu, Xiaojie / Li, Xingzhong / Yang, Ping / Zuo, Qun / Cao, Qiang

    PeerJ

    2023  Volume 11, Page(s) e16173

    Abstract: Objectives: Existing assertions about the relationship between various factors of the built environment and physical activity behaviors are inconsistent and warrant further exploration and analysis.: Methods: This study systematically searched PubMed, ...

    Abstract Objectives: Existing assertions about the relationship between various factors of the built environment and physical activity behaviors are inconsistent and warrant further exploration and analysis.
    Methods: This study systematically searched PubMed, Embase, Web of Science, Scopus, the Cochrane Library and Google Scholar for the effect of the built environment on the physical activity behaviors of older adults. R software was used to calculate the meta-estimated odds ratio with a 95% confidence interval. Simultaneously, the quality of included studies was evaluated using an observational study quality evaluation standard recommended by American health care quality and research institutions.
    Results: A total of 16 original researches were included in this meta-analysis and eight factors of the built environment were evaluated. These factors which ranked from high to low according to their impact were traffic safety (OR = 1.58, 95% CI [1.14-2.20]), destination accessibility (OR = 1.24, 95% CI [1.06-1.44]), aesthetics of sports venues (OR = 1.21, 95% CI [1.07-1.37]), virescence of sports venues (OR = 1.14, 95% CI [1.06-1.23]), building density (OR = 1.07, 95% CI [1.02-1.13]). Additionally, it seemed that there was no potential association between mixed land use (OR = 1.01, 95% CI [0.92-1.10]), the quality of pedestrian facilities (OR = 1.00, 95% CI [0.92-1.08]) or commercial facilities (OR = 0.94, 95% CI [0.88-1.00]) and physical activity behaviors of older adults.
    Conclusions: The built environment has been found to exhibit a significant relationship with the physical activity behaviors of older adults. It is proposed that factors such as traffic safety, destination accessibility, aesthetics of sports venues, virescence of sports venues, and building density be given more consideration when aiming to promote physical activity levels among older adults.
    MeSH term(s) Walking ; Motor Activity ; Built Environment ; Sports ; Observational Studies as Topic
    Language English
    Publishing date 2023-09-25
    Publishing country United States
    Document type Systematic Review ; Meta-Analysis ; Journal Article
    ZDB-ID 2703241-3
    ISSN 2167-8359 ; 2167-8359
    ISSN (online) 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.16173
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  7. Article ; Online: Study on frost resistance and abrasion resistance of fiber mesh reinforced concrete

    Hu Cheng / Weng Xingzhong / Yan Xiangcheng / Liu Pengcheng / Guo Tianxiong

    E3S Web of Conferences, Vol 206, p

    2020  Volume 02020

    Abstract: The frost resistance and abrasion resistance of the fiber mesh reinforced concrete under the simulated treatment of external environment were studied through the frost resistance test and abrasion test. The relative dynamic modulus, the amount of ... ...

    Abstract The frost resistance and abrasion resistance of the fiber mesh reinforced concrete under the simulated treatment of external environment were studied through the frost resistance test and abrasion test. The relative dynamic modulus, the amount of spalling per unit area, the amount of abrasion per unit area and abrasion depth were used as evaluation indexes. The result shows that the frost resistance and abrasion resistance of concrete can be enhanced by fiber mesh. For the frost resistance, enhancement effect of carbon fiber mesh is better than that of basalt fiber mesh, and better than that of aramid fiber mesh. For the abrasion resistance, enhancement effect of aramid fiber mesh is better than that of basalt fiber mesh, and better than that of carbon fiber mesh. On the whole, the frost resistance and abrasion resistance of basalt fiber mesh reinforced concrete are better. Therefore, basalt fiber mesh is recommended to strengthen the frost resistance and abrasion resistance of concrete in engineering practice.
    Keywords Environmental sciences ; GE1-350
    Subject code 621
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Magnetic Fe₃O₄@SiO₂@Ag@COOH NPs/Au Film with Hybrid Localized Surface Plasmon/Surface Plasmon Polariton Modes for Surface-Enhanced Raman Scattering Detection of Thiabendazole.

    Hu, Xiangna / Bian, XingZhong / Yu, Shaozhou / Dan, Kun

    Journal of nanoscience and nanotechnology

    2019  Volume 20, Issue 4, Page(s) 2079–2086

    Abstract: A magnetic Fe₃O₄@SiO₂@Ag@COOH nanoparticle (NPs)/Au film was fabricated as an effective surface-enhanced Raman scattering (SERS) substrate through a combination of a solvothermal reaction, the Stöber method and ... ...

    Abstract A magnetic Fe₃O₄@SiO₂@Ag@COOH nanoparticle (NPs)/Au film was fabricated as an effective surface-enhanced Raman scattering (SERS) substrate through a combination of a solvothermal reaction, the Stöber method and an
    Language English
    Publishing date 2019-08-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1533-4899
    ISSN (online) 1533-4899
    DOI 10.1166/jnn.2020.17323
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Low Serum Cholesterol Level Among Patients with COVID-19 Infection in Wenzhou, China

    Hu, Xingzhong / Chen, Dong / Wu, Lianpeng / He, Guiqing / Ye, Wei

    SSRN Electronic Journal ; ISSN 1556-5068

    2020  

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.2139/ssrn.3544826
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: An interpretation to Cr(Ⅵ) leaching concentration rebound phenomenon with time in ferrous-reduced Cr(Ⅵ)-bearing solid matrices.

    Li, Dong / Gui, Chenxin / Ji, Guozhu / Hu, Siyang / Yuan, Xingzhong

    Journal of hazardous materials

    2019  Volume 378, Page(s) 120734

    Abstract: Toxicity characteristic leaching procedure (TCLP) is a prevalent way to evaluate the treatment effectiveness for Cr(Ⅵ)-bearing solid matrices (CBSM). But when a certain amount of residual reductants are present in the treated CBSM, Cr(Ⅵ) leaching ... ...

    Abstract Toxicity characteristic leaching procedure (TCLP) is a prevalent way to evaluate the treatment effectiveness for Cr(Ⅵ)-bearing solid matrices (CBSM). But when a certain amount of residual reductants are present in the treated CBSM, Cr(Ⅵ) leaching concentration rebound phenomenon (CLCRP) occurs, which invalidates the TCLP. This study explores the microstructure of ferrous-reduced CBSM and proves that the residual Cr(Ⅵ), Fe
    Language English
    Publishing date 2019-06-06
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2019.06.011
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