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  1. Article ; Online: Mitochondria makeover: unlocking the path to healthy longevity.

    Caicedo, Andrés / Singh, Keshav K

    Expert opinion on therapeutic targets

    2023  , Page(s) 1–4

    Language English
    Publishing date 2023-10-30
    Publishing country England
    Document type Editorial
    ZDB-ID 2055208-7
    ISSN 1744-7631 ; 1472-8222
    ISSN (online) 1744-7631
    ISSN 1472-8222
    DOI 10.1080/14728222.2023.2277240
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5244: Show issues Location:
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  2. Article ; Online: Symphyseal plating for pelvic fracture in a morbidly obese patient: operative challenges and innovation of a novel 'wire-ramp plate-sliding method'.

    Keshav, Kumar / Nishani, Manjunath / Singh, Amarendra / Singh, Abhishek

    BMJ case reports

    2023  Volume 16, Issue 7

    Abstract: ... hence, we adopted a novel 'wire-ramp plate-sliding method'. In this method, two strong sturdy K-wires inserted ... During this manoeuvre, the K-wires passing through the plate holes were used as a reduction tool ...

    Abstract We are describing a case report of a morbidly obese patient (body mass index 41) in his mid-40s with Young and Burgess Anteroposterior Compression type II injury (AO Foundation/Orthopaedic Trauma Association type B1.2) managed by symphyseal plating. Morbid obesity made working at a depth very difficult; hence, we adopted a novel 'wire-ramp plate-sliding method'. In this method, two strong sturdy K-wires inserted through the medial-most plate holes into the pubis acted as a ramp over which the plate was pushed/slid distally. During this manoeuvre, the K-wires passing through the plate holes were used as a reduction tool. The patient also had a wedge fracture of the distal femoral shaft which was managed by retrograde femoral nailing. At 1-year follow-up, the pelvic continuity is maintained and the fracture has united. The patient is able to do full weight-bearing and is back to his normal life.
    MeSH term(s) Humans ; Obesity, Morbid/complications ; Fracture Fixation, Internal ; Fractures, Compression ; Pubic Bone ; Joints ; Crush Injuries
    Language English
    Publishing date 2023-07-21
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2022-254279
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Mitochondria and cancer

    Singh, Keshav K.

    2009  

    Author's details Keshav K. Singh ... ed
    Keywords Neoplasms / metabolism ; Mitochondria / physiology ; Cell Transformation, Neoplastic ; Neuplasms / drug therapy ; Mitochondrial Diseases
    Language English
    Size XII, 289 S. : Ill., 235 mm x 155 mm
    Publisher Springer
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT016181529
    ISBN 978-0-387-84834-1 ; 9780387848358 ; 0-387-84834-7 ; 0387848355
    Database Catalogue ZB MED Medicine, Health

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    2010 A 5607 order for loan Magazin

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  4. Article ; Online: Advancing mitochondria as a therapeutic agent.

    Caicedo, Andrés / Singh, Keshav K

    Mitochondrion

    2023  Volume 69, Page(s) 33–35

    Abstract: This article intends to provide an update of the needs in the field working in the artificial mitochondrial transfer/transplant (AMT/T), and an overview of the highlights from the articles in the special issue "Advances of Mitochondria as a therapeutic ... ...

    Abstract This article intends to provide an update of the needs in the field working in the artificial mitochondrial transfer/transplant (AMT/T), and an overview of the highlights from the articles in the special issue "Advances of Mitochondria as a therapeutic agent". In the last 4 decades, scientists have developed innovative therapeutic applications based on the AMT/T, inspired by the natural transfer of mitochondria between cells to repair cellular damage or treat diseases. The clinical application of AMT has become the priority for the field involving the replacement or augmentation of healthy mitochondria in the harmed tissue, especially in the treatment of organ ischemia-reperfusion injury. However, we remark in our article that key questions remain to be answered such as which one is the best isolation protocol, tissue or cell source for isolation, and others of great importance to move the field forward.
    MeSH term(s) Humans ; Mitochondria ; Reperfusion Injury/therapy
    Language English
    Publishing date 2023-01-16
    Publishing country Netherlands
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2056923-3
    ISSN 1872-8278 ; 1567-7249
    ISSN (online) 1872-8278
    ISSN 1567-7249
    DOI 10.1016/j.mito.2023.01.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Mitochondrial Secrets of Youthfulness.

    Singh, Keshav K

    Plastic and reconstructive surgery

    2021  Volume 147, Issue 1S-2, Page(s) 33S–37S

    Abstract: Summary: The genetic basis of youthfulness is poorly understood. The aging of skin depends on both intrinsic factors and extrinsic factors. Intrinsic factors include personal genetics, and extrinsic factors include environmental exposure to solar ... ...

    Abstract Summary: The genetic basis of youthfulness is poorly understood. The aging of skin depends on both intrinsic factors and extrinsic factors. Intrinsic factors include personal genetics, and extrinsic factors include environmental exposure to solar radiation and pollution. We recently reported the critical role of the mitochondria in skin aging phenotypes: wrinkle formation, hair graying, hair loss, and uneven skin pigmentation. This article focuses on molecular mechanisms, specifically mitochondrial mechanisms underlying skin aging. This contribution describes the development of an mitochondrial DNA depleter-repleter mouse model and its usefulness in developing strategies and identifying potential agents that can either prevent, slow, or mitigate skin aging, lentigines, and hair loss. The ongoing research efforts include the transplantation of young mitochondria to rejuvenate aging skin and hair to provide youthfulness in humans.
    MeSH term(s) Alopecia/etiology ; Alopecia/therapy ; Animals ; Antigens, Neoplasm/genetics ; Antigens, Neoplasm/metabolism ; Cosmetic Techniques ; DNA, Mitochondrial/genetics ; Fibroblasts/cytology ; Fibroblasts/metabolism ; Humans ; Lentigo/etiology ; Lentigo/therapy ; Melanins/metabolism ; Melanosomes/metabolism ; Membrane Transport Proteins/genetics ; Membrane Transport Proteins/metabolism ; Mice ; Mitochondria/genetics ; Mitochondria/transplantation ; Models, Animal ; Polymorphism, Single Nucleotide ; Rejuvenation ; Skin/cytology ; Skin/metabolism ; Skin/radiation effects ; Skin Aging/genetics ; Skin Aging/radiation effects ; Skin Pigmentation/genetics ; Skin Pigmentation/radiation effects ; Ultraviolet Rays/adverse effects
    Chemical Substances Antigens, Neoplasm ; DNA, Mitochondrial ; Melanins ; Membrane Transport Proteins ; SLC45A2 protein, human
    Language English
    Publishing date 2021-01-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208012-6
    ISSN 1529-4242 ; 0032-1052 ; 0096-8501
    ISSN (online) 1529-4242
    ISSN 0032-1052 ; 0096-8501
    DOI 10.1097/PRS.0000000000007619
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.142: Show issues Location:
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    Zs.MO 293: Show issues

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  6. Book: Oxidative stress, disease and cancer

    Singh, Keshav K.

    2006  

    Author's details ed. by Keshav K. Singh
    Keywords Oxidative Stress / physiology ; Disease / etiology ; Neoplasms / etiology
    Language English
    Size XX, 1084 S. : Ill., graph. Darst.
    Publisher Imperial College Press
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT014780064
    ISBN 1-86094-609-7 ; 978-1-86094-609-7
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2006 A 3863 order for loan Magazin

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  7. Article ; Online: Harnessing the Flexibility of Lightweight Cellulose Nanofiber Composite Aerogels for Superior Thermal Insulation and Fire Protection.

    Bhardwaj, Shakshi / Singh, Shiva / Dev, Keshav / Chhajed, Monika / Maji, Pradip K

    ACS applied materials & interfaces

    2024  Volume 16, Issue 14, Page(s) 18075–18089

    Abstract: Thermally insulating materials from renewable and readily available resources are in high demand for ecologically beneficial applications. Cellulose aerogels made from lignocellulosic waste have various advantages. However, they are fragile and breakable ...

    Abstract Thermally insulating materials from renewable and readily available resources are in high demand for ecologically beneficial applications. Cellulose aerogels made from lignocellulosic waste have various advantages. However, they are fragile and breakable when bent or compressed. In addition, cellulose aerogels are flammable and weather-sensitive. Hence, to overcome these problems, this work included the preparation of polyurethane (PU)-based cellulose nanofiber (CNF) aerogels that had flexibility, flame retardancy, and thermal insulation. Methyl trimethoxysilane (MTMS) and water-soluble ammonium polyphosphate (APP) were added to improve the cross-linking, hydrophobicity, and flame-retardant properties of aerogels. The flexibility of chemically cross-linked CNF aerogels is enhanced through the incorporation of polyurethane via the wet coagulating process. The aerogels obtained during this study have exhibited low weight (density: 35.3-91.96 kg/m
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.4c01803
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  8. Article ; Online: The mitochondrial landscape of ovarian cancer: emerging insights.

    Shukla, Pallavi / Singh, Keshav K

    Carcinogenesis

    2021  Volume 42, Issue 5, Page(s) 663–671

    Abstract: Ovarian cancer (OC) is known to be the most lethal cancer in women worldwide, and its etiology is poorly understood. Recent studies show that mitochondrial DNA (mtDNA) content as well as mtDNA and nuclear genes encoding mitochondrial proteins influence ... ...

    Abstract Ovarian cancer (OC) is known to be the most lethal cancer in women worldwide, and its etiology is poorly understood. Recent studies show that mitochondrial DNA (mtDNA) content as well as mtDNA and nuclear genes encoding mitochondrial proteins influence OC risk. This review presents an overview of role of mitochondrial genetics in influencing OC development and discusses the contribution of mitochondrial proteome in OC development, progression and therapy. A role of mitochondrial genetics in racial disparity is also highlighted. In-depth understanding of role of mitochondria in OC will help develop strategies toward prevention and treatment and improving overall survival in women with OC.
    MeSH term(s) Cell Nucleus/genetics ; DNA, Mitochondrial/genetics ; Disease Progression ; Female ; Humans ; Mitochondria/genetics ; Mitochondrial Proteins/genetics ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology ; Ovarian Neoplasms/therapy ; Proteome/genetics ; Signal Transduction/genetics
    Chemical Substances DNA, Mitochondrial ; Mitochondrial Proteins ; Proteome
    Language English
    Publishing date 2021-04-13
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 603134-1
    ISSN 1460-2180 ; 0143-3334
    ISSN (online) 1460-2180
    ISSN 0143-3334
    DOI 10.1093/carcin/bgab033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1558: Show issues Location:
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  9. Article ; Online: Mitochondria in biology and medicine - 2023.

    Disha, B / Mathew, Rohan Peter / Dalal, Ashwin B / Mahato, Ajay K / Satyamoorthy, Kapaettu / Singh, Keshav K / Thangaraj, Kumarasamy / Govindaraj, Periyasamy

    Mitochondrion

    2024  Volume 76, Page(s) 101853

    Abstract: Mitochondria are an indispensable part of the cell that plays a crucial role in regulating various signaling pathways, energy metabolism, cell differentiation, proliferation, and cell death. Since mitochondria have their own genetic material, they differ ...

    Abstract Mitochondria are an indispensable part of the cell that plays a crucial role in regulating various signaling pathways, energy metabolism, cell differentiation, proliferation, and cell death. Since mitochondria have their own genetic material, they differ from their nuclear counterparts, and dysregulation is responsible for a broad spectrum of diseases. Mitochondrial dysfunction is associated with several disorders, including neuro-muscular disorders, cancer, and premature aging, among others. The intricacy of the field is due to the cross-talk between nuclear and mitochondrial genes, which has also improved our knowledge of mitochondrial functions and their pathogenesis. Therefore, interdisciplinary research and communication are crucial for mitochondrial biology and medicine due to the challenges they pose for diagnosis and treatment. The ninth annual conference of the Society for Mitochondria Research and Medicine (SMRM)- India, titled "Mitochondria in Biology and Medicine" was organized at the Centre for DNA Fingerprinting and Diagnostics (CDFD), Hyderabad, India, on June 21-23, 2023. The latest advancements in the field of mitochondrial biology and medicine were discussed at the conference. In this article, we summarize the entire event for the benefit of researchers working in the field of mitochondrial biology and medicine.
    Language English
    Publishing date 2024-02-28
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2056923-3
    ISSN 1872-8278 ; 1567-7249
    ISSN (online) 1872-8278
    ISSN 1567-7249
    DOI 10.1016/j.mito.2024.101853
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Impaired Mitochondria Promote Aging-Associated Sebaceous Gland Dysfunction and Pathology.

    Ahmed, Noha S / Foote, Jeremy B / Singh, Keshav K

    The American journal of pathology

    2022  Volume 192, Issue 11, Page(s) 1546–1558

    Abstract: Mitochondrial dysfunction is one of the hallmarks of aging. Changes in sebaceous gland (SG) function and sebum production have been reported during aging. This study shows the direct effects of mitochondrial dysfunction on SG morphology and function. A ... ...

    Abstract Mitochondrial dysfunction is one of the hallmarks of aging. Changes in sebaceous gland (SG) function and sebum production have been reported during aging. This study shows the direct effects of mitochondrial dysfunction on SG morphology and function. A mitochondrial DNA (mtDNA) depleter mouse was used as a model for introducing mitochondrial dysfunction in the whole animal. The effects on skin SGs and modified SGs of the eyelid, lip, clitoral, and preputial glands were characterized. The mtDNA depleter mice showed gross morphologic and histopathologic changes in SGs associated with increased infiltration by mast cells, neutrophils, and polarized macrophages. Consistently, there was increased expression of proinflammatory cytokines. The inflammatory changes were associated with abnormal sebocyte accumulation of lipid, defective sebum delivery at the skin surface, and the up-regulation of key lipogenesis-regulating genes and androgen receptor. The mtDNA depleter mice expressed aging-associated senescent marker. Increased sebocyte proliferation and aberrant expression of stem cell markers were observed. These studies provide, for the first time, a causal link between mitochondrial dysfunction and abnormal sebocyte function within sebaceous and modified SGs throughout the whole body of the animal. They suggest that mtDNA depleter mouse may serve as a novel tool to develop targeted therapeutics to address SG disorders in aging humans.
    MeSH term(s) Humans ; Mice ; Animals ; Sebaceous Glands/metabolism ; Skin/metabolism ; Mitochondria ; Aging ; DNA, Mitochondrial/genetics
    Chemical Substances DNA, Mitochondrial
    Language English
    Publishing date 2022-08-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2943-9
    ISSN 1525-2191 ; 0002-9440
    ISSN (online) 1525-2191
    ISSN 0002-9440
    DOI 10.1016/j.ajpath.2022.07.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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