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  1. Article ; Online: From Waveforms to Wisdom: Gleaning More From the ECG About Biological Aging.

    Ebinger, Joseph E / Cheng, Susan

    Circulation. Cardiovascular quality and outcomes

    2023  Volume 16, Issue 7, Page(s) e010176

    MeSH term(s) Humans ; Aging ; Electrocardiography
    Language English
    Publishing date 2023-06-29
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2483197-9
    ISSN 1941-7705 ; 1941-7713
    ISSN (online) 1941-7705
    ISSN 1941-7713
    DOI 10.1161/CIRCOUTCOMES.123.010176
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Racial and Ethnic Disparities in Co-Occurrence of Nocturnal Hypertension and Nocturnal Blood Pressure Decreases.

    Zhang, Neil / Huang, Tzu Yu / Cheng, Susan / Ebinger, Joseph E

    JAMA network open

    2024  Volume 7, Issue 1, Page(s) e2352227

    MeSH term(s) Humans ; Blood Pressure ; Hypertension/epidemiology ; Vital Signs
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.52227
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Non-Dipping Blood Pressure or Nocturnal Hypertension: Does One Matter More?

    Tang, Amber / Yang, Eugene / Ebinger, Joseph E

    Current hypertension reports

    2023  Volume 26, Issue 1, Page(s) 21–30

    Abstract: Purpose of review: Nocturnal hypertension and non-dipping are both associated with increased cardiovascular risk; however, debate remains over which is a better prognosticator of cardiovascular outcomes. This review explores current literature on ... ...

    Abstract Purpose of review: Nocturnal hypertension and non-dipping are both associated with increased cardiovascular risk; however, debate remains over which is a better prognosticator of cardiovascular outcomes. This review explores current literature on nocturnal hypertension and non-dipping to assess their relationship to cardiovascular disease and implications for clinical practice.
    Recent findings: While current data remain inconclusive, some suggest that nocturnal hypertension is a more reliable and clinically significant marker of cardiovascular risk than non-dipping status. Importantly, reducing nocturnal HTN and non-dipping through chronotherapy, specifically evening dosing of antihypertensives, has not been conclusively shown to provide long-term cardiovascular benefits. Recent data suggests that non-dipping, compared to nocturnal hypertension, may be falling out of favor as a prognostic indicator for adverse cardiovascular outcomes. However, additional information is needed to understand how aberrant nighttime blood pressure patterns modulate cardiovascular risk to guide clinical management.
    MeSH term(s) Humans ; Hypertension ; Blood Pressure/physiology ; Circadian Rhythm ; Blood Pressure Monitoring, Ambulatory ; Antihypertensive Agents/pharmacology
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2023-11-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057367-4
    ISSN 1534-3111 ; 1522-6417
    ISSN (online) 1534-3111
    ISSN 1522-6417
    DOI 10.1007/s11906-023-01273-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Review of Immunologic Manifestations of COVID-19 Infection and Vaccination.

    Pozdnyakova, Valeriya / Weber, Brittany / Cheng, Susan / Ebinger, Joseph E

    Heart failure clinics

    2023  Volume 19, Issue 2, Page(s) 177–184

    Abstract: We herein summarize currently available and clinically relevant information regarding the human immune responses to SARS-CoV-2 infection and vaccination, in relation to COVID-19 outcomes with a focus on acute respiratory distress syndrome (ARDS) and ... ...

    Abstract We herein summarize currently available and clinically relevant information regarding the human immune responses to SARS-CoV-2 infection and vaccination, in relation to COVID-19 outcomes with a focus on acute respiratory distress syndrome (ARDS) and myocarditis.
    MeSH term(s) Humans ; COVID-19/prevention & control ; SARS-CoV-2 ; Vaccination
    Language English
    Publishing date 2023-03-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2212019-1
    ISSN 1551-7136
    ISSN 1551-7136
    DOI 10.1016/j.hfc.2022.08.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Declining Admissions for Acute Cardiovascular Illness: The COVID-19 Paradox.

    Ebinger, Joseph E / Shah, Prediman K

    Journal of the American College of Cardiology

    2020  Volume 76, Issue 3, Page(s) 289–291

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Hospitalization ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-26
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2020.05.039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Association of COVID-19 Vaccination With Risk for Incident Diabetes After COVID-19 Infection.

    Kwan, Alan C / Ebinger, Joseph E / Botting, Patrick / Navarrette, Jesse / Claggett, Brian / Cheng, Susan

    JAMA network open

    2023  Volume 6, Issue 2, Page(s) e2255965

    MeSH term(s) Humans ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Diabetes Mellitus/epidemiology ; Vaccination
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-02-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2022.55965
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Review of Immunologic Manifestations of COVID-19 Infection and Vaccination.

    Pozdnyakova, Valeriya / Weber, Brittany / Cheng, Susan / Ebinger, Joseph E

    Cardiology clinics

    2022  Volume 40, Issue 3, Page(s) 301–308

    Abstract: We herein summarize currently available and clinically relevant information regarding the human immune responses to SARS-CoV-2 infection and vaccination, in relation to COVID-19 outcomes with a focus on acute respiratory distress syndrome (ARDS) and ... ...

    Abstract We herein summarize currently available and clinically relevant information regarding the human immune responses to SARS-CoV-2 infection and vaccination, in relation to COVID-19 outcomes with a focus on acute respiratory distress syndrome (ARDS) and myocarditis.
    MeSH term(s) COVID-19/prevention & control ; Humans ; SARS-CoV-2 ; Vaccination
    Language English
    Publishing date 2022-03-29
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1196385-2
    ISSN 1558-2264 ; 0733-8651
    ISSN (online) 1558-2264
    ISSN 0733-8651
    DOI 10.1016/j.ccl.2022.03.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Early-Onset Hypertension and Sex-Specific Residual Risk for Cardiovascular Disease in Type 2 Diabetes.

    Ji, Hongwei / Ebinger, Joseph E / Kwan, Alan C / Reue, Karen / Sullivan, Jennifer C / Shyy, John / Cheng, Susan

    Diabetes care

    2024  

    Abstract: Objective: To investigate whether the sex disparities in type 2 diabetes-associated cardiovascular disease (CVD) risks may be related to early-onset hypertension that could benefit from intensive blood pressure (BP) control.: Research design and ... ...

    Abstract Objective: To investigate whether the sex disparities in type 2 diabetes-associated cardiovascular disease (CVD) risks may be related to early-onset hypertension that could benefit from intensive blood pressure (BP) control.
    Research design and methods: We analyzed intensive versus standard BP control in relation to incident CVD events in women and men with type 2 diabetes, based on their age of hypertension diagnosis.
    Results: Among 3,792 adults with type 2 diabetes (49% women), multivariable-adjusted CVD risk was increased per decade earlier age at hypertension diagnosis (hazard ratio 1.11 [1.03-1.21], P = 0.006). Excess risk associated with early-diagnosed hypertension was attenuated in the presence of intensive versus standard antihypertensive therapy in women (P = 0.036) but not men (P = 0.76).
    Conclusions: Women with type 2 diabetes and early-onset hypertension may represent a higher-risk subpopulation that not only contributes to the female excess in diabetes-related CVD risk but may benefit from intensive BP control.
    Language English
    Publishing date 2024-04-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 441231-x
    ISSN 1935-5548 ; 0149-5992
    ISSN (online) 1935-5548
    ISSN 0149-5992
    DOI 10.2337/dc23-2275
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Association of blood pressure variability during acute care hospitalization and incident dementia.

    Ebinger, Joseph E / Driver, Matthew P / Botting, Patrick / Wang, Minhao / Cheng, Susan / Tan, Zaldy S

    Frontiers in neurology

    2023  Volume 14, Page(s) 1085885

    Abstract: Background and objectives: Recognized as a potential risk factor for Alzheimer's disease and related dementias (ADRD), blood pressure variability (BPV) could be leveraged to facilitate identification of at-risk individuals at a population level. ... ...

    Abstract Background and objectives: Recognized as a potential risk factor for Alzheimer's disease and related dementias (ADRD), blood pressure variability (BPV) could be leveraged to facilitate identification of at-risk individuals at a population level. Granular BPV data are available during acute care hospitalization periods for potentially high-risk patients, but the incident ADRD risk association with BPV measured in this setting is unknown. Our objective was to evaluate the relation of BPV, measured during acute care hospitalization, and incidence of ADRD.
    Methods: We retrospectively studied adults, without a prior ADRD diagnosis, who were admitted to a large quaternary care medical center in Southern California between January 1, 2013 and December 31, 2019. For all patients, determined BPV, calculated as variability independent of the mean (VIM), using blood pressure readings obtained as part of routine clinical care. We used multivariable Cox proportional hazards regression to examine the association between BP VIM during hospitalization and the development of incident dementia, determined by new ICD-9/10 coding or the new prescription of dementia medication, occurring at least 2 years after the index hospitalization.
    Results: Of 81,892 adults hospitalized without a prior ADRD diagnosis, 2,442 (2.98%) went on to develop ADRD (2.6 to 5.2 years after hospitalization). In multivariable-adjusted Cox models, both systolic (HR 1.05, 95% CI 1.00-1.09) and diastolic (1.06, 1.02-1.10) VIM were associated with incident ADRD. In pre-specified stratified analyses, the VIM associations with incident ADRD were most pronounced in individuals over age 60 years and among those with renal disease or hypertension. Results were similar when repeated to include incident ADRD diagnoses made at least 1 or 3 years after index hospitalization.
    Discussion: We found that measurements of BPV from acute care hospitalizations can be used to identify individuals at risk for developing a diagnosis of ADRD within approximately 5 years. Use of the readily accessible BPV measure may allow healthcare systems to risk stratify patients during periods of intense patient-provider interaction and, in turn, facilitate engagement in ADRD screening programs.
    Language English
    Publishing date 2023-02-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2023.1085885
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Apparent treatment-resistant hypertension associated lifetime cardiovascular risk in a longitudinal national registry.

    Ebinger, Joseph E / Kauko, Anni / Bello, Natalie A / Cheng, Susan / Niiranen, Teemu

    European journal of preventive cardiology

    2023  Volume 30, Issue 10, Page(s) 960–968

    Abstract: Aims: Apparent treatment-resistant hypertension (aRH), wherein blood pressure elevation requires treatment with multiple medications, is associated with adverse cardiovascular events over the short-term. We sought to evaluate the degree of excess risk ... ...

    Abstract Aims: Apparent treatment-resistant hypertension (aRH), wherein blood pressure elevation requires treatment with multiple medications, is associated with adverse cardiovascular events over the short-term. We sought to evaluate the degree of excess risk associated with aRH across the lifespan.
    Methods and results: We identified all individuals with hypertension who were prescribed at least one anti-hypertensive medication from the FinnGen Study, a cohort of randomly selected individuals across Finland. We then identified the maximum number of concurrently prescribed anti-hypertensive medication classes prior to age 55 and classified those co-prescribed ≥4 anti-hypertensive medication classes as aRH. Using multivariable adjusted Cox proportional hazards models, we assessed the association of aRH well as the number of co-prescribed anti-hypertensive classes with cardiorenal outcomes across the lifespan. Among 48 721 hypertensive individuals, 5715 (11.7%) met the aRH criteria. Compared to those prescribed only one anti-hypertensive medication class, the lifetime risk of renal failure increased with the addition of each additional medication class, beginning with the second, while the risk of heart failure and ischaemic stroke increased after addition of the third drug class. Similarly, those with aRH suffered increased risk of renal failure (hazard ratio 2.30, 95% CI 2.00-2.65), intracranial haemorrhage (1.50, 1.08-2.05), heart failure (1.40, 1.24-1.63) cardiac death (1.79, 1.45-2.21), and all-cause death (1.76, 1.52-2.04).
    Conclusion: Among individuals with hypertension, aRH that develops prior to mid-life is associated with substantially elevated cardiorenal disease risk across the lifespan.
    MeSH term(s) Humans ; Middle Aged ; Antihypertensive Agents/therapeutic use ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/chemically induced ; Brain Ischemia ; Stroke/etiology ; Risk Factors ; Hypertension/diagnosis ; Hypertension/drug therapy ; Hypertension/epidemiology ; Heart Failure/drug therapy ; Heart Disease Risk Factors ; Renal Insufficiency/chemically induced ; Renal Insufficiency/complications ; Renal Insufficiency/drug therapy ; Registries ; Blood Pressure
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2023-03-22
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2626011-6
    ISSN 2047-4881 ; 2047-4873
    ISSN (online) 2047-4881
    ISSN 2047-4873
    DOI 10.1093/eurjpc/zwad066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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