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Article: Endogenous PTEN acts as the key determinant for mTOR inhibitor sensitivity by inducing the stress-sensitized PTEN-mediated death axis in KSHV-associated malignant cells.

Das, Piyanki / Pal, Sonali / Das, Nilanjana / Chakraborty, Koushik / Chatterjee, Koustav / Mal, Sudipa / Choudhuri, Tathagata

Frontiers in molecular biosciences

2023 Volume 10, Page(s) 1062462

Abstract: As a part of viral cancer evolution, KSHV-infected human endothelial cells exert a unique transcriptional ... ...

Abstract	As a part of viral cancer evolution, KSHV-infected human endothelial cells exert a unique transcriptional program
Language	English
Publishing date	2023-08-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2814330-9
ISSN	2296-889X
ISSN	2296-889X
DOI	10.3389/fmolb.2023.1062462
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Synthetic antioxidants from a natural source can overtake the oncogenic stress management system and activate the stress‑sensitized death of KSHV‑infected cancer cells.

Das, Piyanki / Brahmachari, Goutam / Chatterjee, Koustav / Choudhuri, Tathagata

International journal of molecular medicine

2022 Volume 50, Issue 3

Abstract: Synthetic and modified natural derivatives are reported as potential bioactive compounds and are being used therapeutically against various diseases in a widespread manner nowadays. Cancerous cells exhibit high levels of reactive oxygen species (ROS) ... ...

Abstract	Synthetic and modified natural derivatives are reported as potential bioactive compounds and are being used therapeutically against various diseases in a widespread manner nowadays. Cancerous cells exhibit high levels of reactive oxygen species (ROS) internally, and thus successfully manage to sustain themselves and proliferate via antioxidative mechanisms that maintain a redox balance. On this note, various antioxidants are applied as anticancer compounds, which strategically affects the ongoing oncogenic stress management system in both a pro‑ and antioxidative manner, resulting in cancer restriction, as well as sustaining cell proliferation via antioxidative mechanisms that promote cancer progression. Alike non‑viral cancers, viral cancers exhibit varying levels of ROS during different stages of cancer progression. Hence, successful stress balance should be addressed, depending on the cancer cell stress response during the therapeutic management. The application of antioxidants is crucial and needs to be carefully designed in such cases; the respective underlying mechanisms are less understood. The role of antioxidants controlling the varied levels of stress response at different stages of Kaposi's sarcoma‑associated herpes virus malignancy have not been fully reported. Therefore, the present study aimed to analyze the activity of certain antioxidants in KSHV‑infected oncogenic cells. For this purpose, two naturally derived flavonoid‑based antioxidants (theaflavin and novel curcumin derivatives) were selected and tested in different KSHV‑infected cell lines. The findings presented herein demonstrate that these compounds can successfully induce the death of different KSHV‑positive cells and can restrict the growth of KSHV‑infected cell lines restricting viral reactivation by counteracting the oncogenic stress management system.
MeSH term(s)	Antioxidants/metabolism ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Carcinogenesis ; Herpesvirus 8, Human/metabolism ; Humans ; Neoplasms/metabolism ; Oxidation-Reduction ; Oxidative Stress ; Reactive Oxygen Species/metabolism
Chemical Substances	Antioxidants ; Reactive Oxygen Species
Language	English
Publishing date	2022-07-20
Publishing country	Greece
Document type	Journal Article
ZDB-ID	1444428-8
ISSN	1791-244X ; 1107-3756
ISSN (online)	1791-244X
ISSN	1107-3756
DOI	10.3892/ijmm.2022.5173
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Article: Decoding the global outbreak of COVID-19: the nature is behind the scene.

Das, Piyanki / Choudhuri, Tathagata

Virusdisease

2020 Volume 31, Issue 2, Page(s) 106–112

Abstract: The sudden emergence of SARS-CoV-2 causing the global pandemic is a major public health concern. Though the virus is considered as a novel entity, it is not a completely new member. It is just a new version of previously emerged human SARS corona virus. ... ...

Abstract	The sudden emergence of SARS-CoV-2 causing the global pandemic is a major public health concern. Though the virus is considered as a novel entity, it is not a completely new member. It is just a new version of previously emerged human SARS corona virus. The rapid evolving nature by changing host body environment and extreme environmental stability, collectively makes SARS-CoV-2 into an extremely virulent genetic variant. The evolution of the virus has been occurred by the continuous process of molecular genetic manipulation, through mutation, deletion and genetic recombinationevents. Different host body environment acts as the supportive system for the pathogen which creates extreme selective pressure. By the process of genetic evolution the pathogen developes new characters. Then the new version of the virus has been naturally selected by susceptible human host and adapt itself inside the host body causing deadly effect. Moreover, extreme environmental stability helps in the process of viral survival outside the host and its transmission. Thus both the host body or internal environment and the external environment performs equally as a source, responsible for shaping the genetic evolution of the SARS-CoV-2 towards theCOVID-19 disease fitness in nature in a pandemic form.
Keywords	covid19
Language	English
Publishing date	2020-06-22
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2846993-8
ISSN	2347-3517 ; 2347-3584
ISSN (online)	2347-3517
ISSN	2347-3584
DOI	10.1007/s13337-020-00605-y
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Article ; Online: Decoding the global outbreak of COVID-19

Das, Piyanki / Choudhuri, Tathagata

VirusDisease

the nature is behind the scene

2020 Volume 31, Issue 2, Page(s) 106–112

Keywords	Virology ; Infectious Diseases ; covid19
Language	English
Publisher	Springer Science and Business Media LLC
Publishing country	us
Document type	Article ; Online
ZDB-ID	2846993-8
ISSN	2347-3517 ; 2347-3584
ISSN (online)	2347-3517
ISSN	2347-3584
DOI	10.1007/s13337-020-00605-y
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Article: Decoding the global outbreak of COVID-19: the nature is behind the scene

Das, Piyanki / Choudhuri, Tathagata

Virusdisease. 2020 June, v. 31, no. 2

2020

Abstract	The sudden emergence of SARS-CoV-2 causing the global pandemic is a major public health concern. Though the virus is considered as a novel entity, it is not a completely new member. It is just a new version of previously emerged human SARS corona virus. The rapid evolving nature by changing host body environment and extreme environmental stability, collectively makes SARS-CoV-2 into an extremely virulent genetic variant. The evolution of the virus has been occurred by the continuous process of molecular genetic manipulation, through mutation, deletion and genetic recombinationevents. Different host body environment acts as the supportive system for the pathogen which creates extreme selective pressure. By the process of genetic evolution the pathogen developes new characters. Then the new version of the virus has been naturally selected by susceptible human host and adapt itself inside the host body causing deadly effect. Moreover, extreme environmental stability helps in the process of viral survival outside the host and its transmission. Thus both the host body or internal environment and the external environment performs equally as a source, responsible for shaping the genetic evolution of the SARS-CoV-2 towards theCOVID-19 disease fitness in nature in a pandemic form.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; evolution ; genetic engineering ; humans ; mutation ; pandemic ; pathogens ; public health ; virulence ; viruses
Language	English
Dates of publication	2020-06
Size	p. 106-112.
Publishing place	Springer India
Document type	Article
Note	Review
ZDB-ID	2846993-8
ISSN	2347-3517 ; 2347-3584
ISSN (online)	2347-3517
ISSN	2347-3584
DOI	10.1007/s13337-020-00605-y
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Article: Decoding the global outbreak of COVID-19: the nature is behind the scene

Das, Piyanki / Choudhuri, Tathagata

VirusDisease

Abstract	The sudden emergence of SARS-CoV-2 causing the global pandemic is a major public health concern. Though the virus is considered as a novel entity, it is not a completely new member. It is just a new version of previously emerged human SARS corona virus. The rapid evolving nature by changing host body environment and extreme environmental stability, collectively makes SARS-CoV-2 into an extremely virulent genetic variant. The evolution of the virus has been occurred by the continuous process of molecular genetic manipulation, through mutation, deletion and genetic recombinationevents. Different host body environment acts as the supportive system for the pathogen which creates extreme selective pressure. By the process of genetic evolution the pathogen developes new characters. Then the new version of the virus has been naturally selected by susceptible human host and adapt itself inside the host body causing deadly effect. Moreover, extreme environmental stability helps in the process of viral survival outside the host and its transmission. Thus both the host body or internal environment and the external environment performs equally as a source, responsible for shaping the genetic evolution of the SARS-CoV-2 towards theCOVID-19 disease fitness in nature in a pandemic form.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #610577
Database	COVID19

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Article: Kaposi's sarcoma-associated herpesvirus related malignancy in India, a rare but emerging member to be considered.

Das, Piyanki / Chattopadhyay, Nabanita Roy / Chatterjee, Koustav / Choudhuri, Tathagata

Virusdisease

2020 Volume 31, Issue 3, Page(s) 209–219

Abstract: Kaposi's sarcoma-associated herpesvirus (KSHV) is associated with viral malignancy, related to HIV-AIDS. With a wide geographical discrimination in its occurrence, Asian countries shows low to moderate prevalence with higher occurrence in some particular ...

Abstract	Kaposi's sarcoma-associated herpesvirus (KSHV) is associated with viral malignancy, related to HIV-AIDS. With a wide geographical discrimination in its occurrence, Asian countries shows low to moderate prevalence with higher occurrence in some particular areas. India is one of the largest countries in Asia, having various geographical and cultural variations where KSHV has been considered as an unthinkable entity to cause any of its associated disease. India has been reported as a low prevalent zone for KSHV malignancy till date. Also there are no reports so far, describing the occurrence pattern of this malignancy. So this review approaches towards figuring out the tendency of prevalence pattern of this malignancy and associated risk factors found to be present in Indian population. From this study it is revealed that, KSHV related malignancy is a relatively newly reported and emerging disease in India and may exist in hidden pockets throughout India in association with tuberculosis. India shows prevalence in HIV-associated Kaposi's sarcoma in regions where socially discriminated LGBT (lesbian, gay, bisexual, and transgender) groups, unprotected sexual behavior and heterosexuality are the important risk factors for sexually transmitted viral diseases. Anti-retro viral therapy is not sufficient to combat the virus and may act adversely. On a note regarding the clinical representations of Kaposi's sarcoma, oral, mucosal, pleural and abdominal involvements are observed in worst cases and these can be considered as the main manifesting criteria for this malignancy among Indians.
Language	English
Publishing date	2020-03-22
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2846993-8
ISSN	2347-3517 ; 2347-3584
ISSN (online)	2347-3517
ISSN	2347-3584
DOI	10.1007/s13337-020-00573-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Evolutionary aspects of Parvovirus B-19V associated diseases and their pathogenesis patterns with an emphasis on vaccine development.

Das, Piyanki / Chatterjee, Koustav / Chattopadhyay, Nabanita Roy / Choudhuri, Tathagata

Virusdisease

2019 Volume 30, Issue 1, Page(s) 32–42

Abstract: Parvovirus B-19, a single human pathogenic member of the Parvoviridae family with it's small ssDNA and non-enveloped structure, is known to cause diseases in erythroid progenitor cells. But a wide range of clinical association of this virus with cells of ...

Abstract	Parvovirus B-19, a single human pathogenic member of the Parvoviridae family with it's small ssDNA and non-enveloped structure, is known to cause diseases in erythroid progenitor cells. But a wide range of clinical association of this virus with cells of non-erythroid origins has recently been discovered and many of those are being investigated for such association. Higher substitution rates in due course of evolution has been suggested for this cellular tropism and persistence. In this report, we have summarized the different disease manifestations of B-19 virus and have tried to find out a pattern of pathogenesis. Finally, we have focused on the vaccination strategies available against B-19 virus to correlate these with the mechanisms involved in various diseases caused by this virus.
Language	English
Publishing date	2019-03-26
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2846993-8
ISSN	2347-3517 ; 2347-3584
ISSN (online)	2347-3517
ISSN	2347-3584
DOI	10.1007/s13337-019-00525-6
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Article ; Online: Nm23-H1 induces apoptosis in primary effusion lymphoma cells via inhibition of NF-κB signaling through interaction with oncogenic latent protein vFLIP K13 of Kaposi's sarcoma-associated herpes virus.

Mohanty, Suchitra / Kumar, Amit / Das, Piyanki / Sahu, Sushil Kumar / Mukherjee, Ratnadeep / Ramachandranpillai, Rajagopal / Nair, Santhosh Sankaran / Choudhuri, Tathagata

Cellular oncology (Dordrecht)

2022 Volume 45, Issue 5, Page(s) 967–989

Abstract: Background: Primary effusion lymphoma (PEL) is an aggressive form of non-Hodgkin lymphoma of B cells caused by Kaposi's Sarcoma-associated Herpes Virus (KSHV). KSHV encoded latent and lytic antigens promote oncogenic transformation and evade apoptosis ... ...

Abstract	Background: Primary effusion lymphoma (PEL) is an aggressive form of non-Hodgkin lymphoma of B cells caused by Kaposi's Sarcoma-associated Herpes Virus (KSHV). KSHV encoded latent and lytic antigens promote oncogenic transformation and evade apoptosis through the modulation of various host cellular signaling pathways. Nm23-H1 is a known metastatic suppressor whose expression inversely correlates with the metastatic potential of different cancers. Here, we set out to assess the role of Nm23-H1 in PEL development. Methods: Flow cytometry and real-time PCR assays were performed for Nm23-H1 expression analysis. Induction of apoptosis was assessed using Western blotting and flow cytometry-based assays in Nm23-H1 overexpressing cells. Co-immunoprecipitation assays, confocal microscopy and imaging flow cytometry were performed to determine Nm23-H1 and vFLIP K13 protein-protein interaction. A PEL cell-induced xenograft model was established in non-obese diabetic/severely combined immunodeficient (NOD/SCID) mice to validate the effect of Nm23-H1 overexpression. Results: We found that Nm23-H1 expression was significantly downregulated both at transcriptional and protein levels in PEL cell lines and that its overexpression triggered mitochondrial-mediated caspase-dependent apoptosis. We revealed Nm23-H1 interacts with the latent protein vFLIP K13 and that Nm23-H1 overexpression leads to inhibition of vFLIP K13 driven nuclear factor-kappa B (NF-κB) signaling with concurrent inhibition of autocrine and paracrine growth factors and downregulation of latent KSHV antigens without induction of active lytic reactivation. We also confirmed the effects of Nm23-H1 overexpression in a PEL cell-induced xenograft model in NOD/SCID mice. Conclusion: Downregulation of Nm23-H1 expression in KSHV-infected PEL cells and its overexpression trigger apoptosis by impairing vFLIP K13-driven NF-κB signaling, suggesting therapeutic implications of Nm23-H1 for primary effusion lymphomas.
MeSH term(s)	Animals ; Humans ; Mice ; Apoptosis ; Herpesvirus 8, Human/metabolism ; Lymphoma, Primary Effusion/metabolism ; Mice, Inbred NOD ; Mice, SCID ; NF-kappa B/metabolism ; Oncogene Proteins/metabolism ; Sarcoma, Kaposi/metabolism ; Viral Proteins/metabolism
Chemical Substances	NF-kappa B ; Oncogene Proteins ; Viral Proteins
Language	English
Publishing date	2022-08-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2595109-9
ISSN	2211-3436 ; 1875-8606 ; 2211-3428
ISSN (online)	2211-3436
ISSN	1875-8606 ; 2211-3428
DOI	10.1007/s13402-022-00701-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 6908: Show issues

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Article: Kaposi’s sarcoma-associated herpesvirus related malignancy in India, a rare but emerging member to be considered

Das, Piyanki / Chattopadhyay, Nabanita Roy / Chatterjee, Koustav / Choudhuri, Tathagata

Virusdisease. 2020 Sept., v. 31, no. 3

2020

Abstract: Kaposi’s sarcoma-associated herpesvirus (KSHV) is associated with viral malignancy, related to HIV-AIDS. With a wide geographical discrimination in its occurrence, Asian countries shows low to moderate prevalence with higher occurrence in some particular ...

Abstract	Kaposi’s sarcoma-associated herpesvirus (KSHV) is associated with viral malignancy, related to HIV-AIDS. With a wide geographical discrimination in its occurrence, Asian countries shows low to moderate prevalence with higher occurrence in some particular areas. India is one of the largest countries in Asia, having various geographical and cultural variations where KSHV has been considered as an unthinkable entity to cause any of its associated disease. India has been reported as a low prevalent zone for KSHV malignancy till date. Also there are no reports so far, describing the occurrence pattern of this malignancy. So this review approaches towards figuring out the tendency of prevalence pattern of this malignancy and associated risk factors found to be present in Indian population. From this study it is revealed that, KSHV related malignancy is a relatively newly reported and emerging disease in India and may exist in hidden pockets throughout India in association with tuberculosis. India shows prevalence in HIV-associated Kaposi’s sarcoma in regions where socially discriminated LGBT (lesbian, gay, bisexual, and transgender) groups, unprotected sexual behavior and heterosexuality are the important risk factors for sexually transmitted viral diseases. Anti-retro viral therapy is not sufficient to combat the virus and may act adversely. On a note regarding the clinical representations of Kaposi’s sarcoma, oral, mucosal, pleural and abdominal involvements are observed in worst cases and these can be considered as the main manifesting criteria for this malignancy among Indians.
Keywords	Human gammaherpesvirus 8 ; disease transmission ; emerging diseases ; heterosexuality ; risk factors ; sarcoma ; social discrimination ; therapeutics ; tuberculosis ; viruses ; India
Language	English
Dates of publication	2020-09
Size	p. 209-219.
Publishing place	Springer India
Document type	Article
Note	Review
ZDB-ID	2846993-8
ISSN	2347-3517 ; 2347-3584
ISSN (online)	2347-3517
ISSN	2347-3584
DOI	10.1007/s13337-020-00573-3
Database	NAL-Catalogue (AGRICOLA)

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