Article ; Online: Oxytetracycline biosynthesis.
The Journal of biological chemistry
2010 Volume 285, Issue 36, Page(s) 27509–27515
Abstract: Oxytetracycline (OTC) is a broad-spectrum antibiotic that acts by inhibiting protein synthesis in bacteria. It is an important member of the bacterial aromatic polyketide family, which is a structurally diverse class of natural products. OTC is ... ...
Abstract | Oxytetracycline (OTC) is a broad-spectrum antibiotic that acts by inhibiting protein synthesis in bacteria. It is an important member of the bacterial aromatic polyketide family, which is a structurally diverse class of natural products. OTC is synthesized by a type II polyketide synthase that generates the poly-beta-ketone backbone through successive decarboxylative condensation of malonyl-CoA extender units, followed by modifications by cyclases, oxygenases, transferases, and additional tailoring enzymes. Genetic and biochemical studies have illuminated most of the steps involved in the biosynthesis of OTC, which is detailed here as a representative case study in type II polyketide biosynthesis. |
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MeSH term(s) | Anti-Bacterial Agents/biosynthesis ; Anti-Bacterial Agents/chemistry ; Cyclization ; Drug Resistance, Bacterial/genetics ; Macrolides/metabolism ; Oxytetracycline/biosynthesis ; Oxytetracycline/chemistry ; Tetracyclines/metabolism |
Chemical Substances | Anti-Bacterial Agents ; Macrolides ; Tetracyclines ; 4-epianhydrotetracycline (680VDL31MX) ; Oxytetracycline (X20I9EN955) |
Language | English |
Publishing date | 2010-06-03 |
Publishing country | United States |
Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review |
ZDB-ID | 2997-x |
ISSN | 1083-351X ; 0021-9258 |
ISSN (online) | 1083-351X |
ISSN | 0021-9258 |
DOI | 10.1074/jbc.R110.130419 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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