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Article: Monitoring Wind-Borne Particle Matter Entering Poultry Farms via the Air-Inlet: Highly Pathogenic Avian Influenza Virus and Other Pathogens Risk.

Elbers, Armin R W / Gonzales, José L / Koene, Miriam G J / Germeraad, Evelien A / Hakze-van der Honing, Renate W / van der Most, Marleen / Rodenboog, Henk / Velkers, Francisca C

Pathogens (Basel, Switzerland)

2022 Volume 11, Issue 12

Abstract: Wind-supported transport of particle matter (PM) contaminated with excreta from highly pathogenic avian influenza virus (HPAIv)-infected wild birds may be a HPAIv-introduction pathway, which may explain infections in indoor-housed poultry. The primary ... ...

Abstract	Wind-supported transport of particle matter (PM) contaminated with excreta from highly pathogenic avian influenza virus (HPAIv)-infected wild birds may be a HPAIv-introduction pathway, which may explain infections in indoor-housed poultry. The primary objective of our study was therefore to measure the nature and quantity of PM entering poultry houses via air-inlets. The air-inlets of two recently HPAIv-infected poultry farms (a broiler farm and a layer farm) were equipped with mosquito-net collection bags. PM was harvested every 5 days for 25 days. Video-camera monitoring registered wild bird visits. PM was tested for avian influenza viruses (AIV),
Language	English
Publishing date	2022-12-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens11121534
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Author Correction: "World in motion" - emulsion adjuvants rising to meet the pandemic challenges.

O'Hagan, Derek T / van der Most, Robbert / Lodaya, Rushit N / Coccia, Margherita / Lofano, Giuseppe

NPJ vaccines

2023 Volume 8, Issue 1, Page(s) 7

Language	English
Publishing date	2023-02-02
Publishing country	England
Document type	Published Erratum
ISSN	2059-0105
ISSN (online)	2059-0105
DOI	10.1038/s41541-023-00601-5
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Article ; Online: Monitoring Wind-Borne Particle Matter Entering Poultry Farms via the Air-Inlet

Elbers, Armin R.W. / Gonzales, José L. / Koene, Miriam G.J. / Germeraad, Evelien A. / Hakze-van der Honing, Renate W. / van der Most, Marleen / Rodenboog, Henk / Velkers, Francisca C.

Pathogens

Highly Pathogenic Avian Influenza Virus and Other Pathogens Risk

2022 Volume 11, Issue 12

Abstract: ... amounts entered the air-inlets, mostly cobweb and plant material, but no wild bird feathers. Substantial ...

Abstract	Wind-supported transport of particle matter (PM) contaminated with excreta from highly pathogenic avian influenza virus (HPAIv)-infected wild birds may be a HPAIv-introduction pathway, which may explain infections in indoor-housed poultry. The primary objective of our study was therefore to measure the nature and quantity of PM entering poultry houses via air-inlets. The air-inlets of two recently HPAIv-infected poultry farms (a broiler farm and a layer farm) were equipped with mosquito-net collection bags. PM was harvested every 5 days for 25 days. Video-camera monitoring registered wild bird visits. PM was tested for avian influenza viruses (AIV), Campylobacter and Salmonella with PCR. Insects, predominantly mosquitoes, were tested for AIV, West Nile, Usutu and Schmallenberg virus. A considerable number of mosquitoes and small PM amounts entered the air-inlets, mostly cobweb and plant material, but no wild bird feathers. Substantial variation in PM entering between air-inlets existed. In stormy periods, significantly larger PM amounts may enter wind-directed air-inlets. PM samples were AIV and Salmonella negative and insect samples were negative for all viruses and bacteria, but several broiler and layer farm PM samples tested Campylobacter positive. Regular wild (water) bird visits were observed near to the poultry houses. Air-borne PM and insects—potentially contaminated with HPAIv or other pathogens—can enter poultry air-inlets. Implementation of measures limiting this potential introduction route are recommended.
Keywords	Campylobacter ; Salmonella ; avian influenza virus ; bird feathers ; cobweb ; faecal material ; highly pathogenic avian influenza ; insects ; particle matter ; plant ; wild aquatic avian species
Subject code	333
Language	English
Publishing country	nl
Document type	Article ; Online
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Novel Technologies to Improve Vaccines for Older Adults.

Laupèze, Béatrice / van der Most, Robbert / Del Giudice, Giuseppe

Interdisciplinary topics in gerontology and geriatrics

2020 Volume 43, Page(s) 218–233

Abstract: Vaccine development has traditionally been driven by the need to prevent high numbers of childhood deaths due to infectious disease. With few exceptions, vaccines for adults are the same as vaccines for infants, although it has long been apparent that ... ...

Abstract	Vaccine development has traditionally been driven by the need to prevent high numbers of childhood deaths due to infectious disease. With few exceptions, vaccines for adults are the same as vaccines for infants, although it has long been apparent that they become less effective as age increases. It is only in the last few years that concerted efforts have commenced to develop life-long vaccination strategies through into older age. Impressive progress has been made in the field of vaccine technologies which, when they will be applied to vaccination of older adults, could change the landscape for disease prevention in this age group. The recently licensed adjuvanted herpes zoster vaccine shows that immunosenescence need not be a barrier to highly effective vaccination, and that highly effective vaccines for older adults can be achieved with good vaccine design. One of the greatest public health challenges of the 21st century is ensuring the health and well-being of the aged. New or improved vaccines targeting pathogens with a high disease burden in older adults have the potential to major contributions to the longevity and productivity of the older aged population.
MeSH term(s)	Adjuvants, Immunologic/standards ; Aged ; Aged, 80 and over ; Communicable Diseases/immunology ; Herpes Zoster/prevention & control ; Herpes Zoster Vaccine/therapeutic use ; Humans ; Immunosenescence/immunology ; Middle Aged ; Vaccination ; Vaccines/standards
Chemical Substances	Adjuvants, Immunologic ; Herpes Zoster Vaccine ; Vaccines
Language	English
Publishing date	2020-04-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ISSN	2297-3486 ; 2297-3508
ISSN (online)	2297-3486
ISSN	2297-3508
DOI	10.1159/000504485
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Book ; Online: Nederland later II - thema klimaatadaptatie

Jeuken, A. / Wolters, H. / Schoonderwoerd, E. / van der Most, H. / Breman, B.C. / Sterk, M. / ter Maat, Judith / Hoogvliet, Marco / de Louw, P.G.B. / Mens, Marjolein / Delsman, Joost / van den Hurk, Bart J.J.M. / Haasnoot, M. / van der Brugge, Rutger

2021

Abstract: ... aandacht voor droogte en watertekorten i.r.t. verdroging, verzilting en bodemdaling. • Het stedelijke ... Doel van de voorliggende studie naar klimaatadaptatie is om de ernst en urgentie van ...

Abstract	Doel van de voorliggende studie naar klimaatadaptatie is om de ernst en urgentie van klimaatverandering, de mogelijke aanpassingsmogelijkheden en de effectiviteit, betaalbaarheid en haalbaarheid daarvan op een rij te zetten voor: • Het landelijke gebied, opgesplitst naar hoog- en laag Nederland en met aandacht voor droogte en watertekorten i.r.t. verdroging, verzilting en bodemdaling. • Het stedelijke gebied met aandacht voor droogte, hittestress en wateroverlast • Het rivierengebied specifiek voor transport over water • Waterveiligheid landelijk.
Keywords	Life Science
Language	Dutch
Publisher	Deltares
Publishing country	nl
Document type	Book ; Online
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Article ; Online: Vaccination as a preventative measure contributing to immune fitness.

Laupèze, Béatrice / Del Giudice, Giuseppe / Doherty, Mark T / Van der Most, Robbert

NPJ vaccines

2021 Volume 6, Issue 1, Page(s) 93

Abstract: The primary goal of vaccination is the prevention of pathogen-specific infection. The indirect consequences may include maintenance of homeostasis through prevention of infection-induced complications; trained immunity that re-programs innate cells to ... ...

Abstract	The primary goal of vaccination is the prevention of pathogen-specific infection. The indirect consequences may include maintenance of homeostasis through prevention of infection-induced complications; trained immunity that re-programs innate cells to respond more efficiently to later, unrelated threats; slowing or reversing immune senescence by altering the epigenetic clock, and leveraging the pool of memory B and T cells to improve responses to new infections. Vaccines may exploit the plasticity of the immune system to drive longer-term immune responses that promote health at a broader level than just the prevention of single, specific infections. In this perspective, we discuss the concept of "immune fitness" and how to potentially build a resilient immune system that could contribute to better health. We argue that vaccines may contribute positively to immune fitness in ways that are only beginning to be understood, and that life-course vaccination is a fundamental tool for achieving healthy aging.
Language	English
Publishing date	2021-07-27
Publishing country	England
Document type	Journal Article ; Review
ISSN	2059-0105
ISSN (online)	2059-0105
DOI	10.1038/s41541-021-00354-z
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Article ; Online: "World in motion" - emulsion adjuvants rising to meet the pandemic challenges.

O'Hagan, Derek T / van der Most, Robbert / Lodaya, Rushit N / Coccia, Margherita / Lofano, Giuseppe

NPJ vaccines

2021 Volume 6, Issue 1, Page(s) 158

Abstract: Emulsion adjuvants such as MF59 and AS03 have been used for more than two decades as key components of licensed vaccines, with over 100 million doses administered to diverse populations in more than 30 countries. Substantial clinical experience of ... ...

Abstract	Emulsion adjuvants such as MF59 and AS03 have been used for more than two decades as key components of licensed vaccines, with over 100 million doses administered to diverse populations in more than 30 countries. Substantial clinical experience of effectiveness and a well-established safety profile, along with the ease of manufacturing have established emulsion adjuvants as one of the leading platforms for the development of pandemic vaccines. Emulsion adjuvants allow for antigen dose sparing, more rapid immune responses, and enhanced quality and quantity of adaptive immune responses. The mechanisms of enhancement of immune responses are well defined and typically characterized by the creation of an "immunocompetent environment" at the site of injection, followed by the induction of strong and long-lasting germinal center responses in the draining lymph nodes. As a result, emulsion adjuvants induce distinct immunological responses, with a mixed Th1/Th2 T cell response, long-lived plasma cells, an expanded repertoire of memory B cells, and high titers of cross-neutralizing polyfunctional antibodies against viral variants. Because of these various properties, emulsion adjuvants were included in pandemic influenza vaccines deployed during the 2009 H1N1 influenza pandemic, are still included in seasonal influenza vaccines, and are currently at the forefront of the development of vaccines against emerging SARS-CoV-2 pandemic variants. Here, we comprehensively review emulsion adjuvants, discuss their mechanism of action, and highlight their profile as a benchmark for the development of additional vaccine adjuvants and as a valuable tool to allow further investigations of the general principles of human immunity.
Language	English
Publishing date	2021-12-21
Publishing country	England
Document type	Journal Article ; Review
ISSN	2059-0105
ISSN (online)	2059-0105
DOI	10.1038/s41541-021-00418-0
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Article ; Online: Identification and single-base gene-editing functional validation of a cis-EPO variant as a genetic predictor for EPO-increasing therapies.

Harlow, Charli E / Gandawijaya, Josan / Bamford, Rosemary A / Martin, Emily-Rose / Wood, Andrew R / van der Most, Peter J / Tanaka, Toshiko / Leonard, Hampton L / Etheridge, Amy S / Innocenti, Federico / Beaumont, Robin N / Tyrrell, Jessica / Nalls, Mike A / Simonsick, Eleanor M / Garimella, Pranav S / Shiroma, Eric J / Verweij, Niek / van der Meer, Peter / Gansevoort, Ron T /

Snieder, Harold / Gallins, Paul J / Jima, Dereje D / Wright, Fred / Zhou, Yi-Hui / Ferrucci, Luigi / Bandinelli, Stefania / Hernandez, Dena G / van der Harst, Pim / Patel, Vickas V / Waterworth, Dawn M / Chu, Audrey Y / Oguro-Ando, Asami / Frayling, Timothy M

American journal of human genetics

2022 Volume 109, Issue 9, Page(s) 1638–1652

Abstract: ... this variant as most likely causal in controlling EPO levels by using genetic and functional approaches ...

Abstract	Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) are currently under clinical development for treating anemia in chronic kidney disease (CKD), but it is important to monitor their cardiovascular safety. Genetic variants can be used as predictors to help inform the potential risk of adverse effects associated with drug treatments. We therefore aimed to use human genetics to help assess the risk of adverse cardiovascular events associated with therapeutically altered EPO levels to help inform clinical trials studying the safety of HIF-PHIs. By performing a genome-wide association meta-analysis of EPO (n = 6,127), we identified a cis-EPO variant (rs1617640) lying in the EPO promoter region. We validated this variant as most likely causal in controlling EPO levels by using genetic and functional approaches, including single-base gene editing. Using this variant as a partial predictor for therapeutic modulation of EPO and large genome-wide association data in Mendelian randomization tests, we found no evidence (at p < 0.05) that genetically predicted long-term rises in endogenous EPO, equivalent to a 2.2-unit increase, increased risk of coronary artery disease (CAD, OR [95% CI] = 1.01 [0.93, 1.07]), myocardial infarction (MI, OR [95% CI] = 0.99 [0.87, 1.15]), or stroke (OR [95% CI] = 0.97 [0.87, 1.07]). We could exclude increased odds of 1.15 for cardiovascular disease for a 2.2-unit EPO increase. A combination of genetic and functional studies provides a powerful approach to investigate the potential therapeutic profile of EPO-increasing therapies for treating anemia in CKD.
MeSH term(s)	Anemia/drug therapy ; Anemia/genetics ; Coronary Artery Disease/genetics ; Genome-Wide Association Study ; Humans ; Mendelian Randomization Analysis ; Myocardial Infarction/genetics ; Renal Insufficiency, Chronic/genetics
Language	English
Publishing date	2022-09-02
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	219384-x
ISSN	1537-6605 ; 0002-9297
ISSN (online)	1537-6605
ISSN	0002-9297
DOI	10.1016/j.ajhg.2022.08.004
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Article ; Online: Systems serology-based comparison of antibody effector functions induced by adjuvanted vaccines to guide vaccine design.

Loos, Carolin / Coccia, Margherita / Didierlaurent, Arnaud M / Essaghir, Ahmed / Fallon, Jonathan K / Lauffenburger, Douglas / Luedemann, Corinne / Michell, Ashlin / van der Most, Robbert / Zhu, Alex Lee / Alter, Galit / Burny, Wivine

NPJ vaccines

2023 Volume 8, Issue 1, Page(s) 34

Abstract: The mechanisms by which antibodies confer protection vary across vaccines, ranging from simple neutralization to functions requiring innate immune recruitment via Fc-dependent mechanisms. The role of adjuvants in shaping the maturation of antibody- ... ...

Abstract	The mechanisms by which antibodies confer protection vary across vaccines, ranging from simple neutralization to functions requiring innate immune recruitment via Fc-dependent mechanisms. The role of adjuvants in shaping the maturation of antibody-effector functions remains under investigated. Using systems serology, we compared adjuvants in licensed vaccines (AS01
Language	English
Publishing date	2023-03-08
Publishing country	England
Document type	Journal Article
ISSN	2059-0105
ISSN (online)	2059-0105
DOI	10.1038/s41541-023-00613-1
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Article ; Online: No Consistent Evidence of Decreased Exposure to Varicella-Zoster Virus Among Older Adults in Countries with Universal Varicella Vaccination.

Carryn, Stephane / Cheuvart, Brigitte / Povey, Michael / Dagnew, Alemnew F / Harpaz, Rafael / van der Most, Robbert / Casabona, Giacomo

The Journal of infectious diseases

2021 Volume 225, Issue 3, Page(s) 413–421

Abstract: Background: Universal varicella vaccination might reduce opportunities for varicella-zoster virus (VZV) exposure and protective immunological boosting, thus increasing herpes zoster incidence in latently infected adults. We assessed humoral and cell- ... ...

Abstract	Background: Universal varicella vaccination might reduce opportunities for varicella-zoster virus (VZV) exposure and protective immunological boosting, thus increasing herpes zoster incidence in latently infected adults. We assessed humoral and cell-mediated immunity (CMI), as markers of VZV exposure, in adults aged ≥50 years. Methods: We repurposed data from placebo recipients in a large multinational clinical trial (ZOE-50). Countries were clustered based on their varicella vaccination program characteristics, as having high, moderate, or low VZV circulation. Anti-VZV antibody geometric mean concentrations, median frequencies of VZV-specific CD4 T cells, and percentages of individuals with increases in VZV-specific CD4 T-cell frequencies were compared across countries and clusters. Sensitivity analyses using a variable number of time points and different thresholds were performed for CMI data. Results: VZV-specific humoral immunity from 17 countries (12 high, 2 moderate, 3 low circulation) varied significantly between countries (P < .0001) but not by VZV circulation. No significant differences were identified in VZV-specific CMI between participants from 2 high versus 1 low circulation country. In 3/5 sensitivity analyses, increases in CMI were more frequent in high VZV circulation countries (.03 ≤ P < .05). Conclusions: We found no consistent evidence of reduced VZV exposure among older adults in countries with universal varicella vaccination. Clinical trials registration: NCT01165177.
MeSH term(s)	Chickenpox/epidemiology ; Chickenpox/prevention & control ; Herpes Zoster/epidemiology ; Herpes Zoster/prevention & control ; Herpes Zoster Vaccine ; Herpesvirus 3, Human ; Humans ; Immunity, Cellular ; Middle Aged ; Vaccination
Chemical Substances	Herpes Zoster Vaccine
Language	English
Publishing date	2021-10-05
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Multicenter Study
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiab500
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